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The map label for this gene is cysK [H]

Identifier: 125624565

GI number: 125624565

Start: 1756264

End: 1757184

Strand: Reverse

Name: cysK [H]

Synonym: llmg_1775

Alternate gene names: 125624565

Gene position: 1757184-1756264 (Counterclockwise)

Preceding gene: 125624566

Following gene: 125624564

Centisome position: 69.47

GC content: 37.79

Gene sequence:

>921_bases
ATGGTAAAAATTGTTGAAAATATTACTGAATTAGTTGGAAATAGTCCAATTATCAAACTAAAAAATGGTCCAGAAAATGG
AGCAGAAATTTATTTAAAACTTGAATATTTTAATCCTGGAGGTTCAGTTAAAGACCGGATTGCTTTACAAATGATTCGGC
AAGCCGAAGCAGATGGTCGCTTAAAAAAGGGAGGAACGATTGTTGAACCTACCTCTGGGAACACAGGAATTGGACTTGCC
ATGGCTGGTGCAGCTTTAGGCTATAATGTGGTTATTATCATGCCTGATAGTTACTCAAAAGAGCGTCGTCAGCTTATTCA
AGCTTATGGAGCAGAATTGATTTTGACTCCAGCAGCTGATGGCATCAAAGCTGCCATTGATTTAGGTCAAAAATTAGTTG
AAGAAAATGGTTGGTTTATGCCAATGCAATTTGAAAATCCAGCTAATTTAAAAGCCCATGAATTAACGACTGGTCCAGAA
ATAATTGAAGCATTTGGTGAAAATGGCCTGGACGCATTTGTTGCTTGTGCAGGCACTGGGGGTACAATTTCTGGCGTTTC
TCACTATCTTAAAAGTCAAAATTCTAAAATCAAAACTTTTGTTGTCGAACCGGCAGAATCACCAATTTTAACAGGAGGTG
AGAGTGGTCCACACCGCATTCAAGGAATTGGTATTCCATTTATGTCACCAAATTTAGATACAGAAGCTTATGATCGAGTA
ATTAATGTAACAAGTGATGAGGCTTTAGAGACCGCACGAAAAATAGGCAAAAATGAAGGATTTTTAGTAGGTATATCTTC
TGGCGCAGCAATTTGGGCAGCTTATGAATTGGCAAAAAAACTTGGCAAAGATCAAAAAGTTCTGGCTCTTTGTGCTGACA
ATGGTGAGCGTTATCTTTCAACAGAACTCTATGATTATTAA

Upstream 100 bases:

>100_bases
TTACTGACAGAAGTGCATACAATTCATCTATCTCCCGCCTCAAGCGCTCATTTGGTTGACTTGAACTGACACAAAGCTGT
CAGTAATTTAGGAATTAATT

Downstream 100 bases:

>100_bases
AACTTGGAATTTTCCAAGTTTTTTTGTCTTATGAGCAGTTTTCTGTACTTTTTGAGCTACGGATGTTAGAATGAGAATAG
ATTAAGAAGATTAAAGGAGG

Product: O-acetylserine sulfhydrylase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MVKIVENITELVGNSPIIKLKNGPENGAEIYLKLEYFNPGGSVKDRIALQMIRQAEADGRLKKGGTIVEPTSGNTGIGLA
MAGAALGYNVVIIMPDSYSKERRQLIQAYGAELILTPAADGIKAAIDLGQKLVEENGWFMPMQFENPANLKAHELTTGPE
IIEAFGENGLDAFVACAGTGGTISGVSHYLKSQNSKIKTFVVEPAESPILTGGESGPHRIQGIGIPFMSPNLDTEAYDRV
INVTSDEALETARKIGKNEGFLVGISSGAAIWAAYELAKKLGKDQKVLALCADNGERYLSTELYDY

Sequences:

>Translated_306_residues
MVKIVENITELVGNSPIIKLKNGPENGAEIYLKLEYFNPGGSVKDRIALQMIRQAEADGRLKKGGTIVEPTSGNTGIGLA
MAGAALGYNVVIIMPDSYSKERRQLIQAYGAELILTPAADGIKAAIDLGQKLVEENGWFMPMQFENPANLKAHELTTGPE
IIEAFGENGLDAFVACAGTGGTISGVSHYLKSQNSKIKTFVVEPAESPILTGGESGPHRIQGIGIPFMSPNLDTEAYDRV
INVTSDEALETARKIGKNEGFLVGISSGAAIWAAYELAKKLGKDQKVLALCADNGERYLSTELYDY
>Mature_306_residues
MVKIVENITELVGNSPIIKLKNGPENGAEIYLKLEYFNPGGSVKDRIALQMIRQAEADGRLKKGGTIVEPTSGNTGIGLA
MAGAALGYNVVIIMPDSYSKERRQLIQAYGAELILTPAADGIKAAIDLGQKLVEENGWFMPMQFENPANLKAHELTTGPE
IIEAFGENGLDAFVACAGTGGTISGVSHYLKSQNSKIKTFVVEPAESPILTGGESGPHRIQGIGIPFMSPNLDTEAYDRV
INVTSDEALETARKIGKNEGFLVGISSGAAIWAAYELAKKLGKDQKVLALCADNGERYLSTELYDY

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=316, Percent_Identity=37.0253164556962, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI295821200, Length=316, Percent_Identity=37.0253164556962, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI4557415, Length=316, Percent_Identity=37.0253164556962, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI11345492, Length=183, Percent_Identity=26.775956284153, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1788754, Length=315, Percent_Identity=45.0793650793651, Blast_Score=221, Evalue=4e-59,
Organism=Escherichia coli, GI2367138, Length=301, Percent_Identity=39.202657807309, Blast_Score=209, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17535051, Length=306, Percent_Identity=44.7712418300654, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI115535073, Length=307, Percent_Identity=46.9055374592834, Blast_Score=231, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17562970, Length=306, Percent_Identity=41.8300653594771, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI32566674, Length=301, Percent_Identity=41.5282392026578, Blast_Score=213, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI17561720, Length=306, Percent_Identity=40.8496732026144, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI32566672, Length=214, Percent_Identity=41.1214953271028, Blast_Score=153, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17534315, Length=319, Percent_Identity=35.423197492163, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25147552, Length=316, Percent_Identity=34.8101265822785, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17561716, Length=121, Percent_Identity=39.6694214876033, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71996324, Length=326, Percent_Identity=25.1533742331288, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321594, Length=320, Percent_Identity=39.375, Blast_Score=194, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6321449, Length=328, Percent_Identity=35.0609756097561, Blast_Score=139, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24643623, Length=315, Percent_Identity=37.1428571428571, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI20129101, Length=315, Percent_Identity=37.1428571428571, Blast_Score=174, Evalue=1e-43,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32752; Mature: 32752

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKIVENITELVGNSPIIKLKNGPENGAEIYLKLEYFNPGGSVKDRIALQMIRQAEADGR
CEEHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCC
LKKGGTIVEPTSGNTGIGLAMAGAALGYNVVIIMPDSYSKERRQLIQAYGAELILTPAAD
CCCCCEEEECCCCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCCCEEEEECCCC
GIKAAIDLGQKLVEENGWFMPMQFENPANLKAHELTTGPEIIEAFGENGLDAFVACAGTG
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCHHHHHHHCCCCCEEEEEECCCC
GTISGVSHYLKSQNSKIKTFVVEPAESPILTGGESGPHRIQGIGIPFMSPNLDTEAYDRV
CCHHHHHHHHHCCCCEEEEEEECCCCCCEEECCCCCCCEEEEECCCCCCCCCCHHHHHHE
INVTSDEALETARKIGKNEGFLVGISSGAAIWAAYELAKKLGKDQKVLALCADNGERYLS
EECCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEE
TELYDY
CCCCCC
>Mature Secondary Structure
MVKIVENITELVGNSPIIKLKNGPENGAEIYLKLEYFNPGGSVKDRIALQMIRQAEADGR
CEEHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCC
LKKGGTIVEPTSGNTGIGLAMAGAALGYNVVIIMPDSYSKERRQLIQAYGAELILTPAAD
CCCCCEEEECCCCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCCCEEEEECCCC
GIKAAIDLGQKLVEENGWFMPMQFENPANLKAHELTTGPEIIEAFGENGLDAFVACAGTG
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCHHHHHHHCCCCCEEEEEECCCC
GTISGVSHYLKSQNSKIKTFVVEPAESPILTGGESGPHRIQGIGIPFMSPNLDTEAYDRV
CCHHHHHHHHHCCCCEEEEEEECCCCCCEEECCCCCCCEEEEECCCCCCCCCCHHHHHHE
INVTSDEALETARKIGKNEGFLVGISSGAAIWAAYELAKKLGKDQKVLALCADNGERYLS
EECCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEE
TELYDY
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA