Click here to switch to the map view.

The map label for this gene is menA [H]

Identifier: 125623074

GI number: 125623074

Start: 185902

End: 186807

Strand: Direct

Name: menA [H]

Synonym: llmg_0197

Alternate gene names: 125623074

Gene position: 185902-186807 (Clockwise)

Preceding gene: 125623073

Following gene: 125623078

Centisome position: 7.35

GC content: 33.33

Gene sequence:

>906_bases
ATGAATTTTAAAACATTCGCTGAACTTATTGAACTAAAAGCTAAAACGGCTTCGGTCTTTCCGTTTCTGCTGGGCCTTTC
GTACTCGTTTTACCATTACCATTCACTGAATTTATTAGCATTAAGTATTTATTTTGTTGCCATGTTTATGTTTAACTGTT
TTGTTGATATTTGGGATAATTATAATGATTATCATAACGCGGTGGATACCAACGATTATCAAAAAAATACAAATATTATT
GGTCGTGAAAACCTGTCAATGGCTTTAATTAAAGCTTTACTTGCTTTTTTCTTTTTTGGAAGTTTAGCATTAGGAATCAT
TGTGGCATTGATGACGGGTTGGGCAGTTTTTTGGCTAGGTCTTCTTTGTTACGCTGTTGGAATCTTTTATGCAGGAGGCC
CAAAACCATTGTCGTCCCTTCCTGTGGGTGAGCTTCTCTCAGGCTTAACAATGGGTTATATCATCTTTCTCATTTGTGTA
TATATTAATAGTTCACAGGCCTTTATTTGGTCATTTTCTAATCTTGCGACTACCTTCTTGATTGCTTTACCCAATACATT
GCTTATCGCTAATCTCATGTTAGCGAATAACACCTGTGATTTAGAAGAAGATGAAGCCAATCATCGTTTTACAATCGTAC
ATTATATTGGAAAAAAAGCAGCACTCATTTGGTGGACTTTGTCTTTAATTTTGTCTTTTATCGCTATTATTGTATCAGTA
ATTTTAGGATTACTTTCTCCGATAATGCTTTTGATTTTATTGATTGTTCCTTTAATGATAAAATTTGCAAAGCCTTATCT
TCAAAAACAAGTTAAAAGAGAAACTTTTATCTGTTCCGTCAAAATTCTAATGGTTTTCCAACTGGTTCAGGTTTTGCTGC
TCTTTATTAGTTTGATTAGATTTTAA

Upstream 100 bases:

>100_bases
TAAAATATGACAGAATGAGGCTTTGAAACCATGTTTATCACTTATTCAAAGTTCAACTATCAATCAAAAAAGTTGATAAA
TCACATTAAAAGAGGAAATA

Downstream 100 bases:

>100_bases
ATAAAAAACTCCAATTAATTAATTTGGAGTTTTTTTATTTATTTTTTTATACTATTTGACTTCCTATTCAGTGGTTTTGC
ACCATTTACCAGAGCTAATA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MNFKTFAELIELKAKTASVFPFLLGLSYSFYHYHSLNLLALSIYFVAMFMFNCFVDIWDNYNDYHNAVDTNDYQKNTNII
GRENLSMALIKALLAFFFFGSLALGIIVALMTGWAVFWLGLLCYAVGIFYAGGPKPLSSLPVGELLSGLTMGYIIFLICV
YINSSQAFIWSFSNLATTFLIALPNTLLIANLMLANNTCDLEEDEANHRFTIVHYIGKKAALIWWTLSLILSFIAIIVSV
ILGLLSPIMLLILLIVPLMIKFAKPYLQKQVKRETFICSVKILMVFQLVQVLLLFISLIRF

Sequences:

>Translated_301_residues
MNFKTFAELIELKAKTASVFPFLLGLSYSFYHYHSLNLLALSIYFVAMFMFNCFVDIWDNYNDYHNAVDTNDYQKNTNII
GRENLSMALIKALLAFFFFGSLALGIIVALMTGWAVFWLGLLCYAVGIFYAGGPKPLSSLPVGELLSGLTMGYIIFLICV
YINSSQAFIWSFSNLATTFLIALPNTLLIANLMLANNTCDLEEDEANHRFTIVHYIGKKAALIWWTLSLILSFIAIIVSV
ILGLLSPIMLLILLIVPLMIKFAKPYLQKQVKRETFICSVKILMVFQLVQVLLLFISLIRF
>Mature_301_residues
MNFKTFAELIELKAKTASVFPFLLGLSYSFYHYHSLNLLALSIYFVAMFMFNCFVDIWDNYNDYHNAVDTNDYQKNTNII
GRENLSMALIKALLAFFFFGSLALGIIVALMTGWAVFWLGLLCYAVGIFYAGGPKPLSSLPVGELLSGLTMGYIIFLICV
YINSSQAFIWSFSNLATTFLIALPNTLLIANLMLANNTCDLEEDEANHRFTIVHYIGKKAALIWWTLSLILSFIAIIVSV
ILGLLSPIMLLILLIVPLMIKFAKPYLQKQVKRETFICSVKILMVFQLVQVLLLFISLIRF

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 34062; Mature: 34062

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFKTFAELIELKAKTASVFPFLLGLSYSFYHYHSLNLLALSIYFVAMFMFNCFVDIWDN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YNDYHNAVDTNDYQKNTNIIGRENLSMALIKALLAFFFFGSLALGIIVALMTGWAVFWLG
CCHHCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLCYAVGIFYAGGPKPLSSLPVGELLSGLTMGYIIFLICVYINSSQAFIWSFSNLATTFL
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHH
IALPNTLLIANLMLANNTCDLEEDEANHRFTIVHYIGKKAALIWWTLSLILSFIAIIVSV
HHHCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ILGLLSPIMLLILLIVPLMIKFAKPYLQKQVKRETFICSVKILMVFQLVQVLLLFISLIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
F
C
>Mature Secondary Structure
MNFKTFAELIELKAKTASVFPFLLGLSYSFYHYHSLNLLALSIYFVAMFMFNCFVDIWDN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YNDYHNAVDTNDYQKNTNIIGRENLSMALIKALLAFFFFGSLALGIIVALMTGWAVFWLG
CCHHCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLCYAVGIFYAGGPKPLSSLPVGELLSGLTMGYIIFLICVYINSSQAFIWSFSNLATTFL
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHH
IALPNTLLIANLMLANNTCDLEEDEANHRFTIVHYIGKKAALIWWTLSLILSFIAIIVSV
HHHCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ILGLLSPIMLLILLIVPLMIKFAKPYLQKQVKRETFICSVKILMVFQLVQVLLLFISLIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
F
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]