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The map label for this gene is prsB [H]

Identifier: 125624818

GI number: 125624818

Start: 2030371

End: 2031336

Strand: Direct

Name: prsB [H]

Synonym: llmg_2046

Alternate gene names: 125624818

Gene position: 2030371-2031336 (Clockwise)

Preceding gene: 125624806

Following gene: 125624820

Centisome position: 80.27

GC content: 38.41

Gene sequence:

>966_bases
GTGGTTTACTCTGATTCACACTTAAAGCTTTTTGCCTTAAACTCAAACCCTGGTCTTGCTGAGAAAATTAGCCAATTTAC
AGGAGTTCCTCTAGGAAAACTTTCTTCAAAACAGTTTTCTGACGGTGAAATTATGATTAACATGGAAGAAAGTGTCCGTA
GTCAAGACATTTTCATCGTTCAATCAACCAGCTGCCCTGTTAATGATCACCTTTGGGAATTGCTTATCATGATTGATGCA
TGTAAACGTGCTTCTGCTCGTACGATTAACATCGTAATTCCTTACTTTGGCTATGCTCGTCAAGACCGTACTGCGACTTC
TCGTGAACCAATCACAGCAAAATTAGTTGCTGATATGATTGTTAAAGCTGGAGCTGACCGCGTACTCACTCTTGATATTC
ATGCTGTTCAGGTTCAAGGATTCTTCGATATTCCTGTAGATAATCTTTTCACTGTTCCACTTTTTGCTGATTACTATCGT
AAAAATGGTTTATTTGGTGACGATGTTATCGTTGTTGCTCCTAAAAATTCTGGTATCAAACGTGCACGTTCACTTGCTGA
ATACTTAGAATCAGCAATTGCCATTGTTGACTATGAAGATGATGATAAAAATCGTAAAAATGGTTATGTGATCGGTAATG
TTGCTGGTAAAAAAGTAATTCTTATTGATGATATCTTAAATACAGGGGTGACTTTTGCTAACGCTGCGAATGTCGTTCGC
GAAGCTGGAGCCAGCGAAATCTATGCTGTTGCCAGTCACGGATTATTCACAACAAATGCTGCTGATGTTCTTGAAAAAGC
AGACATAAAAGAAATCTTAGTAACAGACTCTGTAGTTACTGAGCACCGTAAGCCTTTGAACGTGAAATATTTAAGTGCCG
CTGAATACTTAGCTAGTGCAATTCTTCGTATTCATGAAGGACGTCCAGTTTCTCCACTTTTTGAACATGAAAAACCTCAA
GATTAA

Upstream 100 bases:

>100_bases
ATTAATTCACAAAGATATTTATCGATATAGACTATGAAAATCATCATATTTTTGCTAAAATAGAACTATATTATTTCATA
AAAGAAAATGGAGAGAAATC

Downstream 100 bases:

>100_bases
AAGAATTTTCTAATTTAAAACAATAAAAATACCAAGCTAGATTTGGTATTTTTATAATTCTTTTAGAAAAATAAAAAGTC
ATCTAATGACAACTTTTCTC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK 2; Phosphoribosyl pyrophosphate synthase 2; P-Rib-PP synthase 2; PRPP synthase 2 [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MVYSDSHLKLFALNSNPGLAEKISQFTGVPLGKLSSKQFSDGEIMINMEESVRSQDIFIVQSTSCPVNDHLWELLIMIDA
CKRASARTINIVIPYFGYARQDRTATSREPITAKLVADMIVKAGADRVLTLDIHAVQVQGFFDIPVDNLFTVPLFADYYR
KNGLFGDDVIVVAPKNSGIKRARSLAEYLESAIAIVDYEDDDKNRKNGYVIGNVAGKKVILIDDILNTGVTFANAANVVR
EAGASEIYAVASHGLFTTNAADVLEKADIKEILVTDSVVTEHRKPLNVKYLSAAEYLASAILRIHEGRPVSPLFEHEKPQ
D

Sequences:

>Translated_321_residues
MVYSDSHLKLFALNSNPGLAEKISQFTGVPLGKLSSKQFSDGEIMINMEESVRSQDIFIVQSTSCPVNDHLWELLIMIDA
CKRASARTINIVIPYFGYARQDRTATSREPITAKLVADMIVKAGADRVLTLDIHAVQVQGFFDIPVDNLFTVPLFADYYR
KNGLFGDDVIVVAPKNSGIKRARSLAEYLESAIAIVDYEDDDKNRKNGYVIGNVAGKKVILIDDILNTGVTFANAANVVR
EAGASEIYAVASHGLFTTNAADVLEKADIKEILVTDSVVTEHRKPLNVKYLSAAEYLASAILRIHEGRPVSPLFEHEKPQ
D
>Mature_321_residues
MVYSDSHLKLFALNSNPGLAEKISQFTGVPLGKLSSKQFSDGEIMINMEESVRSQDIFIVQSTSCPVNDHLWELLIMIDA
CKRASARTINIVIPYFGYARQDRTATSREPITAKLVADMIVKAGADRVLTLDIHAVQVQGFFDIPVDNLFTVPLFADYYR
KNGLFGDDVIVVAPKNSGIKRARSLAEYLESAIAIVDYEDDDKNRKNGYVIGNVAGKKVILIDDILNTGVTFANAANVVR
EAGASEIYAVASHGLFTTNAADVLEKADIKEILVTDSVVTEHRKPLNVKYLSAAEYLASAILRIHEGRPVSPLFEHEKPQ
D

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI28557709, Length=313, Percent_Identity=40.8945686900958, Blast_Score=242, Evalue=3e-64,
Organism=Homo sapiens, GI4506127, Length=313, Percent_Identity=40.5750798722045, Blast_Score=238, Evalue=4e-63,
Organism=Homo sapiens, GI4506129, Length=310, Percent_Identity=40, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI84875539, Length=313, Percent_Identity=39.6166134185303, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI4506133, Length=347, Percent_Identity=34.5821325648415, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI194018537, Length=345, Percent_Identity=34.7826086956522, Blast_Score=174, Evalue=7e-44,
Organism=Homo sapiens, GI310128524, Length=140, Percent_Identity=35, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI310115209, Length=140, Percent_Identity=35, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI310118259, Length=140, Percent_Identity=35, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI310119946, Length=140, Percent_Identity=35, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1787458, Length=314, Percent_Identity=45.2229299363057, Blast_Score=263, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI25149168, Length=313, Percent_Identity=39.6166134185303, Blast_Score=231, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17554702, Length=312, Percent_Identity=39.7435897435897, Blast_Score=231, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI71989924, Length=313, Percent_Identity=39.6166134185303, Blast_Score=230, Evalue=9e-61,
Organism=Caenorhabditis elegans, GI17554704, Length=310, Percent_Identity=39.6774193548387, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17570245, Length=341, Percent_Identity=31.6715542521994, Blast_Score=182, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6320946, Length=316, Percent_Identity=42.0886075949367, Blast_Score=240, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6319403, Length=312, Percent_Identity=41.3461538461538, Blast_Score=239, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6321776, Length=313, Percent_Identity=39.9361022364217, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6322667, Length=188, Percent_Identity=39.8936170212766, Blast_Score=155, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6324511, Length=98, Percent_Identity=41.8367346938776, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355239, Length=313, Percent_Identity=40.8945686900958, Blast_Score=238, Evalue=3e-63,
Organism=Drosophila melanogaster, GI45551540, Length=336, Percent_Identity=38.0952380952381, Blast_Score=225, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24651458, Length=365, Percent_Identity=30.958904109589, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24651456, Length=365, Percent_Identity=30.958904109589, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI281362873, Length=365, Percent_Identity=30.6849315068493, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24651454, Length=365, Percent_Identity=30.6849315068493, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24651462, Length=202, Percent_Identity=36.1386138613861, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24651464, Length=202, Percent_Identity=36.1386138613861, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45552010, Length=200, Percent_Identity=36.5, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 35347; Mature: 35347

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYSDSHLKLFALNSNPGLAEKISQFTGVPLGKLSSKQFSDGEIMINMEESVRSQDIFIV
CCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHCCCCEEEEE
QSTSCPVNDHLWELLIMIDACKRASARTINIVIPYFGYARQDRTATSREPITAKLVADMI
ECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHH
VKAGADRVLTLDIHAVQVQGFFDIPVDNLFTVPLFADYYRKNGLFGDDVIVVAPKNSGIK
HHCCCCEEEEEEEEEEEEEEEEECCCCCEEEHHHHHHHHHHCCCCCCCEEEEECCCCCHH
RARSLAEYLESAIAIVDYEDDDKNRKNGYVIGNVAGKKVILIDDILNTGVTFANAANVVR
HHHHHHHHHHHHEEEEEECCCCCCCCCCEEEEECCCCEEEEEECHHHCCCCHHHHHHHHH
EAGASEIYAVASHGLFTTNAADVLEKADIKEILVTDSVVTEHRKPLNVKYLSAAEYLASA
HCCCCCEEEECCCCEEECCHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHH
ILRIHEGRPVSPLFEHEKPQD
HHHHCCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MVYSDSHLKLFALNSNPGLAEKISQFTGVPLGKLSSKQFSDGEIMINMEESVRSQDIFIV
CCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHCCCCEEEEE
QSTSCPVNDHLWELLIMIDACKRASARTINIVIPYFGYARQDRTATSREPITAKLVADMI
ECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHH
VKAGADRVLTLDIHAVQVQGFFDIPVDNLFTVPLFADYYRKNGLFGDDVIVVAPKNSGIK
HHCCCCEEEEEEEEEEEEEEEEECCCCCEEEHHHHHHHHHHCCCCCCCEEEEECCCCCHH
RARSLAEYLESAIAIVDYEDDDKNRKNGYVIGNVAGKKVILIDDILNTGVTFANAANVVR
HHHHHHHHHHHHEEEEEECCCCCCCCCCEEEEECCCCEEEEEECHHHCCCCHHHHHHHHH
EAGASEIYAVASHGLFTTNAADVLEKADIKEILVTDSVVTEHRKPLNVKYLSAAEYLASA
HCCCCCEEEECCCCEEECCHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHH
ILRIHEGRPVSPLFEHEKPQD
HHHHCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]