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The map label for this gene is glpK [H]

Identifier: 125623930

GI number: 125623930

Start: 1058720

End: 1060237

Strand: Reverse

Name: glpK [H]

Synonym: llmg_1099

Alternate gene names: 125623930

Gene position: 1060237-1058720 (Counterclockwise)

Preceding gene: 125623932

Following gene: 125623929

Centisome position: 41.92

GC content: 41.57

Gene sequence:

>1518_bases
ATGTCTGAGGGATTACCATTAGAAGCCACAGAAAAATATATCATGGCAATTGACCAAGGAACCACAAGTTCGCGCGCAAT
TATTTTTGACCATGACGGAAAACACGTCGGAACAAGCCAAAAAGAGTTCACTCAATATTTTCCAGAAGCAGGCTGGGTTG
AGCATGATGCCAATGAAATTTGGAATTCTGTTCAGTCAGTCATTGCTGGTGCTTTTATTGAATCAGGAATTAAACCGGAA
CAAATCGCCGGAATAGGGATTACTAATCAACGCGAAACAACCGTTGTCTGGGATAAAACAACTGGTCTCCCAATCTATCA
CGCCATTGTCTGGCAATCTCGTCAGTCAGCTTCAATTGCTGATGATTTAAAAAATGCCGGTCATGCTGAACTTTTTCATA
AAAAAACAGGATTGATTATCGACTCATATTTCTCAGCCACAAAAATTCGCTGGATACTAGACCACGTCAAAGGGGCACAA
GAACGTGCAGAAAAAGGCGAACTTCTCTTTGGAACGATTGACAGTTGGCTCGTCTACAAATTAACTGACGGAAAAGTTCA
CGTCACTGACTATTCAAATGCCAGCAGGACCATGCTTTTCAATATCAATACTTTAGAATGGGACCAAGAAATTCTTGACC
TTCTCAACATTCCAAAAATCATGCTACCAAAAGCCGTCTCTAATTCTGAAGTTTACGGCCTAACAAAGACTTACCACTTC
TTTGGCTCAAAAGTTCCAATTGCTGGCATGGCAGGAGACCAACAAGCTGCGCTCTTTGGACAAATGGCCTTTGAACCTGG
CATGGTCAAAAATACTTATGGCACAGGTTCATTTATCGTCATGAACACAGGAGATAAACCTCAGCTTTCACACAACAATC
TTTTGACAACCATCGGTTATGGCATTAATGGTGAAATCAATTATGCCCTTGAAGGTTCTGTTTTTGTTGCTGGTTCTTCT
ATTCAGTGGTTACGCGATGGTTTGAAGATTATTGACAAAGCAAGCGACTCAGAAGCTGCCGCTCTTGAATCAAAAAATGA
AGATGAAATCTACATGGTTCCTGCTTTCGTCGGCCTTGGAGCTCCCTATTGGGACCAAGACGCCCGTGGTGCAATCTTTG
GACTAACTAGAGGAACAACAGATAAAGACCTCATCAAAGCAACTTTACAAGGAATTGCCTATCAGGTTCGTGATATTTTA
GGTGCTATGGGTGAAGATACAGGAATCGAAATTCCCGTTCTTAAAGTTGATGGCGGAGCAACGAATAATGAATATCTCAT
GCAATTTCAAGCAGATATTTTAAATACTTCCGTTCAAAGAGCTGGAGATTTAGAAACAACGTCCCTCGGTGCCGCATTCC
TAGCCGGTCTTGCCGTTGGTTATTGGAAAGATTTTGATGAACTTAAAGAATCAGCCAAAGAAGGAAAACGTTTTGACGTT
CAAATGGAAGAGGAACGCCGCAATAAACTCTATTCTGGCTGGAAGAAAGCCGTAGAGGCAACAAGATCTTTTGAATAA

Upstream 100 bases:

>100_bases
ATAACTTTGTGATTTTTTTGCTTGACATCTTTCTGTTATCATACTATAATAGTAACCGTTTACAGAATACATTTAGTCGT
AATTATTAGGAGGAAAACTT

Downstream 100 bases:

>100_bases
ATCATATTAAAAGTATCATAAATGTATCGCTTATTAGAATTGGAGTAACAAGATGTCTATCTCTCGTCAAAAAAATATTG
AATATTTAAAAGCAAATCCC

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MSEGLPLEATEKYIMAIDQGTTSSRAIIFDHDGKHVGTSQKEFTQYFPEAGWVEHDANEIWNSVQSVIAGAFIESGIKPE
QIAGIGITNQRETTVVWDKTTGLPIYHAIVWQSRQSASIADDLKNAGHAELFHKKTGLIIDSYFSATKIRWILDHVKGAQ
ERAEKGELLFGTIDSWLVYKLTDGKVHVTDYSNASRTMLFNINTLEWDQEILDLLNIPKIMLPKAVSNSEVYGLTKTYHF
FGSKVPIAGMAGDQQAALFGQMAFEPGMVKNTYGTGSFIVMNTGDKPQLSHNNLLTTIGYGINGEINYALEGSVFVAGSS
IQWLRDGLKIIDKASDSEAAALESKNEDEIYMVPAFVGLGAPYWDQDARGAIFGLTRGTTDKDLIKATLQGIAYQVRDIL
GAMGEDTGIEIPVLKVDGGATNNEYLMQFQADILNTSVQRAGDLETTSLGAAFLAGLAVGYWKDFDELKESAKEGKRFDV
QMEEERRNKLYSGWKKAVEATRSFE

Sequences:

>Translated_505_residues
MSEGLPLEATEKYIMAIDQGTTSSRAIIFDHDGKHVGTSQKEFTQYFPEAGWVEHDANEIWNSVQSVIAGAFIESGIKPE
QIAGIGITNQRETTVVWDKTTGLPIYHAIVWQSRQSASIADDLKNAGHAELFHKKTGLIIDSYFSATKIRWILDHVKGAQ
ERAEKGELLFGTIDSWLVYKLTDGKVHVTDYSNASRTMLFNINTLEWDQEILDLLNIPKIMLPKAVSNSEVYGLTKTYHF
FGSKVPIAGMAGDQQAALFGQMAFEPGMVKNTYGTGSFIVMNTGDKPQLSHNNLLTTIGYGINGEINYALEGSVFVAGSS
IQWLRDGLKIIDKASDSEAAALESKNEDEIYMVPAFVGLGAPYWDQDARGAIFGLTRGTTDKDLIKATLQGIAYQVRDIL
GAMGEDTGIEIPVLKVDGGATNNEYLMQFQADILNTSVQRAGDLETTSLGAAFLAGLAVGYWKDFDELKESAKEGKRFDV
QMEEERRNKLYSGWKKAVEATRSFE
>Mature_504_residues
SEGLPLEATEKYIMAIDQGTTSSRAIIFDHDGKHVGTSQKEFTQYFPEAGWVEHDANEIWNSVQSVIAGAFIESGIKPEQ
IAGIGITNQRETTVVWDKTTGLPIYHAIVWQSRQSASIADDLKNAGHAELFHKKTGLIIDSYFSATKIRWILDHVKGAQE
RAEKGELLFGTIDSWLVYKLTDGKVHVTDYSNASRTMLFNINTLEWDQEILDLLNIPKIMLPKAVSNSEVYGLTKTYHFF
GSKVPIAGMAGDQQAALFGQMAFEPGMVKNTYGTGSFIVMNTGDKPQLSHNNLLTTIGYGINGEINYALEGSVFVAGSSI
QWLRDGLKIIDKASDSEAAALESKNEDEIYMVPAFVGLGAPYWDQDARGAIFGLTRGTTDKDLIKATLQGIAYQVRDILG
AMGEDTGIEIPVLKVDGGATNNEYLMQFQADILNTSVQRAGDLETTSLGAAFLAGLAVGYWKDFDELKESAKEGKRFDVQ
MEEERRNKLYSGWKKAVEATRSFE

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI41393575, Length=496, Percent_Identity=46.1693548387097, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI189409120, Length=496, Percent_Identity=45.9677419354839, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI4504007, Length=496, Percent_Identity=45.9677419354839, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI42794763, Length=500, Percent_Identity=45.6, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI88196792, Length=503, Percent_Identity=32.20675944334, Blast_Score=296, Evalue=2e-80,
Organism=Escherichia coli, GI1790361, Length=495, Percent_Identity=57.5757575757576, Blast_Score=609, Evalue=1e-175,
Organism=Escherichia coli, GI1790005, Length=492, Percent_Identity=23.9837398373984, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1787789, Length=512, Percent_Identity=23.2421875, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1789987, Length=467, Percent_Identity=22.2698072805139, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789168, Length=494, Percent_Identity=22.8744939271255, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17535599, Length=500, Percent_Identity=38.6, Blast_Score=344, Evalue=7e-95,
Organism=Caenorhabditis elegans, GI71986140, Length=523, Percent_Identity=24.8565965583174, Blast_Score=179, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71986147, Length=267, Percent_Identity=29.9625468164794, Blast_Score=126, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6321755, Length=552, Percent_Identity=34.2391304347826, Blast_Score=306, Evalue=5e-84,
Organism=Drosophila melanogaster, GI17864214, Length=509, Percent_Identity=42.4361493123772, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24655555, Length=493, Percent_Identity=38.9452332657201, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI24655560, Length=493, Percent_Identity=38.9452332657201, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI24655570, Length=493, Percent_Identity=38.9452332657201, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI24655574, Length=493, Percent_Identity=38.9452332657201, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI24655565, Length=493, Percent_Identity=38.9452332657201, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI24654573, Length=461, Percent_Identity=42.7331887201735, Blast_Score=351, Evalue=6e-97,
Organism=Drosophila melanogaster, GI19922058, Length=522, Percent_Identity=33.9080459770115, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI24652871, Length=489, Percent_Identity=34.560327198364, Blast_Score=269, Evalue=4e-72,
Organism=Drosophila melanogaster, GI24656367, Length=495, Percent_Identity=26.4646464646465, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI21357867, Length=509, Percent_Identity=25.7367387033399, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24656372, Length=328, Percent_Identity=28.3536585365854, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI45552909, Length=278, Percent_Identity=24.8201438848921, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 55680; Mature: 55549

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEGLPLEATEKYIMAIDQGTTSSRAIIFDHDGKHVGTSQKEFTQYFPEAGWVEHDANEI
CCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCHHHH
WNSVQSVIAGAFIESGIKPEQIAGIGITNQRETTVVWDKTTGLPIYHAIVWQSRQSASIA
HHHHHHHHHHHHHHCCCCHHHEEECCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCHHH
DDLKNAGHAELFHKKTGLIIDSYFSATKIRWILDHVKGAQERAEKGELLFGTIDSWLVYK
HHHHCCCCHHHHHHCCCCEEECHHHHHHHHHHHHHHCCHHHHHHCCCEEEEECCCEEEEE
LTDGKVHVTDYSNASRTMLFNINTLEWDQEILDLLNIPKIMLPKAVSNSEVYGLTKTYHF
EECCEEEEEECCCCCEEEEEEECCCCHHHHHHHHHCCCHHCCCCCCCCCEEEEEEEEHHH
FGSKVPIAGMAGDQQAALFGQMAFEPGMVKNTYGTGSFIVMNTGDKPQLSHNNLLTTIGY
CCCCCCEECCCCCCHHHHHHHHHCCCCCEEECCCCCEEEEEECCCCCCCCCCCEEEEECC
GINGEINYALEGSVFVAGSSIQWLRDGLKIIDKASDSEAAALESKNEDEIYMVPAFVGLG
CCCCEEEEEEECEEEEECCCHHHHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEEEHHHCC
APYWDQDARGAIFGLTRGTTDKDLIKATLQGIAYQVRDILGAMGEDTGIEIPVLKVDGGA
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
TNNEYLMQFQADILNTSVQRAGDLETTSLGAAFLAGLAVGYWKDFDELKESAKEGKRFDV
CCCHHHEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEECE
QMEEERRNKLYSGWKKAVEATRSFE
EEHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEGLPLEATEKYIMAIDQGTTSSRAIIFDHDGKHVGTSQKEFTQYFPEAGWVEHDANEI
CCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCHHHH
WNSVQSVIAGAFIESGIKPEQIAGIGITNQRETTVVWDKTTGLPIYHAIVWQSRQSASIA
HHHHHHHHHHHHHHCCCCHHHEEECCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCHHH
DDLKNAGHAELFHKKTGLIIDSYFSATKIRWILDHVKGAQERAEKGELLFGTIDSWLVYK
HHHHCCCCHHHHHHCCCCEEECHHHHHHHHHHHHHHCCHHHHHHCCCEEEEECCCEEEEE
LTDGKVHVTDYSNASRTMLFNINTLEWDQEILDLLNIPKIMLPKAVSNSEVYGLTKTYHF
EECCEEEEEECCCCCEEEEEEECCCCHHHHHHHHHCCCHHCCCCCCCCCEEEEEEEEHHH
FGSKVPIAGMAGDQQAALFGQMAFEPGMVKNTYGTGSFIVMNTGDKPQLSHNNLLTTIGY
CCCCCCEECCCCCCHHHHHHHHHCCCCCEEECCCCCEEEEEECCCCCCCCCCCEEEEECC
GINGEINYALEGSVFVAGSSIQWLRDGLKIIDKASDSEAAALESKNEDEIYMVPAFVGLG
CCCCEEEEEEECEEEEECCCHHHHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEEEHHHCC
APYWDQDARGAIFGLTRGTTDKDLIKATLQGIAYQVRDILGAMGEDTGIEIPVLKVDGGA
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
TNNEYLMQFQADILNTSVQRAGDLETTSLGAAFLAGLAVGYWKDFDELKESAKEGKRFDV
CCCHHHEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEECE
QMEEERRNKLYSGWKKAVEATRSFE
EEHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]