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The map label for this gene is pyrR [H]

Identifier: 125623734

GI number: 125623734

Start: 861083

End: 861604

Strand: Direct

Name: pyrR [H]

Synonym: llmg_0890

Alternate gene names: 125623734

Gene position: 861083-861604 (Clockwise)

Preceding gene: 125623733

Following gene: 125623735

Centisome position: 34.04

GC content: 39.46

Gene sequence:

>522_bases
ATGGCTAGAAAAGAAATTATTGACGAAATCACAATGAAACGTGCAATTACACGGATCACTTACGAGATTATTGAACGTAA
TAAAGAACTGGACAAATTGGTTTTGATTGGGATTAAGACACGCGGTGTTTATTTGGCCAAAAGAATCCAAGAACGTTTGC
AACAACTGGAAGGTTTGGAAATTCCTTTTGGTGAGCTGGATACACGTCCATTCCGTGATGATAAACAAGCACAAGAAGAT
ACAACAGAAATTGATATCGATATTACAGGAAAAGATGTCATTCTTGTTGATGATGTGCTCTACACAGGTCGGACAATTCG
TGCGGCAATTGACGGAATCGTAAAACTTGGTCGCCCAGCCCGTGTTCAATTGGCTGTTTTAGTTGACCGTGGACATCGCG
AATTACCAATTCGTGCAGACTACGTTGGGAAAAATATTCCAACAGGTCATGATGAAGAAATCATCGTTCAAATGTCTGAG
CATGATGGCAATGACAGTATTTTAATCAAACGTGAAGATTAA

Upstream 100 bases:

>100_bases
GTATACTGACGGACATCTTATTAATGGAAGTATTAATCGATAAATGAAAGATTTGTCAGTTAACTGACAAATTAATCATT
AAGAATGAAAGGAGCCCCAA

Downstream 100 bases:

>100_bases
GAAATAAGTTCTCTGTCAGTAATTTAAGAAAAAGAGTAATCTATAAGTTACTGACAAAGTTTTCAATAAATATTCAACTT
AGAGTTTTAGGAGAAAAAAG

Product: bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase

Products: uracil; 5-phospho-alpha-D-ribose 1-diphosphate

Alternate protein names: NA

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MARKEIIDEITMKRAITRITYEIIERNKELDKLVLIGIKTRGVYLAKRIQERLQQLEGLEIPFGELDTRPFRDDKQAQED
TTEIDIDITGKDVILVDDVLYTGRTIRAAIDGIVKLGRPARVQLAVLVDRGHRELPIRADYVGKNIPTGHDEEIIVQMSE
HDGNDSILIKRED

Sequences:

>Translated_173_residues
MARKEIIDEITMKRAITRITYEIIERNKELDKLVLIGIKTRGVYLAKRIQERLQQLEGLEIPFGELDTRPFRDDKQAQED
TTEIDIDITGKDVILVDDVLYTGRTIRAAIDGIVKLGRPARVQLAVLVDRGHRELPIRADYVGKNIPTGHDEEIIVQMSE
HDGNDSILIKRED
>Mature_172_residues
ARKEIIDEITMKRAITRITYEIIERNKELDKLVLIGIKTRGVYLAKRIQERLQQLEGLEIPFGELDTRPFRDDKQAQEDT
TEIDIDITGKDVILVDDVLYTGRTIRAAIDGIVKLGRPARVQLAVLVDRGHRELPIRADYVGKNIPTGHDEEIIVQMSEH
DGNDSILIKRED

Specific function: Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines, probably by binding to specific sites on pyr mRNA. This probably disrupts an antiterminator hairpin in the RNA and favors formation of a

COG id: COG2065

COG function: function code F; Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR023050 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: 2.4.2.9

Molecular weight: Translated: 19812; Mature: 19681

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKEIIDEITMKRAITRITYEIIERNKELDKLVLIGIKTRGVYLAKRIQERLQQLEGLE
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCC
IPFGELDTRPFRDDKQAQEDTTEIDIDITGKDVILVDDVLYTGRTIRAAIDGIVKLGRPA
CCCCCCCCCCCCCCCHHCCCCCEEEEEECCCCEEEEECHHHCCCHHHHHHHHHHHCCCCC
RVQLAVLVDRGHRELPIRADYVGKNIPTGHDEEIIVQMSEHDGNDSILIKRED
EEEEEEEEECCCCCCCEEHHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEECC
>Mature Secondary Structure 
ARKEIIDEITMKRAITRITYEIIERNKELDKLVLIGIKTRGVYLAKRIQERLQQLEGLE
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCC
IPFGELDTRPFRDDKQAQEDTTEIDIDITGKDVILVDDVLYTGRTIRAAIDGIVKLGRPA
CCCCCCCCCCCCCCCHHCCCCCEEEEEECCCCEEEEECHHHCCCHHHHHHHHHHHCCCCC
RVQLAVLVDRGHRELPIRADYVGKNIPTGHDEEIIVQMSEHDGNDSILIKRED
EEEEEEEEECCCCCCCEEHHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UMP; diphosphate

Specific reaction: UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]