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The map label for this gene is guaA [H]

Identifier: 125623845

GI number: 125623845

Start: 972641

End: 974182

Strand: Direct

Name: guaA [H]

Synonym: llmg_1008

Alternate gene names: 125623845

Gene position: 972641-974182 (Clockwise)

Preceding gene: 125623844

Following gene: 125623846

Centisome position: 38.45

GC content: 41.89

Gene sequence:

>1542_bases
TTGTCCGACACTACACTTGAAAAAATCATTGTACTCGACTATGGTTCACAATACAATCAACTTATTGCGCGTCGTATCCG
AGAAATCGGTGTTTTCTCAGAACTCATGAGTCACAAAGTCACAGCCAAAGAAATTCGTGAGATTAATCCAATCGGTATTA
TTCTTTCAGGCGGTCCAAATTCAGTTTATGATGAAGGTTCATTCGATATTGACCCTGAAATCTTCGAACTTGGTTTGCCA
GTTCTTGGTATTTGCTACGGCATGCAATTGATGAGCTACAAACTTGGCGGTATGGTAGAAGCAGCAGGCGAACGCGAATA
CGGCGTTGCACCACTTCAACTCACTGAAAAATCAGCATTGTTTGCAGGAACTCCAGAAGTTCAAGATGTTTTGATGAGCC
ATGGTGACCGTGTAACAGCTATTCCTGAAGGTTTCCACGTTGTCGGAACTTCACCAAACAGTCCATTTGCTGCCGTTGAA
AACACTGAACGCAATTTGTACGGCATCCAATTTCACCCAGAAGTTCGTCATTCAGTTCACGGAACAGAAATGCTCAGAAA
CTTTGCGCTTAACATCTGTGGAGCCAAAGGGAACTGGTCAATGGAAAACTTCATTGATATGCAAATCAAAGATATTCGTG
AAAAAGTTGGCGACAAAAAAGTACTCCTTGGACTTTCAGGCGGTGTAGATTCATCAGTTGTGGGTGTTCTTTTACAACGT
GCCATTGGTGACCAATTGACATCAATCTTTGTTGACCACGGTTTCCTTCGTAAAGGCGAAGCTGACCAAGTCATGGAAAC
ATTGGGCGGAAAATTTGGTCTTAATATCATCAAAGTAGATGCTCAAAAACGTTTCATGGACAAACTTGTTGGCCTTTCAG
ACCCAGAAACAAAACGTAAAATTATCGGTAACGAATTTGTTTATGTTTTTGATGATGAAGCAAACAAATTAGAAGGTGTT
GACTTCCTTGCTCAAGGAACACTTTACACCGATGTCATTGAATCAGGAACAGATACAGCTCAAACAATTAAGTCACACCA
TAATGTTGGTGGACTTCCAGAAGACATGCAATTCCAATTGATTGAACCATTGAACACACTTTTCAAAGATGAAGTTCGTG
CGCTTGGAACACAACTTGGAATGCCTGATGAAATTGTTTGGCGTCAACCTTTCCCAGGTCCAGGACTTGCCATTCGTGTC
CTTGGTGATTTAACAGAAGAAAAATTAGAAACTGTTCGCGAATCAGACGCAATTCTTCGCGAAGAAATTGCTGCTTCAGG
ACTTGAACGTGATGTTTGGCAATATTTCACAGTAAATACAGACGTGAAATCAGTCGGTGTCATGGGAGACCAACGGACAT
ATGACTATACATTAGCCATCCGTGCCATCACTTCAATTGATGGGATGACAGCAGACTTTGCCCAACTTCCTTGGGATCTT
CTCCAAAAAATCTCAAAACGTATCGTCAATGAGGTTGACCACGTCAACCGTATCGTCTACGATATTACGAGCAAACCACC
AGCAACTGTTGAGTGGCAATAG

Upstream 100 bases:

>100_bases
GAAGAAAATATGTTAGAATAAGTCTAATAAAATATTTGAACAAAAGTTCGAACTTTCCAATAGGAATTCGGACTTTTGCA
CCTTATAAGAGGAGGGTCCC

Downstream 100 bases:

>100_bases
AATAAAAAAACTGATAGCAACTTACTGTTATCAGTTTTTTTGTTATTAAAAATAAGAAGCGTTAGTTTAAACTGGCGCTT
TTTGCTATCAAGAACATGCA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MSDTTLEKIIVLDYGSQYNQLIARRIREIGVFSELMSHKVTAKEIREINPIGIILSGGPNSVYDEGSFDIDPEIFELGLP
VLGICYGMQLMSYKLGGMVEAAGEREYGVAPLQLTEKSALFAGTPEVQDVLMSHGDRVTAIPEGFHVVGTSPNSPFAAVE
NTERNLYGIQFHPEVRHSVHGTEMLRNFALNICGAKGNWSMENFIDMQIKDIREKVGDKKVLLGLSGGVDSSVVGVLLQR
AIGDQLTSIFVDHGFLRKGEADQVMETLGGKFGLNIIKVDAQKRFMDKLVGLSDPETKRKIIGNEFVYVFDDEANKLEGV
DFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFQLIEPLNTLFKDEVRALGTQLGMPDEIVWRQPFPGPGLAIRV
LGDLTEEKLETVRESDAILREEIAASGLERDVWQYFTVNTDVKSVGVMGDQRTYDYTLAIRAITSIDGMTADFAQLPWDL
LQKISKRIVNEVDHVNRIVYDITSKPPATVEWQ

Sequences:

>Translated_513_residues
MSDTTLEKIIVLDYGSQYNQLIARRIREIGVFSELMSHKVTAKEIREINPIGIILSGGPNSVYDEGSFDIDPEIFELGLP
VLGICYGMQLMSYKLGGMVEAAGEREYGVAPLQLTEKSALFAGTPEVQDVLMSHGDRVTAIPEGFHVVGTSPNSPFAAVE
NTERNLYGIQFHPEVRHSVHGTEMLRNFALNICGAKGNWSMENFIDMQIKDIREKVGDKKVLLGLSGGVDSSVVGVLLQR
AIGDQLTSIFVDHGFLRKGEADQVMETLGGKFGLNIIKVDAQKRFMDKLVGLSDPETKRKIIGNEFVYVFDDEANKLEGV
DFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFQLIEPLNTLFKDEVRALGTQLGMPDEIVWRQPFPGPGLAIRV
LGDLTEEKLETVRESDAILREEIAASGLERDVWQYFTVNTDVKSVGVMGDQRTYDYTLAIRAITSIDGMTADFAQLPWDL
LQKISKRIVNEVDHVNRIVYDITSKPPATVEWQ
>Mature_512_residues
SDTTLEKIIVLDYGSQYNQLIARRIREIGVFSELMSHKVTAKEIREINPIGIILSGGPNSVYDEGSFDIDPEIFELGLPV
LGICYGMQLMSYKLGGMVEAAGEREYGVAPLQLTEKSALFAGTPEVQDVLMSHGDRVTAIPEGFHVVGTSPNSPFAAVEN
TERNLYGIQFHPEVRHSVHGTEMLRNFALNICGAKGNWSMENFIDMQIKDIREKVGDKKVLLGLSGGVDSSVVGVLLQRA
IGDQLTSIFVDHGFLRKGEADQVMETLGGKFGLNIIKVDAQKRFMDKLVGLSDPETKRKIIGNEFVYVFDDEANKLEGVD
FLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFQLIEPLNTLFKDEVRALGTQLGMPDEIVWRQPFPGPGLAIRVL
GDLTEEKLETVRESDAILREEIAASGLERDVWQYFTVNTDVKSVGVMGDQRTYDYTLAIRAITSIDGMTADFAQLPWDLL
QKISKRIVNEVDHVNRIVYDITSKPPATVEWQ

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=547, Percent_Identity=37.1115173674589, Blast_Score=318, Evalue=9e-87,
Organism=Escherichia coli, GI1788854, Length=518, Percent_Identity=52.8957528957529, Blast_Score=562, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI71992717, Length=567, Percent_Identity=38.2716049382716, Blast_Score=331, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI71992710, Length=567, Percent_Identity=38.2716049382716, Blast_Score=331, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI133901714, Length=567, Percent_Identity=38.2716049382716, Blast_Score=331, Evalue=7e-91,
Organism=Saccharomyces cerevisiae, GI6323873, Length=519, Percent_Identity=51.252408477842, Blast_Score=520, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6322638, Length=163, Percent_Identity=29.4478527607362, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI281365319, Length=547, Percent_Identity=37.8427787934186, Blast_Score=315, Evalue=5e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 56889; Mature: 56757

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTTLEKIIVLDYGSQYNQLIARRIREIGVFSELMSHKVTAKEIREINPIGIILSGGPN
CCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCC
SVYDEGSFDIDPEIFELGLPVLGICYGMQLMSYKLGGMVEAAGEREYGVAPLQLTEKSAL
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCEEECCCCEE
FAGTPEVQDVLMSHGDRVTAIPEGFHVVGTSPNSPFAAVENTERNLYGIQFHPEVRHSVH
ECCCHHHHHHHHHCCCEEEECCCCCEEEECCCCCCCEEEECCCCCEEEEEECHHHHHHCC
GTEMLRNFALNICGAKGNWSMENFIDMQIKDIREKVGDKKVLLGLSGGVDSSVVGVLLQR
HHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHH
AIGDQLTSIFVDHGFLRKGEADQVMETLGGKFGLNIIKVDAQKRFMDKLVGLSDPETKRK
HHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEEECHHHHHHHHHCCCCCCHHHHH
IIGNEFVYVFDDEANKLEGVDFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFQL
HCCCCEEEEECCCCCCCCCCHHHHCCCHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHH
IEPLNTLFKDEVRALGTQLGMPDEIVWRQPFPGPGLAIRVLGDLTEEKLETVRESDAILR
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
EEIAASGLERDVWQYFTVNTDVKSVGVMGDQRTYDYTLAIRAITSIDGMTADFAQLPWDL
HHHHHCCCHHHHHHEEEECCCHHHHCCCCCCCCEEEEEEEEEHHHCCCCCCHHHHCCHHH
LQKISKRIVNEVDHVNRIVYDITSKPPATVEWQ
HHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC
>Mature Secondary Structure 
SDTTLEKIIVLDYGSQYNQLIARRIREIGVFSELMSHKVTAKEIREINPIGIILSGGPN
CCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCC
SVYDEGSFDIDPEIFELGLPVLGICYGMQLMSYKLGGMVEAAGEREYGVAPLQLTEKSAL
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCEEECCCCEE
FAGTPEVQDVLMSHGDRVTAIPEGFHVVGTSPNSPFAAVENTERNLYGIQFHPEVRHSVH
ECCCHHHHHHHHHCCCEEEECCCCCEEEECCCCCCCEEEECCCCCEEEEEECHHHHHHCC
GTEMLRNFALNICGAKGNWSMENFIDMQIKDIREKVGDKKVLLGLSGGVDSSVVGVLLQR
HHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHH
AIGDQLTSIFVDHGFLRKGEADQVMETLGGKFGLNIIKVDAQKRFMDKLVGLSDPETKRK
HHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEEECHHHHHHHHHCCCCCCHHHHH
IIGNEFVYVFDDEANKLEGVDFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFQL
HCCCCEEEEECCCCCCCCCCHHHHCCCHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHH
IEPLNTLFKDEVRALGTQLGMPDEIVWRQPFPGPGLAIRVLGDLTEEKLETVRESDAILR
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
EEIAASGLERDVWQYFTVNTDVKSVGVMGDQRTYDYTLAIRAITSIDGMTADFAQLPWDL
HHHHHCCCHHHHHHEEEECCCHHHHCCCCCCCCEEEEEEEEEHHHCCCCCCHHHHCCHHH
LQKISKRIVNEVDHVNRIVYDITSKPPATVEWQ
HHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]