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The map label for this gene is 124486465

Identifier: 124486465

GI number: 124486465

Start: 1681522

End: 1682559

Strand: Reverse

Name: 124486465

Synonym: Mlab_1653

Alternate gene names: NA

Gene position: 1682559-1681522 (Counterclockwise)

Preceding gene: 124486466

Following gene: 124486464

Centisome position: 93.22

GC content: 52.7

Gene sequence:

>1038_bases
ATGACAATCCAACTTCCTCCAATCCTGATCCGTGCCGACCACCTGCAGACTTATGACGAAAGAAAGGCAATCGTCGCCTC
AGCTCTTGAATCCGGGTATACTCATATTATTCTAAGACCCGAAGATGAGGCTCTCCGTCATCTCGGCAGATATACAGCAA
TACTTGCCGACGGCAAAAATCTCATGTATTCCGGGGAACGCATCGGCGTTCTTCTGAATCTGACCGGTGCCGAGGAGATG
GAGGAGGCGTATAGCCTAAAAAATGCCGTTCCAAATCTTATCATCTCTCCCGAAAACTGGAAGGTCATCCCTCTTGAAAA
TCTCATCTCAAGGTTCCAGAATGCCGAGACGAGTGTATATATTTGCGTGAAGACCCCCGAAGAAGCCCGTCTCGCTTTCC
AAACAATGGAGGTGGGCTGCGACGGTATCGTCATCACACCGGACGGTCCGGCCGATCTTGCCGCATTTTCCGGAATCAGA
AATGATGAATACCCAATAGTCGATCTCGAAACCGCAGTGGTTACCAAGATCTCCACGCTCTCTTTAGGGGACCGTGTCTG
TATCGACACCTGTTCGCTTCTGGAGAGGGGCGAAGGCATGCTGATCGGCTCCCAGTCGTCCTGCCTCTTCCTTGTCTGCT
CGGAAAGTTTTGAAAGCGAGTACGTAAACTCGCGGCCTTTCCGGGTGAACGCCGGGGCGGTCCACTCATATATTCTCTGT
CCGGACGGTACGACGAAATATCTCTCCGAGATTGCGAGCGGCAATGAACTGCTTTCCAGAATGCCTGATGGCAATCTCCG
GACCGTGAATGTCGGCAGAGTAAAAATCGAGATCCGCCCCATGCTCTATATCGAGGCAAAAGCCGGAGGAAAGACCTACT
CCGTCGTTCTCCAGAATGCCGAGACCATACGCCTTGGAACTCCCTCGGGCGCGGTTTCCGTATCCGATCTCGCGATCGGC
GATCTGGTCTACGTCAGACTTGAAAGCGGCGGCCGCCACTTCGGGCATACGATGGCGGAAACAATCTGCGAAAAATGA

Upstream 100 bases:

>100_bases
CACAATGATATTATCGGTATTACCTCGGCCGTATCCGATATTGTATTAAGGGATGCATCCGTAGAAGAAGCCGCGAAACA
TCTCACCCGGTGAAAAATAT

Downstream 100 bases:

>100_bases
CTGCAAATTGTGCCGTTATCGTGGCGAAAGATGAGAGAGAAGTTCGAACTCTTTCAGAAGAAGCGATCTCGAAAGGAGCA
GAGGCTCTTGAATTCCGGCT

Product: 3-dehydroquinate synthase II

Products: NA

Alternate protein names: DHQ synthase

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MTIQLPPILIRADHLQTYDERKAIVASALESGYTHIILRPEDEALRHLGRYTAILADGKNLMYSGERIGVLLNLTGAEEM
EEAYSLKNAVPNLIISPENWKVIPLENLISRFQNAETSVYICVKTPEEARLAFQTMEVGCDGIVITPDGPADLAAFSGIR
NDEYPIVDLETAVVTKISTLSLGDRVCIDTCSLLERGEGMLIGSQSSCLFLVCSESFESEYVNSRPFRVNAGAVHSYILC
PDGTTKYLSEIASGNELLSRMPDGNLRTVNVGRVKIEIRPMLYIEAKAGGKTYSVVLQNAETIRLGTPSGAVSVSDLAIG
DLVYVRLESGGRHFGHTMAETICEK

Sequences:

>Translated_345_residues
MTIQLPPILIRADHLQTYDERKAIVASALESGYTHIILRPEDEALRHLGRYTAILADGKNLMYSGERIGVLLNLTGAEEM
EEAYSLKNAVPNLIISPENWKVIPLENLISRFQNAETSVYICVKTPEEARLAFQTMEVGCDGIVITPDGPADLAAFSGIR
NDEYPIVDLETAVVTKISTLSLGDRVCIDTCSLLERGEGMLIGSQSSCLFLVCSESFESEYVNSRPFRVNAGAVHSYILC
PDGTTKYLSEIASGNELLSRMPDGNLRTVNVGRVKIEIRPMLYIEAKAGGKTYSVVLQNAETIRLGTPSGAVSVSDLAIG
DLVYVRLESGGRHFGHTMAETICEK
>Mature_344_residues
TIQLPPILIRADHLQTYDERKAIVASALESGYTHIILRPEDEALRHLGRYTAILADGKNLMYSGERIGVLLNLTGAEEME
EAYSLKNAVPNLIISPENWKVIPLENLISRFQNAETSVYICVKTPEEARLAFQTMEVGCDGIVITPDGPADLAAFSGIRN
DEYPIVDLETAVVTKISTLSLGDRVCIDTCSLLERGEGMLIGSQSSCLFLVCSESFESEYVNSRPFRVNAGAVHSYILCP
DGTTKYLSEIASGNELLSRMPDGNLRTVNVGRVKIEIRPMLYIEAKAGGKTYSVVLQNAETIRLGTPSGAVSVSDLAIGD
LVYVRLESGGRHFGHTMAETICEK

Specific function: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis

COG id: COG1465

COG function: function code E; Predicted alternative 3-dehydroquinate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal-type DHQ synthase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHQS_METLZ (A2SU08)

Other databases:

- EMBL:   CP000559
- RefSeq:   YP_001031081.1
- STRING:   A2SU08
- GeneID:   4794393
- GenomeReviews:   CP000559_GR
- KEGG:   mla:Mlab_1653
- eggNOG:   arNOG05006
- HOGENOM:   HBG670179
- OMA:   DRVCIDT
- BioCyc:   MLAB410358:MLAB_1653-MONOMER
- HAMAP:   MF_01244
- InterPro:   IPR002812
- ProDom:   PD017907

Pfam domain/function: PF01959 DHQS

EC number: NA

Molecular weight: Translated: 37707; Mature: 37575

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIQLPPILIRADHLQTYDERKAIVASALESGYTHIILRPEDEALRHLGRYTAILADGKN
CEEECCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHEEEEEECCCC
LMYSGERIGVLLNLTGAEEMEEAYSLKNAVPNLIISPENWKVIPLENLISRFQNAETSVY
EEECCCEEEEEEEECCHHHHHHHHHHHHCCCCEEECCCCCEEEEHHHHHHHHCCCCCEEE
ICVKTPEEARLAFQTMEVGCDGIVITPDGPADLAAFSGIRNDEYPIVDLETAVVTKISTL
EEEECCHHHHHEEEHHCCCCCEEEECCCCCHHHHHHCCCCCCCCCEEEECHHHHEEEEEE
SLGDRVCIDTCSLLERGEGMLIGSQSSCLFLVCSESFESEYVNSRPFRVNAGAVHSYILC
CCCCCHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCHHHCCCCCEEEECCCEEEEEEC
PDGTTKYLSEIASGNELLSRMPDGNLRTVNVGRVKIEIRPMLYIEAKAGGKTYSVVLQNA
CCCCHHHHHHHHCCHHHHHHCCCCCEEEEEEEEEEEEEEEEEEEEECCCCCEEEEEEECC
ETIRLGTPSGAVSVSDLAIGDLVYVRLESGGRHFGHTMAETICEK
CEEEEECCCCCEEEEEEEECEEEEEEECCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TIQLPPILIRADHLQTYDERKAIVASALESGYTHIILRPEDEALRHLGRYTAILADGKN
EEECCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHEEEEEECCCC
LMYSGERIGVLLNLTGAEEMEEAYSLKNAVPNLIISPENWKVIPLENLISRFQNAETSVY
EEECCCEEEEEEEECCHHHHHHHHHHHHCCCCEEECCCCCEEEEHHHHHHHHCCCCCEEE
ICVKTPEEARLAFQTMEVGCDGIVITPDGPADLAAFSGIRNDEYPIVDLETAVVTKISTL
EEEECCHHHHHEEEHHCCCCCEEEECCCCCHHHHHHCCCCCCCCCEEEECHHHHEEEEEE
SLGDRVCIDTCSLLERGEGMLIGSQSSCLFLVCSESFESEYVNSRPFRVNAGAVHSYILC
CCCCCHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCHHHCCCCCEEEECCCEEEEEEC
PDGTTKYLSEIASGNELLSRMPDGNLRTVNVGRVKIEIRPMLYIEAKAGGKTYSVVLQNA
CCCCHHHHHHHHCCHHHHHHCCCCCEEEEEEEEEEEEEEEEEEEEECCCCCEEEEEEECC
ETIRLGTPSGAVSVSDLAIGDLVYVRLESGGRHFGHTMAETICEK
CEEEEECCCCCEEEEEEEECEEEEEEECCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA