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The map label for this gene is lacA [H]

Identifier: 125624012

GI number: 125624012

Start: 1150512

End: 1151123

Strand: Reverse

Name: lacA [H]

Synonym: llmg_1182

Alternate gene names: 125624012

Gene position: 1151123-1150512 (Counterclockwise)

Preceding gene: 125624054

Following gene: 125624010

Centisome position: 45.51

GC content: 38.73

Gene sequence:

>612_bases
ATGAATAAAGAACAAATTAAAACACTCATCAATTCTGGAAAAACCTATGATGACAATGACCTAGAACTCAGTGAGTATCG
TAATCATGCCCTTTTTGAAACCCGACGTTACAATCAAAAAATCAACAATAATGAGGGTTATCAACCAGAGATTTTAAGAC
AGCTCTTTGAACATTTGGGAGAAAATCCCTGTATTGAATCCAATTTTCGCTGTGAATTTGGCTTTAATATAAAAATTGGG
GATAATGTCCTTATTAATCATGATCTGATTATTTTAGATTGCAATCAGGTCACGATAGGTGATAATGTTTACTTTGGCCC
CCGCTGTGGTTTATTTGCTGCCAATCATTCAGAAGACCCAGCAGTCAGAACAGCTGGTGGGGTCTATTCAAAGCCAATTA
CGGTTGGAAATCACGTCTGGCTTGGAGCAAATGTCAGCTTGCTTCCAGGAGTAACGATTGGTGACAACTGCATTATTGGT
GCAGGAAGTGTCGTTACCAAAGATATCCCAGCAAATGTTGTTGCCGCCGGAAATCCTTGCCAGGTAATTCGGCCAATCCG
AACCAAAGACCAAGAATGGATTAAAAAGGATAAAATATTCATTCCAAAATAA

Upstream 100 bases:

>100_bases
ATTCTGATAATTATATATAAATGTAATTTTTAATAGCTTTATCTAATAGATGAAGACCCTTACAATAGACAAAAAACATC
TAAAATCATAAGATAAAAGA

Downstream 100 bases:

>100_bases
AAAAGCTAAAGAATATTCTTTAGCTTTTTAAATTAATCAACTTTAACAATCCAGCCTTCTGGAGCTTCAACATCACCAAA
TTGAATGCCGACCAACTCGT

Product: putative acetyltransferase

Products: NA

Alternate protein names: GAT; Thiogalactoside acetyltransferase [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MNKEQIKTLINSGKTYDDNDLELSEYRNHALFETRRYNQKINNNEGYQPEILRQLFEHLGENPCIESNFRCEFGFNIKIG
DNVLINHDLIILDCNQVTIGDNVYFGPRCGLFAANHSEDPAVRTAGGVYSKPITVGNHVWLGANVSLLPGVTIGDNCIIG
AGSVVTKDIPANVVAAGNPCQVIRPIRTKDQEWIKKDKIFIPK

Sequences:

>Translated_203_residues
MNKEQIKTLINSGKTYDDNDLELSEYRNHALFETRRYNQKINNNEGYQPEILRQLFEHLGENPCIESNFRCEFGFNIKIG
DNVLINHDLIILDCNQVTIGDNVYFGPRCGLFAANHSEDPAVRTAGGVYSKPITVGNHVWLGANVSLLPGVTIGDNCIIG
AGSVVTKDIPANVVAAGNPCQVIRPIRTKDQEWIKKDKIFIPK
>Mature_203_residues
MNKEQIKTLINSGKTYDDNDLELSEYRNHALFETRRYNQKINNNEGYQPEILRQLFEHLGENPCIESNFRCEFGFNIKIG
DNVLINHDLIILDCNQVTIGDNVYFGPRCGLFAANHSEDPAVRTAGGVYSKPITVGNHVWLGANVSLLPGVTIGDNCIIG
AGSVVTKDIPANVVAAGNPCQVIRPIRTKDQEWIKKDKIFIPK

Specific function: May assist cellular detoxification by acetylating non- metabolizable pyranosides, thereby preventing their reentry into the cell [H]

COG id: COG0110

COG function: function code R; Acetyltransferase (isoleucine patch superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1786537, Length=188, Percent_Identity=42.5531914893617, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1786664, Length=186, Percent_Identity=39.247311827957, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI1788367, Length=138, Percent_Identity=31.1594202898551, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788345, Length=131, Percent_Identity=32.824427480916, Blast_Score=69, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322243, Length=183, Percent_Identity=45.3551912568306, Blast_Score=161, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.18 [H]

Molecular weight: Translated: 22670; Mature: 22670

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKEQIKTLINSGKTYDDNDLELSEYRNHALFETRRYNQKINNNEGYQPEILRQLFEHLG
CCHHHHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHC
ENPCIESNFRCEFGFNIKIGDNVLINHDLIILDCNQVTIGDNVYFGPRCGLFAANHSEDP
CCCCCCCCCEEEECCEEEECCEEEEECCEEEEECCEEEECCCEEECCCCCEEECCCCCCC
AVRTAGGVYSKPITVGNHVWLGANVSLLPGVTIGDNCIIGAGSVVTKDIPANVVAAGNPC
CEEECCCCCCCCEEECCEEEECCCCEECCCCEECCCEEEECCCEEECCCCCCEEECCCCC
QVIRPIRTKDQEWIKKDKIFIPK
EEEECCCCCCHHHHHHCCEECCC
>Mature Secondary Structure
MNKEQIKTLINSGKTYDDNDLELSEYRNHALFETRRYNQKINNNEGYQPEILRQLFEHLG
CCHHHHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHC
ENPCIESNFRCEFGFNIKIGDNVLINHDLIILDCNQVTIGDNVYFGPRCGLFAANHSEDP
CCCCCCCCCEEEECCEEEECCEEEEECCEEEEECCEEEECCCEEECCCCCEEECCCCCCC
AVRTAGGVYSKPITVGNHVWLGANVSLLPGVTIGDNCIIGAGSVVTKDIPANVVAAGNPC
CEEECCCCCCCCEEECCEEEECCCCEECCCCEECCCEEEECCCEEECCCCCCEEECCCCC
QVIRPIRTKDQEWIKKDKIFIPK
EEEECCCCCCHHHHHHCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3922433; 3901000; 9278503; 6444453; 11937062 [H]