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The map label for this gene is kinF [H]

Identifier: 125623602

GI number: 125623602

Start: 734558

End: 735928

Strand: Direct

Name: kinF [H]

Synonym: llmg_0748

Alternate gene names: 125623602

Gene position: 734558-735928 (Clockwise)

Preceding gene: 125623601

Following gene: 125623603

Centisome position: 29.04

GC content: 35.59

Gene sequence:

>1371_bases
TTGAAGAATATAATTAAAAAAGTTAAATCTTCAGCTATCGTAAAAAATGATGGGAAAAATTTCCTTCATTTTTTTCTAGC
TTTTACAGTGATCTTTGTCGCCCTAGCCGTGATTATCATTCAAGTCATGCAATTGGGAATGTACAGGGCGACTGACCAAA
ATTTACATAATTTAGCTCAAAATCGAGTGTTTTTGGAAGAAGCTGCCAATAATCAATTTGGTACGAGTGATTCACAAGAT
AGTGGATTTTATGGGCCAAATAATAGTGTTATTTTTTATGACTCAGAAGGAAAGAGTTTCATGCCCTCATCAGAATCAAA
TGGACGAATCAGTACCAACTTTGTGATGAGTCGTCTGCAAAAGGCTATGAAATTTAATGAAAAGCAAATTAATACCATTC
AGACTGTTTCAGTAAAAAATCCCTATGGTGATAACTGGCATTATCGGTATTTGACCACTTCGCAATTTATTATTACAAAT
TCTGATGGGACAGTCACGCCAGTTTACGTGCAGATATTTTCAAATGTGGATCAAATTCAAGATGCAATGAGTCGGGCGAT
GTGGGTCATTGTGACCACAATGATTACTTTCTGGATTCTGTCAGTAATTATCAGTCTATATCTTGCAAATTGGACCTTAA
AACCAATTTTAGCGGCTTATGAAAAACAAAAAGAGTTTGTTGAAAATGCGTCACATGAATTGAGAACGCCTTTAGCAATC
TTGCAAAATCGTCTAGAATTACTTTTCCAAAAACCAACTGCAACAATTATAGACGAATCTGAAAATATCTCCGAAAGTTT
ATCCGAAGTTCGTAATATGCGGTTGTTGACCTCAAATCTGTTGAACTTGGCAAGACGGGATTCTGGAATAAAGATTGAAC
CAGAGCCCACAACGGCAACCTACTTTGAAAATATTTTCAATAGTTATGAAATGCTTACCGAAAATGCAGGCAAAAAGTTT
TCAGGAAACTTGAAATTAGAAGGCACAGTTAATTTGGACCAAGCGCTCATTAAGCAGTTGCTGACGATATTATTTGATAA
CGCCTTGAAATATACTGACAGTGAAGGTGAAATTTCGGTGGACGTGATAAAAAATGGTGGCTTTCTAACATTTGCAGTTG
CTGATAATGGTGAAGGAATTTCTGATGAAGATAAGAAAAAAATCTTTGACCGATTTTTCCGAGTAGATAAAGCACGAACT
CGCCAAAAAGGTGGCTTAGGTTTGGGACTTTCTTTGGCCAAACAAATTGTTGAAGCCTATAATGGGAAAATAACAGTTGA
AGATAATAAACCTAAAGGAACAAAATTCATTGTCAAGATTCGTGTGGACAGCACAATTTCAAATCCTGCAAAAATTTTCC
AAAAGTTGTAA

Upstream 100 bases:

>100_bases
CAATAAGTCAGTACTAACGAGATGGCCCCAATGCTGAAAGGAGTCAATAAATCGCTAGCTAAAAGAACTGTCAGTAAATC
TATCTAGAAATGAGACCTCT

Downstream 100 bases:

>100_bases
AATATGAGAGAAGAAAATTACTGACAAATTACGATAAGATAATATTATCATCCAAATTATGACAATTTTGTCAGTCAATT
TACTAGTTTTTTAAAGGCAA

Product: sensor protein kinase kinF

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MKNIIKKVKSSAIVKNDGKNFLHFFLAFTVIFVALAVIIIQVMQLGMYRATDQNLHNLAQNRVFLEEAANNQFGTSDSQD
SGFYGPNNSVIFYDSEGKSFMPSSESNGRISTNFVMSRLQKAMKFNEKQINTIQTVSVKNPYGDNWHYRYLTTSQFIITN
SDGTVTPVYVQIFSNVDQIQDAMSRAMWVIVTTMITFWILSVIISLYLANWTLKPILAAYEKQKEFVENASHELRTPLAI
LQNRLELLFQKPTATIIDESENISESLSEVRNMRLLTSNLLNLARRDSGIKIEPEPTTATYFENIFNSYEMLTENAGKKF
SGNLKLEGTVNLDQALIKQLLTILFDNALKYTDSEGEISVDVIKNGGFLTFAVADNGEGISDEDKKKIFDRFFRVDKART
RQKGGLGLGLSLAKQIVEAYNGKITVEDNKPKGTKFIVKIRVDSTISNPAKIFQKL

Sequences:

>Translated_456_residues
MKNIIKKVKSSAIVKNDGKNFLHFFLAFTVIFVALAVIIIQVMQLGMYRATDQNLHNLAQNRVFLEEAANNQFGTSDSQD
SGFYGPNNSVIFYDSEGKSFMPSSESNGRISTNFVMSRLQKAMKFNEKQINTIQTVSVKNPYGDNWHYRYLTTSQFIITN
SDGTVTPVYVQIFSNVDQIQDAMSRAMWVIVTTMITFWILSVIISLYLANWTLKPILAAYEKQKEFVENASHELRTPLAI
LQNRLELLFQKPTATIIDESENISESLSEVRNMRLLTSNLLNLARRDSGIKIEPEPTTATYFENIFNSYEMLTENAGKKF
SGNLKLEGTVNLDQALIKQLLTILFDNALKYTDSEGEISVDVIKNGGFLTFAVADNGEGISDEDKKKIFDRFFRVDKART
RQKGGLGLGLSLAKQIVEAYNGKITVEDNKPKGTKFIVKIRVDSTISNPAKIFQKL
>Mature_456_residues
MKNIIKKVKSSAIVKNDGKNFLHFFLAFTVIFVALAVIIIQVMQLGMYRATDQNLHNLAQNRVFLEEAANNQFGTSDSQD
SGFYGPNNSVIFYDSEGKSFMPSSESNGRISTNFVMSRLQKAMKFNEKQINTIQTVSVKNPYGDNWHYRYLTTSQFIITN
SDGTVTPVYVQIFSNVDQIQDAMSRAMWVIVTTMITFWILSVIISLYLANWTLKPILAAYEKQKEFVENASHELRTPLAI
LQNRLELLFQKPTATIIDESENISESLSEVRNMRLLTSNLLNLARRDSGIKIEPEPTTATYFENIFNSYEMLTENAGKKF
SGNLKLEGTVNLDQALIKQLLTILFDNALKYTDSEGEISVDVIKNGGFLTFAVADNGEGISDEDKKKIFDRFFRVDKART
RQKGGLGLGLSLAKQIVEAYNGKITVEDNKPKGTKFIVKIRVDSTISNPAKIFQKL

Specific function: Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=228, Percent_Identity=29.3859649122807, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=31.1111111111111, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786783, Length=237, Percent_Identity=29.1139240506329, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790346, Length=222, Percent_Identity=27.9279279279279, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1786912, Length=248, Percent_Identity=31.8548387096774, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1787894, Length=227, Percent_Identity=29.0748898678414, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI145693157, Length=231, Percent_Identity=30.3030303030303, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1788279, Length=212, Percent_Identity=29.2452830188679, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788713, Length=230, Percent_Identity=25.6521739130435, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082128, Length=229, Percent_Identity=26.6375545851528, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790861, Length=214, Percent_Identity=27.5700934579439, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790551, Length=236, Percent_Identity=26.6949152542373, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789149, Length=237, Percent_Identity=27.4261603375527, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=27.027027027027, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1787374, Length=220, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI48994928, Length=225, Percent_Identity=28.8888888888889, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790436, Length=232, Percent_Identity=24.5689655172414, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87081816, Length=230, Percent_Identity=23.9130434782609, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51477; Mature: 51477

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIIKKVKSSAIVKNDGKNFLHFFLAFTVIFVALAVIIIQVMQLGMYRATDQNLHNLAQ
CHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
NRVFLEEAANNQFGTSDSQDSGFYGPNNSVIFYDSEGKSFMPSSESNGRISTNFVMSRLQ
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEHHHHHHHHHH
KAMKFNEKQINTIQTVSVKNPYGDNWHYRYLTTSQFIITNSDGTVTPVYVQIFSNVDQIQ
HHHHCCHHHCCEEEEEEECCCCCCCCEEEEEEEEEEEEECCCCCEEHHHHHHHHCHHHHH
DAMSRAMWVIVTTMITFWILSVIISLYLANWTLKPILAAYEKQKEFVENASHELRTPLAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCHHHH
LQNRLELLFQKPTATIIDESENISESLSEVRNMRLLTSNLLNLARRDSGIKIEPEPTTAT
HHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHH
YFENIFNSYEMLTENAGKKFSGNLKLEGTVNLDQALIKQLLTILFDNALKYTDSEGEISV
HHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
DVIKNGGFLTFAVADNGEGISDEDKKKIFDRFFRVDKARTRQKGGLGLGLSLAKQIVEAY
EEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
NGKITVEDNKPKGTKFIVKIRVDSTISNPAKIFQKL
CCEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHCC
>Mature Secondary Structure
MKNIIKKVKSSAIVKNDGKNFLHFFLAFTVIFVALAVIIIQVMQLGMYRATDQNLHNLAQ
CHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
NRVFLEEAANNQFGTSDSQDSGFYGPNNSVIFYDSEGKSFMPSSESNGRISTNFVMSRLQ
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEHHHHHHHHHH
KAMKFNEKQINTIQTVSVKNPYGDNWHYRYLTTSQFIITNSDGTVTPVYVQIFSNVDQIQ
HHHHCCHHHCCEEEEEEECCCCCCCCEEEEEEEEEEEEECCCCCEEHHHHHHHHCHHHHH
DAMSRAMWVIVTTMITFWILSVIISLYLANWTLKPILAAYEKQKEFVENASHELRTPLAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCHHHH
LQNRLELLFQKPTATIIDESENISESLSEVRNMRLLTSNLLNLARRDSGIKIEPEPTTAT
HHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHH
YFENIFNSYEMLTENAGKKFSGNLKLEGTVNLDQALIKQLLTILFDNALKYTDSEGEISV
HHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
DVIKNGGFLTFAVADNGEGISDEDKKKIFDRFFRVDKARTRQKGGLGLGLSLAKQIVEAY
EEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
NGKITVEDNKPKGTKFIVKIRVDSTISNPAKIFQKL
CCEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]