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The map label for this gene is ispA [H]

Identifier: 125624487

GI number: 125624487

Start: 1663829

End: 1664734

Strand: Reverse

Name: ispA [H]

Synonym: llmg_1689

Alternate gene names: 125624487

Gene position: 1664734-1663829 (Counterclockwise)

Preceding gene: 125624488

Following gene: 125624486

Centisome position: 65.81

GC content: 38.19

Gene sequence:

>906_bases
ATGAGGCTTATCAGCAAAGAACACAAAATTTTTGGTATAATTAGGGTAATGGATACGAAGATATTAAAGCTAGAACATTT
TTTAACTGAATTTTATGAAAGCGCTGAATTTCCAAAAGGATTAGCTGAGCCAGCAAAATATTCCTTAATGGCGGGCGGTA
AACGAATTCGTCCTCTCCTTTTTTTGAATCTTTTGGAAGCTTTTGATTTGGAAGTTACAACGGCCCATTATCAAGTGGCC
GCAGCGCTTGAAATGATTCATACGGGCTCGTTAATTCATGATGACTTGCCTGCGATGGACAATGATGATTATCGTCGTGG
AAAGTTAACGAACCATAAAAAATTTGATGAAGCGACAGCAATTCTGGCTGGAGATACTTTATTTTTCGACCCTTTTTATG
TTCTTTCAAGTAGCGATTTGTCGGCGCAAACAATTGTATCATTGACCCGCGAATTGGCTTATGCCTCGGGCTCGTATGGA
ATGGTTGCTGGTCAAATTTTGGATATGGCTGGTGAAGGTAAAGATTTAACTTTGACTCAGATTGAGCAAATTCATCGATT
AAAAACGGGTCGACTTTTAACTTTTCCTTTTGTGGCTGCTGGAATCGTAGCCCAAAAAACAAATCAAGAAATCGAAAAAC
TTCGTGTAGTCGGACAAATTTTAGGATTAGCTTTTCAAATTCGTGATGACATTTTAGATGTGACGGCCACTTTTGCTGAA
CTGGGTAAGACGCCTGGAAAGGATGTTTTAGAAGAAAAGTCGACTTATGTTGCGCATTTAGGACTTGAAGGAGCTAAAAT
ATCACTGACAGATAAGTTGTCAGAAGTAAAAAAATTACTGACAGAGTTGAATGTTACTGACAGCTCCGAGATTTTCAAAA
TAATTGAACAACTGGAAGTGGAATAA

Upstream 100 bases:

>100_bases
ATTCAAATAGAATCAAAAAGTCTTCTTTTATTTAACATTTGATTGATGCTAGTTATCATATAAAGCTCTAAAGCTTGAAA
GCAAAGGCTTTCAAGAGCCA

Downstream 100 bases:

>100_bases
ATGTATTTTGAACTTAGAATTCTCACAGAGAATGATAAAAACATCATTGAGCATTTTTTTGAAGAAGCCAGTGATTATGC
TATTCTTGAGAGCGGAGAGT

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MRLISKEHKIFGIIRVMDTKILKLEHFLTEFYESAEFPKGLAEPAKYSLMAGGKRIRPLLFLNLLEAFDLEVTTAHYQVA
AALEMIHTGSLIHDDLPAMDNDDYRRGKLTNHKKFDEATAILAGDTLFFDPFYVLSSSDLSAQTIVSLTRELAYASGSYG
MVAGQILDMAGEGKDLTLTQIEQIHRLKTGRLLTFPFVAAGIVAQKTNQEIEKLRVVGQILGLAFQIRDDILDVTATFAE
LGKTPGKDVLEEKSTYVAHLGLEGAKISLTDKLSEVKKLLTELNVTDSSEIFKIIEQLEVE

Sequences:

>Translated_301_residues
MRLISKEHKIFGIIRVMDTKILKLEHFLTEFYESAEFPKGLAEPAKYSLMAGGKRIRPLLFLNLLEAFDLEVTTAHYQVA
AALEMIHTGSLIHDDLPAMDNDDYRRGKLTNHKKFDEATAILAGDTLFFDPFYVLSSSDLSAQTIVSLTRELAYASGSYG
MVAGQILDMAGEGKDLTLTQIEQIHRLKTGRLLTFPFVAAGIVAQKTNQEIEKLRVVGQILGLAFQIRDDILDVTATFAE
LGKTPGKDVLEEKSTYVAHLGLEGAKISLTDKLSEVKKLLTELNVTDSSEIFKIIEQLEVE
>Mature_301_residues
MRLISKEHKIFGIIRVMDTKILKLEHFLTEFYESAEFPKGLAEPAKYSLMAGGKRIRPLLFLNLLEAFDLEVTTAHYQVA
AALEMIHTGSLIHDDLPAMDNDDYRRGKLTNHKKFDEATAILAGDTLFFDPFYVLSSSDLSAQTIVSLTRELAYASGSYG
MVAGQILDMAGEGKDLTLTQIEQIHRLKTGRLLTFPFVAAGIVAQKTNQEIEKLRVVGQILGLAFQIRDDILDVTATFAE
LGKTPGKDVLEEKSTYVAHLGLEGAKISLTDKLSEVKKLLTELNVTDSSEIFKIIEQLEVE

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=216, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786623, Length=245, Percent_Identity=44.4897959183673, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1789578, Length=210, Percent_Identity=34.2857142857143, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17505681, Length=234, Percent_Identity=27.7777777777778, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24651612, Length=251, Percent_Identity=28.6852589641434, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 33466; Mature: 33466

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLISKEHKIFGIIRVMDTKILKLEHFLTEFYESAEFPKGLAEPAKYSLMAGGKRIRPLL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHH
FLNLLEAFDLEVTTAHYQVAAALEMIHTGSLIHDDLPAMDNDDYRRGKLTNHKKFDEATA
HHHHHHHHCCEEEHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
ILAGDTLFFDPFYVLSSSDLSAQTIVSLTRELAYASGSYGMVAGQILDMAGEGKDLTLTQ
EEECCEEEECCEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHH
IEQIHRLKTGRLLTFPFVAAGIVAQKTNQEIEKLRVVGQILGLAFQIRDDILDVTATFAE
HHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGKTPGKDVLEEKSTYVAHLGLEGAKISLTDKLSEVKKLLTELNVTDSSEIFKIIEQLEV
HCCCCCHHHHHHHHHEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
E
C
>Mature Secondary Structure
MRLISKEHKIFGIIRVMDTKILKLEHFLTEFYESAEFPKGLAEPAKYSLMAGGKRIRPLL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHH
FLNLLEAFDLEVTTAHYQVAAALEMIHTGSLIHDDLPAMDNDDYRRGKLTNHKKFDEATA
HHHHHHHHCCEEEHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
ILAGDTLFFDPFYVLSSSDLSAQTIVSLTRELAYASGSYGMVAGQILDMAGEGKDLTLTQ
EEECCEEEECCEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHH
IEQIHRLKTGRLLTFPFVAAGIVAQKTNQEIEKLRVVGQILGLAFQIRDDILDVTATFAE
HHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGKTPGKDVLEEKSTYVAHLGLEGAKISLTDKLSEVKKLLTELNVTDSSEIFKIIEQLEV
HCCCCCHHHHHHHHHEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515931 [H]