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The map label for this gene is nudF [H]

Identifier: 125624847

GI number: 125624847

Start: 2055563

End: 2056147

Strand: Reverse

Name: nudF [H]

Synonym: llmg_2075

Alternate gene names: 125624847

Gene position: 2056147-2055563 (Counterclockwise)

Preceding gene: 125624848

Following gene: 125624846

Centisome position: 81.29

GC content: 36.24

Gene sequence:

>585_bases
ATGTTAAATTTTGATGATAAAAAATTTGAAGAAAAAACTTTGACTAGAGATGAAATTTTTCAAGGAAAGATTTTTCATGT
TGTGAGGGATACGGTTAGTTTGCCAGGAGGAACAGAAAGTTTTCGAGAACTTGTTTTTCATAATGGTGGAACGGCTATTG
CACCCGTTCACAATAATAAAATGATTTTGGTTGGTCAATATCGTAAGGCATTGGAAAAATTTATTTTTGAAATTCCGGCT
GGAAAGCTTGAAATAGGAGAAGAAAAAGACCCCAAGGCTGCTGCGCTTCGTGAACTTGAGGAAGAAACAGGCTACCGAGC
AGAAAATTTAACAGAAATCACAGCTTTTTATGGAACACCTGGTTTTTCATCAGAAAAAACTTATGTGTACTTCTCGTCAG
ACCTAACAAAGGTAGAGCATCCAAGACCCGCTGATGATGGAGAGTTTTTGGAACAAATTGAAGTTACTTTAAGCGAAGCG
AAAAGAATGATTGAACTTGAACAAATTGCCGATGCAAAAACAATTATGGCTATTTGGTATTGGGAAATGCAACACTTTAA
AAAGGAGGTTGAAGACAATGCCTAA

Upstream 100 bases:

>100_bases
TTTAAGATAATAAGAAAGAGTTTCTCGTGAAGCTCTTTCCTTCGATTTGATGAGAGGGAAATTTTACTTTTTCAAAAGTA
AATTCCATGGAAAGGGTACA

Downstream 100 bases:

>100_bases
ACCACTTTTAACGGATGAGGTAATTGAACAAGCAAACCAAGAGAAGAAAAATCTTGAACGTAGGCTTCAAAGAGAGCTTG
AAGAAGATACTGAAATTGCT

Product: ADP-ribose pyrophosphatase

Products: NA

Alternate protein names: ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ASPPase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase [H]

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MLNFDDKKFEEKTLTRDEIFQGKIFHVVRDTVSLPGGTESFRELVFHNGGTAIAPVHNNKMILVGQYRKALEKFIFEIPA
GKLEIGEEKDPKAAALRELEEETGYRAENLTEITAFYGTPGFSSEKTYVYFSSDLTKVEHPRPADDGEFLEQIEVTLSEA
KRMIELEQIADAKTIMAIWYWEMQHFKKEVEDNA

Sequences:

>Translated_194_residues
MLNFDDKKFEEKTLTRDEIFQGKIFHVVRDTVSLPGGTESFRELVFHNGGTAIAPVHNNKMILVGQYRKALEKFIFEIPA
GKLEIGEEKDPKAAALRELEEETGYRAENLTEITAFYGTPGFSSEKTYVYFSSDLTKVEHPRPADDGEFLEQIEVTLSEA
KRMIELEQIADAKTIMAIWYWEMQHFKKEVEDNA
>Mature_194_residues
MLNFDDKKFEEKTLTRDEIFQGKIFHVVRDTVSLPGGTESFRELVFHNGGTAIAPVHNNKMILVGQYRKALEKFIFEIPA
GKLEIGEEKDPKAAALRELEEETGYRAENLTEITAFYGTPGFSSEKTYVYFSSDLTKVEHPRPADDGEFLEQIEVTLSEA
KRMIELEQIADAKTIMAIWYWEMQHFKKEVEDNA

Specific function: Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004385
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: =3.6.1.13 [H]

Molecular weight: Translated: 22288; Mature: 22288

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNFDDKKFEEKTLTRDEIFQGKIFHVVRDTVSLPGGTESFRELVFHNGGTAIAPVHNNK
CCCCCCCHHHHHHCCHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEECCCC
MILVGQYRKALEKFIFEIPAGKLEIGEEKDPKAAALRELEEETGYRAENLTEITAFYGTP
EEEEHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCHHEEEEEECCC
GFSSEKTYVYFSSDLTKVEHPRPADDGEFLEQIEVTLSEAKRMIELEQIADAKTIMAIWY
CCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
WEMQHFKKEVEDNA
HHHHHHHHHHCCCC
>Mature Secondary Structure
MLNFDDKKFEEKTLTRDEIFQGKIFHVVRDTVSLPGGTESFRELVFHNGGTAIAPVHNNK
CCCCCCCHHHHHHCCHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEECCCC
MILVGQYRKALEKFIFEIPAGKLEIGEEKDPKAAALRELEEETGYRAENLTEITAFYGTP
EEEEHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCHHEEEEEECCC
GFSSEKTYVYFSSDLTKVEHPRPADDGEFLEQIEVTLSEAKRMIELEQIADAKTIMAIWY
CCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
WEMQHFKKEVEDNA
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10542272 [H]