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The map label for this gene is tyrA [H]

Identifier: 124486460

GI number: 124486460

Start: 1675877

End: 1676932

Strand: Reverse

Name: tyrA [H]

Synonym: Mlab_1648

Alternate gene names: 124486460

Gene position: 1676932-1675877 (Counterclockwise)

Preceding gene: 124486461

Following gene: 124486458

Centisome position: 92.91

GC content: 49.72

Gene sequence:

>1056_bases
TTGTCTGATATTAATGGATTCAGGGATGAACTGGCGTCGATCGACCGCGAGATCATGGAACTTGTCGGCCGCAGAAACAA
AATAGCTCTGGAGATCGGTGAGAAAAAGGCAGCCGCCAACAAGGAGATTGTCGTTCCATCCGTCGAAACAAACGTCGTTC
AAAGATATGTTGATGCCGGGAAAGTTTCCGGCGTGAGTGCGGAAACGGCTGCACGAATCGCCCGGGCGGTTATCGATGAG
TCGGTGGATGTACAGGGTATGATTCCACGCCGTTCTGTTCCGCAGAAAATCTTCATTATCGGAGGGAACGGCGGGATGGG
CAGATGGCTCTCTGAGTTTTTTTCTTCCAGAGGTCATATCGTAACAATCAATGACCAGAAACACAATGGGGCTGTCTATC
CAGTTGTGGATATTTTTTCGGGATGCAGGAATGCCGATGTCATTATCGTAGCAACGCCGATAAAAATCTCTGCAGAAATC
CTTGAGACCGTCCTATCCGAAAACAAAAACGCTCTCATTTTTGATCTCATCTCCGTTAAAACTCCGGTCATTCCGGTTCT
CTGTAAAGCGTCAGCTTTGGGTGCGAAAGTCTGCTCGGTTCATCCGATGTTTGGGTCCAGTGCCCCTTCGATAGCCGGCA
GAAACATCATCGTATGTTCATGCGGCAACGATGAAGCGGCGGATGAAGCGGCGGATCTTTTCAGCGGAGGGACCATTCTT
CGGCTGAATATCGAAGATCACGATCCGATCACTGCCTACGTTCTCGGCCTTTCCCATGCGGTGAATCTTGCTTTCAGCGA
AGCACTTGTTAGAAGCGGCTTTTCTTCAGAAACACTCTGTGCCGCGGCCTCGACAACGTTTCAGAGACAGACGGCCGTAT
CCTCTGATGTTTCCCGGGAAAACGGCGAACTCTATTACTCCATCCAGAAGGAAAATCCATATAACGAAGCGGCCGTCCAA
AACCTGCTGGACGCTCTTTTGGACCTTCGGTCATCCAATAAGGACGTATTCATAGAGAAAATGCATGAGGGTGCTGCCTG
GTACCCGAAAAAATAG

Upstream 100 bases:

>100_bases
AAAGGACGCCACGATCCGTGCATTGCGAATCGGGGAGCGATCGTAGTCGAAGCGATGACCGTGTTCACGCTTGCGGATCT
CGCACTCAGAGGGGGATTTC

Downstream 100 bases:

>100_bases
AAATATTTTTTTACACTTTTATTACCCTGTCAAAAACACCGCGAGGAGCGGTAGCGTCACGAGACAAAGCAGTGTTGAGA
TACAGATGCCCTGGGCCGCA

Product: hypothetical protein

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSDINGFRDELASIDREIMELVGRRNKIALEIGEKKAAANKEIVVPSVETNVVQRYVDAGKVSGVSAETAARIARAVIDE
SVDVQGMIPRRSVPQKIFIIGGNGGMGRWLSEFFSSRGHIVTINDQKHNGAVYPVVDIFSGCRNADVIIVATPIKISAEI
LETVLSENKNALIFDLISVKTPVIPVLCKASALGAKVCSVHPMFGSSAPSIAGRNIIVCSCGNDEAADEAADLFSGGTIL
RLNIEDHDPITAYVLGLSHAVNLAFSEALVRSGFSSETLCAAASTTFQRQTAVSSDVSRENGELYYSIQKENPYNEAAVQ
NLLDALLDLRSSNKDVFIEKMHEGAAWYPKK

Sequences:

>Translated_351_residues
MSDINGFRDELASIDREIMELVGRRNKIALEIGEKKAAANKEIVVPSVETNVVQRYVDAGKVSGVSAETAARIARAVIDE
SVDVQGMIPRRSVPQKIFIIGGNGGMGRWLSEFFSSRGHIVTINDQKHNGAVYPVVDIFSGCRNADVIIVATPIKISAEI
LETVLSENKNALIFDLISVKTPVIPVLCKASALGAKVCSVHPMFGSSAPSIAGRNIIVCSCGNDEAADEAADLFSGGTIL
RLNIEDHDPITAYVLGLSHAVNLAFSEALVRSGFSSETLCAAASTTFQRQTAVSSDVSRENGELYYSIQKENPYNEAAVQ
NLLDALLDLRSSNKDVFIEKMHEGAAWYPKK
>Mature_350_residues
SDINGFRDELASIDREIMELVGRRNKIALEIGEKKAAANKEIVVPSVETNVVQRYVDAGKVSGVSAETAARIARAVIDES
VDVQGMIPRRSVPQKIFIIGGNGGMGRWLSEFFSSRGHIVTINDQKHNGAVYPVVDIFSGCRNADVIIVATPIKISAEIL
ETVLSENKNALIFDLISVKTPVIPVLCKASALGAKVCSVHPMFGSSAPSIAGRNIIVCSCGNDEAADEAADLFSGGTILR
LNIEDHDPITAYVLGLSHAVNLAFSEALVRSGFSSETLCAAASTTFQRQTAVSSDVSRENGELYYSIQKENPYNEAAVQN
LLDALLDLRSSNKDVFIEKMHEGAAWYPKK

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=357, Percent_Identity=22.6890756302521, Blast_Score=105, Evalue=4e-24,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 37814; Mature: 37683

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDINGFRDELASIDREIMELVGRRNKIALEIGEKKAAANKEIVVPSVETNVVQRYVDAG
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEECCHHHHHHHHHHHHC
KVSGVSAETAARIARAVIDESVDVQGMIPRRSVPQKIFIIGGNGGMGRWLSEFFSSRGHI
CCCCCCHHHHHHHHHHHHCCCCCCEECCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCE
VTINDQKHNGAVYPVVDIFSGCRNADVIIVATPIKISAEILETVLSENKNALIFDLISVK
EEEECCCCCCCEEHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEEEECCC
TPVIPVLCKASALGAKVCSVHPMFGSSAPSIAGRNIIVCSCGNDEAADEAADLFSGGTIL
CCCHHHHHCCHHHCCHHEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEE
RLNIEDHDPITAYVLGLSHAVNLAFSEALVRSGFSSETLCAAASTTFQRQTAVSSDVSRE
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
NGELYYSIQKENPYNEAAVQNLLDALLDLRSSNKDVFIEKMHEGAAWYPKK
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHCCCCCCCCC
>Mature Secondary Structure 
SDINGFRDELASIDREIMELVGRRNKIALEIGEKKAAANKEIVVPSVETNVVQRYVDAG
CCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEECCHHHHHHHHHHHHC
KVSGVSAETAARIARAVIDESVDVQGMIPRRSVPQKIFIIGGNGGMGRWLSEFFSSRGHI
CCCCCCHHHHHHHHHHHHCCCCCCEECCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCE
VTINDQKHNGAVYPVVDIFSGCRNADVIIVATPIKISAEILETVLSENKNALIFDLISVK
EEEECCCCCCCEEHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEEEECCC
TPVIPVLCKASALGAKVCSVHPMFGSSAPSIAGRNIIVCSCGNDEAADEAADLFSGGTIL
CCCHHHHHCCHHHCCHHEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEE
RLNIEDHDPITAYVLGLSHAVNLAFSEALVRSGFSSETLCAAASTTFQRQTAVSSDVSRE
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
NGELYYSIQKENPYNEAAVQNLLDALLDLRSSNKDVFIEKMHEGAAWYPKK
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]