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The map label for this gene is panF [H]

Identifier: 124485883

GI number: 124485883

Start: 1075678

End: 1077258

Strand: Reverse

Name: panF [H]

Synonym: Mlab_1063

Alternate gene names: 124485883

Gene position: 1077258-1075678 (Counterclockwise)

Preceding gene: 124485889

Following gene: 124485868

Centisome position: 59.68

GC content: 50.6

Gene sequence:

>1581_bases
ATGATGATGACGGTAAGCACTGAGCTGACAATCGGCATCGTCGCATTCTACCTTGTGATGATCATAGGTATCGGATATTA
CGGATATAGGCGAACAAAAAAGGTAGAAGACTATATGGTTGCCGGACGAAATACGCATCCGGCTATAATTGCCCTATCCT
ATGGAGCCACGTTCATCAGTACATCCGCCATCATCGGGTTCGGCGGGACGTCGGCGCAATACGGTATGAGCCTGATGTGG
CTGACCGTATTGTGTATCGTCGTTGGGGTGATCATCGCGTTCATCTGTATGGGAAAACGGATCAGACGGATCGGGAAAGA
TCTTGGGGCCCTGACATATCCCGAACTCCTCGGCAAGATGTACGGATCGAAGAAGATCATCTATGCAACCGGCGCGATTT
TCGTTGCAGCAATGCCCCTTTATACTGCGGCCGTTCTGATAGGCGGGGCACGATTCATTGAAACTACACTCGGCATCCCG
TACCTCACAGCCCTGCTTGGATTTGCCGGTGTTGTCGCGCTCTATGTCGTCATTGGCGGTTTGATGGCCGTCATGTACAC
AGATGCGGTACAGGGAGCTATTATGCTGGTTGGGATGGGAGTCCTGCTGGTTCTGACCTATGTATATCTTGGAGGTATAG
TGGCAGCGAACAATGCGCTTGAGTCGATGAGCGGTCTTGTTCCAAGTACACTCTCATCTATGGGAATGACCGGTTGGACT
TCGATGCCGGAGTTCGGCTCTCCCATTTGGATGACGGTCATTACGACACTCGTTCTCGGGGTTGGCGTGGGTGTTCTTGC
CCAACCGCAGCTTGCGGTCAGGTTCATGACGGCAAAAGACGGAAAATCACTGAATCGGGCAATTCCAATCGGCGCTCTCT
TCATCGTGATGATGACTGGAGTAGCCTTCACGGTCGGACCGCTGACGAATGTATATTTCATGGATAAACTTGGAATGCTG
GCAATCGATGCTGCCGGGGGAAATGCAGATCTGATCATTCCGCTCTACATCAACTCGGCAATGCCCGAACTGTTCGTCAT
TATCTTTATGCTGACGCTGCTTTCGGCGGCCATGTCGACACTTTCATCTCTTCTGCATACTATGGGAACAACACTCGGCG
GGGATATCTTTGCCAGAATGAGAGGTGTTCGTTACTCCATCAGAGCGAATCAGATCGGCATCATGATCATGATGATCGTC
AGTATCATCCTCGCAGTAATGATGCCGGGAAGTATTATTGCACGTGCTACTGCCATGTTCATGGGGTTATGTACTGCTGC
TCTTCTTCCGGCGTTTGTTCATGGAATCACCTCAAAGAATCCATCCTATCTCGCTGCGAAATGGAGTATGGCAGTTGGTG
CCGGCGGCTGGCTTATTTGGGCGGTTTTCTGCCACACAGCGGAGTCGAAGATGCTTGGAATTTGCAATGCACTGTTTGGC
GTCAACTCTCTGGTAGGATCGCCCTGGTGCTATCTCGATCCGCTGGTCGTCGGAGTCGTGCTTTCAGTTACTGTGCTTCT
TGTCCTGATACCCTTGGACAAAAAGAGAATAACACATGAAGATCAGATGAAACTGATCTGA

Upstream 100 bases:

>100_bases
GGCATCAGTGACCCGTGGGTATGGATGACATACCTCATCTGCTTGATAGCACTGCTATTCTGCGGAATTTACGGATATAT
GAATTGGAACAAGGACAGTG

Downstream 100 bases:

>100_bases
AACATCCTTTTTTTAATGAGTATTATTATCTGTTGAATACGGAAATCTTCCTGCGAGAATTTTGCGTCAGAAAAAAAGAG
AGATTTAGGTGGTTGTACCG

Product: hypothetical protein

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MMMTVSTELTIGIVAFYLVMIIGIGYYGYRRTKKVEDYMVAGRNTHPAIIALSYGATFISTSAIIGFGGTSAQYGMSLMW
LTVLCIVVGVIIAFICMGKRIRRIGKDLGALTYPELLGKMYGSKKIIYATGAIFVAAMPLYTAAVLIGGARFIETTLGIP
YLTALLGFAGVVALYVVIGGLMAVMYTDAVQGAIMLVGMGVLLVLTYVYLGGIVAANNALESMSGLVPSTLSSMGMTGWT
SMPEFGSPIWMTVITTLVLGVGVGVLAQPQLAVRFMTAKDGKSLNRAIPIGALFIVMMTGVAFTVGPLTNVYFMDKLGML
AIDAAGGNADLIIPLYINSAMPELFVIIFMLTLLSAAMSTLSSLLHTMGTTLGGDIFARMRGVRYSIRANQIGIMIMMIV
SIILAVMMPGSIIARATAMFMGLCTAALLPAFVHGITSKNPSYLAAKWSMAVGAGGWLIWAVFCHTAESKMLGICNALFG
VNSLVGSPWCYLDPLVVGVVLSVTVLLVLIPLDKKRITHEDQMKLI

Sequences:

>Translated_526_residues
MMMTVSTELTIGIVAFYLVMIIGIGYYGYRRTKKVEDYMVAGRNTHPAIIALSYGATFISTSAIIGFGGTSAQYGMSLMW
LTVLCIVVGVIIAFICMGKRIRRIGKDLGALTYPELLGKMYGSKKIIYATGAIFVAAMPLYTAAVLIGGARFIETTLGIP
YLTALLGFAGVVALYVVIGGLMAVMYTDAVQGAIMLVGMGVLLVLTYVYLGGIVAANNALESMSGLVPSTLSSMGMTGWT
SMPEFGSPIWMTVITTLVLGVGVGVLAQPQLAVRFMTAKDGKSLNRAIPIGALFIVMMTGVAFTVGPLTNVYFMDKLGML
AIDAAGGNADLIIPLYINSAMPELFVIIFMLTLLSAAMSTLSSLLHTMGTTLGGDIFARMRGVRYSIRANQIGIMIMMIV
SIILAVMMPGSIIARATAMFMGLCTAALLPAFVHGITSKNPSYLAAKWSMAVGAGGWLIWAVFCHTAESKMLGICNALFG
VNSLVGSPWCYLDPLVVGVVLSVTVLLVLIPLDKKRITHEDQMKLI
>Mature_526_residues
MMMTVSTELTIGIVAFYLVMIIGIGYYGYRRTKKVEDYMVAGRNTHPAIIALSYGATFISTSAIIGFGGTSAQYGMSLMW
LTVLCIVVGVIIAFICMGKRIRRIGKDLGALTYPELLGKMYGSKKIIYATGAIFVAAMPLYTAAVLIGGARFIETTLGIP
YLTALLGFAGVVALYVVIGGLMAVMYTDAVQGAIMLVGMGVLLVLTYVYLGGIVAANNALESMSGLVPSTLSSMGMTGWT
SMPEFGSPIWMTVITTLVLGVGVGVLAQPQLAVRFMTAKDGKSLNRAIPIGALFIVMMTGVAFTVGPLTNVYFMDKLGML
AIDAAGGNADLIIPLYINSAMPELFVIIFMLTLLSAAMSTLSSLLHTMGTTLGGDIFARMRGVRYSIRANQIGIMIMMIV
SIILAVMMPGSIIARATAMFMGLCTAALLPAFVHGITSKNPSYLAAKWSMAVGAGGWLIWAVFCHTAESKMLGICNALFG
VNSLVGSPWCYLDPLVVGVVLSVTVLLVLIPLDKKRITHEDQMKLI

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=515, Percent_Identity=26.2135922330097, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI14140236, Length=487, Percent_Identity=22.5872689938398, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI17941285, Length=411, Percent_Identity=23.8442822384428, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4507031, Length=415, Percent_Identity=24.578313253012, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI110835708, Length=439, Percent_Identity=22.5512528473804, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4507033, Length=411, Percent_Identity=22.6277372262774, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI109659836, Length=370, Percent_Identity=24.8648648648649, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI4507035, Length=383, Percent_Identity=24.5430809399478, Blast_Score=66, Evalue=1e-10,
Organism=Escherichia coli, GI87082237, Length=378, Percent_Identity=28.8359788359788, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1787251, Length=378, Percent_Identity=26.1904761904762, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1790503, Length=419, Percent_Identity=22.9116945107399, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790113, Length=373, Percent_Identity=25.7372654155496, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 55920; Mature: 55920

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
7.4 %Met     (Translated Protein)
8.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
7.4 %Met     (Mature Protein)
8.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMMTVSTELTIGIVAFYLVMIIGIGYYGYRRTKKVEDYMVAGRNTHPAIIALSYGATFIS
CEEEEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHH
TSAIIGFGGTSAQYGMSLMWLTVLCIVVGVIIAFICMGKRIRRIGKDLGALTYPELLGKM
HHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
YGSKKIIYATGAIFVAAMPLYTAAVLIGGARFIETTLGIPYLTALLGFAGVVALYVVIGG
HCCCEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LMAVMYTDAVQGAIMLVGMGVLLVLTYVYLGGIVAANNALESMSGLVPSTLSSMGMTGWT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHCCCCCCC
SMPEFGSPIWMTVITTLVLGVGVGVLAQPQLAVRFMTAKDGKSLNRAIPIGALFIVMMTG
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHEEEEECCCCCCHHHHCHHHHHHHHHHHH
VAFTVGPLTNVYFMDKLGMLAIDAAGGNADLIIPLYINSAMPELFVIIFMLTLLSAAMST
HHHHHCCHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
LSSLLHTMGTTLGGDIFARMRGVRYSIRANQIGIMIMMIVSIILAVMMPGSIIARATAMF
HHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
MGLCTAALLPAFVHGITSKNPSYLAAKWSMAVGAGGWLIWAVFCHTAESKMLGICNALFG
HHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VNSLVGSPWCYLDPLVVGVVLSVTVLLVLIPLDKKRITHEDQMKLI
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHCCCC
>Mature Secondary Structure
MMMTVSTELTIGIVAFYLVMIIGIGYYGYRRTKKVEDYMVAGRNTHPAIIALSYGATFIS
CEEEEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHH
TSAIIGFGGTSAQYGMSLMWLTVLCIVVGVIIAFICMGKRIRRIGKDLGALTYPELLGKM
HHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
YGSKKIIYATGAIFVAAMPLYTAAVLIGGARFIETTLGIPYLTALLGFAGVVALYVVIGG
HCCCEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LMAVMYTDAVQGAIMLVGMGVLLVLTYVYLGGIVAANNALESMSGLVPSTLSSMGMTGWT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHCCCCCCC
SMPEFGSPIWMTVITTLVLGVGVGVLAQPQLAVRFMTAKDGKSLNRAIPIGALFIVMMTG
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHEEEEECCCCCCHHHHCHHHHHHHHHHHH
VAFTVGPLTNVYFMDKLGMLAIDAAGGNADLIIPLYINSAMPELFVIIFMLTLLSAAMST
HHHHHCCHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
LSSLLHTMGTTLGGDIFARMRGVRYSIRANQIGIMIMMIVSIILAVMMPGSIIARATAMF
HHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
MGLCTAALLPAFVHGITSKNPSYLAAKWSMAVGAGGWLIWAVFCHTAESKMLGICNALFG
HHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VNSLVGSPWCYLDPLVVGVVLSVTVLLVLIPLDKKRITHEDQMKLI
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]