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The map label for this gene is lacA [H]

Identifier: 124484861

GI number: 124484861

Start: 35450

End: 36055

Strand: Reverse

Name: lacA [H]

Synonym: Mlab_0032

Alternate gene names: 124484861

Gene position: 36055-35450 (Counterclockwise)

Preceding gene: 124484862

Following gene: 124484860

Centisome position: 2.0

GC content: 49.34

Gene sequence:

>606_bases
ATGACGGAAGAGGAGAGGATATTTGCAGGCCGGCTCTTTGACGCACGTTCAAAGGAACTTCGCGATTTGAAGCATAAGGC
CCATGTTCTCTGTCAGAAATTCAATGCTTTGGACGAGTACGATGAGGGCCGTCTGCCGATCATCAGAGAGTTTATCGGAA
GAATCGGTGAGAATTATTATTTCCAGGGACCGATCCAGTTCAATTACGGCTGTCATACGTTTATCGGGGAGAATTTCTTT
GCGAATTTCAATACGACGATCATGGACGACGGCCGGATTTTTATCGGGGACAATGTGATGTTCGGCCCGAATGTTTCTCT
GATGGCGACCTCACATCCGCTGATCCCAACGGAGCGGACAGCTATGCGGTATGAGGACGGACATGTTTCGATGTCCGAAT
ACGCAGAAGAGATCTATATCGGGAATAATGTCTGGCTCGCATGCAATGTTGTTGTGCTGGGCGGCGTGCATATCGGGGAT
AATGCGGTGATCGGGGCCGGAAGCGTTGTAACGAAGGATGTTCCGGAAAATTTTGTTGCTTTCGGGAATCCGTGTAAGCC
GGTCAGACGGATCACGGAGAAGGATTCGAAAATGAATCTGCTGTGA

Upstream 100 bases:

>100_bases
CAGAAATGTAGTATATCCAATGGATTCAGCCAATGTATGTACAGACCTAAAACGGGATATGAGTAGATTTATAGGCCATA
CAGGAGGAGGTTTTATTTAA

Downstream 100 bases:

>100_bases
GTGGGCAGAGAATTGACTGATTGAGCCAGAGCGATTATATATTTCCGGAACGAAAGACCCATCATGCAGAAATCAAAAGC
GCTTCTGTGGATTACCGTGA

Product: hypothetical protein

Products: NA

Alternate protein names: GAT; Thiogalactoside acetyltransferase [H]

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MTEEERIFAGRLFDARSKELRDLKHKAHVLCQKFNALDEYDEGRLPIIREFIGRIGENYYFQGPIQFNYGCHTFIGENFF
ANFNTTIMDDGRIFIGDNVMFGPNVSLMATSHPLIPTERTAMRYEDGHVSMSEYAEEIYIGNNVWLACNVVVLGGVHIGD
NAVIGAGSVVTKDVPENFVAFGNPCKPVRRITEKDSKMNLL

Sequences:

>Translated_201_residues
MTEEERIFAGRLFDARSKELRDLKHKAHVLCQKFNALDEYDEGRLPIIREFIGRIGENYYFQGPIQFNYGCHTFIGENFF
ANFNTTIMDDGRIFIGDNVMFGPNVSLMATSHPLIPTERTAMRYEDGHVSMSEYAEEIYIGNNVWLACNVVVLGGVHIGD
NAVIGAGSVVTKDVPENFVAFGNPCKPVRRITEKDSKMNLL
>Mature_200_residues
TEEERIFAGRLFDARSKELRDLKHKAHVLCQKFNALDEYDEGRLPIIREFIGRIGENYYFQGPIQFNYGCHTFIGENFFA
NFNTTIMDDGRIFIGDNVMFGPNVSLMATSHPLIPTERTAMRYEDGHVSMSEYAEEIYIGNNVWLACNVVVLGGVHIGDN
AVIGAGSVVTKDVPENFVAFGNPCKPVRRITEKDSKMNLL

Specific function: May assist cellular detoxification by acetylating non- metabolizable pyranosides, thereby preventing their reentry into the cell [H]

COG id: COG0110

COG function: function code R; Acetyltransferase (isoleucine patch superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1786537, Length=196, Percent_Identity=43.3673469387755, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1786664, Length=191, Percent_Identity=36.1256544502618, Blast_Score=127, Evalue=3e-31,
Organism=Escherichia coli, GI1788367, Length=152, Percent_Identity=28.9473684210526, Blast_Score=62, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322243, Length=194, Percent_Identity=41.2371134020619, Blast_Score=153, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.18 [H]

Molecular weight: Translated: 22720; Mature: 22589

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEEERIFAGRLFDARSKELRDLKHKAHVLCQKFNALDEYDEGRLPIIREFIGRIGENYY
CCCCHHEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCE
FQGPIQFNYGCHTFIGENFFANFNTTIMDDGRIFIGDNVMFGPNVSLMATSHPLIPTERT
EECCEEECCCCCEECCCCEEECCCCEEEECCEEEECCCEEECCCEEEEECCCCCCCCCCC
AMRYEDGHVSMSEYAEEIYIGNNVWLACNVVVLGGVHIGDNAVIGAGSVVTKDVPENFVA
EEEECCCCEEHHHHHHHEEECCCEEEEEEEEEEECEEECCCCEEECCCEEECCCCCHHHH
FGNPCKPVRRITEKDSKMNLL
CCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TEEERIFAGRLFDARSKELRDLKHKAHVLCQKFNALDEYDEGRLPIIREFIGRIGENYY
CCCHHEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCE
FQGPIQFNYGCHTFIGENFFANFNTTIMDDGRIFIGDNVMFGPNVSLMATSHPLIPTERT
EECCEEECCCCCEECCCCEEECCCCEEEECCEEEECCCEEECCCEEEEECCCCCCCCCCC
AMRYEDGHVSMSEYAEEIYIGNNVWLACNVVVLGGVHIGDNAVIGAGSVVTKDVPENFVA
EEEECCCCEEHHHHHHHEEECCCEEEEEEEEEEECEEECCCCEEECCCEEECCCCCHHHH
FGNPCKPVRRITEKDSKMNLL
CCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3922433; 3901000; 9278503; 6444453; 11937062 [H]