Click here to switch to the map view.

The map label for this gene is cycA [C]

Identifier: 125622960

GI number: 125622960

Start: 76060

End: 77373

Strand: Direct

Name: cycA [C]

Synonym: llmg_0081

Alternate gene names: 125622960

Gene position: 76060-77373 (Clockwise)

Preceding gene: 125622959

Following gene: 125622961

Centisome position: 3.01

GC content: 34.78

Gene sequence:

>1314_bases
ATGAAAGAAAATAAATTATTATCACCGGCTGCCATTTTTTTGTTGGGAGTGAATTCCATAATTGGCTCAGGTATTTTCTT
ACTTTCTGGAAAAATTTATGAAGACGCTGGGATTTGGAGTTTGCTAGCCATTTTATTTGCTGGTCTATCCATTTTTGTGA
TTGCTTTTGCTTATGCAAATATGAGTAAGATTTACTCTAAAAATGGTGGGGCTTTCGTCTATGCCAAAGAAACATTTGGG
CGCTTTCCAGGTTTTATCGTTGGAATGGTAACTTGGTTATTGGGCACAGTGACATTGGCAACGGAAGTTTCAGCCTTGCT
CACAGCCTTGAAAATGATTTTACCGAATCTTAATAGTCGATTAATTGGCTTGATTATTATTTTAGCTCTGGGCTTGATTT
CCTATTTTGGAAGTTCAATTATTGCTGGTTTAGATAATCTGACCTCATTTGTGAAGATATTATTGGTTCTTGTTTTTGTT
TGTACTTGTCTTTGGTTAGTGCGTGCTGTTAATTTTACAAGTCCACATTTATTGACTGTCTCATCAGCAAATTTAGGTGG
TTTCAAAGGATTTTTATCAGCTTATGGAACAGTTTTCTTCTTTTTTACAGGATTTTCTTTTTTACCGGTCAATGCTGAAA
AGATGAAAAATCCAGCGAAAAATTTACCTAAAATGATGGCACTTGTGATGCTCACTTGCTTAACTGTCTATTTGATTATT
CAAGCAATTACAATTGGAGCACTTGGTCCTGAATTGACTAAAACATTGGTTCCAGCGGCAACGGCTTTTAGTAGAGTTGT
AGGGGCAATCGGGATTCCACTCTTTGTCATTGGGATTTGTTTTTCAATTTTTGGTGTGATTGTAGCAACTACGTTTAATA
CACCAACTATCCTAGCAAGTTTAGCTCAAGCACATGAAGATGTTCCAATGTTTGTTGCGAAAAATAATCGCTTTGGAACA
CCAAGTTGGGCGATTATTTTGACGACACTGTGTGCCATGGGACTTTTTCTAAGTGGTAACTATGTTTTTCTGAGTGGTTT
AACCGTATTTATGAGTTTTGTTCAATATTTATCAACCGGTCTTGCCAATATTAAGAAAAAATTTCTGTGGATTGGAATTG
GTTCAGTACTTTTTTCTCTTGTTTTACTGACAAGTTTTACTTTGTCTGTTCTACTTTTAGGTCTAGGAATAATAATTTTA
TTAGTGATTATTTATTTTGTAGTCAAATTAGATGATGATGAACGTGAAAAATGGCTTAAAGAACATCAAGAAAAATCAAA
AGCTGCGGATGTTAATACTGTTAAGCGTTTATAA

Upstream 100 bases:

>100_bases
ATACTGGGGAAATAATGAGAAAAAAGGGGAGCTTTCTGATATAATTTAACTAATAAAAATTTTAATAAAGTCTTGTCTTA
TTAAAGTAAGAGAGGTTTCG

Downstream 100 bases:

>100_bases
GTGATTTTTATGTGTTTTATCTTATTGATAGCTTTGTCAGCAATTTATGGAGAAAAAATATGACAAAAAAAGAATACATT
TTTTGGTTACTAAGCAGTAT

Product: putative amino-acid permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MKENKLLSPAAIFLLGVNSIIGSGIFLLSGKIYEDAGIWSLLAILFAGLSIFVIAFAYANMSKIYSKNGGAFVYAKETFG
RFPGFIVGMVTWLLGTVTLATEVSALLTALKMILPNLNSRLIGLIIILALGLISYFGSSIIAGLDNLTSFVKILLVLVFV
CTCLWLVRAVNFTSPHLLTVSSANLGGFKGFLSAYGTVFFFFTGFSFLPVNAEKMKNPAKNLPKMMALVMLTCLTVYLII
QAITIGALGPELTKTLVPAATAFSRVVGAIGIPLFVIGICFSIFGVIVATTFNTPTILASLAQAHEDVPMFVAKNNRFGT
PSWAIILTTLCAMGLFLSGNYVFLSGLTVFMSFVQYLSTGLANIKKKFLWIGIGSVLFSLVLLTSFTLSVLLLGLGIIIL
LVIIYFVVKLDDDEREKWLKEHQEKSKAADVNTVKRL

Sequences:

>Translated_437_residues
MKENKLLSPAAIFLLGVNSIIGSGIFLLSGKIYEDAGIWSLLAILFAGLSIFVIAFAYANMSKIYSKNGGAFVYAKETFG
RFPGFIVGMVTWLLGTVTLATEVSALLTALKMILPNLNSRLIGLIIILALGLISYFGSSIIAGLDNLTSFVKILLVLVFV
CTCLWLVRAVNFTSPHLLTVSSANLGGFKGFLSAYGTVFFFFTGFSFLPVNAEKMKNPAKNLPKMMALVMLTCLTVYLII
QAITIGALGPELTKTLVPAATAFSRVVGAIGIPLFVIGICFSIFGVIVATTFNTPTILASLAQAHEDVPMFVAKNNRFGT
PSWAIILTTLCAMGLFLSGNYVFLSGLTVFMSFVQYLSTGLANIKKKFLWIGIGSVLFSLVLLTSFTLSVLLLGLGIIIL
LVIIYFVVKLDDDEREKWLKEHQEKSKAADVNTVKRL
>Mature_437_residues
MKENKLLSPAAIFLLGVNSIIGSGIFLLSGKIYEDAGIWSLLAILFAGLSIFVIAFAYANMSKIYSKNGGAFVYAKETFG
RFPGFIVGMVTWLLGTVTLATEVSALLTALKMILPNLNSRLIGLIIILALGLISYFGSSIIAGLDNLTSFVKILLVLVFV
CTCLWLVRAVNFTSPHLLTVSSANLGGFKGFLSAYGTVFFFFTGFSFLPVNAEKMKNPAKNLPKMMALVMLTCLTVYLII
QAITIGALGPELTKTLVPAATAFSRVVGAIGIPLFVIGICFSIFGVIVATTFNTPTILASLAQAHEDVPMFVAKNNRFGT
PSWAIILTTLCAMGLFLSGNYVFLSGLTVFMSFVQYLSTGLANIKKKFLWIGIGSVLFSLVLLTSFTLSVLLLGLGIIIL
LVIIYFVVKLDDDEREKWLKEHQEKSKAADVNTVKRL

Specific function: Probable amino-acid or metabolite transport protein [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=269, Percent_Identity=24.907063197026, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1790653, Length=346, Percent_Identity=23.121387283237, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87082250, Length=352, Percent_Identity=23.5795454545455, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17540018, Length=366, Percent_Identity=22.9508196721311, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24651635, Length=367, Percent_Identity=26.9754768392371, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24651633, Length=367, Percent_Identity=26.9754768392371, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45550968, Length=339, Percent_Identity=24.7787610619469, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921172, Length=339, Percent_Identity=24.7787610619469, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281366235, Length=328, Percent_Identity=25.3048780487805, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116007820, Length=328, Percent_Identity=25.3048780487805, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116007818, Length=328, Percent_Identity=25.3048780487805, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI85725152, Length=328, Percent_Identity=25.3048780487805, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221331183, Length=261, Percent_Identity=26.8199233716475, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17647653, Length=261, Percent_Identity=26.8199233716475, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24664379, Length=261, Percent_Identity=26.8199233716475, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24667468, Length=264, Percent_Identity=23.1060606060606, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 47279; Mature: 47279

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKENKLLSPAAIFLLGVNSIIGSGIFLLSGKIYEDAGIWSLLAILFAGLSIFVIAFAYAN
CCCCCCCCHHHHHHHHHHHHHHCCHHHEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
MSKIYSKNGGAFVYAKETFGRFPGFIVGMVTWLLGTVTLATEVSALLTALKMILPNLNSR
HHHHHHCCCCEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LIGLIIILALGLISYFGSSIIAGLDNLTSFVKILLVLVFVCTCLWLVRAVNFTSPHLLTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
SSANLGGFKGFLSAYGTVFFFFTGFSFLPVNAEKMKNPAKNLPKMMALVMLTCLTVYLII
ECCCCCHHHHHHHHHHHHHHHHHCCCEECCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
QAITIGALGPELTKTLVPAATAFSRVVGAIGIPLFVIGICFSIFGVIVATTFNTPTILAS
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LAQAHEDVPMFVAKNNRFGTPSWAIILTTLCAMGLFLSGNYVFLSGLTVFMSFVQYLSTG
HHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LANIKKKFLWIGIGSVLFSLVLLTSFTLSVLLLGLGIIILLVIIYFVVKLDDDEREKWLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EHQEKSKAADVNTVKRL
HHHHHHHHCCHHHHHCC
>Mature Secondary Structure
MKENKLLSPAAIFLLGVNSIIGSGIFLLSGKIYEDAGIWSLLAILFAGLSIFVIAFAYAN
CCCCCCCCHHHHHHHHHHHHHHCCHHHEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
MSKIYSKNGGAFVYAKETFGRFPGFIVGMVTWLLGTVTLATEVSALLTALKMILPNLNSR
HHHHHHCCCCEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LIGLIIILALGLISYFGSSIIAGLDNLTSFVKILLVLVFVCTCLWLVRAVNFTSPHLLTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
SSANLGGFKGFLSAYGTVFFFFTGFSFLPVNAEKMKNPAKNLPKMMALVMLTCLTVYLII
ECCCCCHHHHHHHHHHHHHHHHHCCCEECCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
QAITIGALGPELTKTLVPAATAFSRVVGAIGIPLFVIGICFSIFGVIVATTFNTPTILAS
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LAQAHEDVPMFVAKNNRFGTPSWAIILTTLCAMGLFLSGNYVFLSGLTVFMSFVQYLSTG
HHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LANIKKKFLWIGIGSVLFSLVLLTSFTLSVLLLGLGIIILLVIIYFVVKLDDDEREKWLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EHQEKSKAADVNTVKRL
HHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]