Click here to switch to the map view.

The map label for this gene is pcp [H]

Identifier: 125623521

GI number: 125623521

Start: 659931

End: 660578

Strand: Direct

Name: pcp [H]

Synonym: llmg_0663

Alternate gene names: 125623521

Gene position: 659931-660578 (Clockwise)

Preceding gene: 125623520

Following gene: 125623523

Centisome position: 26.09

GC content: 46.6

Gene sequence:

>648_bases
ATGAAAATTCTTGTTACCGGATTTGATCCCTTTGGCGACGATAAAATTAATCCTGCGATTGAAGCCGTGAAACGTTTGCC
GGATGAAATTGCTGGGGCACAAATCGTTAAATTGGAAATTCCGACAAAGTTTAATGTTTCAGCCGATGTCGTTAAAGATG
CTATTGCCAAAGAAAAGCCTGACTATGTGTTGAGCATTGGTCAGGCTGGTGGCCGGTTTGAACTCACGCCGGAGCGAGTT
GCGATTAACTTGGATGACGGTCGGATTCAAGATAATGCCGGGTATCAGCCACTTAATCACACGATTCATGGCGATGACGA
GAATGCCTACTTTACCCAGTTACCAATTAAGGCCATGGCCAAAGCCATTCGGGAAGCTGGTGTTCCGTCAGCAGTCTCCA
ACACAGCAGGCACTTACGTCTGCAACCACATTTTTTATCAGGTACAGTATATGCGGGATAAGATGTTTCCCGATATTAAG
GCCGGCTTCATGCATATTCCATTTTTGCCGGAACAGGTTGTCACTCGTCCGGAAACACCAGCGTTGTCATTGGATGATGA
TGTTTTAGGCATCACTGCCGCTATCAAGGCCATCGTGTCCCGTGACGGCAAAGGCGATATCGAAACGATTGAAGGCAAGG
ATCACTAA

Upstream 100 bases:

>100_bases
TTGTCCTACCCATCAAAGACTCCAACGTCTTAAAGATGGTACAAGATACACTTCTCGATAGCTTCTGTACTTCTTGGCAT
TTTAGAAAGGAAATCTTCTC

Downstream 100 bases:

>100_bases
AAGCCTGTTTAGTGTTTTTGGACTATTATCAAATAAATAGACATAAAAAAGAAAAGCGTTCTAATCGTTTTTCCTTTTTT
ATCAGATGTTCAGAAAATGG

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MKILVTGFDPFGDDKINPAIEAVKRLPDEIAGAQIVKLEIPTKFNVSADVVKDAIAKEKPDYVLSIGQAGGRFELTPERV
AINLDDGRIQDNAGYQPLNHTIHGDDENAYFTQLPIKAMAKAIREAGVPSAVSNTAGTYVCNHIFYQVQYMRDKMFPDIK
AGFMHIPFLPEQVVTRPETPALSLDDDVLGITAAIKAIVSRDGKGDIETIEGKDH

Sequences:

>Translated_215_residues
MKILVTGFDPFGDDKINPAIEAVKRLPDEIAGAQIVKLEIPTKFNVSADVVKDAIAKEKPDYVLSIGQAGGRFELTPERV
AINLDDGRIQDNAGYQPLNHTIHGDDENAYFTQLPIKAMAKAIREAGVPSAVSNTAGTYVCNHIFYQVQYMRDKMFPDIK
AGFMHIPFLPEQVVTRPETPALSLDDDVLGITAAIKAIVSRDGKGDIETIEGKDH
>Mature_215_residues
MKILVTGFDPFGDDKINPAIEAVKRLPDEIAGAQIVKLEIPTKFNVSADVVKDAIAKEKPDYVLSIGQAGGRFELTPERV
AINLDDGRIQDNAGYQPLNHTIHGDDENAYFTQLPIKAMAKAIREAGVPSAVSNTAGTYVCNHIFYQVQYMRDKMFPDIK
AGFMHIPFLPEQVVTRPETPALSLDDDVLGITAAIKAIVSRDGKGDIETIEGKDH

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline [H]

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000816
- InterPro:   IPR016125 [H]

Pfam domain/function: PF01470 Peptidase_C15 [H]

EC number: =3.4.19.3 [H]

Molecular weight: Translated: 23519; Mature: 23519

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS01333 PYRASE_GLU ; PS01334 PYRASE_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVTGFDPFGDDKINPAIEAVKRLPDEIAGAQIVKLEIPTKFNVSADVVKDAIAKEKP
CEEEEECCCCCCCCCCCHHHHHHHHCHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCC
DYVLSIGQAGGRFELTPERVAINLDDGRIQDNAGYQPLNHTIHGDDENAYFTQLPIKAMA
CEEEEECCCCCEEEECHHHEEEECCCCEEECCCCCCCCCCCCCCCCCCCEEEECCHHHHH
KAIREAGVPSAVSNTAGTYVCNHIFYQVQYMRDKMFPDIKAGFMHIPFLPEQVVTRPETP
HHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHCCEEECCCCCHHHHCCCCCC
ALSLDDDVLGITAAIKAIVSRDGKGDIETIEGKDH
CCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCC
>Mature Secondary Structure
MKILVTGFDPFGDDKINPAIEAVKRLPDEIAGAQIVKLEIPTKFNVSADVVKDAIAKEKP
CEEEEECCCCCCCCCCCHHHHHHHHCHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCC
DYVLSIGQAGGRFELTPERVAINLDDGRIQDNAGYQPLNHTIHGDDENAYFTQLPIKAMA
CEEEEECCCCCEEEECHHHEEEECCCCEEECCCCCCCCCCCCCCCCCCCEEEECCHHHHH
KAIREAGVPSAVSNTAGTYVCNHIFYQVQYMRDKMFPDIKAGFMHIPFLPEQVVTRPETP
HHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHCCEEECCCCCHHHHCCCCCC
ALSLDDDVLGITAAIKAIVSRDGKGDIETIEGKDH
CCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA