Click here to switch to the map view.

The map label for this gene is dut [H]

Identifier: 125623068

GI number: 125623068

Start: 179759

End: 180211

Strand: Direct

Name: dut [H]

Synonym: llmg_0191

Alternate gene names: 125623068

Gene position: 179759-180211 (Clockwise)

Preceding gene: 125623067

Following gene: 125623069

Centisome position: 7.11

GC content: 37.31

Gene sequence:

>453_bases
ATGAAAATTCGTGGATTTGAAGTAGTAGCTAAATATAAAAATGCTGGAATTAACTTACCAAAACGTTCAACTGAACATTC
GGCAGGTTATGATATTGAAGCGGCAGAAACAGTTCGTTTTGCTCCAGGTGAAATTAAATTAATCCCAACAGGTTTAAAGG
CTTATATGCAGACAGGCGAAGTTCTTTATATGTATGATCGCTCATCAAATCCTCGTAAAAAAGGCTTGGTTTTAATCAAT
TCGGTTGGTGTCATCGACAAGGATTATTATAATAATCCTGATAATGAAGGACACATGTTTATGCAAATGCGTAATTTCAC
TGATGAAGAGGTTTTAGTTGAAAAAGGAGAGCGCGTGGTTCAAGGAGTATTTATGCCTTTCTTAGTTGCTGATGGCGATG
AAAATCAAGAAAAAGAAGAACGAACAGGAGGGTTCGGGTCAACGGGTGCTTAA

Upstream 100 bases:

>100_bases
AACATCTTATTGAAACAAATGGCGAAGAGCTCTAAACAAAGAGCACTCAAGTGAGTGCTCTTTTTATGTTATAATAATAA
AAAAACAAAAGAGGTGAAGA

Downstream 100 bases:

>100_bases
TTCAAATTAAAGTAATTTAAGAAGCGCAATCGCGCTTCTTATTTTTGTGAACGGAGGCTTTCAAAGCTTATTACTTATGA
TATAATAGTATTATGAATAA

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 150; Mature: 150

Protein sequence:

>150_residues
MKIRGFEVVAKYKNAGINLPKRSTEHSAGYDIEAAETVRFAPGEIKLIPTGLKAYMQTGEVLYMYDRSSNPRKKGLVLIN
SVGVIDKDYYNNPDNEGHMFMQMRNFTDEEVLVEKGERVVQGVFMPFLVADGDENQEKEERTGGFGSTGA

Sequences:

>Translated_150_residues
MKIRGFEVVAKYKNAGINLPKRSTEHSAGYDIEAAETVRFAPGEIKLIPTGLKAYMQTGEVLYMYDRSSNPRKKGLVLIN
SVGVIDKDYYNNPDNEGHMFMQMRNFTDEEVLVEKGERVVQGVFMPFLVADGDENQEKEERTGGFGSTGA
>Mature_150_residues
MKIRGFEVVAKYKNAGINLPKRSTEHSAGYDIEAAETVRFAPGEIKLIPTGLKAYMQTGEVLYMYDRSSNPRKKGLVLIN
SVGVIDKDYYNNPDNEGHMFMQMRNFTDEEVLVEKGERVVQGVFMPFLVADGDENQEKEERTGGFGSTGA

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Escherichia coli, GI1790071, Length=140, Percent_Identity=35, Blast_Score=74, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 16791; Mature: 16791

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIRGFEVVAKYKNAGINLPKRSTEHSAGYDIEAAETVRFAPGEIKLIPTGLKAYMQTGE
CCCCHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEEECCHHHHHCCCC
VLYMYDRSSNPRKKGLVLINSVGVIDKDYYNNPDNEGHMFMQMRNFTDEEVLVEKGERVV
EEEEEECCCCCCCCCEEEEECCCCEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHH
QGVFMPFLVADGDENQEKEERTGGFGSTGA
HHHHHHEEEECCCCCCHHHHHCCCCCCCCC
>Mature Secondary Structure
MKIRGFEVVAKYKNAGINLPKRSTEHSAGYDIEAAETVRFAPGEIKLIPTGLKAYMQTGE
CCCCHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEEECCHHHHHCCCC
VLYMYDRSSNPRKKGLVLINSVGVIDKDYYNNPDNEGHMFMQMRNFTDEEVLVEKGERVV
EEEEEECCCCCCCCCEEEEECCCCEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHH
QGVFMPFLVADGDENQEKEERTGGFGSTGA
HHHHHHEEEECCCCCCHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]