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The map label for this gene is icd [H]

Identifier: 125623497

GI number: 125623497

Start: 632149

End: 633387

Strand: Direct

Name: icd [H]

Synonym: llmg_0637

Alternate gene names: 125623497

Gene position: 632149-633387 (Clockwise)

Preceding gene: 125623496

Following gene: 125623499

Centisome position: 24.99

GC content: 35.67

Gene sequence:

>1239_bases
ATGAAAATTGAAATGAAGAACGGGAAATTAATTGTACCAGATTATCCAACAATTGGTTACATAAGAGGAGATGGTGTTGG
TGAGGACATTTTTCCACAAGCTAAGCGTGTTTTTGATGCAGCTGTTCTAAAAATCTTTGGCGAAAAAAAGAAAATAGATT
GGCAAAAATTATTGGCAGGCGGAGAAGCTTTCGCAAGTAGAGGTGAATATCTTCCTGATGAAACACTTGAGCAGATTAAA
GAAAATTTGATCGCAATTAAGGGACCGTTAATGACTCCAGTTGGTGAGAGTTTTCGTTCTATTAATGTCACTTTGAGACA
AAAGTTAGATTTGTATGCTTGCGTAAGACCTGTAGAATACTTTACAGGGATAAAATCTCCTGTAAGAGCACCAGAGAAAG
TCAATATGACAATTTTTAGGGAAAATACAGAGGATATTTATGCAGGAATTGAATTTTCTTCTTCGTCAAAAGAATCTAAA
AAGTTAATAAATTTTTTGGAAAGAGAGCTGTCTGTCCATTCGATTCGCTTTCCAGAAACTTCTGCGATTGGAATTAAACC
CGTTAGCCCTGATGGAAGCAAACGTCTGGTTAGCGCAGCTTTTGATTATGCTATAAAGATGAATAAGAAGCGCGTGACAT
TTGTTCATAAAGGAAATATCATGAAATTTACAGAAGGAGGATTTAGAAAATGGGGCTATGAGGTTGCTAAAAATTATCCA
ACTTTTACAAAACTAGAATACGATAAGATAAAAGAAGAAAAAGGCACTGAACAGTCTGAAAAAGAGAAAAATATTGCACT
GAAATCAGGTAAAATTTATGTTGATGATGCGATTGCTGATAATTTTCTTCAACAGATTATCCTTAATCCTGATAATTTTG
AGGTTGTTGCCACTCTTAATTTAAATGGGGATTATATTTCTGATGCCCTCGCTGCCCAAGTTGGAGGTATTGGAATCGCA
CCTGGAGCAAATATTAACTATGAAAGTGGCCATGCTATCTTTGAAGCAACTCATGGAACAGCTCCGGATATCGCTGGGAA
AAATATAGCAAACCCTTCCAGTTTAATTTTATCTGGTGTAATGATGTTTGAATACTTAGGCTGGCAAGAGGTAGCAGAAT
TAATCAAAATAGCTCTTTCGGCTTCTTTCCATAGCGGAGCTTTGACAGCTGATTTGGGTGGAAAACTTTCAACTTCTGAA
TTTACTGATACTTTGGTTCAATATATAAAAAACTATTAA

Upstream 100 bases:

>100_bases
CTCTTACGCTTTGATTCACAGGTAGATTTGGATTACTACACTAATGATGGAATTATGCCTTATGTGATTCGTAAAAAATA
AAAATTAGGTGAAAATTATT

Downstream 100 bases:

>100_bases
AATGTTTTATCAATAACAAAAAAAGTCCTATATCAGGACTTTTTTAATTTACATGCGTATTATTTTAATGAATTATTTTC
CATAATTTCATCAATGAAAC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MKIEMKNGKLIVPDYPTIGYIRGDGVGEDIFPQAKRVFDAAVLKIFGEKKKIDWQKLLAGGEAFASRGEYLPDETLEQIK
ENLIAIKGPLMTPVGESFRSINVTLRQKLDLYACVRPVEYFTGIKSPVRAPEKVNMTIFRENTEDIYAGIEFSSSSKESK
KLINFLERELSVHSIRFPETSAIGIKPVSPDGSKRLVSAAFDYAIKMNKKRVTFVHKGNIMKFTEGGFRKWGYEVAKNYP
TFTKLEYDKIKEEKGTEQSEKEKNIALKSGKIYVDDAIADNFLQQIILNPDNFEVVATLNLNGDYISDALAAQVGGIGIA
PGANINYESGHAIFEATHGTAPDIAGKNIANPSSLILSGVMMFEYLGWQEVAELIKIALSASFHSGALTADLGGKLSTSE
FTDTLVQYIKNY

Sequences:

>Translated_412_residues
MKIEMKNGKLIVPDYPTIGYIRGDGVGEDIFPQAKRVFDAAVLKIFGEKKKIDWQKLLAGGEAFASRGEYLPDETLEQIK
ENLIAIKGPLMTPVGESFRSINVTLRQKLDLYACVRPVEYFTGIKSPVRAPEKVNMTIFRENTEDIYAGIEFSSSSKESK
KLINFLERELSVHSIRFPETSAIGIKPVSPDGSKRLVSAAFDYAIKMNKKRVTFVHKGNIMKFTEGGFRKWGYEVAKNYP
TFTKLEYDKIKEEKGTEQSEKEKNIALKSGKIYVDDAIADNFLQQIILNPDNFEVVATLNLNGDYISDALAAQVGGIGIA
PGANINYESGHAIFEATHGTAPDIAGKNIANPSSLILSGVMMFEYLGWQEVAELIKIALSASFHSGALTADLGGKLSTSE
FTDTLVQYIKNY
>Mature_412_residues
MKIEMKNGKLIVPDYPTIGYIRGDGVGEDIFPQAKRVFDAAVLKIFGEKKKIDWQKLLAGGEAFASRGEYLPDETLEQIK
ENLIAIKGPLMTPVGESFRSINVTLRQKLDLYACVRPVEYFTGIKSPVRAPEKVNMTIFRENTEDIYAGIEFSSSSKESK
KLINFLERELSVHSIRFPETSAIGIKPVSPDGSKRLVSAAFDYAIKMNKKRVTFVHKGNIMKFTEGGFRKWGYEVAKNYP
TFTKLEYDKIKEEKGTEQSEKEKNIALKSGKIYVDDAIADNFLQQIILNPDNFEVVATLNLNGDYISDALAAQVGGIGIA
PGANINYESGHAIFEATHGTAPDIAGKNIANPSSLILSGVMMFEYLGWQEVAELIKIALSASFHSGALTADLGGKLSTSE
FTDTLVQYIKNY

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=396, Percent_Identity=34.5959595959596, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI4758582, Length=398, Percent_Identity=29.1457286432161, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI28178816, Length=390, Percent_Identity=30, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI28178821, Length=394, Percent_Identity=29.6954314720812, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI28178838, Length=370, Percent_Identity=29.1891891891892, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI28178819, Length=230, Percent_Identity=31.7391304347826, Blast_Score=105, Evalue=8e-23,
Organism=Escherichia coli, GI1787381, Length=418, Percent_Identity=50.7177033492823, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI1788101, Length=404, Percent_Identity=27.7227722772277, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI87081683, Length=408, Percent_Identity=26.7156862745098, Blast_Score=115, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71986051, Length=403, Percent_Identity=32.0099255583127, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI25144293, Length=392, Percent_Identity=29.0816326530612, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17505779, Length=397, Percent_Identity=29.2191435768262, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17550882, Length=401, Percent_Identity=27.930174563591, Blast_Score=122, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6324709, Length=400, Percent_Identity=33.25, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6322097, Length=401, Percent_Identity=32.6683291770574, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324291, Length=395, Percent_Identity=30.6329113924051, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6319830, Length=409, Percent_Identity=25.4278728606357, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24661184, Length=394, Percent_Identity=32.741116751269, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24643268, Length=390, Percent_Identity=32.5641025641026, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24643270, Length=390, Percent_Identity=32.5641025641026, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI281362242, Length=403, Percent_Identity=29.0322580645161, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24648872, Length=403, Percent_Identity=29.0322580645161, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI161078635, Length=391, Percent_Identity=28.1329923273657, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI161078633, Length=391, Percent_Identity=28.1329923273657, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24650122, Length=391, Percent_Identity=28.1329923273657, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI161078637, Length=391, Percent_Identity=28.1329923273657, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI161078639, Length=391, Percent_Identity=27.8772378516624, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI20130355, Length=398, Percent_Identity=23.1155778894472, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45613; Mature: 45613

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIEMKNGKLIVPDYPTIGYIRGDGVGEDIFPQAKRVFDAAVLKIFGEKKKIDWQKLLAG
CEEEECCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCC
GEAFASRGEYLPDETLEQIKENLIAIKGPLMTPVGESFRSINVTLRQKLDLYACVRPVEY
CHHHHHCCCCCCHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FTGIKSPVRAPEKVNMTIFRENTEDIYAGIEFSSSSKESKKLINFLERELSVHSIRFPET
HHCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHEEECCCC
SAIGIKPVSPDGSKRLVSAAFDYAIKMNKKRVTFVHKGNIMKFTEGGFRKWGYEVAKNYP
CCCEEEECCCCCHHHHHHHHHHHHEEECCEEEEEEECCCEEEECCCCHHHHHHHHHHCCC
TFTKLEYDKIKEEKGTEQSEKEKNIALKSGKIYVDDAIADNFLQQIILNPDNFEVVATLN
CCEEEEHHHHHHHCCCCHHHHHHCEEEECCCEEEEHHHHHHHHHHHHCCCCCEEEEEEEE
LNGDYISDALAAQVGGIGIAPGANINYESGHAIFEATHGTAPDIAGKNIANPSSLILSGV
CCCHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHH
MMFEYLGWQEVAELIKIALSASFHSGALTADLGGKLSTSEFTDTLVQYIKNY
HHHHHCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIEMKNGKLIVPDYPTIGYIRGDGVGEDIFPQAKRVFDAAVLKIFGEKKKIDWQKLLAG
CEEEECCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCC
GEAFASRGEYLPDETLEQIKENLIAIKGPLMTPVGESFRSINVTLRQKLDLYACVRPVEY
CHHHHHCCCCCCHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FTGIKSPVRAPEKVNMTIFRENTEDIYAGIEFSSSSKESKKLINFLERELSVHSIRFPET
HHCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHEEECCCC
SAIGIKPVSPDGSKRLVSAAFDYAIKMNKKRVTFVHKGNIMKFTEGGFRKWGYEVAKNYP
CCCEEEECCCCCHHHHHHHHHHHHEEECCEEEEEEECCCEEEECCCCHHHHHHHHHHCCC
TFTKLEYDKIKEEKGTEQSEKEKNIALKSGKIYVDDAIADNFLQQIILNPDNFEVVATLN
CCEEEEHHHHHHHCCCCHHHHHHCEEEECCCEEEEHHHHHHHHHHHHCCCCCEEEEEEEE
LNGDYISDALAAQVGGIGIAPGANINYESGHAIFEATHGTAPDIAGKNIANPSSLILSGV
CCCHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHH
MMFEYLGWQEVAELIKIALSASFHSGALTADLGGKLSTSEFTDTLVQYIKNY
HHHHHCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA