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The map label for this gene is cobD [H]

Identifier: 124484890

GI number: 124484890

Start: 61507

End: 62424

Strand: Reverse

Name: cobD [H]

Synonym: Mlab_0061

Alternate gene names: 124484890

Gene position: 62424-61507 (Counterclockwise)

Preceding gene: 124484891

Following gene: 124484889

Centisome position: 3.46

GC content: 51.53

Gene sequence:

>918_bases
ATGGCGATCGGTGCAGTAACTCTTTTTTTCGGACTGGTCATCGACCGTCTGATCGGTGATCCGCGTTCTAATTTTCATCC
GGTAGCGCTGATTGGGAGATTCATCGGTCTATGGGGACGAACGAATTATTATCCCAAACGAACCGAACGATTCGTGGGAA
TCTGCGGCTGGCTGCTGACCGTAAGTATCGTGATCCTGCCGTGTCTCCTCATTCTGCTCTACACGCCGTGGTATATTTCC
CTCCCGTTCTCCACACTCGCCCTTGCATTCTGCATCGGATGGCGCTCCTTGGAAGAACATGTCGGAGCCGTCGAAAAGGC
TCTGGAACAGGGTGAAGAAGAGGGGAGAAAAGCCGTCCAGTATCTCGTAAGCAGGGACACAAAGAATCTGACCTTCGAAC
AAATCAGATCGGGAGCGTATGAATCCGCAGCAGAAAACCTGGTCGACAGCATTATCGCACCGATCTTCTGGTTCGTGGTT
TTTGAACTCCTCTTCGGCATGGGGATCGTCGGGGCAGTATTGTTTCGATCGGCAAACACCATGGATGCCATGCTCGGCTA
CAAAGACGACCGAATCCGCCTTGGCTGGTTCCCTGCGAGAATGGACGATATCCTCGCGTATATCCCGGCACGGATTACCG
GAGCAGTTTTGCTTCTCATCTTCCTTTTGAAAGGGAGAATCAAACAGGCATGGTACATCTTCAAACACGACCGGAAATCA
CGGCCGGGTTTCAACGGCGGTATTCCCATGAGTCTGATCGCCGGCGGCTGCGGGGTCATGTTCGAAAAACCCGGCGTCTA
TCAGATAGGATATCCCGAACAAACCCTTGAAGAGGGAGGGAAAACGATCATCAAAACGATTCGATGGTGTACGGTTATCT
GTGCCGCAATCGGCATGCTCCTTCTTATTTTGATATAA

Upstream 100 bases:

>100_bases
TCATCGTACTCATCTTCTGGATACTAGCTCCCGACGCAGTCAATAACACCGTCATGGCAGTGATTCTCTATATTATCATG
CTCGCCGGAATCATCATTAC

Downstream 100 bases:

>100_bases
AAATTCATTACCTTTTACCCCGAATACAGTATTCATGGAGACATATCTGAAAATAATAGCGGTCATTTTTGCAGTCTGCA
TGGTAACGACCGGGGTTGCC

Product: adenosylcobinamide-phosphate synthase

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MAIGAVTLFFGLVIDRLIGDPRSNFHPVALIGRFIGLWGRTNYYPKRTERFVGICGWLLTVSIVILPCLLILLYTPWYIS
LPFSTLALAFCIGWRSLEEHVGAVEKALEQGEEEGRKAVQYLVSRDTKNLTFEQIRSGAYESAAENLVDSIIAPIFWFVV
FELLFGMGIVGAVLFRSANTMDAMLGYKDDRIRLGWFPARMDDILAYIPARITGAVLLLIFLLKGRIKQAWYIFKHDRKS
RPGFNGGIPMSLIAGGCGVMFEKPGVYQIGYPEQTLEEGGKTIIKTIRWCTVICAAIGMLLLILI

Sequences:

>Translated_305_residues
MAIGAVTLFFGLVIDRLIGDPRSNFHPVALIGRFIGLWGRTNYYPKRTERFVGICGWLLTVSIVILPCLLILLYTPWYIS
LPFSTLALAFCIGWRSLEEHVGAVEKALEQGEEEGRKAVQYLVSRDTKNLTFEQIRSGAYESAAENLVDSIIAPIFWFVV
FELLFGMGIVGAVLFRSANTMDAMLGYKDDRIRLGWFPARMDDILAYIPARITGAVLLLIFLLKGRIKQAWYIFKHDRKS
RPGFNGGIPMSLIAGGCGVMFEKPGVYQIGYPEQTLEEGGKTIIKTIRWCTVICAAIGMLLLILI
>Mature_304_residues
AIGAVTLFFGLVIDRLIGDPRSNFHPVALIGRFIGLWGRTNYYPKRTERFVGICGWLLTVSIVILPCLLILLYTPWYISL
PFSTLALAFCIGWRSLEEHVGAVEKALEQGEEEGRKAVQYLVSRDTKNLTFEQIRSGAYESAAENLVDSIIAPIFWFVVF
ELLFGMGIVGAVLFRSANTMDAMLGYKDDRIRLGWFPARMDDILAYIPARITGAVLLLIFLLKGRIKQAWYIFKHDRKSR
PGFNGGIPMSLIAGGCGVMFEKPGVYQIGYPEQTLEEGGKTIIKTIRWCTVICAAIGMLLLILI

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group [H]

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004485 [H]

Pfam domain/function: PF03186 CobD_Cbib [H]

EC number: 6.3.1.10

Molecular weight: Translated: 34139; Mature: 34008

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIGAVTLFFGLVIDRLIGDPRSNFHPVALIGRFIGLWGRTNYYPKRTERFVGICGWLLT
CCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
VSIVILPCLLILLYTPWYISLPFSTLALAFCIGWRSLEEHVGAVEKALEQGEEEGRKAVQ
HHHHHHHHHHHHHHCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLVSRDTKNLTFEQIRSGAYESAAENLVDSIIAPIFWFVVFELLFGMGIVGAVLFRSANT
HHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
MDAMLGYKDDRIRLGWFPARMDDILAYIPARITGAVLLLIFLLKGRIKQAWYIFKHDRKS
HHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RPGFNGGIPMSLIAGGCGVMFEKPGVYQIGYPEQTLEEGGKTIIKTIRWCTVICAAIGML
CCCCCCCCCHHHHHCCCCCEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLILI
HHHHC
>Mature Secondary Structure 
AIGAVTLFFGLVIDRLIGDPRSNFHPVALIGRFIGLWGRTNYYPKRTERFVGICGWLLT
CHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
VSIVILPCLLILLYTPWYISLPFSTLALAFCIGWRSLEEHVGAVEKALEQGEEEGRKAVQ
HHHHHHHHHHHHHHCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLVSRDTKNLTFEQIRSGAYESAAENLVDSIIAPIFWFVVFELLFGMGIVGAVLFRSANT
HHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
MDAMLGYKDDRIRLGWFPARMDDILAYIPARITGAVLLLIFLLKGRIKQAWYIFKHDRKS
HHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RPGFNGGIPMSLIAGGCGVMFEKPGVYQIGYPEQTLEEGGKTIIKTIRWCTVICAAIGML
CCCCCCCCCHHHHHCCCCCEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLILI
HHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA