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The map label for this gene is ubiE [H]

Identifier: 124484993

GI number: 124484993

Start: 151443

End: 152216

Strand: Reverse

Name: ubiE [H]

Synonym: Mlab_0166

Alternate gene names: 124484993

Gene position: 152216-151443 (Counterclockwise)

Preceding gene: 124484994

Following gene: 124484992

Centisome position: 8.43

GC content: 44.57

Gene sequence:

>774_bases
ATGAATGATGAAAAAATTAAACAGGAAATTGCAAATGCATGGAACCAGGAGTCAAATTTCTATGATTCCCATGTATCTCA
CGGAATGAAATCTGACGAAGAGAAAAAGTTGTGGATGGAAGCTTTTTCCACCAGAGTCAAAAACGATACGCAGCTTCAGG
TTCTTGACGTAGGATGCGGAACTGGAGCCATGGGCCTGATTTTTGCTGAGATGGGACATACAGTTGAAGGAATTGATTTA
TCGGAAGGAATGATGGATGTCGGCAGAAAAAAAGCGGCCGACATGCACCTTGCGATGAACTTTTCATCGGGTGATGCAGA
GCATCCTCCGTTCGATGACGGGAAATTCGACGTGGTTGTGAATCGTCATCTGCTCTGGACGCTGCCAAATCCCGACAAAG
CCATTTCAAGCTGGTTCCGCGTTCTCAAACCGAATGGAACTTTACTGGTGATCGACGGAGTCTGGGATGACGGTTCCAGA
CTGAATACCGTAAAAAAGAAGATATCCCACAAAATTGCATCTTTAGTCGAGGCACATCCGCATGGAGGAAAGAGCCGTTA
CAGTGAAGAGGTGTCGTCTTATCTCCCGAACAAAGGAGGAACTTCGGAAGAAAAGGCGAAAGAATACTTTGAAAATGCCG
GATTTACCAACATTACCGTCGTCAATTTGGATGCGATTACCGATGAACAGAGAAAATATTTCAGCTGGTATATGAAGATC
GCGCCAAAGAGTACATACTACCTGATCTCGGGAAAAAAACCTGAATCCACATGA

Upstream 100 bases:

>100_bases
CCATTATTGATTATGATACTTCACGGTTTGACGGCAGCGGCAGGATGACTGAAGTTTCAAAAAACCATTTCGTTCTTATC
TAATTATTACTGGTATTACT

Downstream 100 bases:

>100_bases
ACGTTATGATGATTTCAACATAACTCGCGATATCGCAATAGTTTACCTGTTCATACCGAAAATAAAACCTTTTTTGATTG
AGATAAATCTCAGTCAGTCT

Product: DNA topoisomerase VI subunit A-like protein

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MNDEKIKQEIANAWNQESNFYDSHVSHGMKSDEEKKLWMEAFSTRVKNDTQLQVLDVGCGTGAMGLIFAEMGHTVEGIDL
SEGMMDVGRKKAADMHLAMNFSSGDAEHPPFDDGKFDVVVNRHLLWTLPNPDKAISSWFRVLKPNGTLLVIDGVWDDGSR
LNTVKKKISHKIASLVEAHPHGGKSRYSEEVSSYLPNKGGTSEEKAKEYFENAGFTNITVVNLDAITDEQRKYFSWYMKI
APKSTYYLISGKKPEST

Sequences:

>Translated_257_residues
MNDEKIKQEIANAWNQESNFYDSHVSHGMKSDEEKKLWMEAFSTRVKNDTQLQVLDVGCGTGAMGLIFAEMGHTVEGIDL
SEGMMDVGRKKAADMHLAMNFSSGDAEHPPFDDGKFDVVVNRHLLWTLPNPDKAISSWFRVLKPNGTLLVIDGVWDDGSR
LNTVKKKISHKIASLVEAHPHGGKSRYSEEVSSYLPNKGGTSEEKAKEYFENAGFTNITVVNLDAITDEQRKYFSWYMKI
APKSTYYLISGKKPEST
>Mature_257_residues
MNDEKIKQEIANAWNQESNFYDSHVSHGMKSDEEKKLWMEAFSTRVKNDTQLQVLDVGCGTGAMGLIFAEMGHTVEGIDL
SEGMMDVGRKKAADMHLAMNFSSGDAEHPPFDDGKFDVVVNRHLLWTLPNPDKAISSWFRVLKPNGTLLVIDGVWDDGSR
LNTVKKKISHKIASLVEAHPHGGKSRYSEEVSSYLPNKGGTSEEKAKEYFENAGFTNITVVNLDAITDEQRKYFSWYMKI
APKSTYYLISGKKPEST

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Caenorhabditis elegans, GI25143945, Length=129, Percent_Identity=29.4573643410853, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 28844; Mature: 28844

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDEKIKQEIANAWNQESNFYDSHVSHGMKSDEEKKLWMEAFSTRVKNDTQLQVLDVGCG
CCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCC
TGAMGLIFAEMGHTVEGIDLSEGMMDVGRKKAADMHLAMNFSSGDAEHPPFDDGKFDVVV
CCHHHHHHHHHCCEECCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCEEEEE
NRHLLWTLPNPDKAISSWFRVLKPNGTLLVIDGVWDDGSRLNTVKKKISHKIASLVEAHP
ECEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC
HGGKSRYSEEVSSYLPNKGGTSEEKAKEYFENAGFTNITVVNLDAITDEQRKYFSWYMKI
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHEE
APKSTYYLISGKKPEST
CCCCEEEEEECCCCCCC
>Mature Secondary Structure
MNDEKIKQEIANAWNQESNFYDSHVSHGMKSDEEKKLWMEAFSTRVKNDTQLQVLDVGCG
CCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCC
TGAMGLIFAEMGHTVEGIDLSEGMMDVGRKKAADMHLAMNFSSGDAEHPPFDDGKFDVVV
CCHHHHHHHHHCCEECCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCEEEEE
NRHLLWTLPNPDKAISSWFRVLKPNGTLLVIDGVWDDGSRLNTVKKKISHKIASLVEAHP
ECEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC
HGGKSRYSEEVSSYLPNKGGTSEEKAKEYFENAGFTNITVVNLDAITDEQRKYFSWYMKI
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHEE
APKSTYYLISGKKPEST
CCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA