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The map label for this gene is lysQ [H]

Identifier: 125623255

GI number: 125623255

Start: 377428

End: 378861

Strand: Direct

Name: lysQ [H]

Synonym: llmg_0386

Alternate gene names: 125623255

Gene position: 377428-378861 (Clockwise)

Preceding gene: 125623253

Following gene: 125623256

Centisome position: 14.92

GC content: 39.26

Gene sequence:

>1434_bases
ATGGAAAATCAAAATCAGGTCAAGCGCAACCTCAAACAGCGCCACATTACTATGATTGCTTTAGGGGGAACAATTGGAAC
AGGTTTGTTTTTAACCTCAGGAGCAACAATTAGTCAAGCGGGTCCTTGGGGAGCAGTCCTTGCTTATTGTTTTATTGGAA
TCATGGTTTATTTTGTAATGACTTCACTGGGAGAGATGGCGACTTATCTGCCTACCTCTGGTTCATTTTCTGACTATGGT
GGGCGTTATGTTGACCCTGCCTTTGGATTTGCACTAGGTTGGAATTATTGGCTAAATGGAGCCATTACGATTGCCGTGGA
TTTAACGACGGCTGGATTGATTACTCAGTTTTGGTTCCCACACCTTCCTTCCTGGATTTTTTCAGGAATTGCGACAGTTC
TAATTTTTATCATTAATGTTATGGCAGTTGGTGCTTTTGGGGAAACTGAGTATTGGCTATCAACGATTAAAGTGATTACG
ATTGTTCTCTTCTTAGCTATTGGCCTACTAACAATTTTTGGAGTCTTGGGACAAGGAAATGTTGATGTTGTTGCCAATTT
GACAGCAGGAAATCATGGCTTTGTTGGTGGAATTTCAGGTTTTGTTGGCGTTTTACTCATTGCAGGATTCTCTTTCCAAG
GAACTGAAATGTTAGGAATTACTGCAGGAGAATCTGAAGACCCAGGGAAAACGATTCCTAAAGCAATGAATTCTATTTTC
TGGAGAATCTTACTCTTTTACATCTTTTCAATTATTGTCATAGCAGCTATTATTAATTTCAAAGACCCTCGTTTGTTGAA
CCCAAGCTCAACAGCTGTCATGAGTCCATTTACCATAGTCTTTAAAAATATTGGATTTGCAGTAGCAGCATCAGTGATGA
ATGCGGTCATTCTCACCTCTGTCATTTCGTCAGCAAATTCAGTGATGTACGCTTCAACTCGGATTCTTTATTCTTTAGGT
CAAGAAAAGGGAGCGCCAAAATTCTTTGGTCGCACGGCTAAAAATGGAATTCCTTTTTATGCGCTTCTAGCAACGACAAT
CATTTGTTTCATTGCTTTCTTAACGGGAATATTTGGAACGCAAATCTATCTTTTCTTGATTGATTTGTCCTCACTGACAG
GATTTCTTGCTTGGCTTGGAATTTCTGTCAGCCACATTCGTTTTAGAAGAGCTTATATTGCTCAAGGAAAAAAATTGGAA
GATCTTCCTTACAAAGCAAAATGGTTCCCATTTGGACCAATTGTGGCGCTCTTGATGACTGGAGCCATCGCAATTAATCT
TGACCCAGCCATGCTCTTTAGTGAGCACTGGGGCGAAGGATTAGCTTTATATGCGGCTATTCCGATTTTCATTGTTCTTT
ATTTTGGTTATAAATGGAAGTATAATACAAAAATTATTCCACTTGAAGAAGTCGATTTAAGTCGAGAAAAATAA

Upstream 100 bases:

>100_bases
TGCCGGTGATTCTCAAGAGACCGGTTGTAAAGACAACTGGTCTTTTTATTTGTTCGTGCTCTGGTTTGTAAAAAAAACAA
GAGATTAGAAAGTAAAGATT

Downstream 100 bases:

>100_bases
TATCTGAATCACAATTCTTATAGAGTTGTGATTTTTTATTTATAATATAAAGAGCAGTAAGTCGAAATAGACATCAATAT
AGTACAAATACTACTATTAA

Product: amino-acid permease lysQ

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MENQNQVKRNLKQRHITMIALGGTIGTGLFLTSGATISQAGPWGAVLAYCFIGIMVYFVMTSLGEMATYLPTSGSFSDYG
GRYVDPAFGFALGWNYWLNGAITIAVDLTTAGLITQFWFPHLPSWIFSGIATVLIFIINVMAVGAFGETEYWLSTIKVIT
IVLFLAIGLLTIFGVLGQGNVDVVANLTAGNHGFVGGISGFVGVLLIAGFSFQGTEMLGITAGESEDPGKTIPKAMNSIF
WRILLFYIFSIIVIAAIINFKDPRLLNPSSTAVMSPFTIVFKNIGFAVAASVMNAVILTSVISSANSVMYASTRILYSLG
QEKGAPKFFGRTAKNGIPFYALLATTIICFIAFLTGIFGTQIYLFLIDLSSLTGFLAWLGISVSHIRFRRAYIAQGKKLE
DLPYKAKWFPFGPIVALLMTGAIAINLDPAMLFSEHWGEGLALYAAIPIFIVLYFGYKWKYNTKIIPLEEVDLSREK

Sequences:

>Translated_477_residues
MENQNQVKRNLKQRHITMIALGGTIGTGLFLTSGATISQAGPWGAVLAYCFIGIMVYFVMTSLGEMATYLPTSGSFSDYG
GRYVDPAFGFALGWNYWLNGAITIAVDLTTAGLITQFWFPHLPSWIFSGIATVLIFIINVMAVGAFGETEYWLSTIKVIT
IVLFLAIGLLTIFGVLGQGNVDVVANLTAGNHGFVGGISGFVGVLLIAGFSFQGTEMLGITAGESEDPGKTIPKAMNSIF
WRILLFYIFSIIVIAAIINFKDPRLLNPSSTAVMSPFTIVFKNIGFAVAASVMNAVILTSVISSANSVMYASTRILYSLG
QEKGAPKFFGRTAKNGIPFYALLATTIICFIAFLTGIFGTQIYLFLIDLSSLTGFLAWLGISVSHIRFRRAYIAQGKKLE
DLPYKAKWFPFGPIVALLMTGAIAINLDPAMLFSEHWGEGLALYAAIPIFIVLYFGYKWKYNTKIIPLEEVDLSREK
>Mature_477_residues
MENQNQVKRNLKQRHITMIALGGTIGTGLFLTSGATISQAGPWGAVLAYCFIGIMVYFVMTSLGEMATYLPTSGSFSDYG
GRYVDPAFGFALGWNYWLNGAITIAVDLTTAGLITQFWFPHLPSWIFSGIATVLIFIINVMAVGAFGETEYWLSTIKVIT
IVLFLAIGLLTIFGVLGQGNVDVVANLTAGNHGFVGGISGFVGVLLIAGFSFQGTEMLGITAGESEDPGKTIPKAMNSIF
WRILLFYIFSIIVIAAIINFKDPRLLNPSSTAVMSPFTIVFKNIGFAVAASVMNAVILTSVISSANSVMYASTRILYSLG
QEKGAPKFFGRTAKNGIPFYALLATTIICFIAFLTGIFGTQIYLFLIDLSSLTGFLAWLGISVSHIRFRRAYIAQGKKLE
DLPYKAKWFPFGPIVALLMTGAIAINLDPAMLFSEHWGEGLALYAAIPIFIVLYFGYKWKYNTKIIPLEEVDLSREK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=475, Percent_Identity=50.9473684210526, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI87081708, Length=464, Percent_Identity=35.1293103448276, Blast_Score=300, Evalue=2e-82,
Organism=Escherichia coli, GI1786789, Length=423, Percent_Identity=36.8794326241135, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI1786302, Length=468, Percent_Identity=36.1111111111111, Blast_Score=265, Evalue=6e-72,
Organism=Escherichia coli, GI48994972, Length=438, Percent_Identity=35.8447488584475, Blast_Score=258, Evalue=7e-70,
Organism=Escherichia coli, GI1790653, Length=353, Percent_Identity=39.6600566572238, Blast_Score=238, Evalue=8e-64,
Organism=Escherichia coli, GI1789017, Length=400, Percent_Identity=33.5, Blast_Score=234, Evalue=9e-63,
Organism=Escherichia coli, GI1786602, Length=392, Percent_Identity=37.5, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI87081915, Length=417, Percent_Identity=33.5731414868106, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI87082023, Length=443, Percent_Identity=23.0248306997743, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082250, Length=438, Percent_Identity=26.4840182648402, Blast_Score=65, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=419, Percent_Identity=42.4821002386635, Blast_Score=318, Evalue=8e-88,
Organism=Saccharomyces cerevisiae, GI6324061, Length=485, Percent_Identity=37.5257731958763, Blast_Score=316, Evalue=6e-87,
Organism=Saccharomyces cerevisiae, GI6324990, Length=495, Percent_Identity=34.3434343434343, Blast_Score=274, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6324059, Length=499, Percent_Identity=35.0701402805611, Blast_Score=273, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6324924, Length=495, Percent_Identity=32.1212121212121, Blast_Score=258, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6321629, Length=496, Percent_Identity=32.8629032258064, Blast_Score=252, Evalue=9e-68,
Organism=Saccharomyces cerevisiae, GI6322892, Length=487, Percent_Identity=33.8809034907598, Blast_Score=246, Evalue=6e-66,
Organism=Saccharomyces cerevisiae, GI6321053, Length=490, Percent_Identity=31.6326530612245, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6324553, Length=403, Percent_Identity=34.2431761786601, Blast_Score=230, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6320717, Length=492, Percent_Identity=31.7073170731707, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6319824, Length=511, Percent_Identity=29.7455968688845, Blast_Score=223, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6319543, Length=492, Percent_Identity=31.0975609756098, Blast_Score=216, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6319542, Length=493, Percent_Identity=29.6146044624746, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6320251, Length=512, Percent_Identity=28.515625, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6319608, Length=497, Percent_Identity=26.1569416498994, Blast_Score=204, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6322967, Length=471, Percent_Identity=30.9978768577495, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6324981, Length=484, Percent_Identity=31.8181818181818, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6320364, Length=553, Percent_Identity=26.7631103074141, Blast_Score=180, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51947; Mature: 51947

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENQNQVKRNLKQRHITMIALGGTIGTGLFLTSGATISQAGPWGAVLAYCFIGIMVYFVM
CCCHHHHHHHHHHHCEEEEEECCCHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
TSLGEMATYLPTSGSFSDYGGRYVDPAFGFALGWNYWLNGAITIAVDLTTAGLITQFWFP
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCHHHEECCEEEEEEECHHHHHHHHHHHH
HLPSWIFSGIATVLIFIINVMAVGAFGETEYWLSTIKVITIVLFLAIGLLTIFGVLGQGN
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VDVVANLTAGNHGFVGGISGFVGVLLIAGFSFQGTEMLGITAGESEDPGKTIPKAMNSIF
EEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHH
WRILLFYIFSIIVIAAIINFKDPRLLNPSSTAVMSPFTIVFKNIGFAVAASVMNAVILTS
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
VISSANSVMYASTRILYSLGQEKGAPKFFGRTAKNGIPFYALLATTIICFIAFLTGIFGT
HHHCCCCCHHHHHHHHHHHHHCCCCCHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
QIYLFLIDLSSLTGFLAWLGISVSHIRFRRAYIAQGKKLEDLPYKAKWFPFGPIVALLMT
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
GAIAINLDPAMLFSEHWGEGLALYAAIPIFIVLYFGYKWKYNTKIIPLEEVDLSREK
CCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEECCEEEEHHHCCCCCCC
>Mature Secondary Structure
MENQNQVKRNLKQRHITMIALGGTIGTGLFLTSGATISQAGPWGAVLAYCFIGIMVYFVM
CCCHHHHHHHHHHHCEEEEEECCCHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
TSLGEMATYLPTSGSFSDYGGRYVDPAFGFALGWNYWLNGAITIAVDLTTAGLITQFWFP
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCHHHEECCEEEEEEECHHHHHHHHHHHH
HLPSWIFSGIATVLIFIINVMAVGAFGETEYWLSTIKVITIVLFLAIGLLTIFGVLGQGN
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VDVVANLTAGNHGFVGGISGFVGVLLIAGFSFQGTEMLGITAGESEDPGKTIPKAMNSIF
EEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHH
WRILLFYIFSIIVIAAIINFKDPRLLNPSSTAVMSPFTIVFKNIGFAVAASVMNAVILTS
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
VISSANSVMYASTRILYSLGQEKGAPKFFGRTAKNGIPFYALLATTIICFIAFLTGIFGT
HHHCCCCCHHHHHHHHHHHHHCCCCCHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
QIYLFLIDLSSLTGFLAWLGISVSHIRFRRAYIAQGKKLEDLPYKAKWFPFGPIVALLMT
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
GAIAINLDPAMLFSEHWGEGLALYAAIPIFIVLYFGYKWKYNTKIIPLEEVDLSREK
CCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEECCEEEEHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]