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The map label for this gene is obgE [H]

Identifier: 125623758

GI number: 125623758

Start: 882441

End: 883754

Strand: Direct

Name: obgE [H]

Synonym: llmg_0915

Alternate gene names: 125623758

Gene position: 882441-883754 (Clockwise)

Preceding gene: 125623757

Following gene: 125623759

Centisome position: 34.89

GC content: 40.79

Gene sequence:

>1314_bases
ATGTCTTTATTTTTAGATACAGCACGAATTGAAGTAAAAGCTGGTAAAGGTGGCGATGGCGCAGTTGCTTTTCGTCGTGA
AAAATATGTACCAGATGGCGGTCCTGCCGGTGGTGATGGAGGTAAAGGGGGTTCTGTAATCTTTAAAGTTGATGAAGGAA
TGTCAACTTTGATGGATTTCCGATACAACCGCATCTTCCGTGGGAAACCCGGTGAAAAAGGAATGAACAAAGGGATGCAC
GGTCGTGGAGCCGAAGATTTAATTGTTCATGTTCCTCAAGGGACAACTGTTAAAGATAATGAAACTGGCGATGTTTTAGT
CGATTTGATTGAAAAAGATCAAGAATTTGTGGTTGCTAAAGGTGGCCGCGGTGGTCGTGGAAATATTCGCTTTGCTACAC
CACGTAATCCAGCGCCAGAAGTGGCAGAAAATGGAGAACCTGGAGAAGATAAGATTCTACTTTTGGAACTTCGTGTTTTA
GCAGATGTTGGTTTAGTTGGATTCCCATCAGTTGGGAAATCTACTTTGCTGTCAGTAGTTTCAAATGCTCGTCCTAAAAT
TGGAGCTTACCATTTTACAACAATTACACCAAATATTGGGATGGTTCAAGTCGGTTATGGCGATAGTTTTGTTATGGCGG
ATATGCCAGGATTAATTGAAGGAGCACACTCTGGTGCAGGACTTGGAATTCAATTTTTGCGTCATATTGAACGGACACGT
GTCCTTCTCCATATTCTTGACATGTCTGAACTTGAGGGACGTGACCCTTATGAAGATTACAAAACAATCAATGATGAATT
GGAATCTTACAATCTCCGCTTGATGGAACGTCCACAACTTATTGTTGCCAATAAGATGGATATGCCAGAAGCAGCAGAAC
GTTTGGCCGAATTTAAAGAAAAATTAGCTGCTGATTTAGAAGCAGATCAAGAGATGCCTGAAATTTTTGAAGTATCTGGG
TTGACTAAAACAGGATTACAAGGCTTGTTAGCTCGTACGAGTGAATTACTTGCTCAAACACCAGAATTCTTACTTTATGA
CGAAGATGCCTTGGGTGATGAAGTAGCTTACTATGGCTTTGAAGACGAAGAAAAACCATTCAAAGTTTCACGCGATGATG
ATGGTGGATGGCGTTTATCTGGTGAGAAAATTGAAAAACTCTTTATCATGACAAACTTTGACCATGATGAATCAGTAATG
AAATTTGCTCGGCAAATGCGTGCCTTCGGTGTCGATGAAACGCTTCGCTCAATGGGTGCCAAAGACGGAGATTATGTACG
AATTCAAAAATTTGAATTTGAATTTGTAGACTAA

Upstream 100 bases:

>100_bases
AGCTATAAAAAAGCTGGATAAAATGCTATAATGAATAGCACGCATTTTTGTGGAAAAATAATATATAAACTATTTAAAGA
AAATTTAGAGGAGAAACTGT

Downstream 100 bases:

>100_bases
AAATATCAATATTTTCGGAGATTAAAAATGGGATTTAAAATTATTGGTGACCGTGACAAAGACGGAAATTTTATTGCCTC
AGCCGATTATTGGACAGATG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MSLFLDTARIEVKAGKGGDGAVAFRREKYVPDGGPAGGDGGKGGSVIFKVDEGMSTLMDFRYNRIFRGKPGEKGMNKGMH
GRGAEDLIVHVPQGTTVKDNETGDVLVDLIEKDQEFVVAKGGRGGRGNIRFATPRNPAPEVAENGEPGEDKILLLELRVL
ADVGLVGFPSVGKSTLLSVVSNARPKIGAYHFTTITPNIGMVQVGYGDSFVMADMPGLIEGAHSGAGLGIQFLRHIERTR
VLLHILDMSELEGRDPYEDYKTINDELESYNLRLMERPQLIVANKMDMPEAAERLAEFKEKLAADLEADQEMPEIFEVSG
LTKTGLQGLLARTSELLAQTPEFLLYDEDALGDEVAYYGFEDEEKPFKVSRDDDGGWRLSGEKIEKLFIMTNFDHDESVM
KFARQMRAFGVDETLRSMGAKDGDYVRIQKFEFEFVD

Sequences:

>Translated_437_residues
MSLFLDTARIEVKAGKGGDGAVAFRREKYVPDGGPAGGDGGKGGSVIFKVDEGMSTLMDFRYNRIFRGKPGEKGMNKGMH
GRGAEDLIVHVPQGTTVKDNETGDVLVDLIEKDQEFVVAKGGRGGRGNIRFATPRNPAPEVAENGEPGEDKILLLELRVL
ADVGLVGFPSVGKSTLLSVVSNARPKIGAYHFTTITPNIGMVQVGYGDSFVMADMPGLIEGAHSGAGLGIQFLRHIERTR
VLLHILDMSELEGRDPYEDYKTINDELESYNLRLMERPQLIVANKMDMPEAAERLAEFKEKLAADLEADQEMPEIFEVSG
LTKTGLQGLLARTSELLAQTPEFLLYDEDALGDEVAYYGFEDEEKPFKVSRDDDGGWRLSGEKIEKLFIMTNFDHDESVM
KFARQMRAFGVDETLRSMGAKDGDYVRIQKFEFEFVD
>Mature_436_residues
SLFLDTARIEVKAGKGGDGAVAFRREKYVPDGGPAGGDGGKGGSVIFKVDEGMSTLMDFRYNRIFRGKPGEKGMNKGMHG
RGAEDLIVHVPQGTTVKDNETGDVLVDLIEKDQEFVVAKGGRGGRGNIRFATPRNPAPEVAENGEPGEDKILLLELRVLA
DVGLVGFPSVGKSTLLSVVSNARPKIGAYHFTTITPNIGMVQVGYGDSFVMADMPGLIEGAHSGAGLGIQFLRHIERTRV
LLHILDMSELEGRDPYEDYKTINDELESYNLRLMERPQLIVANKMDMPEAAERLAEFKEKLAADLEADQEMPEIFEVSGL
TKTGLQGLLARTSELLAQTPEFLLYDEDALGDEVAYYGFEDEEKPFKVSRDDDGGWRLSGEKIEKLFIMTNFDHDESVMK
FARQMRAFGVDETLRSMGAKDGDYVRIQKFEFEFVD

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=327, Percent_Identity=41.8960244648318, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI111955139, Length=323, Percent_Identity=34.0557275541796, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI111955063, Length=219, Percent_Identity=35.1598173515982, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI4758796, Length=127, Percent_Identity=38.5826771653543, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI4557537, Length=114, Percent_Identity=36.8421052631579, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1789574, Length=359, Percent_Identity=42.6183844011142, Blast_Score=254, Evalue=5e-69,
Organism=Escherichia coli, GI1787454, Length=138, Percent_Identity=31.8840579710145, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790615, Length=187, Percent_Identity=27.807486631016, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17508313, Length=333, Percent_Identity=39.9399399399399, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17552324, Length=311, Percent_Identity=28.9389067524116, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17555344, Length=118, Percent_Identity=37.2881355932203, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71981008, Length=118, Percent_Identity=35.5932203389831, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17509631, Length=140, Percent_Identity=31.4285714285714, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=187, Percent_Identity=39.572192513369, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319281, Length=126, Percent_Identity=37.3015873015873, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321649, Length=141, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321612, Length=126, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI20129375, Length=300, Percent_Identity=42.3333333333333, Blast_Score=198, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24585318, Length=374, Percent_Identity=34.7593582887701, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI17981711, Length=127, Percent_Identity=37.007874015748, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21356473, Length=117, Percent_Identity=36.7521367521368, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 48236; Mature: 48105

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFLDTARIEVKAGKGGDGAVAFRREKYVPDGGPAGGDGGKGGSVIFKVDEGMSTLMDF
CCEEEEEEEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHH
RYNRIFRGKPGEKGMNKGMHGRGAEDLIVHVPQGTTVKDNETGDVLVDLIEKDQEFVVAK
HHHHEECCCCCCHHHCCCCCCCCCCCEEEECCCCCEECCCCCCHHHHHHHHCCCEEEEEE
GGRGGRGNIRFATPRNPAPEVAENGEPGEDKILLLELRVLADVGLVGFPSVGKSTLLSVV
CCCCCCCCEEEECCCCCCCHHHCCCCCCCCCEEEEEEEHHHHCCCCCCCCCCHHHHHHHH
SNARPKIGAYHFTTITPNIGMVQVGYGDSFVMADMPGLIEGAHSGAGLGIQFLRHIERTR
HCCCCCCCEEEEEEECCCCCEEEECCCCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHHH
VLLHILDMSELEGRDPYEDYKTINDELESYNLRLMERPQLIVANKMDMPEAAERLAEFKE
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEECCCCEEEECCCCCHHHHHHHHHHHH
KLAADLEADQEMPEIFEVSGLTKTGLQGLLARTSELLAQTPEFLLYDEDALGDEVAYYGF
HHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEECCC
EDEEKPFKVSRDDDGGWRLSGEKIEKLFIMTNFDHDESVMKFARQMRAFGVDETLRSMGA
CCCCCCEEECCCCCCCEEECHHHEEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHCCC
KDGDYVRIQKFEFEFVD
CCCCEEEEEEEEEEECC
>Mature Secondary Structure 
SLFLDTARIEVKAGKGGDGAVAFRREKYVPDGGPAGGDGGKGGSVIFKVDEGMSTLMDF
CEEEEEEEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHH
RYNRIFRGKPGEKGMNKGMHGRGAEDLIVHVPQGTTVKDNETGDVLVDLIEKDQEFVVAK
HHHHEECCCCCCHHHCCCCCCCCCCCEEEECCCCCEECCCCCCHHHHHHHHCCCEEEEEE
GGRGGRGNIRFATPRNPAPEVAENGEPGEDKILLLELRVLADVGLVGFPSVGKSTLLSVV
CCCCCCCCEEEECCCCCCCHHHCCCCCCCCCEEEEEEEHHHHCCCCCCCCCCHHHHHHHH
SNARPKIGAYHFTTITPNIGMVQVGYGDSFVMADMPGLIEGAHSGAGLGIQFLRHIERTR
HCCCCCCCEEEEEEECCCCCEEEECCCCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHHH
VLLHILDMSELEGRDPYEDYKTINDELESYNLRLMERPQLIVANKMDMPEAAERLAEFKE
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEECCCCEEEECCCCCHHHHHHHHHHHH
KLAADLEADQEMPEIFEVSGLTKTGLQGLLARTSELLAQTPEFLLYDEDALGDEVAYYGF
HHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEECCC
EDEEKPFKVSRDDDGGWRLSGEKIEKLFIMTNFDHDESVMKFARQMRAFGVDETLRSMGA
CCCCCCEEECCCCCCCEEECHHHEEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHCCC
KDGDYVRIQKFEFEFVD
CCCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]