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The map label for this gene is drrB [H]

Identifier: 125623288

GI number: 125623288

Start: 413110

End: 413922

Strand: Reverse

Name: drrB [H]

Synonym: llmg_0421

Alternate gene names: 125623288

Gene position: 413922-413110 (Counterclockwise)

Preceding gene: 125623289

Following gene: 125623287

Centisome position: 16.36

GC content: 41.7

Gene sequence:

>813_bases
ATGGACACAACTGTAATTAACAAAAATACTACAACGATGAAAACAATCAGTTTAAAATCTTGGTTGACAGATATTATCGT
CATGGCCAAGCGTGAACTTCTCAAAGTCAAACATAGCCAAGAAAAACTATTTGATGTGACCGTCATGCCAATTATCATGG
TCATCGTTTTCTCCCAACTTTTTGGTGGAGCAATCATGGGAAATGTCAAAGCTTATCTCCCTCTTGTTGTTCCCGGAATT
TTAATCCAAACACTTGTTATGGCATCTGGCGCTGCTGGAACCCAACTTCGTGAGGATTTGGACAAGGGAGCTACAGACCG
CTTCAATTCTTTGCCAATTTCACGAATTGCACCCTTAGCTGGAACGTTAATCTCGGATATTATCCGTTATATTATTGCCG
CTGTCTTTGCATTAGGCACAGGTGCAGCTCTCGGTTGGCGAGCAAGCGCCGGATTTGGTTGGCTGCTTGTTGCAATCGGC
CGCCTTGCAATCGTTACAACTTGGGCGCTCAGTTGGCTCTTTGCTTTAGTTGGTGTCCTTGCTAAAGGTGCAGCAACTGT
GACAACCATTTCGAGCTTTTTGACCATGTTTTTGGCCTTTTTGTCAAATGCTTATATTCCCGTCACTTCTTTACCAAAAT
GGCTGAAAGTCATTGCCGAAAATAATCCTGTTTCTCATTTGATTACTGCCTTTAAAGAAGTGGCTTATAATGGTAATTTT
GGTCATGAAGCCTGGTTGGTTCTTCTAATCAGCCTTCTGATTGTTCTCATTTTAGCACCCGTTACCGTTCTTACTTATTC
AAAGAAAAACTAA

Upstream 100 bases:

>100_bases
TTTGGAAACTGAACACATAGCCATCAATGAATTTGAAACACGTAAACCAACACTTGATGAAGTTTTTCTTGAGCTGACAG
GAAAATAGGAGAAAATAAAA

Downstream 100 bases:

>100_bases
GCAGTGCTGTTATTTTGTTTACATAAACAGAGATAAAAGTAGTATAATACAATCAGTAAACGAAAGGACAAACAATGGAA
AATCAATATGAAATACTTCA

Product: daunorubicin resistance transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MDTTVINKNTTTMKTISLKSWLTDIIVMAKRELLKVKHSQEKLFDVTVMPIIMVIVFSQLFGGAIMGNVKAYLPLVVPGI
LIQTLVMASGAAGTQLREDLDKGATDRFNSLPISRIAPLAGTLISDIIRYIIAAVFALGTGAALGWRASAGFGWLLVAIG
RLAIVTTWALSWLFALVGVLAKGAATVTTISSFLTMFLAFLSNAYIPVTSLPKWLKVIAENNPVSHLITAFKEVAYNGNF
GHEAWLVLLISLLIVLILAPVTVLTYSKKN

Sequences:

>Translated_270_residues
MDTTVINKNTTTMKTISLKSWLTDIIVMAKRELLKVKHSQEKLFDVTVMPIIMVIVFSQLFGGAIMGNVKAYLPLVVPGI
LIQTLVMASGAAGTQLREDLDKGATDRFNSLPISRIAPLAGTLISDIIRYIIAAVFALGTGAALGWRASAGFGWLLVAIG
RLAIVTTWALSWLFALVGVLAKGAATVTTISSFLTMFLAFLSNAYIPVTSLPKWLKVIAENNPVSHLITAFKEVAYNGNF
GHEAWLVLLISLLIVLILAPVTVLTYSKKN
>Mature_270_residues
MDTTVINKNTTTMKTISLKSWLTDIIVMAKRELLKVKHSQEKLFDVTVMPIIMVIVFSQLFGGAIMGNVKAYLPLVVPGI
LIQTLVMASGAAGTQLREDLDKGATDRFNSLPISRIAPLAGTLISDIIRYIIAAVFALGTGAALGWRASAGFGWLLVAIG
RLAIVTTWALSWLFALVGVLAKGAATVTTISSFLTMFLAFLSNAYIPVTSLPKWLKVIAENNPVSHLITAFKEVAYNGNF
GHEAWLVLLISLLIVLILAPVTVLTYSKKN

Specific function: Part of the ABC transporter complex drrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 29174; Mature: 29174

Theoretical pI: Translated: 10.44; Mature: 10.44

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure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CHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1924314 [H]