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The map label for this gene is pgk [H]

Identifier: 125623129

GI number: 125623129

Start: 239673

End: 240869

Strand: Direct

Name: pgk [H]

Synonym: llmg_0253

Alternate gene names: 125623129

Gene position: 239673-240869 (Clockwise)

Preceding gene: 125623128

Following gene: 125623130

Centisome position: 9.48

GC content: 41.69

Gene sequence:

>1197_bases
ATGGCAAAATTGACTGTAAAAGACGTTGAACTTAAAGGCAAAAAAGTCCTCGTACGTGTTGACTTTAATGTTCCAATTAA
AGATGGCGTAATCACAAATGATAACCGTATCACTGCCGCGCTTCCAACAATCAAATACATCCTTGAACAAGGTGGACGTG
CAGTCCTCTTCTCTCACTTGGGACGTGTTAAAGAAGAATCTGATAAAGCTGGTAAATCACTTGCACCAGTAGCTAAAGCT
CTCTCTGAAAAACTTGGTCAAGACGTTGTTTTCCCAGGAGCTACTCGTGGAGCAGAACTTGAAGCAGCAATCAACGAACT
TAAAGATGGAGAAATCCTTCTCGTTGAAAACACTCGTTTTGAAGATATCGACGGTAAAAAAGAATCTAAAAACGATCCAG
AACTTGGTAAATACTGGGCTTCACTCGGTGACGGAATCTTCGTTAACGATGCATTTGGTACAGCTCACCGTGCTCACGCA
TCAAACGTTGGTATCTCAGCAAACGTTGAAAAAGCCGTTGCTGGTTTCCTTCTTGAAAACGAAATTGCTTATATCCAAGA
AGCAGTTGAAGCTCCAGAACGTCCATTCGTAGCAATCCTTGGTGGTTCTAAAGTTTCAGATAAAATCGGTGTTATCGAAA
ACCTCCTTTCAAAAGCTGATAAAGTTATCATCGGTGGTGGGATGGCTTACACATTCTTGAAAGCACAAGGTTACGAAATC
GGAACTTCACTCGTTGAAGATGACAAACTTGACCTTGCTAAAGAATTGCTTGAAAAAGCAGCAGGAAAATTGATTTTGCC
ACTTGACCATAAAGTTGCTAACGCATTTGCTGGTTACACAGAAGTAAAAGAAACTGCTGACCAAAACATTCCTGCAGGCT
TCATGGGACTTGACGTAGCAAACAAAACAATTGCTGACTACAACACACAACTTGAAGGCGCTAAAACAGTTGTTTGGAAT
GGCCCAGTTGGTGTATTCGAAAACCCAGACTTCCAAGCAGGTACTGTTGGATTGATGGAAGCTATCGTTAAACAACCAGG
TGTTAAATCAATCATCGGTGGTGGTGACTCAGCAGCAGCAGCTATCAACCTCGGTTATGCAGAAAAATTCTCATGGATTT
CAACTGGTGGTGGAGCTTCAATGGAACTCCTTGAAGGTAAAGTACTTCCAGGACTTGCAGCTTTGACTGAAAAATAA

Upstream 100 bases:

>100_bases
TATCCGAATTTGTGATATAATTAACCTATCGATTTGAATTGAATCAGCATGGTGCTTTTTCAATCTCAACAAAATTATCT
TATAAGGAGAATTTTTCCAA

Downstream 100 bases:

>100_bases
GAATTAAAAAAAGCTTGTCTCTGATAAGCTTTTTCTTTACAATGAAAAGAGATTAAGATGACAGGAAAATACCCTATTCT
TGTTTTTGATATCAATGAAA

Product: phosphoglycerate kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MAKLTVKDVELKGKKVLVRVDFNVPIKDGVITNDNRITAALPTIKYILEQGGRAVLFSHLGRVKEESDKAGKSLAPVAKA
LSEKLGQDVVFPGATRGAELEAAINELKDGEILLVENTRFEDIDGKKESKNDPELGKYWASLGDGIFVNDAFGTAHRAHA
SNVGISANVEKAVAGFLLENEIAYIQEAVEAPERPFVAILGGSKVSDKIGVIENLLSKADKVIIGGGMAYTFLKAQGYEI
GTSLVEDDKLDLAKELLEKAAGKLILPLDHKVANAFAGYTEVKETADQNIPAGFMGLDVANKTIADYNTQLEGAKTVVWN
GPVGVFENPDFQAGTVGLMEAIVKQPGVKSIIGGGDSAAAAINLGYAEKFSWISTGGGASMELLEGKVLPGLAALTEK

Sequences:

>Translated_398_residues
MAKLTVKDVELKGKKVLVRVDFNVPIKDGVITNDNRITAALPTIKYILEQGGRAVLFSHLGRVKEESDKAGKSLAPVAKA
LSEKLGQDVVFPGATRGAELEAAINELKDGEILLVENTRFEDIDGKKESKNDPELGKYWASLGDGIFVNDAFGTAHRAHA
SNVGISANVEKAVAGFLLENEIAYIQEAVEAPERPFVAILGGSKVSDKIGVIENLLSKADKVIIGGGMAYTFLKAQGYEI
GTSLVEDDKLDLAKELLEKAAGKLILPLDHKVANAFAGYTEVKETADQNIPAGFMGLDVANKTIADYNTQLEGAKTVVWN
GPVGVFENPDFQAGTVGLMEAIVKQPGVKSIIGGGDSAAAAINLGYAEKFSWISTGGGASMELLEGKVLPGLAALTEK
>Mature_397_residues
AKLTVKDVELKGKKVLVRVDFNVPIKDGVITNDNRITAALPTIKYILEQGGRAVLFSHLGRVKEESDKAGKSLAPVAKAL
SEKLGQDVVFPGATRGAELEAAINELKDGEILLVENTRFEDIDGKKESKNDPELGKYWASLGDGIFVNDAFGTAHRAHAS
NVGISANVEKAVAGFLLENEIAYIQEAVEAPERPFVAILGGSKVSDKIGVIENLLSKADKVIIGGGMAYTFLKAQGYEIG
TSLVEDDKLDLAKELLEKAAGKLILPLDHKVANAFAGYTEVKETADQNIPAGFMGLDVANKTIADYNTQLEGAKTVVWNG
PVGVFENPDFQAGTVGLMEAIVKQPGVKSIIGGGDSAAAAINLGYAEKFSWISTGGGASMELLEGKVLPGLAALTEK

Specific function: Second phase of glycolysis; second step. [C]

COG id: COG0126

COG function: function code G; 3-phosphoglycerate kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4505763, Length=413, Percent_Identity=46.0048426150121, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI31543397, Length=413, Percent_Identity=44.5520581113801, Blast_Score=317, Evalue=2e-86,
Organism=Escherichia coli, GI1789294, Length=398, Percent_Identity=42.964824120603, Blast_Score=285, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI17508823, Length=416, Percent_Identity=47.8365384615385, Blast_Score=337, Evalue=5e-93,
Organism=Saccharomyces cerevisiae, GI6319857, Length=415, Percent_Identity=47.2289156626506, Blast_Score=334, Evalue=1e-92,
Organism=Drosophila melanogaster, GI17136394, Length=414, Percent_Identity=46.8599033816425, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24581203, Length=415, Percent_Identity=45.0602409638554, Blast_Score=314, Evalue=8e-86,

Paralogues:

None

Copy number: 2990 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1460 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001576
- InterPro:   IPR015901
- InterPro:   IPR015911
- InterPro:   IPR015824 [H]

Pfam domain/function: PF00162 PGK [H]

EC number: =2.7.2.3 [H]

Molecular weight: Translated: 42108; Mature: 41976

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00111 PGLYCERATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLTVKDVELKGKKVLVRVDFNVPIKDGVITNDNRITAALPTIKYILEQGGRAVLFSHL
CCCEEEEEEEECCCEEEEEEECCCCCCCCEEECCCEEEEHHHHHHHHHHCCCCEEHHHHH
GRVKEESDKAGKSLAPVAKALSEKLGQDVVFPGATRGAELEAAINELKDGEILLVENTRF
HHHHHHHHHCCCHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHCCCCCEEEEECCCC
EDIDGKKESKNDPELGKYWASLGDGIFVNDAFGTAHRAHASNVGISANVEKAVAGFLLEN
CCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHH
EIAYIQEAVEAPERPFVAILGGSKVSDKIGVIENLLSKADKVIIGGGMAYTFLKAQGYEI
HHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEECCCCEEEEEEECCCCC
GTSLVEDDKLDLAKELLEKAAGKLILPLDHKVANAFAGYTEVKETADQNIPAGFMGLDVA
CCHHHCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHC
NKTIADYNTQLEGAKTVVWNGPVGVFENPDFQAGTVGLMEAIVKQPGVKSIIGGGDSAAA
CCHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCEE
AINLGYAEKFSWISTGGGASMELLEGKVLPGLAALTEK
EEECCHHHHCCEEECCCCCCHHHHCCCCCCCHHHHCCC
>Mature Secondary Structure 
AKLTVKDVELKGKKVLVRVDFNVPIKDGVITNDNRITAALPTIKYILEQGGRAVLFSHL
CCEEEEEEEECCCEEEEEEECCCCCCCCEEECCCEEEEHHHHHHHHHHCCCCEEHHHHH
GRVKEESDKAGKSLAPVAKALSEKLGQDVVFPGATRGAELEAAINELKDGEILLVENTRF
HHHHHHHHHCCCHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHCCCCCEEEEECCCC
EDIDGKKESKNDPELGKYWASLGDGIFVNDAFGTAHRAHASNVGISANVEKAVAGFLLEN
CCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHH
EIAYIQEAVEAPERPFVAILGGSKVSDKIGVIENLLSKADKVIIGGGMAYTFLKAQGYEI
HHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEECCCCEEEEEEECCCCC
GTSLVEDDKLDLAKELLEKAAGKLILPLDHKVANAFAGYTEVKETADQNIPAGFMGLDVA
CCHHHCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHC
NKTIADYNTQLEGAKTVVWNGPVGVFENPDFQAGTVGLMEAIVKQPGVKSIIGGGDSAAA
CCHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCEE
AINLGYAEKFSWISTGGGASMELLEGKVLPGLAALTEK
EEECCHHHHCCEEECCCCCCHHHHCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]