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The map label for this gene is argS

Identifier: 124486323

GI number: 124486323

Start: 1541943

End: 1543619

Strand: Reverse

Name: argS

Synonym: Mlab_1508

Alternate gene names: 124486323

Gene position: 1543619-1541943 (Counterclockwise)

Preceding gene: 124486324

Following gene: 124486322

Centisome position: 85.52

GC content: 51.88

Gene sequence:

>1677_bases
ATGTATCGAGAATATATTCAGAAAACAATCGATCTGCTTCGCGAAGCAACAGGTCTTGAAGATGTCATGATCACCGACGG
AGGAGATCATGCGGATCTTGCCTCGACCGTTTCATTTGCGCTTGCAAAAACGCAGAGAAAGAATCCTGCCGTGATTGCCG
GAGAACTCGTTGCCGTGCTTTCGGCAAAACCCGAGGCAAAAGGTATCGAGATTTCTGCGAAAGGACCGTATATCAACTTC
ATCTTCGGCGGAGACTACGTCGCCGAATCCGTTCATGCGGCACGTAGAGAAGACTACGGAACTCTTCCAGCGAGAACCGA
CAAAGTCATCATCGAACACACCAGTGCAAATCCGAACGGACCCCTGCATGTTGGCCACATCAGAAATACCGTTATCGGCG
ATACACTCGTTCGTGCATTCCGGAAAGCAGGCTACCCGGTCGAAGCACAATATTATTTGAACGACATGGGTCGTCAGATC
GCGATCGTTGCATGGGGTGTCCAAAATCTCCATTACGACCGGATCCCCGGAGAAAAAGGCGATGAATATATTGTTCGCCA
TTATGTCGAGGCAAACAAAATCGCCAAGGCAAAGCCCGAGATCGAACCCGAGTTCGATCTGCTGATGGAAAAAATCGAAG
CCGGCGACCCCGAGACCGTGAAACTTTTCCACGACTCGGTCGACATCTGCGCTGACGGGATCAAGGAGACCTTGTCTTCG
ATGAACGTCGTCCATGATAAATTCGTGCGTGAGACAACATTCCTTTGGAACGGCTCGATGCAGGATGTCCTCAACAGAAT
TGAAAAACTGCCGATCGTACATCACGAAGGACAGATGATGTATCTCGATCTTTCCGACGAAGGATTTGGAAACAGATACG
TTCTTCGGCGAAGCAACGGGACCTCGGTGTATGCAGCGCGTGATCTTGCATTCCATCTCTGGAAAAATGCTCAGTGCGAT
AGAAGCATCGACGTTCTCGGCGCCGACCACAAACTGATCGGGGCTCAGTTGCAGACAACGCTGAAACTTATCGGCGAGCG
TCCCCCGGAAATCGTTCACTTTGAGTTTGTCTCTCTTCCGGAAGGTTCCATGACGACCCGTGGTGGTGTTTTCATCACGG
CCGACGAGCTAATTGCTGAGACGAAGAAGCGTGCGATGGAGGAAGTCACCGTCCGCCGGCCGGAACTTGGCGAAGACGAG
CGTGAAAAAATCGCCAAAGCCGTCGCCGTTGGAGCGGTCCGCTACGATATCGTGAAGGTTTCTGCGGAAAAGTCGACCGT
CTTCGACTGGAAGGAAGCTCTCGATTTCGAACGTCAGAGTGCTCCGTATATCCAGTATGCCCATGCAAGGGCATGCTCGA
TCATGGAGAAAGCGAAGGCCGAAGGCGGGTTTGCCGAGTGTTATGAATATTCGGATCCCTATGAACTCGCTCTGGCAAAA
CACATCGCCCGGTTCCCGTATGTTCTCGAAAAAGTTGTATGCGAACTTCGCCCGCATCTTCTCGCAACCTACGTTCGCGA
TCTTGCGGATCTTTTCAACTCCTTCTACCGGTTTGCCCCGGTTCTCAAAGCGGAAGGAAACGTTCGGGATGCACGGCTCA
CCCTTGTCGATGCCTGCAGAAATACCCTTTATCAGGCCCTCGGCGTCCTCGGCATCGAGGCTCTGGAAAGTATGTAA

Upstream 100 bases:

>100_bases
AGAGTAGAGATCATTTCAGAAGATTTCGAGGAAGGAGCCATGCTTTACTCCGCATTCGGCGGGATTGCAGCCGTCCTTCG
ATATCCAACGGGGATGTAAC

Downstream 100 bases:

>100_bases
TATCAGGCATTAGGCCTGATTTCTTTCTTTTTTACCCCGATAGAATCTATTATCTCCTCATCCGTGTTAGTATCATTTAT
GTCAAAAACGAAAGCGGACG

Product: arginyl-tRNA synthetase

Products: NA

Alternate protein names: Arginine--tRNA ligase; ArgRS

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MYREYIQKTIDLLREATGLEDVMITDGGDHADLASTVSFALAKTQRKNPAVIAGELVAVLSAKPEAKGIEISAKGPYINF
IFGGDYVAESVHAARREDYGTLPARTDKVIIEHTSANPNGPLHVGHIRNTVIGDTLVRAFRKAGYPVEAQYYLNDMGRQI
AIVAWGVQNLHYDRIPGEKGDEYIVRHYVEANKIAKAKPEIEPEFDLLMEKIEAGDPETVKLFHDSVDICADGIKETLSS
MNVVHDKFVRETTFLWNGSMQDVLNRIEKLPIVHHEGQMMYLDLSDEGFGNRYVLRRSNGTSVYAARDLAFHLWKNAQCD
RSIDVLGADHKLIGAQLQTTLKLIGERPPEIVHFEFVSLPEGSMTTRGGVFITADELIAETKKRAMEEVTVRRPELGEDE
REKIAKAVAVGAVRYDIVKVSAEKSTVFDWKEALDFERQSAPYIQYAHARACSIMEKAKAEGGFAECYEYSDPYELALAK
HIARFPYVLEKVVCELRPHLLATYVRDLADLFNSFYRFAPVLKAEGNVRDARLTLVDACRNTLYQALGVLGIEALESM

Sequences:

>Translated_558_residues
MYREYIQKTIDLLREATGLEDVMITDGGDHADLASTVSFALAKTQRKNPAVIAGELVAVLSAKPEAKGIEISAKGPYINF
IFGGDYVAESVHAARREDYGTLPARTDKVIIEHTSANPNGPLHVGHIRNTVIGDTLVRAFRKAGYPVEAQYYLNDMGRQI
AIVAWGVQNLHYDRIPGEKGDEYIVRHYVEANKIAKAKPEIEPEFDLLMEKIEAGDPETVKLFHDSVDICADGIKETLSS
MNVVHDKFVRETTFLWNGSMQDVLNRIEKLPIVHHEGQMMYLDLSDEGFGNRYVLRRSNGTSVYAARDLAFHLWKNAQCD
RSIDVLGADHKLIGAQLQTTLKLIGERPPEIVHFEFVSLPEGSMTTRGGVFITADELIAETKKRAMEEVTVRRPELGEDE
REKIAKAVAVGAVRYDIVKVSAEKSTVFDWKEALDFERQSAPYIQYAHARACSIMEKAKAEGGFAECYEYSDPYELALAK
HIARFPYVLEKVVCELRPHLLATYVRDLADLFNSFYRFAPVLKAEGNVRDARLTLVDACRNTLYQALGVLGIEALESM
>Mature_558_residues
MYREYIQKTIDLLREATGLEDVMITDGGDHADLASTVSFALAKTQRKNPAVIAGELVAVLSAKPEAKGIEISAKGPYINF
IFGGDYVAESVHAARREDYGTLPARTDKVIIEHTSANPNGPLHVGHIRNTVIGDTLVRAFRKAGYPVEAQYYLNDMGRQI
AIVAWGVQNLHYDRIPGEKGDEYIVRHYVEANKIAKAKPEIEPEFDLLMEKIEAGDPETVKLFHDSVDICADGIKETLSS
MNVVHDKFVRETTFLWNGSMQDVLNRIEKLPIVHHEGQMMYLDLSDEGFGNRYVLRRSNGTSVYAARDLAFHLWKNAQCD
RSIDVLGADHKLIGAQLQTTLKLIGERPPEIVHFEFVSLPEGSMTTRGGVFITADELIAETKKRAMEEVTVRRPELGEDE
REKIAKAVAVGAVRYDIVKVSAEKSTVFDWKEALDFERQSAPYIQYAHARACSIMEKAKAEGGFAECYEYSDPYELALAK
HIARFPYVLEKVVCELRPHLLATYVRDLADLFNSFYRFAPVLKAEGNVRDARLTLVDACRNTLYQALGVLGIEALESM

Specific function: Unknown

COG id: COG0018

COG function: function code J; Arginyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI197100773, Length=507, Percent_Identity=23.4714003944773, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI15149476, Length=553, Percent_Identity=23.5081374321881, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI1788184, Length=546, Percent_Identity=27.2893772893773, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71985061, Length=545, Percent_Identity=24.7706422018349, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71985068, Length=513, Percent_Identity=24.7563352826511, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17532153, Length=525, Percent_Identity=23.8095238095238, Blast_Score=85, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320548, Length=518, Percent_Identity=26.6409266409266, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6321883, Length=574, Percent_Identity=24.5644599303136, Blast_Score=164, Evalue=4e-41,
Organism=Drosophila melanogaster, GI28571570, Length=479, Percent_Identity=25.678496868476, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI18859963, Length=542, Percent_Identity=21.4022140221402, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: 789 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYR_METLZ (A2STL6)

Other databases:

- EMBL:   CP000559
- RefSeq:   YP_001030939.1
- ProteinModelPortal:   A2STL6
- SMR:   A2STL6
- STRING:   A2STL6
- GeneID:   4795221
- GenomeReviews:   CP000559_GR
- KEGG:   mla:Mlab_1508
- eggNOG:   arNOG04487
- HOGENOM:   HBG695395
- OMA:   NDMGRQI
- PhylomeDB:   A2STL6
- ProtClustDB:   PRK01611
- BioCyc:   MLAB410358:MLAB_1508-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00123
- InterPro:   IPR001412
- InterPro:   IPR001278
- InterPro:   IPR015945
- InterPro:   IPR005148
- InterPro:   IPR008909
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.30.1360.70
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11956
- PRINTS:   PR01038
- SMART:   SM00836
- TIGRFAMs:   TIGR00456

Pfam domain/function: PF03485 Arg_tRNA_synt_N; PF05746 DALR_1; PF00750 tRNA-synt_1d; SSF55190 Arg-tRNA-synth_Ic_N; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.19

Molecular weight: Translated: 62505; Mature: 62505

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYREYIQKTIDLLREATGLEDVMITDGGDHADLASTVSFALAKTQRKNPAVIAGELVAVL
CCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
SAKPEAKGIEISAKGPYINFIFGGDYVAESVHAARREDYGTLPARTDKVIIEHTSANPNG
CCCCCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCC
PLHVGHIRNTVIGDTLVRAFRKAGYPVEAQYYLNDMGRQIAIVAWGVQNLHYDRIPGEKG
CEEECHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHCCCEEEEEEECCCCCEECCCCCCCC
DEYIVRHYVEANKIAKAKPEIEPEFDLLMEKIEAGDPETVKLFHDSVDICADGIKETLSS
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHH
MNVVHDKFVRETTFLWNGSMQDVLNRIEKLPIVHHEGQMMYLDLSDEGFGNRYVLRRSNG
HHHHHHHHHHHHHEEECCCHHHHHHHHHHCCEEEECCCEEEEEECCCCCCCEEEEEECCC
TSVYAARDLAFHLWKNAQCDRSIDVLGADHKLIGAQLQTTLKLIGERPPEIVHFEFVSLP
CEEEEHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEECC
EGSMTTRGGVFITADELIAETKKRAMEEVTVRRPELGEDEREKIAKAVAVGAVRYDIVKV
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEEEEEEE
SAEKSTVFDWKEALDFERQSAPYIQYAHARACSIMEKAKAEGGFAECYEYSDPYELALAK
ECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHH
HIARFPYVLEKVVCELRPHLLATYVRDLADLFNSFYRFAPVLKAEGNVRDARLTLVDACR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHH
NTLYQALGVLGIEALESM
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYREYIQKTIDLLREATGLEDVMITDGGDHADLASTVSFALAKTQRKNPAVIAGELVAVL
CCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
SAKPEAKGIEISAKGPYINFIFGGDYVAESVHAARREDYGTLPARTDKVIIEHTSANPNG
CCCCCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCC
PLHVGHIRNTVIGDTLVRAFRKAGYPVEAQYYLNDMGRQIAIVAWGVQNLHYDRIPGEKG
CEEECHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHCCCEEEEEEECCCCCEECCCCCCCC
DEYIVRHYVEANKIAKAKPEIEPEFDLLMEKIEAGDPETVKLFHDSVDICADGIKETLSS
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHH
MNVVHDKFVRETTFLWNGSMQDVLNRIEKLPIVHHEGQMMYLDLSDEGFGNRYVLRRSNG
HHHHHHHHHHHHHEEECCCHHHHHHHHHHCCEEEECCCEEEEEECCCCCCCEEEEEECCC
TSVYAARDLAFHLWKNAQCDRSIDVLGADHKLIGAQLQTTLKLIGERPPEIVHFEFVSLP
CEEEEHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEECC
EGSMTTRGGVFITADELIAETKKRAMEEVTVRRPELGEDEREKIAKAVAVGAVRYDIVKV
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEEEEEEE
SAEKSTVFDWKEALDFERQSAPYIQYAHARACSIMEKAKAEGGFAECYEYSDPYELALAK
ECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHH
HIARFPYVLEKVVCELRPHLLATYVRDLADLFNSFYRFAPVLKAEGNVRDARLTLVDACR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHH
NTLYQALGVLGIEALESM
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA