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The map label for this gene is degS [H]

Identifier: 124266220

GI number: 124266220

Start: 1097494

End: 1098864

Strand: Reverse

Name: degS [H]

Synonym: Mpe_A1027

Alternate gene names: 124266220

Gene position: 1098864-1097494 (Counterclockwise)

Preceding gene: 124266227

Following gene: 124266219

Centisome position: 27.17

GC content: 70.68

Gene sequence:

>1371_bases
ATGCGACTCAAGAGCAAGATCGTCCTCCTCGCCGTGGTGCCGCTGCTGGCGTCGATCGTGCTGATCGCGCTGGCCGTGCG
CCACCAGGAGCGCGCGCTGGCGGCGCGCGAACGCGAGCTGGTCGAGAGCGCCTACATGAGCTCCAAGCGCACCGAGCTGC
GCCACTACGTCGAGCTCGCGCGCAGCACCATCGCGCCGCTGTACGACTCGGGCGACGACAGCGAGGCCACGCGCCAGGCC
GCGATGAAGCTGCTGGCGTCGCTGGACTACGGCACCGACGGCTACTTCTTCCTCTACGACCTGCAGGGCCGGAGCCTGAT
GCACCCACGCCAGCCCGAGCTGGTGGGCAACGACCTGTGGGAGCTGCGCGACGAGGCGGGCCACCCGACCATCCAGCAGC
TGATCGCCAAGGCGAGCGAGGGCGGCGGCTTCATCGACTACCTGTGGCGCAAGCCATCCACACGGCAGACCACGCCCAAG
CTGGGCTACGTGATCGCGCTGCCGCGCTGGAACTGGATGCTCGGCACCGGCCTCTACCTCGACGACGTGCAAGCCACGAT
GGCGCAGCTGGACCATCAGGTGGCGGCCAACATCGAGACCACGTTCCTGTGGATCGCCGGCATCGCGCTGTCGGGCATCG
CGCTGATCACGGTGTGCGGCCTGGCGCTCAACCTCAGCGAACACAAGGAGGCCGACGCCAAGCTGCGCCAGCTCGCGCAG
CAGGTGGTGCAGTCACAGGAGTCCGAGCGCGCCCACCTCTCGCGCGAGCTGCACGACGGCACCAGCCAGACGCTGGTGTC
GATCAAGCTGCTGATCGAGTCGGCGATCGAGCAGATCGAGCGCGAGCCGGCCCAGGCCGCCGTGCCGCTGGAGCGCGCCG
CGGTGCGCCTGGCCGACGCGCTGACCGAGGTGCGGCGCATCTCGCACCGCCTGCGCCCGGCGATGCTCGACGTGCTGGGC
CTGCCCGCAGCGCTGGAGCACCTGGGCCGGGAGTTCGGCGACCACAGCGGGCTGGCGTTCTCGATGCGCATGCGCGGGCC
GTCGATCGAGTTGCCGGACGACGTGAAGACCGTGCTGTTCCGCGTGACGCAGGAGGCGCTGACCAACATCGAGAAGCACG
CCGCCGCGCAGTCGGTGCGCATCCGGCTGGCGTTCCGGCCCAGCGGCCTGCGGCTCGCGATCCTCGACGACGGCCGCGGC
TTCGACCTCGCCGCGGTGCAGCTCGACCCGCGTCGCGGGATCGGCCTGCGCAACATGCGCGAGCGCCTCGCCTCGATCGG
CGGATCGTTCCGCATCCGCTCGCGCAGCGGTCTCACCGAGCTGATCGCCGACGTGCCCGAGGCGCAGCTGCGCCGCCTGA
AGGAGGCCTGA

Upstream 100 bases:

>100_bases
CGCCGGACATCGGACGCCGCCGCGAGCGCGGGTAGCGGCTGTCCTACAGGGCCCTGCGGCAGACCGCCCGCCCTGCCGCT
GTGGATACCATCCACGAAAC

Downstream 100 bases:

>100_bases
TGAGCCACGAACCCGACGCGCCCCGCGTCCGACTGCTGATCGTCGACGACCACCCGCTCGTGCGCGAGGGCCTGCGCTCG
CGCCTGCAGGCGATCGCCTG

Product: putative transmembrane sensor histidine kinase transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MRLKSKIVLLAVVPLLASIVLIALAVRHQERALAARERELVESAYMSSKRTELRHYVELARSTIAPLYDSGDDSEATRQA
AMKLLASLDYGTDGYFFLYDLQGRSLMHPRQPELVGNDLWELRDEAGHPTIQQLIAKASEGGGFIDYLWRKPSTRQTTPK
LGYVIALPRWNWMLGTGLYLDDVQATMAQLDHQVAANIETTFLWIAGIALSGIALITVCGLALNLSEHKEADAKLRQLAQ
QVVQSQESERAHLSRELHDGTSQTLVSIKLLIESAIEQIEREPAQAAVPLERAAVRLADALTEVRRISHRLRPAMLDVLG
LPAALEHLGREFGDHSGLAFSMRMRGPSIELPDDVKTVLFRVTQEALTNIEKHAAAQSVRIRLAFRPSGLRLAILDDGRG
FDLAAVQLDPRRGIGLRNMRERLASIGGSFRIRSRSGLTELIADVPEAQLRRLKEA

Sequences:

>Translated_456_residues
MRLKSKIVLLAVVPLLASIVLIALAVRHQERALAARERELVESAYMSSKRTELRHYVELARSTIAPLYDSGDDSEATRQA
AMKLLASLDYGTDGYFFLYDLQGRSLMHPRQPELVGNDLWELRDEAGHPTIQQLIAKASEGGGFIDYLWRKPSTRQTTPK
LGYVIALPRWNWMLGTGLYLDDVQATMAQLDHQVAANIETTFLWIAGIALSGIALITVCGLALNLSEHKEADAKLRQLAQ
QVVQSQESERAHLSRELHDGTSQTLVSIKLLIESAIEQIEREPAQAAVPLERAAVRLADALTEVRRISHRLRPAMLDVLG
LPAALEHLGREFGDHSGLAFSMRMRGPSIELPDDVKTVLFRVTQEALTNIEKHAAAQSVRIRLAFRPSGLRLAILDDGRG
FDLAAVQLDPRRGIGLRNMRERLASIGGSFRIRSRSGLTELIADVPEAQLRRLKEA
>Mature_456_residues
MRLKSKIVLLAVVPLLASIVLIALAVRHQERALAARERELVESAYMSSKRTELRHYVELARSTIAPLYDSGDDSEATRQA
AMKLLASLDYGTDGYFFLYDLQGRSLMHPRQPELVGNDLWELRDEAGHPTIQQLIAKASEGGGFIDYLWRKPSTRQTTPK
LGYVIALPRWNWMLGTGLYLDDVQATMAQLDHQVAANIETTFLWIAGIALSGIALITVCGLALNLSEHKEADAKLRQLAQ
QVVQSQESERAHLSRELHDGTSQTLVSIKLLIESAIEQIEREPAQAAVPLERAAVRLADALTEVRRISHRLRPAMLDVLG
LPAALEHLGREFGDHSGLAFSMRMRGPSIELPDDVKTVLFRVTQEALTNIEKHAAAQSVRIRLAFRPSGLRLAILDDGRG
FDLAAVQLDPRRGIGLRNMRERLASIGGSFRIRSRSGLTELIADVPEAQLRRLKEA

Specific function: Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4564

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=229, Percent_Identity=33.6244541484716, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1787474, Length=201, Percent_Identity=27.8606965174129, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788812, Length=196, Percent_Identity=26.530612244898, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50667; Mature: 50667

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLKSKIVLLAVVPLLASIVLIALAVRHQERALAARERELVESAYMSSKRTELRHYVELA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSTIAPLYDSGDDSEATRQAAMKLLASLDYGTDGYFFLYDLQGRSLMHPRQPELVGNDLW
HHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHH
ELRDEAGHPTIQQLIAKASEGGGFIDYLWRKPSTRQTTPKLGYVIALPRWNWMLGTGLYL
HHHHHCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCEEEEECCCCEEECCCCHH
DDVQATMAQLDHQVAANIETTFLWIAGIALSGIALITVCGLALNLSEHKEADAKLRQLAQ
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
QVVQSQESERAHLSRELHDGTSQTLVSIKLLIESAIEQIEREPAQAAVPLERAAVRLADA
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHH
LTEVRRISHRLRPAMLDVLGLPAALEHLGREFGDHSGLAFSMRMRGPSIELPDDVKTVLF
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHH
RVTQEALTNIEKHAAAQSVRIRLAFRPSGLRLAILDDGRGFDLAAVQLDPRRGIGLRNMR
HHHHHHHHHHHHHHHHHEEEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHH
ERLASIGGSFRIRSRSGLTELIADVPEAQLRRLKEA
HHHHHCCCCEEEECCCCHHHHHHCCCHHHHHHHHCC
>Mature Secondary Structure
MRLKSKIVLLAVVPLLASIVLIALAVRHQERALAARERELVESAYMSSKRTELRHYVELA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSTIAPLYDSGDDSEATRQAAMKLLASLDYGTDGYFFLYDLQGRSLMHPRQPELVGNDLW
HHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHH
ELRDEAGHPTIQQLIAKASEGGGFIDYLWRKPSTRQTTPKLGYVIALPRWNWMLGTGLYL
HHHHHCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCEEEEECCCCEEECCCCHH
DDVQATMAQLDHQVAANIETTFLWIAGIALSGIALITVCGLALNLSEHKEADAKLRQLAQ
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
QVVQSQESERAHLSRELHDGTSQTLVSIKLLIESAIEQIEREPAQAAVPLERAAVRLADA
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHH
LTEVRRISHRLRPAMLDVLGLPAALEHLGREFGDHSGLAFSMRMRGPSIELPDDVKTVLF
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHH
RVTQEALTNIEKHAAAQSVRIRLAFRPSGLRLAILDDGRGFDLAAVQLDPRRGIGLRNMR
HHHHHHHHHHHHHHHHHEEEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHH
ERLASIGGSFRIRSRSGLTELIADVPEAQLRRLKEA
HHHHHCCCCEEEECCCCHHHHHHCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]