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The map label for this gene is hisE

Identifier: 124486201

GI number: 124486201

Start: 1410788

End: 1411102

Strand: Reverse

Name: hisE

Synonym: Mlab_1384

Alternate gene names: 124486201

Gene position: 1411102-1410788 (Counterclockwise)

Preceding gene: 124486202

Following gene: 124486200

Centisome position: 78.18

GC content: 47.94

Gene sequence:

>315_bases
ATGACGGATGCAAAAGTATTCGATGAGTTATGGCAGGTCATCTGCGAAAGGGCGGCGTCTGAAAGTTTAGAGAAGTCATA
TGTGCGGCATCTCCTGTTTCATGAAAAGGGCATCGACAAATCCCTTGAAAAGGTAGGAGAAGAGGCCGTTGAATTCATTC
TCGCCGCAAAGAACGGCGTTTCTGAAAAAACGGTGGGAGAAGCAGCGGATCTCATTTTCCATATGATGGTTGCTTTAAAA
GCGGCTGATGTGGACTTTGATCTCGTGGAAGAAGAGCTCGCCGTTCGTCGCGCCGGGATGCATCTTCACGATTAA

Upstream 100 bases:

>100_bases
TCGGAAAAGGCGGGTCGACGATCGAAAAAGCCAGAATTCTGGTCCGAAGGTTTTATGGTAAAGAGGTTGGAGATATCCTC
ATACCGAACAGAGGAAGCGT

Downstream 100 bases:

>100_bases
TCCGGCGAATCTGTGGTTTCTTATCTCATTCAGACGTAACCCCTATTAACCCGAACCGCCACATAATATACATGAAACTC
TTAGTCAGCCCAAGTTCAAT

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 104; Mature: 103

Protein sequence:

>104_residues
MTDAKVFDELWQVICERAASESLEKSYVRHLLFHEKGIDKSLEKVGEEAVEFILAAKNGVSEKTVGEAADLIFHMMVALK
AADVDFDLVEEELAVRRAGMHLHD

Sequences:

>Translated_104_residues
MTDAKVFDELWQVICERAASESLEKSYVRHLLFHEKGIDKSLEKVGEEAVEFILAAKNGVSEKTVGEAADLIFHMMVALK
AADVDFDLVEEELAVRRAGMHLHD
>Mature_103_residues
TDAKVFDELWQVICERAASESLEKSYVRHLLFHEKGIDKSLEKVGEEAVEFILAAKNGVSEKTVGEAADLIFHMMVALKA
ADVDFDLVEEELAVRRAGMHLHD

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_METLZ (A2ST94)

Other databases:

- EMBL:   CP000559
- RefSeq:   YP_001030817.1
- ProteinModelPortal:   A2ST94
- SMR:   A2ST94
- STRING:   A2ST94
- GeneID:   4794616
- GenomeReviews:   CP000559_GR
- KEGG:   mla:Mlab_1384
- eggNOG:   arNOG13425
- HOGENOM:   HBG646527
- OMA:   TIDERAN
- ProtClustDB:   CLSK852329
- BioCyc:   MLAB410358:MLAB_1384-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 11672; Mature: 11541

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAKVFDELWQVICERAASESLEKSYVRHLLFHEKGIDKSLEKVGEEAVEFILAAKNGV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCC
SEKTVGEAADLIFHMMVALKAADVDFDLVEEELAVRRAGMHLHD
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TDAKVFDELWQVICERAASESLEKSYVRHLLFHEKGIDKSLEKVGEEAVEFILAAKNGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCC
SEKTVGEAADLIFHMMVALKAADVDFDLVEEELAVRRAGMHLHD
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA