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The map label for this gene is yvbW [H]

Identifier: 125624786

GI number: 125624786

Start: 1997679

End: 1999052

Strand: Reverse

Name: yvbW [H]

Synonym: llmg_2011

Alternate gene names: 125624786

Gene position: 1999052-1997679 (Counterclockwise)

Preceding gene: 125624787

Following gene: 125624784

Centisome position: 79.03

GC content: 38.65

Gene sequence:

>1374_bases
ATGGAAAATTCTACAGGCTTGAAGTCTTCTTTAAAGACTCGCCACATTGTTATGCTCTCACTTGGGGGAGCGATTGGATC
AGGACTATTTTTAGGTTCTGGTAAAGTCATCGCACAAGCAGGGCCAAGTGTGCTGCTCTCCTACGTCTTAGCTGGGCTGA
CCCTTTATGTCGTCATGTATGGTGTTGGAAAAATGGTCATTCATCAAGATGACCATAAAGCTGGGATGGCTGGAGTTGTT
GCACCTTTTATTGGAGATCATTGGGCGCATTTTGCAGACTGGGTTTACTGGGCAACTTGGATGGCGGTCCTCATCGCAGA
AGAAGCGGGAGTTTCAACTTTCCTTGCTATACTGATTCCTGGCGTCCCACTTTGGGTTTTTGCTTTGGTTGTTGCGGTTC
TTGGAACGGCAATTAATCTTTGGTCAGTCAAAGCTTTTGCCGAAACGGAATATTGGTTGGCCTTTATCAAGGTCGCTGTT
ATCCTACTTTTGATTGCTTTGGGTATTTATTTATTGGTTATCAATGATGCTCATCTTGGTTTTGTTGCCGATAGTGCTCA
AAAAGTAACTACGAAAAGTACAGCACCAAGTTTTGCTCCAAATGGTTTTTCAGGATTTTTAACTTCACTATTAGTCGTTA
TTTTCTCATTTGGTGGTTCTGAATTGGCGGCCATTACAGTTGCTGAAACAGAAAATCCAAAAGTGGCTATTCCGAGAGCT
ATTCGAGGCGTTTTAATTCGGATTATTAGTTTTTATGTTATTCCAATCTTTTTATTCTTGCATTTATTGCCATGGAGCGA
AGTGTCAAATCCAGACGCCGCTAGTCCATTTGCGACAATTTTTGCTCGAGTTGGAATTCCTCACGCAGATAAAATTGTAC
TTGTAATTATTGTTATTGCTATTTTCTCAGCCGTGAATTCGGCAATTTATGCTACTTCACGTTCACTTTATTCTCGAATT
CAAGGTTCTAGCACTTATGTGGGTAAAAAATTAGGTAAATTATCAAAAAATCAGGTGCCAACGAATGCGATTTTAGTTTC
TTCATTTGTTCTATTTATCGGAGTTCTTTTATCAGCTGTTTTGGGTGATGGTTTCTGGCAATTTGTCGCTGGTTCAATCT
CATTTACCATTTCAATCGTATGGATTCTCTTATTAGTTGCTGCTTTAGTTTTGTATTTTAAACATAAAGAAGTCACAAAT
TGGTTTGTTAAATTGGCAACACTTGTAGTACTTATCGCTTTAAGCCTCGTGTTTATCATGCAAATTATCACAAATCCTTG
GACATTGTCCGTCTTTGCCTTGGTTATTTGCCTTTTGTCTTACTTTAGTTACCGCAAAAAAAAAAGCATAATAGAAAAAA
CATTCATTTTATAA

Upstream 100 bases:

>100_bases
TTAATCGTAAAGACCGACTCCAAGCAGGGTTTTGCTAGGTGACTGGAAGGTAACTTATAAAAGAAAGCTTTGCTTTCACA
CATTAGAAAAGAGGAATTTT

Downstream 100 bases:

>100_bases
TGAATGTTTTTATTTTTGCTTGGCTAAAAGATACTCTAAAAATTTTTCTTTAATCAAATTATTTTTGATAAGTTTCAATT
TTTGCTGACGAACAAGTTTA

Product: putative amino acid permease

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MENSTGLKSSLKTRHIVMLSLGGAIGSGLFLGSGKVIAQAGPSVLLSYVLAGLTLYVVMYGVGKMVIHQDDHKAGMAGVV
APFIGDHWAHFADWVYWATWMAVLIAEEAGVSTFLAILIPGVPLWVFALVVAVLGTAINLWSVKAFAETEYWLAFIKVAV
ILLLIALGIYLLVINDAHLGFVADSAQKVTTKSTAPSFAPNGFSGFLTSLLVVIFSFGGSELAAITVAETENPKVAIPRA
IRGVLIRIISFYVIPIFLFLHLLPWSEVSNPDAASPFATIFARVGIPHADKIVLVIIVIAIFSAVNSAIYATSRSLYSRI
QGSSTYVGKKLGKLSKNQVPTNAILVSSFVLFIGVLLSAVLGDGFWQFVAGSISFTISIVWILLLVAALVLYFKHKEVTN
WFVKLATLVVLIALSLVFIMQIITNPWTLSVFALVICLLSYFSYRKKKSIIEKTFIL

Sequences:

>Translated_457_residues
MENSTGLKSSLKTRHIVMLSLGGAIGSGLFLGSGKVIAQAGPSVLLSYVLAGLTLYVVMYGVGKMVIHQDDHKAGMAGVV
APFIGDHWAHFADWVYWATWMAVLIAEEAGVSTFLAILIPGVPLWVFALVVAVLGTAINLWSVKAFAETEYWLAFIKVAV
ILLLIALGIYLLVINDAHLGFVADSAQKVTTKSTAPSFAPNGFSGFLTSLLVVIFSFGGSELAAITVAETENPKVAIPRA
IRGVLIRIISFYVIPIFLFLHLLPWSEVSNPDAASPFATIFARVGIPHADKIVLVIIVIAIFSAVNSAIYATSRSLYSRI
QGSSTYVGKKLGKLSKNQVPTNAILVSSFVLFIGVLLSAVLGDGFWQFVAGSISFTISIVWILLLVAALVLYFKHKEVTN
WFVKLATLVVLIALSLVFIMQIITNPWTLSVFALVICLLSYFSYRKKKSIIEKTFIL
>Mature_457_residues
MENSTGLKSSLKTRHIVMLSLGGAIGSGLFLGSGKVIAQAGPSVLLSYVLAGLTLYVVMYGVGKMVIHQDDHKAGMAGVV
APFIGDHWAHFADWVYWATWMAVLIAEEAGVSTFLAILIPGVPLWVFALVVAVLGTAINLWSVKAFAETEYWLAFIKVAV
ILLLIALGIYLLVINDAHLGFVADSAQKVTTKSTAPSFAPNGFSGFLTSLLVVIFSFGGSELAAITVAETENPKVAIPRA
IRGVLIRIISFYVIPIFLFLHLLPWSEVSNPDAASPFATIFARVGIPHADKIVLVIIVIAIFSAVNSAIYATSRSLYSRI
QGSSTYVGKKLGKLSKNQVPTNAILVSSFVLFIGVLLSAVLGDGFWQFVAGSISFTISIVWILLLVAALVLYFKHKEVTN
WFVKLATLVVLIALSLVFIMQIITNPWTLSVFALVICLLSYFSYRKKKSIIEKTFIL

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of The Aromatic Amino Acids (Phenylalanine, Tyrosine, And Tryptophan). [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786302, Length=450, Percent_Identity=32, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1790653, Length=351, Percent_Identity=33.6182336182336, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1786789, Length=390, Percent_Identity=33.3333333333333, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1789017, Length=355, Percent_Identity=35.2112676056338, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI48994972, Length=407, Percent_Identity=32.1867321867322, Blast_Score=191, Evalue=7e-50,
Organism=Escherichia coli, GI87081708, Length=400, Percent_Identity=31.25, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1786602, Length=397, Percent_Identity=32.2418136020151, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI87081915, Length=404, Percent_Identity=29.9504950495049, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1788480, Length=358, Percent_Identity=30.7262569832402, Blast_Score=171, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6324990, Length=372, Percent_Identity=31.1827956989247, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6324061, Length=420, Percent_Identity=27.3809523809524, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6319824, Length=320, Percent_Identity=27.1875, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6320772, Length=369, Percent_Identity=28.9972899728997, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6322892, Length=329, Percent_Identity=30.3951367781155, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6324553, Length=329, Percent_Identity=31.306990881459, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6321053, Length=326, Percent_Identity=29.1411042944785, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320251, Length=364, Percent_Identity=27.1978021978022, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319542, Length=358, Percent_Identity=28.2122905027933, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320717, Length=361, Percent_Identity=26.8698060941828, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6324059, Length=378, Percent_Identity=29.6296296296296, Blast_Score=113, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6324924, Length=368, Percent_Identity=28.804347826087, Blast_Score=113, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6321629, Length=374, Percent_Identity=28.8770053475936, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6319543, Length=373, Percent_Identity=29.4906166219839, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322967, Length=383, Percent_Identity=27.154046997389, Blast_Score=103, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6319608, Length=383, Percent_Identity=24.8041775456919, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324981, Length=381, Percent_Identity=28.3464566929134, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320364, Length=282, Percent_Identity=27.3049645390071, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49432; Mature: 49432

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENSTGLKSSLKTRHIVMLSLGGAIGSGLFLGSGKVIAQAGPSVLLSYVLAGLTLYVVMY
CCCCCCCHHHHHHHEEEEEEECCHHHCCEEECCCCEEECCCHHHHHHHHHHHHHHHHHHH
GVGKMVIHQDDHKAGMAGVVAPFIGDHWAHFADWVYWATWMAVLIAEEAGVSTFLAILIP
HCCHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
GVPLWVFALVVAVLGTAINLWSVKAFAETEYWLAFIKVAVILLLIALGIYLLVINDAHLG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
FVADSAQKVTTKSTAPSFAPNGFSGFLTSLLVVIFSFGGSELAAITVAETENPKVAIPRA
EEECCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEECHHH
IRGVLIRIISFYVIPIFLFLHLLPWSEVSNPDAASPFATIFARVGIPHADKIVLVIIVIA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
IFSAVNSAIYATSRSLYSRIQGSSTYVGKKLGKLSKNQVPTNAILVSSFVLFIGVLLSAV
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
LGDGFWQFVAGSISFTISIVWILLLVAALVLYFKHKEVTNWFVKLATLVVLIALSLVFIM
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QIITNPWTLSVFALVICLLSYFSYRKKKSIIEKTFIL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MENSTGLKSSLKTRHIVMLSLGGAIGSGLFLGSGKVIAQAGPSVLLSYVLAGLTLYVVMY
CCCCCCCHHHHHHHEEEEEEECCHHHCCEEECCCCEEECCCHHHHHHHHHHHHHHHHHHH
GVGKMVIHQDDHKAGMAGVVAPFIGDHWAHFADWVYWATWMAVLIAEEAGVSTFLAILIP
HCCHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
GVPLWVFALVVAVLGTAINLWSVKAFAETEYWLAFIKVAVILLLIALGIYLLVINDAHLG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
FVADSAQKVTTKSTAPSFAPNGFSGFLTSLLVVIFSFGGSELAAITVAETENPKVAIPRA
EEECCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEECHHH
IRGVLIRIISFYVIPIFLFLHLLPWSEVSNPDAASPFATIFARVGIPHADKIVLVIIVIA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
IFSAVNSAIYATSRSLYSRIQGSSTYVGKKLGKLSKNQVPTNAILVSSFVLFIGVLLSAV
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
LGDGFWQFVAGSISFTISIVWILLLVAALVLYFKHKEVTNWFVKLATLVVLIALSLVFIM
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QIITNPWTLSVFALVICLLSYFSYRKKKSIIEKTFIL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]