Click here to switch to the map view.

The map label for this gene is ctrA [H]

Identifier: 125622997

GI number: 125622997

Start: 111440

End: 112837

Strand: Direct

Name: ctrA [H]

Synonym: llmg_0118

Alternate gene names: 125622997

Gene position: 111440-112837 (Clockwise)

Preceding gene: 125622996

Following gene: 125622998

Centisome position: 4.41

GC content: 42.49

Gene sequence:

>1398_bases
ATGGGATTTATGAGAAAAGCCGATTTTGAGCTTTATCGTGATGCAGATAAACATTATAATCAGGTACTAACCACACGTGA
TTTTCTTGCACTAGGTGTTGGAACAATTATTTCAACTTCTATCTTTACCTTGCCAGGACAAGTTGCCGCTCAATTTGCGG
GCCCAGGGGTTGTCTTTTCTTATCTACTTGCCGCTTTGGTCGCTGGTTTTGTGGCCTTGGCTTATGCTGAAATGTCAACA
GTAATGCCCTTTGCTGGTTCAGCCTATTCTTGGATTTCGGTCTTATTTGGCGAAGGTTTCGGCTGGATTGCTGGTTGGGC
TTTGCTTGCGGAATATTTTATTGCTGTTGCCTTTGTTGGCTCAGGTTTCTCAGCAAATCTTCAGCAATTACTAGCGCCAC
TCGGTTTCCAACTGCCAAAAGTATTGGCCAACCCTTTTGGTACAGATGGTGGAATCGTTGATATTATTTCACTTTTGGTC
ATTTTGCTCTCGGCAATTATTGTCTTTCGTGGGGCATCTGATGCTGGACGAATCAGTCAAATTCTTGTTGTGCTTAAAGT
GGCAGCGGTTATTGCTTTCATCATTGTGGGGATTACGGTCATTAAGCCAGCAAATTACCATCCATTTATTCCGCCACACA
ATCCGAAAACAGGTTTTGGTGGCTTCTCGGGGATTTGGTCTGGGGTGTCGATGATTTTCTTGGCCTATATCGGTTTTGAT
TCAATTGCAGCCAATTCAGCGGAAGCTAAAAATCCCCAAAAAACAATGCCACGTGGAATTATTGGGTCGCTTCTCATTGC
TGTTGTTCTATTTGCAGCAGTAACCTTGGTACTTGTAGGGATGCATCCTTACTCAGCCTATGCAGGAAATGCAGCGCCAG
TTGGTTGGGCCCTTCAACAATCAGGTTATTCTGTTTTATCAGAAGTTGTCACAGCGATTGCACTTGCCGGAATGTTTATC
GCTCTTTTGGGAATGGTCCTTGCAGGTTCGCGTTTGCTTTATGCTTTTGGACGCGATGGACTTTTGCCTAAAGGTTTAGG
TAAAATGAATGCTCGAAATCTTCCAGCAAATGGTGTGTGGACCTTAGCCATTGTTGCTATTGTCATTGGGGCATTCTTCC
CCTTTGCTTTTCTTGCTCAACTTATCTCAGCCGGAACTTTGATTGCTTTCATGTTTGTAACTCTTGGAATTTATTCGCTC
CGTCGTCGTCAAGGAAAAGATTTACCAGAAGCAACTTATAAAATGCCTTTTTATCCAGTACTACCAGCTCTTGGTTTTAT
TGGGTCATTATTTGTCTTTTGGGGACTGGATGTTCAAGCAAAACTTTATTCTGGAATTTGGTTCCTTATTGGAATTGCGA
TTTATTTTGCTTATGGAAATCGTCGCAAAAAGAAATAA

Upstream 100 bases:

>100_bases
ATACTGCATAAAGTTAATTCTTGACAATTGTCTGACAATTCGGTAAAATACAGTTTATTGAAATTATTTAGTTACAAATT
CAGAAAAATGAGGATTTATT

Downstream 100 bases:

>100_bases
GACGAAAAATAAAAAAATTAGCTTAGAGATTACAAAAAATGGTTTCAAAATTTTTGAGACCATTTTTTTGTCATTATTTT
GGAGCTGACAAAAATTGCTA

Product: putative amino-acid transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MGFMRKADFELYRDADKHYNQVLTTRDFLALGVGTIISTSIFTLPGQVAAQFAGPGVVFSYLLAALVAGFVALAYAEMST
VMPFAGSAYSWISVLFGEGFGWIAGWALLAEYFIAVAFVGSGFSANLQQLLAPLGFQLPKVLANPFGTDGGIVDIISLLV
ILLSAIIVFRGASDAGRISQILVVLKVAAVIAFIIVGITVIKPANYHPFIPPHNPKTGFGGFSGIWSGVSMIFLAYIGFD
SIAANSAEAKNPQKTMPRGIIGSLLIAVVLFAAVTLVLVGMHPYSAYAGNAAPVGWALQQSGYSVLSEVVTAIALAGMFI
ALLGMVLAGSRLLYAFGRDGLLPKGLGKMNARNLPANGVWTLAIVAIVIGAFFPFAFLAQLISAGTLIAFMFVTLGIYSL
RRRQGKDLPEATYKMPFYPVLPALGFIGSLFVFWGLDVQAKLYSGIWFLIGIAIYFAYGNRRKKK

Sequences:

>Translated_465_residues
MGFMRKADFELYRDADKHYNQVLTTRDFLALGVGTIISTSIFTLPGQVAAQFAGPGVVFSYLLAALVAGFVALAYAEMST
VMPFAGSAYSWISVLFGEGFGWIAGWALLAEYFIAVAFVGSGFSANLQQLLAPLGFQLPKVLANPFGTDGGIVDIISLLV
ILLSAIIVFRGASDAGRISQILVVLKVAAVIAFIIVGITVIKPANYHPFIPPHNPKTGFGGFSGIWSGVSMIFLAYIGFD
SIAANSAEAKNPQKTMPRGIIGSLLIAVVLFAAVTLVLVGMHPYSAYAGNAAPVGWALQQSGYSVLSEVVTAIALAGMFI
ALLGMVLAGSRLLYAFGRDGLLPKGLGKMNARNLPANGVWTLAIVAIVIGAFFPFAFLAQLISAGTLIAFMFVTLGIYSL
RRRQGKDLPEATYKMPFYPVLPALGFIGSLFVFWGLDVQAKLYSGIWFLIGIAIYFAYGNRRKKK
>Mature_464_residues
GFMRKADFELYRDADKHYNQVLTTRDFLALGVGTIISTSIFTLPGQVAAQFAGPGVVFSYLLAALVAGFVALAYAEMSTV
MPFAGSAYSWISVLFGEGFGWIAGWALLAEYFIAVAFVGSGFSANLQQLLAPLGFQLPKVLANPFGTDGGIVDIISLLVI
LLSAIIVFRGASDAGRISQILVVLKVAAVIAFIIVGITVIKPANYHPFIPPHNPKTGFGGFSGIWSGVSMIFLAYIGFDS
IAANSAEAKNPQKTMPRGIIGSLLIAVVLFAAVTLVLVGMHPYSAYAGNAAPVGWALQQSGYSVLSEVVTAIALAGMFIA
LLGMVLAGSRLLYAFGRDGLLPKGLGKMNARNLPANGVWTLAIVAIVIGAFFPFAFLAQLISAGTLIAFMFVTLGIYSLR
RRQGKDLPEATYKMPFYPVLPALGFIGSLFVFWGLDVQAKLYSGIWFLIGIAIYFAYGNRRKKK

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Lysine. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=435, Percent_Identity=31.0344827586207, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI258645169, Length=435, Percent_Identity=28.2758620689655, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI258614003, Length=437, Percent_Identity=28.3752860411899, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI258614005, Length=436, Percent_Identity=28.4403669724771, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI181337167, Length=406, Percent_Identity=29.5566502463054, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI114326544, Length=426, Percent_Identity=29.3427230046948, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI114326550, Length=426, Percent_Identity=29.3427230046948, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI110347453, Length=394, Percent_Identity=29.6954314720812, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1790653, Length=487, Percent_Identity=24.0246406570842, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788480, Length=453, Percent_Identity=24.9448123620309, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786302, Length=420, Percent_Identity=22.1428571428571, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87081708, Length=452, Percent_Identity=22.3451327433628, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082250, Length=419, Percent_Identity=27.2076372315036, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI2367353, Length=470, Percent_Identity=22.1276595744681, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786602, Length=470, Percent_Identity=22.9787234042553, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87081915, Length=425, Percent_Identity=21.4117647058824, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786908, Length=306, Percent_Identity=23.5294117647059, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI87081869, Length=424, Percent_Identity=25, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI48994972, Length=476, Percent_Identity=23.3193277310924, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1786789, Length=423, Percent_Identity=21.9858156028369, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI87082023, Length=424, Percent_Identity=24.5283018867925, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789017, Length=426, Percent_Identity=22.7699530516432, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786694, Length=404, Percent_Identity=25, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=451, Percent_Identity=27.9379157427938, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17531343, Length=421, Percent_Identity=28.2660332541568, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17533459, Length=405, Percent_Identity=28.8888888888889, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6321053, Length=323, Percent_Identity=23.8390092879257, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324061, Length=454, Percent_Identity=22.9074889867841, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319542, Length=431, Percent_Identity=22.0417633410673, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6321629, Length=450, Percent_Identity=22.2222222222222, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221512776, Length=420, Percent_Identity=31.6666666666667, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24666159, Length=420, Percent_Identity=31.6666666666667, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24668806, Length=426, Percent_Identity=29.81220657277, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI21356285, Length=426, Percent_Identity=29.81220657277, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24668802, Length=426, Percent_Identity=29.81220657277, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24667468, Length=412, Percent_Identity=29.126213592233, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI161077963, Length=411, Percent_Identity=28.7104622871046, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI281366235, Length=406, Percent_Identity=30.5418719211823, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI116007820, Length=406, Percent_Identity=30.5418719211823, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI116007818, Length=403, Percent_Identity=30.7692307692308, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI85725152, Length=403, Percent_Identity=30.7692307692308, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49581; Mature: 49450

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GFMRKADFELYRDADKHYNQVLTTRDFLALGVGTIISTSIFTLPGQVAAQFAGPGVVFS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHH
YLLAALVAGFVALAYAEMSTVMPFAGSAYSWISVLFGEGFGWIAGWALLAEYFIAVAFVG
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
SGFSANLQQLLAPLGFQLPKVLANPFGTDGGIVDIISLLVILLSAIIVFRGASDAGRISQ
CCCCCCHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
ILVVLKVAAVIAFIIVGITVIKPANYHPFIPPHNPKTGFGGFSGIWSGVSMIFLAYIGFD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
SIAANSAEAKNPQKTMPRGIIGSLLIAVVLFAAVTLVLVGMHPYSAYAGNAAPVGWALQQ
HHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHH
SGYSVLSEVVTAIALAGMFIALLGMVLAGSRLLYAFGRDGLLPKGLGKMNARNLPANGVW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHCCCCCCCCCCCCCCCCCCCCCCHH
TLAIVAIVIGAFFPFAFLAQLISAGTLIAFMFVTLGIYSLRRRQGKDLPEATYKMPFYPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHH
LPALGFIGSLFVFWGLDVQAKLYSGIWFLIGIAIYFAYGNRRKKK
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]