Click here to switch to the map view.

The map label for this gene is comEC [H]

Identifier: 124485216

GI number: 124485216

Start: 366137

End: 367147

Strand: Reverse

Name: comEC [H]

Synonym: Mlab_0389

Alternate gene names: 124485216

Gene position: 367147-366137 (Counterclockwise)

Preceding gene: 124485217

Following gene: 124485215

Centisome position: 20.34

GC content: 50.35

Gene sequence:

>1011_bases
ATGGCAAAGAGATCCGGCAAAAGAAAACGTTCGTCCAAAACGGCACAAACGAAGATCATCAGTCTCGTCTGCGGTCTGCT
CGTCATCGCCGCGATAGTGATCTTCGGCGGAGCGGAACTTGAAGGGACCGGCAGTTCGAATCCCTTAGCTTCGCAGATAA
CGGATGAACACGCCTTTTCCGTGCATGTCATCGATATCGGACAAGGGGACGCGATCCTTCTCTCTAAAGACGATACATAC
GCGCTTATCGACGCAGGGGAGACGATGTCCCCGTCGGACCGCGAATCACGTACGGCGATATTCGCATACCTTGATTCGCT
CGACATTGACAGGCTGGAGTTCCTGCTCATAACCCATCAGGATTACGATCATATCGGTTCAGCAAAGGATGTCCTCTCCA
CCTACGATGTTGGAACCTTCTACGATAACGGTGTCGAACATACATCCGCGACGTATGAAAAGCTCATGACATACATCTCT
GAAGAAAACGTCACCTACTCGATCGTTAGAGAAGGAGATCAAATCGAAAGCCCCTGGACAGATGTGACGATCGAGATCAT
CTCCCCGCCGCAGGATCTTATCATGACCGGATCATCGCCCGACATCAATGAAAACTCCATCGTTTTGAATATAACATACG
GTGAGGTTTCGTTTATTCTCGCAGGAGATGCCGGCGAAAAGGCGGAAGAATACATCATCTCGACCGGAACATCGATCGAC
GCGGAGATCCTGAAAGCCGGCCATCACGGAAGTTCCGGCTCATCCACGGACGCCTTCCTTGAAGCAGTCAGTCCAAACGT
TATCGTCATGAGCGTTGGTGCAGACAACGATTATGGCCACCCCCACCTCGAAACCCTAACGCGTTTCGCACAATACACTG
AAAACATATACCGGACAGATCTTGACGGGGACGTCATCATAACGACCGACGGATCGGAATACTCGGTCATTACCGAAAAT
GAGCATATAGCAGAAAATATTCTCGTCTCAGGAAACGGGGTTAGTGTATGA

Upstream 100 bases:

>100_bases
GATGATCTTTTCCTGGACCGCAGGGTCGAGAAGGAGAATATAATCCAAAATCCAACAACCACTCACTTTTTTTCCTGCCG
CCTTCATAGTATTACCTCAT

Downstream 100 bases:

>100_bases
AAATGCTCGTGACCGTGGATGAGATAGAAAACGGCAAAGCCGCTCTCCTGCTTCGCGGTCCAAACGGCGAAAAACCACTT
GGAACATTTCCTTTGGAAAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAKRSGKRKRSSKTAQTKIISLVCGLLVIAAIVIFGGAELEGTGSSNPLASQITDEHAFSVHVIDIGQGDAILLSKDDTY
ALIDAGETMSPSDRESRTAIFAYLDSLDIDRLEFLLITHQDYDHIGSAKDVLSTYDVGTFYDNGVEHTSATYEKLMTYIS
EENVTYSIVREGDQIESPWTDVTIEIISPPQDLIMTGSSPDINENSIVLNITYGEVSFILAGDAGEKAEEYIISTGTSID
AEILKAGHHGSSGSSTDAFLEAVSPNVIVMSVGADNDYGHPHLETLTRFAQYTENIYRTDLDGDVIITTDGSEYSVITEN
EHIAENILVSGNGVSV

Sequences:

>Translated_336_residues
MAKRSGKRKRSSKTAQTKIISLVCGLLVIAAIVIFGGAELEGTGSSNPLASQITDEHAFSVHVIDIGQGDAILLSKDDTY
ALIDAGETMSPSDRESRTAIFAYLDSLDIDRLEFLLITHQDYDHIGSAKDVLSTYDVGTFYDNGVEHTSATYEKLMTYIS
EENVTYSIVREGDQIESPWTDVTIEIISPPQDLIMTGSSPDINENSIVLNITYGEVSFILAGDAGEKAEEYIISTGTSID
AEILKAGHHGSSGSSTDAFLEAVSPNVIVMSVGADNDYGHPHLETLTRFAQYTENIYRTDLDGDVIITTDGSEYSVITEN
EHIAENILVSGNGVSV
>Mature_335_residues
AKRSGKRKRSSKTAQTKIISLVCGLLVIAAIVIFGGAELEGTGSSNPLASQITDEHAFSVHVIDIGQGDAILLSKDDTYA
LIDAGETMSPSDRESRTAIFAYLDSLDIDRLEFLLITHQDYDHIGSAKDVLSTYDVGTFYDNGVEHTSATYEKLMTYISE
ENVTYSIVREGDQIESPWTDVTIEIISPPQDLIMTGSSPDINENSIVLNITYGEVSFILAGDAGEKAEEYIISTGTSIDA
EILKAGHHGSSGSSTDAFLEAVSPNVIVMSVGADNDYGHPHLETLTRFAQYTENIYRTDLDGDVIITTDGSEYSVITENE
HIAENILVSGNGVSV

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 36289; Mature: 36158

Theoretical pI: Translated: 4.07; Mature: 4.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRSGKRKRSSKTAQTKIISLVCGLLVIAAIVIFGGAELEGTGSSNPLASQITDEHAFS
CCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHCCCCCEE
VHVIDIGQGDAILLSKDDTYALIDAGETMSPSDRESRTAIFAYLDSLDIDRLEFLLITHQ
EEEEEECCCCEEEEECCCCEEEEECCCCCCCCCCCHHEEEEEEECCCCCCCEEEEEEECC
DYDHIGSAKDVLSTYDVGTFYDNGVEHTSATYEKLMTYISEENVTYSIVREGDQIESPWT
CHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
DVTIEIISPPQDLIMTGSSPDINENSIVLNITYGEVSFILAGDAGEKAEEYIISTGTSID
EEEEEEECCCHHHEEECCCCCCCCCEEEEEEEECCEEEEEECCCCCCCHHEEEECCCCCC
AEILKAGHHGSSGSSTDAFLEAVSPNVIVMSVGADNDYGHPHLETLTRFAQYTENIYRTD
HHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHEEEC
LDGDVIITTDGSEYSVITENEHIAENILVSGNGVSV
CCCCEEEEECCCCEEEEECCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
AKRSGKRKRSSKTAQTKIISLVCGLLVIAAIVIFGGAELEGTGSSNPLASQITDEHAFS
CCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHCCCCCEE
VHVIDIGQGDAILLSKDDTYALIDAGETMSPSDRESRTAIFAYLDSLDIDRLEFLLITHQ
EEEEEECCCCEEEEECCCCEEEEECCCCCCCCCCCHHEEEEEEECCCCCCCEEEEEEECC
DYDHIGSAKDVLSTYDVGTFYDNGVEHTSATYEKLMTYISEENVTYSIVREGDQIESPWT
CHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
DVTIEIISPPQDLIMTGSSPDINENSIVLNITYGEVSFILAGDAGEKAEEYIISTGTSID
EEEEEEECCCHHHEEECCCCCCCCCEEEEEEEECCEEEEEECCCCCCCHHEEEECCCCCC
AEILKAGHHGSSGSSTDAFLEAVSPNVIVMSVGADNDYGHPHLETLTRFAQYTENIYRTD
HHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHEEEC
LDGDVIITTDGSEYSVITENEHIAENILVSGNGVSV
CCCCEEEEECCCCEEEEECCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]