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The map label for this gene is ung [H]

Identifier: 125623120

GI number: 125623120

Start: 232047

End: 232706

Strand: Direct

Name: ung [H]

Synonym: llmg_0244

Alternate gene names: 125623120

Gene position: 232047-232706 (Clockwise)

Preceding gene: 125623119

Following gene: 125623124

Centisome position: 9.17

GC content: 40.91

Gene sequence:

>660_bases
ATGAAAAAAACAGATTGGTCACAGCCCTTACGCAACCGATTAGCAGAAGGTTATTTCCCTAAAATGATTGAATTTATCAA
TCAGACTTATCAAGAGGGGAAAATTTATCCACCAGAAAATCAAATTTTTCGGGCAATTGAACTGACTCCTTTGGCACAAA
CAAAGGTTATTATTGTTGGACAAGACCCTTATCCACAGCCGGGGAAAGCTCAAGGCTTGGCTTTCTCTTATCCAGCGACC
TTCAAAGTGAATCGTCCAGACTCGATTGTTAATATCCAAAAAGAATTGCGTGAGGAAGGTTTTTCTAAAGAAGATAGTGA
TTTGACGGCTTGGGCCGAGCAAGGCGTATTGCTTTTAAATGCGGTCTTGACCGTACCCGAGTTTGCTTCAAATGCCCATG
CTGGGAAAATTTGGGAACCATTGACAGACGAAATTATCAAAATTGCCTCAGATGATGAGCGACCAAAAGTTTTCATTCTT
TGGGGAGGTTTTGCTAGAAAGAAAGCCAAACTAATTGATGGAAGTAAGCATCTCATACTAGAAGCGGCTCATCCGTCACC
TTTATCAGCAAGTCGTGGTTTTTTTGGCTCGCATCCTTTTTCAAAAACCAATGATTTTCTGGTTCAAACGGGTCAAAGTC
CGATTGATTGGAGCAAATAA

Upstream 100 bases:

>100_bases
AGTTTCATCATCGAGAAATTTATATCAGTGATTTCAGAAAGACAGCAGCAGAAAAATTGAAAACAACAGTCCGAATTTTT
GTGGAGAAGGAACAAGAAAA

Downstream 100 bases:

>100_bases
AAAGCGGTCAGTAATCTGACAGCTTTTTTTATTTATCTAAAAGTAAAGAACGATTTTTCCGTGAGTGTGACGGCTCATTT
GTAAATTGACTGCTTCTAAA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MKKTDWSQPLRNRLAEGYFPKMIEFINQTYQEGKIYPPENQIFRAIELTPLAQTKVIIVGQDPYPQPGKAQGLAFSYPAT
FKVNRPDSIVNIQKELREEGFSKEDSDLTAWAEQGVLLLNAVLTVPEFASNAHAGKIWEPLTDEIIKIASDDERPKVFIL
WGGFARKKAKLIDGSKHLILEAAHPSPLSASRGFFGSHPFSKTNDFLVQTGQSPIDWSK

Sequences:

>Translated_219_residues
MKKTDWSQPLRNRLAEGYFPKMIEFINQTYQEGKIYPPENQIFRAIELTPLAQTKVIIVGQDPYPQPGKAQGLAFSYPAT
FKVNRPDSIVNIQKELREEGFSKEDSDLTAWAEQGVLLLNAVLTVPEFASNAHAGKIWEPLTDEIIKIASDDERPKVFIL
WGGFARKKAKLIDGSKHLILEAAHPSPLSASRGFFGSHPFSKTNDFLVQTGQSPIDWSK
>Mature_219_residues
MKKTDWSQPLRNRLAEGYFPKMIEFINQTYQEGKIYPPENQIFRAIELTPLAQTKVIIVGQDPYPQPGKAQGLAFSYPAT
FKVNRPDSIVNIQKELREEGFSKEDSDLTAWAEQGVLLLNAVLTVPEFASNAHAGKIWEPLTDEIIKIASDDERPKVFIL
WGGFARKKAKLIDGSKHLILEAAHPSPLSASRGFFGSHPFSKTNDFLVQTGQSPIDWSK

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI6224979, Length=215, Percent_Identity=42.3255813953488, Blast_Score=180, Evalue=8e-46,
Organism=Homo sapiens, GI19718751, Length=215, Percent_Identity=42.3255813953488, Blast_Score=180, Evalue=9e-46,
Organism=Escherichia coli, GI1788934, Length=216, Percent_Identity=43.0555555555556, Blast_Score=174, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17556304, Length=218, Percent_Identity=44.4954128440367, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6323620, Length=236, Percent_Identity=38.5593220338983, Blast_Score=150, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 24598; Mature: 24598

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTDWSQPLRNRLAEGYFPKMIEFINQTYQEGKIYPPENQIFRAIELTPLAQTKVIIVG
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCCCCEEEEEEC
QDPYPQPGKAQGLAFSYPATFKVNRPDSIVNIQKELREEGFSKEDSDLTAWAEQGVLLLN
CCCCCCCCCCCCEEEECCCEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCEEH
AVLTVPEFASNAHAGKIWEPLTDEIIKIASDDERPKVFILWGGFARKKAKLIDGSKHLIL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHCCCCCEEEE
EAAHPSPLSASRGFFGSHPFSKTNDFLVQTGQSPIDWSK
EECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCC
>Mature Secondary Structure
MKKTDWSQPLRNRLAEGYFPKMIEFINQTYQEGKIYPPENQIFRAIELTPLAQTKVIIVG
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCCCCEEEEEEC
QDPYPQPGKAQGLAFSYPATFKVNRPDSIVNIQKELREEGFSKEDSDLTAWAEQGVLLLN
CCCCCCCCCCCCEEEECCCEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCEEH
AVLTVPEFASNAHAGKIWEPLTDEIIKIASDDERPKVFILWGGFARKKAKLIDGSKHLIL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHCCCCCEEEE
EAAHPSPLSASRGFFGSHPFSKTNDFLVQTGQSPIDWSK
EECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]