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The map label for this gene is hisI

Identifier: 124486223

GI number: 124486223

Start: 1438490

End: 1438861

Strand: Reverse

Name: hisI

Synonym: Mlab_1406

Alternate gene names: 124486223

Gene position: 1438861-1438490 (Counterclockwise)

Preceding gene: 124486224

Following gene: 124486222

Centisome position: 79.72

GC content: 50.54

Gene sequence:

>372_bases
ATGCCTGACCTTTTCCCTTCACTCAAATACCATGACGGACTCATCCCGGTGATCGTCCAGGATGCAAAGACCCTCCAGGT
CCTCATGTTTGCTTTTGCGAATGAAGAGGCCGTTTCTCTGACCCGCTCAACCGGCTATGCCCACTACTTCAGCCGTTCGA
GAAACAAACTCTGGAAAAAAGGCGAGGAGTCGGGCCACCTGCAAAAGATCGTCCGTATCTGTGTCGACTGCGATGAGGAT
TGTCTGTTGTATCTGGTTGAACAGACCGGGTGTGCCTGCCATGAAGGATACGCCAGTTGTTTTTTTAGAACGATGGAAGG
CGAGGTGATTCTTCCAAGATTGAAGGATCCGGCAGATATCTACTCAAGGTGA

Upstream 100 bases:

>100_bases
CCGATCTCTCCACAGTCTCATGGAATCTTCGGATAAAAGGCGTGAACAACCGCCGGGAAGAGATTCTCTTATCTCATAAA
AAAACCAACAGTGAATAATT

Downstream 100 bases:

>100_bases
ATCATTTACTGCACCTTTTGGAACACTATACTAATATCCTATTGAAACCCCATAAATATTGGTTGAATATTTTATGATAC
TCGTACCTGATACCAGCGTC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 123; Mature: 122

Protein sequence:

>123_residues
MPDLFPSLKYHDGLIPVIVQDAKTLQVLMFAFANEEAVSLTRSTGYAHYFSRSRNKLWKKGEESGHLQKIVRICVDCDED
CLLYLVEQTGCACHEGYASCFFRTMEGEVILPRLKDPADIYSR

Sequences:

>Translated_123_residues
MPDLFPSLKYHDGLIPVIVQDAKTLQVLMFAFANEEAVSLTRSTGYAHYFSRSRNKLWKKGEESGHLQKIVRICVDCDED
CLLYLVEQTGCACHEGYASCFFRTMEGEVILPRLKDPADIYSR
>Mature_122_residues
PDLFPSLKYHDGLIPVIVQDAKTLQVLMFAFANEEAVSLTRSTGYAHYFSRSRNKLWKKGEESGHLQKIVRICVDCDEDC
LLYLVEQTGCACHEGYASCFFRTMEGEVILPRLKDPADIYSR

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=104, Percent_Identity=44.2307692307692, Blast_Score=96, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6319819, Length=119, Percent_Identity=36.9747899159664, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_METLZ (A2STB6)

Other databases:

- EMBL:   CP000559
- RefSeq:   YP_001030839.1
- ProteinModelPortal:   A2STB6
- SMR:   A2STB6
- STRING:   A2STB6
- GeneID:   4794816
- GenomeReviews:   CP000559_GR
- KEGG:   mla:Mlab_1406
- eggNOG:   arNOG12274
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- PhylomeDB:   A2STB6
- BioCyc:   MLAB410358:MLAB_1406-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 14040; Mature: 13909

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDLFPSLKYHDGLIPVIVQDAKTLQVLMFAFANEEAVSLTRSTGYAHYFSRSRNKLWKK
CCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHC
GEESGHLQKIVRICVDCDEDCLLYLVEQTGCACHEGYASCFFRTMEGEVILPRLKDPADI
CCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHH
YSR
HCC
>Mature Secondary Structure 
PDLFPSLKYHDGLIPVIVQDAKTLQVLMFAFANEEAVSLTRSTGYAHYFSRSRNKLWKK
CCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHC
GEESGHLQKIVRICVDCDEDCLLYLVEQTGCACHEGYASCFFRTMEGEVILPRLKDPADI
CCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHH
YSR
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA