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The map label for this gene is tetR [H]

Identifier: 125623833

GI number: 125623833

Start: 962586

End: 963212

Strand: Reverse

Name: tetR [H]

Synonym: llmg_0996

Alternate gene names: 125623833

Gene position: 963212-962586 (Counterclockwise)

Preceding gene: 125623838

Following gene: 125623828

Centisome position: 38.08

GC content: 34.93

Gene sequence:

>627_bases
ATGGCGACTCAACCAACAAAAGACAAAATTATTAGCAGTAGCTGGGAACTTCTACAAGAGCTTCCACTCACAGAATTTTC
AATGCGCAAATTAGCTAGTCGGCTAGGAATGACCGTCTCTTCTCTTTACTATCATTTTTCAAGTAAAGAGGCACTTTTTG
CTGAACTGATTGATAAAGCCAGCCTTGAAATCATTTTTCCAGCAAACGAAAAAACTTGGCAAAATCGCCTTTTGGTTTAT
GGAAAAAATATTTATGCTGTTTTAGAATCTTATCCAAATCTTGCTCAATTGATGATGGATTATCCACCAGAATCCGAAAA
TTATCTACGACTTTTTGACAAACTTTTGATGATTGTAGATGATCTTAATCTCACTGATGACCGTAAATTTTATACCGTTA
ACCTTTATCTAAATTTTATCTACAGCAGTAAAATAGATAGTGATCGCTTAGTAGAACAACCCGAAAAACCTCTTTCGACT
GTCAAAATTCCTCTTATTCAACTTGCTCCTTTTCTCGATAAATATTGGCAGACAGAAAGTCTTACCAGCTTAAGTTCGTC
TGAAAGTTTTGAATTTGGACTAGAACTTATCATTTCGGGCATCGAAAAAATGGTTCAAACTGATTAA

Upstream 100 bases:

>100_bases
AAAAATTTATAGATTACCTTTTATTTATTTTTTCTTCCTATCGCATTTTTCTTTAAAAACATGTAAAATAAATTTAAGTA
GAAATAGAAAGTAGAATATC

Downstream 100 bases:

>100_bases
TTCATAAAAAACTTCTAAAAGGAAGTTTTTTTCTTGACTTTATTTTAGAACGATGGTATTATTTTTACCGAACAATGTTC
TAAAACAAAAAAAGAAGGTT

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MATQPTKDKIISSSWELLQELPLTEFSMRKLASRLGMTVSSLYYHFSSKEALFAELIDKASLEIIFPANEKTWQNRLLVY
GKNIYAVLESYPNLAQLMMDYPPESENYLRLFDKLLMIVDDLNLTDDRKFYTVNLYLNFIYSSKIDSDRLVEQPEKPLST
VKIPLIQLAPFLDKYWQTESLTSLSSSESFEFGLELIISGIEKMVQTD

Sequences:

>Translated_208_residues
MATQPTKDKIISSSWELLQELPLTEFSMRKLASRLGMTVSSLYYHFSSKEALFAELIDKASLEIIFPANEKTWQNRLLVY
GKNIYAVLESYPNLAQLMMDYPPESENYLRLFDKLLMIVDDLNLTDDRKFYTVNLYLNFIYSSKIDSDRLVEQPEKPLST
VKIPLIQLAPFLDKYWQTESLTSLSSSESFEFGLELIISGIEKMVQTD
>Mature_207_residues
ATQPTKDKIISSSWELLQELPLTEFSMRKLASRLGMTVSSLYYHFSSKEALFAELIDKASLEIIFPANEKTWQNRLLVYG
KNIYAVLESYPNLAQLMMDYPPESENYLRLFDKLLMIVDDLNLTDDRKFYTVNLYLNFIYSSKIDSDRLVEQPEKPLSTV
KIPLIQLAPFLDKYWQTESLTSLSSSESFEFGLELIISGIEKMVQTD

Specific function: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to tetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter opera

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR003012
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR004111
- InterPro:   IPR001647 [H]

Pfam domain/function: PF02909 TetR_C; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24097; Mature: 23966

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATQPTKDKIISSSWELLQELPLTEFSMRKLASRLGMTVSSLYYHFSSKEALFAELIDKA
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHCCC
SLEIIFPANEKTWQNRLLVYGKNIYAVLESYPNLAQLMMDYPPESENYLRLFDKLLMIVD
CEEEEECCCCCHHHCEEEEECCHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHH
DLNLTDDRKFYTVNLYLNFIYSSKIDSDRLVEQPEKPLSTVKIPLIQLAPFLDKYWQTES
CCCCCCCCEEEEEEEEEEEHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHH
LTSLSSSESFEFGLELIISGIEKMVQTD
HHHCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATQPTKDKIISSSWELLQELPLTEFSMRKLASRLGMTVSSLYYHFSSKEALFAELIDKA
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHCCC
SLEIIFPANEKTWQNRLLVYGKNIYAVLESYPNLAQLMMDYPPESENYLRLFDKLLMIVD
CEEEEECCCCCHHHCEEEEECCHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHH
DLNLTDDRKFYTVNLYLNFIYSSKIDSDRLVEQPEKPLSTVKIPLIQLAPFLDKYWQTES
CCCCCCCCEEEEEEEEEEEHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHH
LTSLSSSESFEFGLELIISGIEKMVQTD
HHHCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6330687; 3208760; 6311683; 3062183 [H]