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The map label for this gene is leuS [H]

Identifier: 125624531

GI number: 125624531

Start: 1721185

End: 1723674

Strand: Reverse

Name: leuS [H]

Synonym: llmg_1741

Alternate gene names: 125624531

Gene position: 1723674-1721185 (Counterclockwise)

Preceding gene: 125624532

Following gene: 125624530

Centisome position: 68.14

GC content: 39.16

Gene sequence:

>2490_bases
ATGGAATACAATCATCAAAAAATAGAAGCCAAATGGCAAAAATACTGGGCGGATAACAAAACTTTCCGTACAGGAACAGA
TAAAAATAAACCAAAATTTTATGCTCTAGACATGTTCCCTTATCCATCTGGTGCAGGACTTCACGTTGGACACCCCGAAG
GTTATACTGCAACTGATATTTTGAGCCGTTACAAACGCGCTCAAGGGTTCAATGTTCTTCATCCAATGGGCTGGGATGCC
TTTGGTTTACCTGCTGAACAATATGCAATGGATACAGGAAATGACCCAGCAGAATTTACAGCTGAAAATATTGCTAACTT
TAAACGTCAAATCAATAGCTTAGGTTTTAGTTATGACTGGGAACGTGAAGTTAATACAACTGACCCAAATTTTTATAAAT
GGACACAGTGGATTTTTACTAAACTTTATGAAAAAGGGTTAGCTTATGAAGCAGAAGTAGCTGTTAACTGGGTTGAAGAA
CTCGGAACGGCTATTGCTAATGAAGAAGTGCTTCCAGACGGAACTTCTGAACGCGGGGGTTATCCTGTTGTTCGTAAACC
AATGCGCCAATGGATGCTTAAAATTACAGCTTATGCGGAACGTTTACTTGAAGACCTTGAAGAAGTTGATTGGCCTGAAT
CAATCAAAGAAATGCAACGGAATTGGATAGGGAAATCAGTAGGAGCAGATGTGACTTTTGAAGTTGCAGGAACCGACAAA
TCATTTGAAGTCTTTACGACTCGTCCTGATACCCTTTTTGGGGCAACTTATGCTGTGCTTGCACCTGAACATGATTTAGT
TGATGCTATTACGACACCTGAGCAAAAAGAAGCTGTTGCTGAATACCGTCGCAAAGCGAGCTTGAAATCTGATTTAGCCC
GTACAGACCTTTCTAAAGAAAAAACTGGAGCATTTACCGGAGCTTACGCGATTAACCCAATTAATGGCCGTAAAATGCCA
ATTTGGGTTGCAGATTATGTTCTTGCTTCTTATGGACATGGTGCTGTTATGGCAGTTCCTGCTCACGACGAACGTGACTG
GGAATTTGCTAAGGTCTATGGACTTGAAATTTTGCCTGTTGTTGAAGGTGGAAATGTAGAAGAAGCTGTTTATACAGAAG
ATGGCCCTCATATTAATTCAGAATTTTTGAATGGACTTGACAAAGCACAAGCGATTGAAAAAGCCATTGAATTTTTAGAA
GAAAAGAAAATTGGGAAAAAGAAAATCACTTACCGCTTGCGTGACTGGCTCTTTAGTCGTCAACGTTATTGGGGTGAACC
AATTCCAATTATTCATTGGGAAGATGGCACATCAACAGCGCTCTCAGAAGATGAACTTCCTCTTGTTTTACCAGTAACCT
CTGATATCAAACCGTCAGGAACTGGTGAGTCTCCTTTGGCTAACTTAACAGATTGGTTGGAAGTCACACGCGCAGATGGC
CTAAAAGGTCGCCGTGAAACTAATACAATGCCACAATGGGCAGGTTCAAGTTGGTATTACCTTCGCTATATTGACCCAAA
TAATAGCGAAGCTTTGGCAGACCCAGAACTTCTCAAAGAATGGTTGCCAGTTGATATCTATGTGGGAGGGGCTGAACATG
CTGTTCTTCACTTACTTTACGCTCGTTTCTGGCATAAAGTGCTTTATGATTTAGGAGTTGTTCCAACTAAAGAACCTTTC
CAAAAACTCTTTAACCAAGGAATGATTCTCGGAACCTCTTATCGTGATCATCGTGGGGCTTTGGTTGCAACTGATAAGGT
TGAAAAACGTGATGGTGGCTTTTACCATATGGAAACAGGTGAAGCCCTTGAACAAGCTCCAGCTAAAATGTCTAAATCTC
TTAAAAATGTTGTTAATCCTGATGATGTTGTTGAACATTATGGAGCTGATACTTTACGTGTTTATGAAATGTTCATGGGT
CCACTTGATGCAAGTATTCCATGGTCAGAAGAAGGCCTTGAAGGGGCTCGTAAATTCCTAGACCGAGCTGTTCGAATGAT
TGAAAATTCAGAGATTAAAGCTGAAAATAATGGAGAGTTGGACAAAGTTTACAATGAAACAGTGAAAAATGTTACTGAGC
GTTTGGACTTGATGTACTTTAACACTGCAATTTCCCAATTAATGATTTTTGTTAATGCAGTTAATAAAGCAAAAGCTTTA
CCGTTAGAATACGCTAATGGCTTTGTCCAACTTTTGGCGCCATTTGCACCACATATTGCTGAAGAACTTTGGGTAAAATT
AGGTAATGAAGCTGGAATTTCTTATGTTGCTTGGCCAACATTTGACGAAAGCAAATTAATTGAATCAGAAGTTGAAATTG
TTGTTCAAATTAATGGTAAATTAAAAGCAAAAATTAAAATTGCTAAAGATTTAGCGCGTGAAGAACTTGAAAAAATTGGT
CGTGAATCAGTTGCTGAGGCTCTTGAAGGTAAAAACGTGGTCAAAGTAATTGCTGTTCCAAATAAATTAGTTAATATTGT
TGTAAAATAA

Upstream 100 bases:

>100_bases
GACCTAACTCTCGCTTATAATTTATTATAAAAGACAATTTACATTAGCAATATTATGAGAAAGGAACTGAGTTTAATAAA
ATTGAACTCAAATCTTTAAT

Downstream 100 bases:

>100_bases
AGATGACAATCTGAACATTTATCAGTTAAATCTTATAATAATTAGCTGTCAGTAAAAAAATGAGAGCTAAAGAATAAAAA
GTAAAATAAGCTGGTTGACA

Product: leucyl-tRNA synthetase

Products: NA

Alternate protein names: Leucine--tRNA ligase; LeuRS [H]

Number of amino acids: Translated: 829; Mature: 829

Protein sequence:

>829_residues
MEYNHQKIEAKWQKYWADNKTFRTGTDKNKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRYKRAQGFNVLHPMGWDA
FGLPAEQYAMDTGNDPAEFTAENIANFKRQINSLGFSYDWEREVNTTDPNFYKWTQWIFTKLYEKGLAYEAEVAVNWVEE
LGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKEMQRNWIGKSVGADVTFEVAGTDK
SFEVFTTRPDTLFGATYAVLAPEHDLVDAITTPEQKEAVAEYRRKASLKSDLARTDLSKEKTGAFTGAYAINPINGRKMP
IWVADYVLASYGHGAVMAVPAHDERDWEFAKVYGLEILPVVEGGNVEEAVYTEDGPHINSEFLNGLDKAQAIEKAIEFLE
EKKIGKKKITYRLRDWLFSRQRYWGEPIPIIHWEDGTSTALSEDELPLVLPVTSDIKPSGTGESPLANLTDWLEVTRADG
LKGRRETNTMPQWAGSSWYYLRYIDPNNSEALADPELLKEWLPVDIYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPF
QKLFNQGMILGTSYRDHRGALVATDKVEKRDGGFYHMETGEALEQAPAKMSKSLKNVVNPDDVVEHYGADTLRVYEMFMG
PLDASIPWSEEGLEGARKFLDRAVRMIENSEIKAENNGELDKVYNETVKNVTERLDLMYFNTAISQLMIFVNAVNKAKAL
PLEYANGFVQLLAPFAPHIAEELWVKLGNEAGISYVAWPTFDESKLIESEVEIVVQINGKLKAKIKIAKDLAREELEKIG
RESVAEALEGKNVVKVIAVPNKLVNIVVK

Sequences:

>Translated_829_residues
MEYNHQKIEAKWQKYWADNKTFRTGTDKNKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRYKRAQGFNVLHPMGWDA
FGLPAEQYAMDTGNDPAEFTAENIANFKRQINSLGFSYDWEREVNTTDPNFYKWTQWIFTKLYEKGLAYEAEVAVNWVEE
LGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKEMQRNWIGKSVGADVTFEVAGTDK
SFEVFTTRPDTLFGATYAVLAPEHDLVDAITTPEQKEAVAEYRRKASLKSDLARTDLSKEKTGAFTGAYAINPINGRKMP
IWVADYVLASYGHGAVMAVPAHDERDWEFAKVYGLEILPVVEGGNVEEAVYTEDGPHINSEFLNGLDKAQAIEKAIEFLE
EKKIGKKKITYRLRDWLFSRQRYWGEPIPIIHWEDGTSTALSEDELPLVLPVTSDIKPSGTGESPLANLTDWLEVTRADG
LKGRRETNTMPQWAGSSWYYLRYIDPNNSEALADPELLKEWLPVDIYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPF
QKLFNQGMILGTSYRDHRGALVATDKVEKRDGGFYHMETGEALEQAPAKMSKSLKNVVNPDDVVEHYGADTLRVYEMFMG
PLDASIPWSEEGLEGARKFLDRAVRMIENSEIKAENNGELDKVYNETVKNVTERLDLMYFNTAISQLMIFVNAVNKAKAL
PLEYANGFVQLLAPFAPHIAEELWVKLGNEAGISYVAWPTFDESKLIESEVEIVVQINGKLKAKIKIAKDLAREELEKIG
RESVAEALEGKNVVKVIAVPNKLVNIVVK
>Mature_829_residues
MEYNHQKIEAKWQKYWADNKTFRTGTDKNKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRYKRAQGFNVLHPMGWDA
FGLPAEQYAMDTGNDPAEFTAENIANFKRQINSLGFSYDWEREVNTTDPNFYKWTQWIFTKLYEKGLAYEAEVAVNWVEE
LGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKEMQRNWIGKSVGADVTFEVAGTDK
SFEVFTTRPDTLFGATYAVLAPEHDLVDAITTPEQKEAVAEYRRKASLKSDLARTDLSKEKTGAFTGAYAINPINGRKMP
IWVADYVLASYGHGAVMAVPAHDERDWEFAKVYGLEILPVVEGGNVEEAVYTEDGPHINSEFLNGLDKAQAIEKAIEFLE
EKKIGKKKITYRLRDWLFSRQRYWGEPIPIIHWEDGTSTALSEDELPLVLPVTSDIKPSGTGESPLANLTDWLEVTRADG
LKGRRETNTMPQWAGSSWYYLRYIDPNNSEALADPELLKEWLPVDIYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPF
QKLFNQGMILGTSYRDHRGALVATDKVEKRDGGFYHMETGEALEQAPAKMSKSLKNVVNPDDVVEHYGADTLRVYEMFMG
PLDASIPWSEEGLEGARKFLDRAVRMIENSEIKAENNGELDKVYNETVKNVTERLDLMYFNTAISQLMIFVNAVNKAKAL
PLEYANGFVQLLAPFAPHIAEELWVKLGNEAGISYVAWPTFDESKLIESEVEIVVQINGKLKAKIKIAKDLAREELEKIG
RESVAEALEGKNVVKVIAVPNKLVNIVVK

Specific function: Unknown

COG id: COG0495

COG function: function code J; Leucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7661872, Length=875, Percent_Identity=33.4857142857143, Blast_Score=464, Evalue=1e-130,
Organism=Homo sapiens, GI94721239, Length=181, Percent_Identity=28.7292817679558, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI94721241, Length=181, Percent_Identity=28.7292817679558, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1786861, Length=866, Percent_Identity=41.5704387990762, Blast_Score=657, Evalue=0.0,
Organism=Escherichia coli, GI1790708, Length=391, Percent_Identity=25.8312020460358, Blast_Score=103, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71997510, Length=279, Percent_Identity=40.1433691756272, Blast_Score=199, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI71997517, Length=270, Percent_Identity=40, Blast_Score=199, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI212645227, Length=323, Percent_Identity=30.6501547987616, Blast_Score=152, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17541896, Length=186, Percent_Identity=26.3440860215054, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323414, Length=851, Percent_Identity=34.6650998824912, Blast_Score=462, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6321531, Length=425, Percent_Identity=26.8235294117647, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319395, Length=186, Percent_Identity=27.9569892473118, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21355409, Length=841, Percent_Identity=31.7479191438763, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI17864482, Length=456, Percent_Identity=23.6842105263158, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24653289, Length=456, Percent_Identity=23.6842105263158, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI281366294, Length=726, Percent_Identity=22.8650137741047, Blast_Score=80, Evalue=6e-15,

Paralogues:

None

Copy number: 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002300
- InterPro:   IPR002302
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155
- InterPro:   IPR009008 [H]

Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1 [H]

EC number: =6.1.1.4 [H]

Molecular weight: Translated: 93791; Mature: 93791

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYNHQKIEAKWQKYWADNKTFRTGTDKNKPKFYALDMFPYPSGAGLHVGHPEGYTATDI
CCCCHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEEECCCCCCCCEECCCCCCCCHHHH
LSRYKRAQGFNVLHPMGWDAFGLPAEQYAMDTGNDPAEFTAENIANFKRQINSLGFSYDW
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
EREVNTTDPNFYKWTQWIFTKLYEKGLAYEAEVAVNWVEELGTAIANEEVLPDGTSERGG
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
YPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKEMQRNWIGKSVGADVTFEVAGTDK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCC
SFEVFTTRPDTLFGATYAVLAPEHDLVDAITTPEQKEAVAEYRRKASLKSDLARTDLSKE
CEEEEECCCCCHHCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
KTGAFTGAYAINPINGRKMPIWVADYVLASYGHGAVMAVPAHDERDWEFAKVYGLEILPV
HCCCEECEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECEEEEEE
VEGGNVEEAVYTEDGPHINSEFLNGLDKAQAIEKAIEFLEEKKIGKKKITYRLRDWLFSR
ECCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
QRYWGEPIPIIHWEDGTSTALSEDELPLVLPVTSDIKPSGTGESPLANLTDWLEVTRADG
HHHCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCC
LKGRRETNTMPQWAGSSWYYLRYIDPNNSEALADPELLKEWLPVDIYVGGAEHAVLHLLY
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCEEEEECCHHHHHHHHHH
ARFWHKVLYDLGVVPTKEPFQKLFNQGMILGTSYRDHRGALVATDKVEKRDGGFYHMETG
HHHHHHHHHHCCCCCCHHHHHHHHHCCEEEECCCCCCCCCEEEECCCHHCCCCEEEECCC
EALEQAPAKMSKSLKNVVNPDDVVEHYGADTLRVYEMFMGPLDASIPWSEEGLEGARKFL
HHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
DRAVRMIENSEIKAENNGELDKVYNETVKNVTERLDLMYFNTAISQLMIFVNAVNKAKAL
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PLEYANGFVQLLAPFAPHIAEELWVKLGNEAGISYVAWPTFDESKLIESEVEIVVQINGK
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHCCEEEEEEECCC
LKAKIKIAKDLAREELEKIGRESVAEALEGKNVVKVIAVPNKLVNIVVK
EEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHEEEECC
>Mature Secondary Structure
MEYNHQKIEAKWQKYWADNKTFRTGTDKNKPKFYALDMFPYPSGAGLHVGHPEGYTATDI
CCCCHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEEECCCCCCCCEECCCCCCCCHHHH
LSRYKRAQGFNVLHPMGWDAFGLPAEQYAMDTGNDPAEFTAENIANFKRQINSLGFSYDW
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
EREVNTTDPNFYKWTQWIFTKLYEKGLAYEAEVAVNWVEELGTAIANEEVLPDGTSERGG
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
YPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKEMQRNWIGKSVGADVTFEVAGTDK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCC
SFEVFTTRPDTLFGATYAVLAPEHDLVDAITTPEQKEAVAEYRRKASLKSDLARTDLSKE
CEEEEECCCCCHHCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
KTGAFTGAYAINPINGRKMPIWVADYVLASYGHGAVMAVPAHDERDWEFAKVYGLEILPV
HCCCEECEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECEEEEEE
VEGGNVEEAVYTEDGPHINSEFLNGLDKAQAIEKAIEFLEEKKIGKKKITYRLRDWLFSR
ECCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
QRYWGEPIPIIHWEDGTSTALSEDELPLVLPVTSDIKPSGTGESPLANLTDWLEVTRADG
HHHCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCC
LKGRRETNTMPQWAGSSWYYLRYIDPNNSEALADPELLKEWLPVDIYVGGAEHAVLHLLY
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCEEEEECCHHHHHHHHHH
ARFWHKVLYDLGVVPTKEPFQKLFNQGMILGTSYRDHRGALVATDKVEKRDGGFYHMETG
HHHHHHHHHHCCCCCCHHHHHHHHHCCEEEECCCCCCCCCEEEECCCHHCCCCEEEECCC
EALEQAPAKMSKSLKNVVNPDDVVEHYGADTLRVYEMFMGPLDASIPWSEEGLEGARKFL
HHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
DRAVRMIENSEIKAENNGELDKVYNETVKNVTERLDLMYFNTAISQLMIFVNAVNKAKAL
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PLEYANGFVQLLAPFAPHIAEELWVKLGNEAGISYVAWPTFDESKLIESEVEIVVQINGK
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHCCEEEEEEECCC
LKAKIKIAKDLAREELEKIGRESVAEALEGKNVVKVIAVPNKLVNIVVK
EEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]