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The map label for this gene is accC [H]

Identifier: 125624569

GI number: 125624569

Start: 1760411

End: 1761778

Strand: Reverse

Name: accC [H]

Synonym: llmg_1779

Alternate gene names: 125624569

Gene position: 1761778-1760411 (Counterclockwise)

Preceding gene: 125624570

Following gene: 125624568

Centisome position: 69.65

GC content: 38.96

Gene sequence:

>1368_bases
ATGTTTAATAAAATTTTGATTGCCAATCGTGGCGAAATTGCTGTAAGAATTATTCGTGCAGCTCGTGAATTAGGAGTGGG
TACAGTTGCCATTTATTCAACTGCAGACCGCGATGCTTTACATGTTCATTTAGCTGACGAAGCAATTTGTGTGGGCCCAG
CTAGAAGTACTGAGTCTTATCTTAATATGAATAACATTCTGTCAGCCGCTGTGGCAACAGGCGCACAAGCGATTCACCCA
GGTTTTGGATTCCTTTCTGAGAATTCAAAATTTGCTCGTCTTTGTGAAGAAATGAATATTAAATTTATCGGTCCGTCAGC
AAAAGTTATGGATATGATGGGTGATAAAATCAATGCTCGTGCAGAAATGATTAAAGCTGATGTTCCTGTAACACCGGGTT
CTGAGGGCGAAGTTCATACCACTGATGAAGCAGTAAAAATTGCTGAAGAAATTGGCTATCCAATCATGCTTAAAGCATCA
GCTGGTGGTGGTGGTAAAGGAATTCGTAAGGTTAATAATGTTGAGGAACTTGTTCCAGCATTTGAGGCAGCCCAAGCGGA
AGCACAAGCAGCTTTTGGTAATGGAGCCATGTTCATCGAACGAATGATTTTCCCAGCGCGTCATATTGAGGTTCAAATCT
TAGGAGATAGTCAAGGAAATGTGATTCATCTTGGTGAACGTGATTGTTCATTGCAAAGAAATAATCAAAAAGTTCTTGAA
GAATCTCCGTCAGTTGCAATTGGACACACTTTACGAAATGAAATAACAGCTGCGGCTGTTAAAGCTGCTCAGCATGTTTC
TTATGAAAATGCGGGAACCATTGAGTTCTTACTTGATGAATCTTCTGGTAAGTTTTATTTCATGGAAATGAACACACGTG
TTCAAGTTGAACATCCGGTCACAGAGTTTGTATCAGGTGTTGATATTGTAAAAGAACAAATTCGTGTAGCCAATGGCAAT
GAATTGTCTGTCAAGCAAGAAGATGTGACTTTTAGTGGACATGCAATTGAATGTCGAATTAATGCTGAAAATCCTAAATT
TAATTTTGCACCAAGTCCAGGAAAAATTACTAATCTTTTCTTGCCAAGTGGTGGAGTTGGTTTGCGGGTTGATAGCGCTA
TGTACAGTGGTTACAGCATTCCGCCATATTATGATAGTATGATTGCTAAAGTCATTGTTCATGGTGAAAATCGTTTTGAA
GCACTGATGAAAATGCAACGCGCCCTTCTTGAATTTGACGTTGAAGGGGTCATTACAAATGTTGATTTCCAACTAGAATT
AATTTCTGACCCACATGTTGTGGCAGGAGATTATGATACAAGCTTCTTAGGAAATGTTTTCTTACCAGAATATCAAAAAG
AAGATTAA

Upstream 100 bases:

>100_bases
CAAAAAATTGTTTTGTTGGGAATGACTTTCTTTTTTATCATTCCTTTCAAAACACCCATTGAGCAAAAGCTCGGGGTATT
TTCCCATATGGAGAACATCT

Downstream 100 bases:

>100_bases
TCAATAGATTAGTGACAGAATTGTCAGATGGCTTACAATTCATCTGTCAGTAAAATTTATAAAAAAATGAGAAAAGGATG
CAAAGATGGCTCTTTTCCAA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MFNKILIANRGEIAVRIIRAARELGVGTVAIYSTADRDALHVHLADEAICVGPARSTESYLNMNNILSAAVATGAQAIHP
GFGFLSENSKFARLCEEMNIKFIGPSAKVMDMMGDKINARAEMIKADVPVTPGSEGEVHTTDEAVKIAEEIGYPIMLKAS
AGGGGKGIRKVNNVEELVPAFEAAQAEAQAAFGNGAMFIERMIFPARHIEVQILGDSQGNVIHLGERDCSLQRNNQKVLE
ESPSVAIGHTLRNEITAAAVKAAQHVSYENAGTIEFLLDESSGKFYFMEMNTRVQVEHPVTEFVSGVDIVKEQIRVANGN
ELSVKQEDVTFSGHAIECRINAENPKFNFAPSPGKITNLFLPSGGVGLRVDSAMYSGYSIPPYYDSMIAKVIVHGENRFE
ALMKMQRALLEFDVEGVITNVDFQLELISDPHVVAGDYDTSFLGNVFLPEYQKED

Sequences:

>Translated_455_residues
MFNKILIANRGEIAVRIIRAARELGVGTVAIYSTADRDALHVHLADEAICVGPARSTESYLNMNNILSAAVATGAQAIHP
GFGFLSENSKFARLCEEMNIKFIGPSAKVMDMMGDKINARAEMIKADVPVTPGSEGEVHTTDEAVKIAEEIGYPIMLKAS
AGGGGKGIRKVNNVEELVPAFEAAQAEAQAAFGNGAMFIERMIFPARHIEVQILGDSQGNVIHLGERDCSLQRNNQKVLE
ESPSVAIGHTLRNEITAAAVKAAQHVSYENAGTIEFLLDESSGKFYFMEMNTRVQVEHPVTEFVSGVDIVKEQIRVANGN
ELSVKQEDVTFSGHAIECRINAENPKFNFAPSPGKITNLFLPSGGVGLRVDSAMYSGYSIPPYYDSMIAKVIVHGENRFE
ALMKMQRALLEFDVEGVITNVDFQLELISDPHVVAGDYDTSFLGNVFLPEYQKED
>Mature_455_residues
MFNKILIANRGEIAVRIIRAARELGVGTVAIYSTADRDALHVHLADEAICVGPARSTESYLNMNNILSAAVATGAQAIHP
GFGFLSENSKFARLCEEMNIKFIGPSAKVMDMMGDKINARAEMIKADVPVTPGSEGEVHTTDEAVKIAEEIGYPIMLKAS
AGGGGKGIRKVNNVEELVPAFEAAQAEAQAAFGNGAMFIERMIFPARHIEVQILGDSQGNVIHLGERDCSLQRNNQKVLE
ESPSVAIGHTLRNEITAAAVKAAQHVSYENAGTIEFLLDESSGKFYFMEMNTRVQVEHPVTEFVSGVDIVKEQIRVANGN
ELSVKQEDVTFSGHAIECRINAENPKFNFAPSPGKITNLFLPSGGVGLRVDSAMYSGYSIPPYYDSMIAKVIVHGENRFE
ALMKMQRALLEFDVEGVITNVDFQLELISDPHVVAGDYDTSFLGNVFLPEYQKED

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=447, Percent_Identity=48.7695749440716, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI65506442, Length=447, Percent_Identity=48.7695749440716, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI295821183, Length=447, Percent_Identity=48.7695749440716, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI116805327, Length=453, Percent_Identity=45.4746136865342, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI106049528, Length=446, Percent_Identity=46.6367713004484, Blast_Score=397, Evalue=1e-111,
Organism=Homo sapiens, GI106049295, Length=446, Percent_Identity=46.6367713004484, Blast_Score=397, Evalue=1e-111,
Organism=Homo sapiens, GI106049292, Length=446, Percent_Identity=46.6367713004484, Blast_Score=397, Evalue=1e-111,
Organism=Homo sapiens, GI38679960, Length=518, Percent_Identity=32.046332046332, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI38679977, Length=518, Percent_Identity=32.046332046332, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI38679967, Length=518, Percent_Identity=32.046332046332, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI38679974, Length=518, Percent_Identity=32.046332046332, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI38679971, Length=518, Percent_Identity=32.046332046332, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI134142062, Length=514, Percent_Identity=31.1284046692607, Blast_Score=226, Evalue=3e-59,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=52.7027027027027, Blast_Score=458, Evalue=1e-130,
Organism=Escherichia coli, GI1786216, Length=286, Percent_Identity=23.0769230769231, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=452, Percent_Identity=45.7964601769911, Blast_Score=408, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=47.427293064877, Blast_Score=401, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=453, Percent_Identity=45.0331125827815, Blast_Score=396, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI133931226, Length=484, Percent_Identity=30.7851239669421, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI71997168, Length=440, Percent_Identity=32.9545454545455, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71997163, Length=440, Percent_Identity=32.9545454545455, Blast_Score=216, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6319685, Length=454, Percent_Identity=42.9515418502203, Blast_Score=380, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6319695, Length=451, Percent_Identity=44.3458980044346, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6321376, Length=451, Percent_Identity=45.4545454545455, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323863, Length=462, Percent_Identity=30.7359307359307, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6324343, Length=502, Percent_Identity=31.8725099601594, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24651757, Length=446, Percent_Identity=44.1704035874439, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652212, Length=444, Percent_Identity=47.2972972972973, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652210, Length=444, Percent_Identity=47.2972972972973, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652214, Length=444, Percent_Identity=47.2972972972973, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI19921944, Length=444, Percent_Identity=47.2972972972973, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652216, Length=444, Percent_Identity=47.2972972972973, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI281363050, Length=444, Percent_Identity=47.2972972972973, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652224, Length=444, Percent_Identity=47.2972972972973, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652222, Length=444, Percent_Identity=47.2972972972973, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652220, Length=444, Percent_Identity=47.2972972972973, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652218, Length=444, Percent_Identity=47.2972972972973, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=42.6470588235294, Blast_Score=358, Evalue=4e-99,
Organism=Drosophila melanogaster, GI24586458, Length=511, Percent_Identity=31.5068493150685, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI161076407, Length=511, Percent_Identity=31.5068493150685, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24586460, Length=511, Percent_Identity=31.5068493150685, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI161076409, Length=511, Percent_Identity=31.5068493150685, Blast_Score=238, Evalue=6e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49558; Mature: 49558

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNKILIANRGEIAVRIIRAARELGVGTVAIYSTADRDALHVHLADEAICVGPARSTESY
CCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCEEEECCCCCCHHH
LNMNNILSAAVATGAQAIHPGFGFLSENSKFARLCEEMNIKFIGPSAKVMDMMGDKINAR
HHHHHHHHHHHHCCCHHCCCCCCEECCCCHHHHHHHHCCEEEECCCHHHHHHHCCCCCCC
AEMIKADVPVTPGSEGEVHTTDEAVKIAEEIGYPIMLKASAGGGGKGIRKVNNVEELVPA
HHHEEECCCCCCCCCCCEECCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCHHHHHHH
FEAAQAEAQAAFGNGAMFIERMIFPARHIEVQILGDSQGNVIHLGERDCSLQRNNQKVLE
HHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEEEECCCCCEEEECCCCCCCCCCCHHHHH
ESPSVAIGHTLRNEITAAAVKAAQHVSYENAGTIEFLLDESSGKFYFMEMNTRVQVEHPV
CCCCEEECHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEECCEEEEECCH
TEFVSGVDIVKEQIRVANGNELSVKQEDVTFSGHAIECRINAENPKFNFAPSPGKITNLF
HHHHHHHHHHHHHHEECCCCEEEEEECCEEECCCEEEEEEECCCCCEECCCCCCCEEEEE
LPSGGVGLRVDSAMYSGYSIPPYYDSMIAKVIVHGENRFEALMKMQRALLEFDVEGVITN
ECCCCCCEEECHHHHCCCCCCCHHHHHHHHHEECCCHHHHHHHHHHHHHHHCCCCEEEEE
VDFQLELISDPHVVAGDYDTSFLGNVFLPEYQKED
CEEEEEEECCCCEEECCCCCHHHCCCCCCCCCCCC
>Mature Secondary Structure
MFNKILIANRGEIAVRIIRAARELGVGTVAIYSTADRDALHVHLADEAICVGPARSTESY
CCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCEEEECCCCCCHHH
LNMNNILSAAVATGAQAIHPGFGFLSENSKFARLCEEMNIKFIGPSAKVMDMMGDKINAR
HHHHHHHHHHHHCCCHHCCCCCCEECCCCHHHHHHHHCCEEEECCCHHHHHHHCCCCCCC
AEMIKADVPVTPGSEGEVHTTDEAVKIAEEIGYPIMLKASAGGGGKGIRKVNNVEELVPA
HHHEEECCCCCCCCCCCEECCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCHHHHHHH
FEAAQAEAQAAFGNGAMFIERMIFPARHIEVQILGDSQGNVIHLGERDCSLQRNNQKVLE
HHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEEEECCCCCEEEECCCCCCCCCCCHHHHH
ESPSVAIGHTLRNEITAAAVKAAQHVSYENAGTIEFLLDESSGKFYFMEMNTRVQVEHPV
CCCCEEECHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEECCEEEEECCH
TEFVSGVDIVKEQIRVANGNELSVKQEDVTFSGHAIECRINAENPKFNFAPSPGKITNLF
HHHHHHHHHHHHHHEECCCCEEEEEECCEEECCCEEEEEEECCCCCEECCCCCCCEEEEE
LPSGGVGLRVDSAMYSGYSIPPYYDSMIAKVIVHGENRFEALMKMQRALLEFDVEGVITN
ECCCCCCEEECHHHHCCCCCCCHHHHHHHHHEECCCHHHHHHHHHHHHHHHCCCCEEEEE
VDFQLELISDPHVVAGDYDTSFLGNVFLPEYQKED
CEEEEEEECCCCEEECCCCCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]