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The map label for this gene is pth [H]

Identifier: 125622894

GI number: 125622894

Start: 14436

End: 15002

Strand: Direct

Name: pth [H]

Synonym: llmg_0012

Alternate gene names: 125622894

Gene position: 14436-15002 (Clockwise)

Preceding gene: 125622893

Following gene: 125622895

Centisome position: 0.57

GC content: 36.68

Gene sequence:

>567_bases
ATGACAAAAATGATTGTTGGCTTGGGAAATCCAGGCGATAAATATGAAAAAACGAAGCATAACATGGGCTTTATGGCACT
TGATTTACTGGCAAAAGAGCTAAATGTAGATTTTAAAGAGGAAAAACCTTTTATGTCGCTTGTCGCGTCAACATTTGTGA
ATGGTGAAAAATTGTTTCTCGTGAAACCTTTGACTTTCATGAATGAATCTGGCCGTGCGGTGGCACCACTTTTGAAATAT
TATAATATAGACGAAGCAGATTTAACGGTCATGCATGATGATTTGGATTCACCAGTTGGGCGCGTGCGTCTAAGACAAAA
AGGTTCATCAGGTGGTCAAAATGGGATAAAATCAGTTATTACACATGTAGGAAGTCAAACATTCAACCGTGTAAAAATTG
GAATTGGCCGTCCAAAGCATGGCATGACGGTGGTAAATCATGTGCTTTCTGGTTTTGACAATGAAGATAAGGAAATCGCT
CAAGATGGAATTTTTAAAGCTGTTGATGCAATGAAATTCTATCTTGAAAATGGTGATTTTCAAAAGACAATGAATAAATT
TAACTAA

Upstream 100 bases:

>100_bases
ATTGATAAAAGCACAAAAAAAGACTATTATTTTAAAAAATCAAAGAGAAATTCGGCAATTTATAAAAAAGTTTTCAAAAA
TAGAGAAGAAAGAATAGAAA

Downstream 100 bases:

>100_bases
ATGAATATTATTGAATTTTTTGACCAAAATTGGCAACTGCAAAAATGGCAACAAGGATTTTCAAAGCGTGAGCGAACTTT
ACTGACAGGTTTGTCAGGAA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MTKMIVGLGNPGDKYEKTKHNMGFMALDLLAKELNVDFKEEKPFMSLVASTFVNGEKLFLVKPLTFMNESGRAVAPLLKY
YNIDEADLTVMHDDLDSPVGRVRLRQKGSSGGQNGIKSVITHVGSQTFNRVKIGIGRPKHGMTVVNHVLSGFDNEDKEIA
QDGIFKAVDAMKFYLENGDFQKTMNKFN

Sequences:

>Translated_188_residues
MTKMIVGLGNPGDKYEKTKHNMGFMALDLLAKELNVDFKEEKPFMSLVASTFVNGEKLFLVKPLTFMNESGRAVAPLLKY
YNIDEADLTVMHDDLDSPVGRVRLRQKGSSGGQNGIKSVITHVGSQTFNRVKIGIGRPKHGMTVVNHVLSGFDNEDKEIA
QDGIFKAVDAMKFYLENGDFQKTMNKFN
>Mature_187_residues
TKMIVGLGNPGDKYEKTKHNMGFMALDLLAKELNVDFKEEKPFMSLVASTFVNGEKLFLVKPLTFMNESGRAVAPLLKYY
NIDEADLTVMHDDLDSPVGRVRLRQKGSSGGQNGIKSVITHVGSQTFNRVKIGIGRPKHGMTVVNHVLSGFDNEDKEIAQ
DGIFKAVDAMKFYLENGDFQKTMNKFN

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=168, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=2e-24,
Organism=Escherichia coli, GI1787455, Length=187, Percent_Identity=35.2941176470588, Blast_Score=111, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6321983, Length=138, Percent_Identity=31.1594202898551, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 20963; Mature: 20832

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKMIVGLGNPGDKYEKTKHNMGFMALDLLAKELNVDFKEEKPFMSLVASTFVNGEKLFL
CCEEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEE
VKPLTFMNESGRAVAPLLKYYNIDEADLTVMHDDLDSPVGRVRLRQKGSSGGQNGIKSVI
ECCHHHHCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHH
THVGSQTFNRVKIGIGRPKHGMTVVNHVLSGFDNEDKEIAQDGIFKAVDAMKFYLENGDF
HHHCHHHHCEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCH
QKTMNKFN
HHHHHHCC
>Mature Secondary Structure 
TKMIVGLGNPGDKYEKTKHNMGFMALDLLAKELNVDFKEEKPFMSLVASTFVNGEKLFL
CEEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEE
VKPLTFMNESGRAVAPLLKYYNIDEADLTVMHDDLDSPVGRVRLRQKGSSGGQNGIKSVI
ECCHHHHCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHH
THVGSQTFNRVKIGIGRPKHGMTVVNHVLSGFDNEDKEIAQDGIFKAVDAMKFYLENGDF
HHHCHHHHCEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCH
QKTMNKFN
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]