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The map label for this gene is ffh [H]

Identifier: 125623722

GI number: 125623722

Start: 850424

End: 851980

Strand: Direct

Name: ffh [H]

Synonym: llmg_0878

Alternate gene names: 125623722

Gene position: 850424-851980 (Clockwise)

Preceding gene: 125623721

Following gene: 125623725

Centisome position: 33.62

GC content: 39.37

Gene sequence:

>1557_bases
ATGGCATTTGAAAACTTAACTGAACGTTTACAAAACGTTTTTAAAAATCTGCGTGGAAAGAAAAAAATTACTGAGGCAGA
CGTCACAGAAATTACAAAAGAAATTCGAGTAGCTCTTCTTGAAGCCGACGTTGCTCTCCCAGTTGTCAAAAAATTTATTA
AGGCAATTCGTGAGCGAGCTGTCGGTATTGAAGTATCAGAGGCTTTGAACCCAGCTCAACAAGTTATCAAAATTGTTGAT
GAAGAATTAACAACTATCTTAGGCGGTGGTGAAGCCGAATTACTCAAATCTCCTAAAATCCCAACAATTATCATGATGGT
TGGTTTGCAAGGGGCAGGTAAAACAACCTTTGCTGGTAAACTTGCAAAAAAACTTAAAGAAGAACAAAATGCTCGCCCAC
TGATGATTGCAGCCGACGTTTATCGTCCAGCAGCGATTGACCAATTAAAAACCTTGGGAGAACAACTTGACATTCCTGTT
TATGATGAAGGAACGTCTGAAAAACCCGTTAATATTGTCCGTAATGGTCTTTTAAAAGCTCAAGAAGAACGTAAAGATTA
TGTGTTGATTGATACGGCAGGTCGTCTTGAAATTGATGATACATTGATGAATGAGCTTCAAGAGATTAAAGCACTCGCGC
AACCAACAGAAATTTTACTCGTTGTTGATGCGATGACTGGTCAAGTGGCCGCACAAGTGGCTAAAACTTTTGATGAAAAA
TTAGATATTACCGGTGTTATCATCACCAAACTCGATGGGGACACACGTGGTGGTGCGGCTTTATCAATTCGTGAAATTAC
CGGAAAACCTATTAAATTTACAGGGACTGGTGAAAAATTAACCGACCTTGAAGTTTTCTACCCTGATCGTATGAGCTCAA
GAATTCTTGGTATGGGTGATATGCTCACTCTGATTGAGAAGGCGCAAGCTAATTATGATGAGGAACAATCTGCAAAACTC
GCTGAAAAAATGGCTGATAACCGTTTTGATTATGAGGATTTCGTTGAGCAACTAGATCAAGTTACAAATATGGGACCAAT
GGAAGATATTATGAAAATGATTCCAGGAATGTCACAAATGCCTGGCTTGGATAAAGTTAAAGTTGACCCTAAAGATGTTG
CTAGAAAACGAGCAATGGTATTGTCAATGACCCCAGCTGAACGTCATTTAGAAGCAGAACTATCGCCAGCTCGTCGTCGT
CGAATCGCCGCAGGTTCTGGGAATTCATTTATTGAAGTAAATAAATTCATTAAGCAATTTAATCAATCCAAAGAAATGAT
GCAAGGAATCATGAATGGTGATATGAATGCGATGATGCAAAAAATGATGGGTGGAGCTGGTGGACAAATGCCAAATATGC
CAACCGGTTCTGGAATGCCAGATATGTCAGCCTTGGGAGATTTACAAGGAATGATGGGAAATGGTTCCGCAAACGGAATG
CCAGATATGAGTTCTATGTTTGGTGGTGGTTTGAAAGGTAAAGCAACTGAATTTGCTATGAAGCAAGCCATGAAACGTGC
TCAAAAGAAAATGAAAAAAGGTAAGAAAAAACGCTAA

Upstream 100 bases:

>100_bases
GAGAAAAAAAGATAATAACTAAAACTTTAGATGTATTCAAATTTAAGTAAAGAAATGTTATAATGAAGTTATTGTAAAAA
ATAGAATTGGATTATAAAAT

Downstream 100 bases:

>100_bases
GAAATAAAAAAACAGGAATTTCTCCTGTTTTTTTTATTTAATCATTTTTTCTTTCTGGGCATACTCGGATTTAAGAATCC
CCATGAAATAACTGTCATGA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MAFENLTERLQNVFKNLRGKKKITEADVTEITKEIRVALLEADVALPVVKKFIKAIRERAVGIEVSEALNPAQQVIKIVD
EELTTILGGGEAELLKSPKIPTIIMMVGLQGAGKTTFAGKLAKKLKEEQNARPLMIAADVYRPAAIDQLKTLGEQLDIPV
YDEGTSEKPVNIVRNGLLKAQEERKDYVLIDTAGRLEIDDTLMNELQEIKALAQPTEILLVVDAMTGQVAAQVAKTFDEK
LDITGVIITKLDGDTRGGAALSIREITGKPIKFTGTGEKLTDLEVFYPDRMSSRILGMGDMLTLIEKAQANYDEEQSAKL
AEKMADNRFDYEDFVEQLDQVTNMGPMEDIMKMIPGMSQMPGLDKVKVDPKDVARKRAMVLSMTPAERHLEAELSPARRR
RIAAGSGNSFIEVNKFIKQFNQSKEMMQGIMNGDMNAMMQKMMGGAGGQMPNMPTGSGMPDMSALGDLQGMMGNGSANGM
PDMSSMFGGGLKGKATEFAMKQAMKRAQKKMKKGKKKR

Sequences:

>Translated_518_residues
MAFENLTERLQNVFKNLRGKKKITEADVTEITKEIRVALLEADVALPVVKKFIKAIRERAVGIEVSEALNPAQQVIKIVD
EELTTILGGGEAELLKSPKIPTIIMMVGLQGAGKTTFAGKLAKKLKEEQNARPLMIAADVYRPAAIDQLKTLGEQLDIPV
YDEGTSEKPVNIVRNGLLKAQEERKDYVLIDTAGRLEIDDTLMNELQEIKALAQPTEILLVVDAMTGQVAAQVAKTFDEK
LDITGVIITKLDGDTRGGAALSIREITGKPIKFTGTGEKLTDLEVFYPDRMSSRILGMGDMLTLIEKAQANYDEEQSAKL
AEKMADNRFDYEDFVEQLDQVTNMGPMEDIMKMIPGMSQMPGLDKVKVDPKDVARKRAMVLSMTPAERHLEAELSPARRR
RIAAGSGNSFIEVNKFIKQFNQSKEMMQGIMNGDMNAMMQKMMGGAGGQMPNMPTGSGMPDMSALGDLQGMMGNGSANGM
PDMSSMFGGGLKGKATEFAMKQAMKRAQKKMKKGKKKR
>Mature_517_residues
AFENLTERLQNVFKNLRGKKKITEADVTEITKEIRVALLEADVALPVVKKFIKAIRERAVGIEVSEALNPAQQVIKIVDE
ELTTILGGGEAELLKSPKIPTIIMMVGLQGAGKTTFAGKLAKKLKEEQNARPLMIAADVYRPAAIDQLKTLGEQLDIPVY
DEGTSEKPVNIVRNGLLKAQEERKDYVLIDTAGRLEIDDTLMNELQEIKALAQPTEILLVVDAMTGQVAAQVAKTFDEKL
DITGVIITKLDGDTRGGAALSIREITGKPIKFTGTGEKLTDLEVFYPDRMSSRILGMGDMLTLIEKAQANYDEEQSAKLA
EKMADNRFDYEDFVEQLDQVTNMGPMEDIMKMIPGMSQMPGLDKVKVDPKDVARKRAMVLSMTPAERHLEAELSPARRRR
IAAGSGNSFIEVNKFIKQFNQSKEMMQGIMNGDMNAMMQKMMGGAGGQMPNMPTGSGMPDMSALGDLQGMMGNGSANGMP
DMSSMFGGGLKGKATEFAMKQAMKRAQKKMKKGKKKR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=507, Percent_Identity=31.7554240631164, Blast_Score=223, Evalue=5e-58,
Organism=Homo sapiens, GI226371618, Length=444, Percent_Identity=32.6576576576577, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI89061728, Length=143, Percent_Identity=41.2587412587413, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI23308697, Length=303, Percent_Identity=26.0726072607261, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI295424842, Length=303, Percent_Identity=26.0726072607261, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1788963, Length=420, Percent_Identity=49.2857142857143, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1789874, Length=266, Percent_Identity=34.5864661654135, Blast_Score=146, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17539958, Length=493, Percent_Identity=29.2089249492901, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI193206261, Length=294, Percent_Identity=29.9319727891156, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6325345, Length=486, Percent_Identity=33.5390946502058, Blast_Score=235, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6320498, Length=313, Percent_Identity=27.4760383386581, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17647949, Length=359, Percent_Identity=34.8189415041783, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24641198, Length=306, Percent_Identity=28.1045751633987, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 56861; Mature: 56730

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
7.3 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
7.2 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFENLTERLQNVFKNLRGKKKITEADVTEITKEIRVALLEADVALPVVKKFIKAIRERA
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGIEVSEALNPAQQVIKIVDEELTTILGGGEAELLKSPKIPTIIMMVGLQGAGKTTFAGK
CCCCHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEEECCCCCCCHHHHH
LAKKLKEEQNARPLMIAADVYRPAAIDQLKTLGEQLDIPVYDEGTSEKPVNIVRNGLLKA
HHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
QEERKDYVLIDTAGRLEIDDTLMNELQEIKALAQPTEILLVVDAMTGQVAAQVAKTFDEK
HHCCCCEEEEECCCCCEECHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHH
LDITGVIITKLDGDTRGGAALSIREITGKPIKFTGTGEKLTDLEVFYPDRMSSRILGMGD
CCCEEEEEEEECCCCCCCCEEEEEECCCCCEEEECCCCCCCCEEEECCCHHHHHHCCCHH
MLTLIEKAQANYDEEQSAKLAEKMADNRFDYEDFVEQLDQVTNMGPMEDIMKMIPGMSQM
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
PGLDKVKVDPKDVARKRAMVLSMTPAERHLEAELSPARRRRIAAGSGNSFIEVNKFIKQF
CCCCCCCCCHHHHHHHHHHHEEECCHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHH
NQSKEMMQGIMNGDMNAMMQKMMGGAGGQMPNMPTGSGMPDMSALGDLQGMMGNGSANGM
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
PDMSSMFGGGLKGKATEFAMKQAMKRAQKKMKKGKKKR
CCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AFENLTERLQNVFKNLRGKKKITEADVTEITKEIRVALLEADVALPVVKKFIKAIRERA
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGIEVSEALNPAQQVIKIVDEELTTILGGGEAELLKSPKIPTIIMMVGLQGAGKTTFAGK
CCCCHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEEECCCCCCCHHHHH
LAKKLKEEQNARPLMIAADVYRPAAIDQLKTLGEQLDIPVYDEGTSEKPVNIVRNGLLKA
HHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
QEERKDYVLIDTAGRLEIDDTLMNELQEIKALAQPTEILLVVDAMTGQVAAQVAKTFDEK
HHCCCCEEEEECCCCCEECHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHH
LDITGVIITKLDGDTRGGAALSIREITGKPIKFTGTGEKLTDLEVFYPDRMSSRILGMGD
CCCEEEEEEEECCCCCCCCEEEEEECCCCCEEEECCCCCCCCEEEECCCHHHHHHCCCHH
MLTLIEKAQANYDEEQSAKLAEKMADNRFDYEDFVEQLDQVTNMGPMEDIMKMIPGMSQM
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
PGLDKVKVDPKDVARKRAMVLSMTPAERHLEAELSPARRRRIAAGSGNSFIEVNKFIKQF
CCCCCCCCCHHHHHHHHHHHEEECCHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHH
NQSKEMMQGIMNGDMNAMMQKMMGGAGGQMPNMPTGSGMPDMSALGDLQGMMGNGSANGM
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
PDMSSMFGGGLKGKATEFAMKQAMKRAQKKMKKGKKKR
CCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12397186; 8763945 [H]