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The map label for this gene is hadL [H]

Identifier: 125623130

GI number: 125623130

Start: 240927

End: 241601

Strand: Direct

Name: hadL [H]

Synonym: llmg_0254

Alternate gene names: 125623130

Gene position: 240927-241601 (Clockwise)

Preceding gene: 125623129

Following gene: 125623131

Centisome position: 9.52

GC content: 35.41

Gene sequence:

>675_bases
ATGACAGGAAAATACCCTATTCTTGTTTTTGATATCAATGAAACCTTGCTAAGTTTCGAAAGCTTAGAAAGGTTTTTCGC
TAAATATTTTGATGATAAAAAAGTACTACGTCAGTGGTTTTCTGAACAAATTTTATACAGTCAGGCTCTAACCTTGAGTA
GGAACTATTATGATTTTGGAGAACTTGCGACATCAGTTTTGCAAATGGTTGCTGAACTCCATAATCTTTCTTTAAATGAT
AGAGTTTTGTTAGAGTTCAAACAGTTGCTTGGACAGCTCCTGCCTTATCCAGAGGTAGAAAAAGGACTTGAAATGTTGAA
ACAATCAGGTTTCCGTATGATTGCTTTGACTAATTCACCTACGCTTAGCAGTCAGGTTTCGCTTGAACGCTCTGGTCTAC
GTAAGTATTTTGAAAATGTCATCTCTGTGGAAGAAGTTCAGCAGTATAAACCAGCCCCAGCCACTTATAGACGAGTTCGT
GAGTTAATTGGATTTGAGGAAAAATATTGCATGATTGCTTGTCATATTTGGGATTTATTAGGCGCTCAAAGTGAAAACTT
TGATACCGCTTTTATCAAACGACAAGGCAATGCGACTTTGCCCAATCTATTTCAAGCTAATTTTGTAGCTGATGATTTAC
AAGAATTATCAAAATTGCTAATAAAAAAATATTAA

Upstream 100 bases:

>100_bases
AGGTAAAGTACTTCCAGGACTTGCAGCTTTGACTGAAAAATAAGAATTAAAAAAAGCTTGTCTCTGATAAGCTTTTTCTT
TACAATGAAAAGAGATTAAG

Downstream 100 bases:

>100_bases
ACAAAGTTCTCTTAACTTTTTAGCAGCTTCACAAGATCAAAATTTTCTGTTGAGATAAATAAAAAGAGTTTGTTTTTTAA
AATCAAGCTCTTTTTGTATC

Product: cryptic haloacid dehalogenase 1

Products: NA

Alternate protein names: 2-haloalkanoic acid dehalogenase IVA; Halocarboxylic acid halidohydrolase IVA; L-2-haloacid dehalogenase IVA [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MTGKYPILVFDINETLLSFESLERFFAKYFDDKKVLRQWFSEQILYSQALTLSRNYYDFGELATSVLQMVAELHNLSLND
RVLLEFKQLLGQLLPYPEVEKGLEMLKQSGFRMIALTNSPTLSSQVSLERSGLRKYFENVISVEEVQQYKPAPATYRRVR
ELIGFEEKYCMIACHIWDLLGAQSENFDTAFIKRQGNATLPNLFQANFVADDLQELSKLLIKKY

Sequences:

>Translated_224_residues
MTGKYPILVFDINETLLSFESLERFFAKYFDDKKVLRQWFSEQILYSQALTLSRNYYDFGELATSVLQMVAELHNLSLND
RVLLEFKQLLGQLLPYPEVEKGLEMLKQSGFRMIALTNSPTLSSQVSLERSGLRKYFENVISVEEVQQYKPAPATYRRVR
ELIGFEEKYCMIACHIWDLLGAQSENFDTAFIKRQGNATLPNLFQANFVADDLQELSKLLIKKY
>Mature_223_residues
TGKYPILVFDINETLLSFESLERFFAKYFDDKKVLRQWFSEQILYSQALTLSRNYYDFGELATSVLQMVAELHNLSLNDR
VLLEFKQLLGQLLPYPEVEKGLEMLKQSGFRMIALTNSPTLSSQVSLERSGLRKYFENVISVEEVQQYKPAPATYRRVRE
LIGFEEKYCMIACHIWDLLGAQSENFDTAFIKRQGNATLPNLFQANFVADDLQELSKLLIKKY

Specific function: Catalyzes the hydrolytic dehalogenation of small (S)-2- haloalkanoic acids to yield the corresponding (R)-2- hydroxyalkanoic acids. Acts on acids of short chain lengths, C(2) to C(4), with inversion of configuration at C-3 [H]

COG id: COG1011

COG function: function code R; Predicted hydrolase (HAD superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. S-2- haloalkanoic acid dehalogenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006388
- InterPro:   IPR006402
- InterPro:   IPR006328
- InterPro:   IPR005833 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.8.1.2 [H]

Molecular weight: Translated: 26055; Mature: 25924

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGKYPILVFDINETLLSFESLERFFAKYFDDKKVLRQWFSEQILYSQALTLSRNYYDFG
CCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ELATSVLQMVAELHNLSLNDRVLLEFKQLLGQLLPYPEVEKGLEMLKQSGFRMIALTNSP
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEECCC
TLSSQVSLERSGLRKYFENVISVEEVQQYKPAPATYRRVRELIGFEEKYCMIACHIWDLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
GAQSENFDTAFIKRQGNATLPNLFQANFVADDLQELSKLLIKKY
CCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TGKYPILVFDINETLLSFESLERFFAKYFDDKKVLRQWFSEQILYSQALTLSRNYYDFG
CCCCCEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ELATSVLQMVAELHNLSLNDRVLLEFKQLLGQLLPYPEVEKGLEMLKQSGFRMIALTNSP
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEECCC
TLSSQVSLERSGLRKYFENVISVEEVQQYKPAPATYRRVRELIGFEEKYCMIACHIWDLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
GAQSENFDTAFIKRQGNATLPNLFQANFVADDLQELSKLLIKKY
CCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1376111 [H]