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The map label for this gene is pyrF [H]

Identifier: 125623938

GI number: 125623938

Start: 1068466

End: 1069179

Strand: Direct

Name: pyrF [H]

Synonym: llmg_1107

Alternate gene names: 125623938

Gene position: 1068466-1069179 (Clockwise)

Preceding gene: 125623937

Following gene: 125623939

Centisome position: 42.24

GC content: 39.64

Gene sequence:

>714_bases
ATGCAAGAAAATAGACCTGTTATTGCCCTAGATTTCCCAGAATTCTCAGATGTGAAAGATTTCCTTGAAAAATTTGACCC
ATCTGAAAAACTCTACATCAAACTTGGTATGGAACTTTTTTATACCGCCGGCCCACAAGTAGTATATTATGTGAAATCGC
TCGGTCATAGCGTTTTCCTTGATTTAAAACTTCATGATATTCCAAATACAGTTGAATCATCCATGCGTGTTTTAGCCCGT
TTGGGAGTTGATATGGTCAATGTTCACGCTGCTGGCGGGGTTGAGATGATGGTTGCAGCTAAACGCGGTTTAGAAGCAGG
GACTCCAATTGGACGTCAAAGACCAAAACTAATTGCCGTTACGCAATTAACCTCGACTTCTGAGGAAATTATGCAAAATG
ACCAAAAAATTATGACCAGTCTTGAAGAATCTGTTATTAATTACGCACAAAAAACAGCCCAAGCCGGACTTGATGGTGTC
GTTTGCTCCGCTCATGAAGTTGAAAAAATTAAAGCGGCAACATCAAAAGAATTCATTTGTTTAACACCGGGAATTCGTCC
AGAAGGAGCAAGTAAAGGCGACCAAAAACGAGTAATGACACCAAAAGAAGCAAGAACAATTGGTTCAGATTACATTGTTG
TTGGTCGACCAATTACACAAGCAAAAGACCCTGTTTCAGCTTATCATGCGATAAAGGAAGAATGGAATCAATAA

Upstream 100 bases:

>100_bases
CCTCATCGGTTAAAAATTGAGCATTTTATCATTAAATAAAAGAACCGTCAGTAAATCTGGCAGTTCTGTCAATAAATATT
AAGAAAAGAAAGAAGAAAAA

Downstream 100 bases:

>100_bases
TATGAAAAGAATTTCGCATTTTTTCATTGTTTTAATTGGAATTTGTACTGCACTTGTCCTTGGATATCTCTTCACGGTCA
TTTATACTGAGGTTGGAAAT

Product: orotidine 5'-phosphate decarboxylase

Products: NA

Alternate protein names: OMP decarboxylase; OMPDCase; OMPdecase [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MQENRPVIALDFPEFSDVKDFLEKFDPSEKLYIKLGMELFYTAGPQVVYYVKSLGHSVFLDLKLHDIPNTVESSMRVLAR
LGVDMVNVHAAGGVEMMVAAKRGLEAGTPIGRQRPKLIAVTQLTSTSEEIMQNDQKIMTSLEESVINYAQKTAQAGLDGV
VCSAHEVEKIKAATSKEFICLTPGIRPEGASKGDQKRVMTPKEARTIGSDYIVVGRPITQAKDPVSAYHAIKEEWNQ

Sequences:

>Translated_237_residues
MQENRPVIALDFPEFSDVKDFLEKFDPSEKLYIKLGMELFYTAGPQVVYYVKSLGHSVFLDLKLHDIPNTVESSMRVLAR
LGVDMVNVHAAGGVEMMVAAKRGLEAGTPIGRQRPKLIAVTQLTSTSEEIMQNDQKIMTSLEESVINYAQKTAQAGLDGV
VCSAHEVEKIKAATSKEFICLTPGIRPEGASKGDQKRVMTPKEARTIGSDYIVVGRPITQAKDPVSAYHAIKEEWNQ
>Mature_237_residues
MQENRPVIALDFPEFSDVKDFLEKFDPSEKLYIKLGMELFYTAGPQVVYYVKSLGHSVFLDLKLHDIPNTVESSMRVLAR
LGVDMVNVHAAGGVEMMVAAKRGLEAGTPIGRQRPKLIAVTQLTSTSEEIMQNDQKIMTSLEESVINYAQKTAQAGLDGV
VCSAHEVEKIKAATSKEFICLTPGIRPEGASKGDQKRVMTPKEARTIGSDYIVVGRPITQAKDPVSAYHAIKEEWNQ

Specific function: Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) [H]

COG id: COG0284

COG function: function code F; Orotidine-5'-phosphate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the OMP decarboxylase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787537, Length=234, Percent_Identity=45.2991452991453, Blast_Score=192, Evalue=2e-50,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR014732
- InterPro:   IPR018089
- InterPro:   IPR001754
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00215 OMPdecase [H]

EC number: =4.1.1.23 [H]

Molecular weight: Translated: 26169; Mature: 26169

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00156 OMPDECASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQENRPVIALDFPEFSDVKDFLEKFDPSEKLYIKLGMELFYTAGPQVVYYVKSLGHSVFL
CCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEEECHHHEECCCCHHHHHHHHCCCEEEE
DLKLHDIPNTVESSMRVLARLGVDMVNVHAAGGVEMMVAAKRGLEAGTPIGRQRPKLIAV
EEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCHHEEHHHHCCCCCCCCCCCCCCCEEEE
TQLTSTSEEIMQNDQKIMTSLEESVINYAQKTAQAGLDGVVCSAHEVEKIKAATSKEFIC
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHCCCCEEE
LTPGIRPEGASKGDQKRVMTPKEARTIGSDYIVVGRPITQAKDPVSAYHAIKEEWNQ
ECCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQENRPVIALDFPEFSDVKDFLEKFDPSEKLYIKLGMELFYTAGPQVVYYVKSLGHSVFL
CCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEEECHHHEECCCCHHHHHHHHCCCEEEE
DLKLHDIPNTVESSMRVLARLGVDMVNVHAAGGVEMMVAAKRGLEAGTPIGRQRPKLIAV
EEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCHHEEHHHHCCCCCCCCCCCCCCCEEEE
TQLTSTSEEIMQNDQKIMTSLEESVINYAQKTAQAGLDGVVCSAHEVEKIKAATSKEFIC
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHCCCCEEE
LTPGIRPEGASKGDQKRVMTPKEARTIGSDYIVVGRPITQAKDPVSAYHAIKEEWNQ
ECCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10742196; 11337471 [H]