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The map label for this gene is noxC [H]

Identifier: 125624560

GI number: 125624560

Start: 1753404

End: 1755047

Strand: Reverse

Name: noxC [H]

Synonym: llmg_1770

Alternate gene names: 125624560

Gene position: 1755047-1753404 (Counterclockwise)

Preceding gene: 125624561

Following gene: 125624559

Centisome position: 69.38

GC content: 37.9

Gene sequence:

>1644_bases
ATGATAGAAAAAATATTAATTGTTGGCGGAGTTGCGGGTGGAATGTCAGCTGCAACCCGTTTGCGACGTCTTAACGAAAA
TGCAGAAATCATCGTTTTTGAAAAAGGCCCTTACGTTTCGTTTGCCAATTGTGGCTTACCTTACTATGTGGGGGGAGAAA
TTGCAGAGCGAGAAAAGTTAATTGTTCAATCTGCTAAAGCTCTAAAAAACCGTTTTAACCTAGAGGTGCGCGAAAATTCT
GAAGTTATTGCGATTGATAGTGAAGGAAAGAAAGTGACTGTAGTTTCAAACGGCGAAAGCTATGTTGAAAGCTATGATAA
ATTGATTCTTTCACCAGGGGCTAAACCCTTAATTCCACAAATCAAAGGTTTGAACCAAGCGACAAATGTTTTTAGCTTAC
GAAATATTCCTGATGTGGATAAAATAATGGCCTATTTGGCAGCAAAAGAGTCTAAAAGTGCAACAATTATTGGTGCTGGT
TTTATCGGCTTAGAAATGGCTGAAAATCTTGCTAAACGAGGGTTAAGTGTCACAATCGTCGAAAAAGCACCACATGTTTT
ACCAACCATTGATCGCGAAATGGCAGCTTTTGTCAATGAAGAATTAATTAAAAATAATCTTTCAGTAATGACAAATAGAG
GAGCTGTCGAATTTAAAAATGATGAAATTTTGCTAGATAATGGTGAAAGTCTGCAATCGGATTTAACGATTCTTTCTGTG
GGAATTCAGCCAGAAACGAGTCTAGCTAAAAGTGCGGGCATCAAATTAGGACTAAGAAATGCAATTCTTGTTGACGAACA
TTATGAAACATCGGTTAAGGATATTTACGCAGTAGGCGATGCCATTGTTGTCAAAAATCAATTAGGGCAGGATGCTTTAA
TTTCATTGGCTTCTCCAGCTAATCGTCAAGGGCGTCAGGTAGCCGATATCATTAGTGGATTATCAATTAAAAATCGCGGT
TCACTTGGAACGGCCATTGTCCGTGTTTTTGATTTGCAAGTGGCAAGTACAGGCCTTTCTGAGTTTCAGCTTAGAGGTTT
AAAGATTAATCATAAAATTGTTCATGTCACGGCAAATAATCACGCGGGATATTATCCAGATGCAACTTCTATTGTTTTGA
AATTAATTTTTGAACCAGAAAGTGGACAAATATTTGGTGCGCAAGCAATTGGTAAAGAAGGAGTAGATAAAAGAATTGAT
ATTTTATCTACGGCTATCAAAGCAAAACTAACCGTTTTTGATTTACCAGAATTGGAATTGACCTATGCCCCTCCTTTTGG
TTCAGCCAAAGACCCAGTAAATATGGCTGGCTATGCCGCAATAAACCTTCTCTTGGGGCAATCAGAAAATATTCAGTGGC
ATGAACTTGCGGCTGAATTAGCAAAAGGGAAAGTCTTACTTGATGTGAGAAAACCAAATGAGTTGGCAAAAGGGAAATTT
AAAAATTCTCAAAATATTCCACTTGATGACTTACGTGAGCGGCTAAATGAACTCGATAAAAAGACTGAATATATTGTTAG
CTGCCAGTCAGGACTTCGCTCTTACAATGCAGAACGTATTCTAAAACAAGAGGGCTACAAAGTGAAAAATTTGGATGGTG
CCTTTGGATTATACAGCAAAGTTACCAAGGAATTACTTGATTAG

Upstream 100 bases:

>100_bases
GAATGCGGTCAAAAAAAGCCTACAAAATATTAAACAAAGCTAATTATGATGTGACAAACGTAAATGGAGGAATGCGAGCT
TGGAGAGGGAAAATTAAAAA

Downstream 100 bases:

>100_bases
GGAGCGAAACAAGAAAAGGATGACTGATGAAAAAATATGACAAAAAAATGGAAAATCGCTTGAAACGAGCAACAGGACAA
CTCACAGGAATACTTAAGAT

Product: NADH oxidase

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MIEKILIVGGVAGGMSAATRLRRLNENAEIIVFEKGPYVSFANCGLPYYVGGEIAEREKLIVQSAKALKNRFNLEVRENS
EVIAIDSEGKKVTVVSNGESYVESYDKLILSPGAKPLIPQIKGLNQATNVFSLRNIPDVDKIMAYLAAKESKSATIIGAG
FIGLEMAENLAKRGLSVTIVEKAPHVLPTIDREMAAFVNEELIKNNLSVMTNRGAVEFKNDEILLDNGESLQSDLTILSV
GIQPETSLAKSAGIKLGLRNAILVDEHYETSVKDIYAVGDAIVVKNQLGQDALISLASPANRQGRQVADIISGLSIKNRG
SLGTAIVRVFDLQVASTGLSEFQLRGLKINHKIVHVTANNHAGYYPDATSIVLKLIFEPESGQIFGAQAIGKEGVDKRID
ILSTAIKAKLTVFDLPELELTYAPPFGSAKDPVNMAGYAAINLLLGQSENIQWHELAAELAKGKVLLDVRKPNELAKGKF
KNSQNIPLDDLRERLNELDKKTEYIVSCQSGLRSYNAERILKQEGYKVKNLDGAFGLYSKVTKELLD

Sequences:

>Translated_547_residues
MIEKILIVGGVAGGMSAATRLRRLNENAEIIVFEKGPYVSFANCGLPYYVGGEIAEREKLIVQSAKALKNRFNLEVRENS
EVIAIDSEGKKVTVVSNGESYVESYDKLILSPGAKPLIPQIKGLNQATNVFSLRNIPDVDKIMAYLAAKESKSATIIGAG
FIGLEMAENLAKRGLSVTIVEKAPHVLPTIDREMAAFVNEELIKNNLSVMTNRGAVEFKNDEILLDNGESLQSDLTILSV
GIQPETSLAKSAGIKLGLRNAILVDEHYETSVKDIYAVGDAIVVKNQLGQDALISLASPANRQGRQVADIISGLSIKNRG
SLGTAIVRVFDLQVASTGLSEFQLRGLKINHKIVHVTANNHAGYYPDATSIVLKLIFEPESGQIFGAQAIGKEGVDKRID
ILSTAIKAKLTVFDLPELELTYAPPFGSAKDPVNMAGYAAINLLLGQSENIQWHELAAELAKGKVLLDVRKPNELAKGKF
KNSQNIPLDDLRERLNELDKKTEYIVSCQSGLRSYNAERILKQEGYKVKNLDGAFGLYSKVTKELLD
>Mature_547_residues
MIEKILIVGGVAGGMSAATRLRRLNENAEIIVFEKGPYVSFANCGLPYYVGGEIAEREKLIVQSAKALKNRFNLEVRENS
EVIAIDSEGKKVTVVSNGESYVESYDKLILSPGAKPLIPQIKGLNQATNVFSLRNIPDVDKIMAYLAAKESKSATIIGAG
FIGLEMAENLAKRGLSVTIVEKAPHVLPTIDREMAAFVNEELIKNNLSVMTNRGAVEFKNDEILLDNGESLQSDLTILSV
GIQPETSLAKSAGIKLGLRNAILVDEHYETSVKDIYAVGDAIVVKNQLGQDALISLASPANRQGRQVADIISGLSIKNRG
SLGTAIVRVFDLQVASTGLSEFQLRGLKINHKIVHVTANNHAGYYPDATSIVLKLIFEPESGQIFGAQAIGKEGVDKRID
ILSTAIKAKLTVFDLPELELTYAPPFGSAKDPVNMAGYAAINLLLGQSENIQWHELAAELAKGKVLLDVRKPNELAKGKF
KNSQNIPLDDLRERLNELDKKTEYIVSCQSGLRSYNAERILKQEGYKVKNLDGAFGLYSKVTKELLD

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI226437568, Length=286, Percent_Identity=26.2237762237762, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI21389617, Length=285, Percent_Identity=25.9649122807018, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI65787454, Length=286, Percent_Identity=25.8741258741259, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1789065, Length=236, Percent_Identity=26.271186440678, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789765, Length=319, Percent_Identity=25.3918495297806, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788892, Length=297, Percent_Identity=27.9461279461279, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786307, Length=313, Percent_Identity=24.6006389776358, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI87082354, Length=301, Percent_Identity=24.5847176079734, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17559934, Length=283, Percent_Identity=27.5618374558304, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24639257, Length=289, Percent_Identity=26.643598615917, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281359715, Length=289, Percent_Identity=26.643598615917, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI281359713, Length=289, Percent_Identity=26.643598615917, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24639250, Length=289, Percent_Identity=26.643598615917, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI18543267, Length=289, Percent_Identity=26.643598615917, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24639252, Length=289, Percent_Identity=26.643598615917, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 59545; Mature: 59545

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEKILIVGGVAGGMSAATRLRRLNENAEIIVFEKGPYVSFANCGLPYYVGGEIAEREKL
CCCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCEEECCCHHHHHHH
IVQSAKALKNRFNLEVRENSEVIAIDSEGKKVTVVSNGESYVESYDKLILSPGAKPLIPQ
HHHHHHHHHHHCCEEEECCCCEEEEECCCCEEEEEECCHHHHHHHHHEEECCCCCCCCHH
IKGLNQATNVFSLRNIPDVDKIMAYLAAKESKSATIIGAGFIGLEMAENLAKRGLSVTIV
HCCCCHHHCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHCCCEEEEE
EKAPHVLPTIDREMAAFVNEELIKNNLSVMTNRGAVEFKNDEILLDNGESLQSDLTILSV
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCEEECCCEEEEECCCCCCCCEEEEEE
GIQPETSLAKSAGIKLGLRNAILVDEHYETSVKDIYAVGDAIVVKNQLGQDALISLASPA
CCCCCHHHHHHCCCEEECCCEEEEECCCCCHHHHHHHCCCEEEEECCCCCHHHEEECCCC
NRQGRQVADIISGLSIKNRGSLGTAIVRVFDLQVASTGLSEFQLRGLKINHKIVHVTANN
CCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHEEECEEEEEEEEEEEECC
HAGYYPDATSIVLKLIFEPESGQIFGAQAIGKEGVDKRIDILSTAIKAKLTVFDLPELEL
CCCCCCCHHHEEEEEEEECCCCCEEEHHHHCCCCCHHHHHHHHHHHHHEEEEEECCCEEE
TYAPPFGSAKDPVNMAGYAAINLLLGQSENIQWHELAAELAKGKVLLDVRKPNELAKGKF
EECCCCCCCCCCCCHHHHHEEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCHHHCCCC
KNSQNIPLDDLRERLNELDKKTEYIVSCQSGLRSYNAERILKQEGYKVKNLDGAFGLYSK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEECCCCHHHHHHH
VTKELLD
HHHHHCC
>Mature Secondary Structure
MIEKILIVGGVAGGMSAATRLRRLNENAEIIVFEKGPYVSFANCGLPYYVGGEIAEREKL
CCCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCEEECCCHHHHHHH
IVQSAKALKNRFNLEVRENSEVIAIDSEGKKVTVVSNGESYVESYDKLILSPGAKPLIPQ
HHHHHHHHHHHCCEEEECCCCEEEEECCCCEEEEEECCHHHHHHHHHEEECCCCCCCCHH
IKGLNQATNVFSLRNIPDVDKIMAYLAAKESKSATIIGAGFIGLEMAENLAKRGLSVTIV
HCCCCHHHCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHCCCEEEEE
EKAPHVLPTIDREMAAFVNEELIKNNLSVMTNRGAVEFKNDEILLDNGESLQSDLTILSV
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCEEECCCEEEEECCCCCCCCEEEEEE
GIQPETSLAKSAGIKLGLRNAILVDEHYETSVKDIYAVGDAIVVKNQLGQDALISLASPA
CCCCCHHHHHHCCCEEECCCEEEEECCCCCHHHHHHHCCCEEEEECCCCCHHHEEECCCC
NRQGRQVADIISGLSIKNRGSLGTAIVRVFDLQVASTGLSEFQLRGLKINHKIVHVTANN
CCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHEEECEEEEEEEEEEEECC
HAGYYPDATSIVLKLIFEPESGQIFGAQAIGKEGVDKRIDILSTAIKAKLTVFDLPELEL
CCCCCCCHHHEEEEEEEECCCCCEEEHHHHCCCCCHHHHHHHHHHHHHEEEEEECCCEEE
TYAPPFGSAKDPVNMAGYAAINLLLGQSENIQWHELAAELAKGKVLLDVRKPNELAKGKF
EECCCCCCCCCCCCHHHHHEEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCHHHCCCC
KNSQNIPLDDLRERLNELDKKTEYIVSCQSGLRSYNAERILKQEGYKVKNLDGAFGLYSK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEECCCCHHHHHHH
VTKELLD
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA