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The map label for this gene is degU [H]

Identifier: 124266219

GI number: 124266219

Start: 1096841

End: 1097494

Strand: Reverse

Name: degU [H]

Synonym: Mpe_A1026

Alternate gene names: 124266219

Gene position: 1097494-1096841 (Counterclockwise)

Preceding gene: 124266220

Following gene: 124266218

Centisome position: 27.14

GC content: 70.49

Gene sequence:

>654_bases
ATGAGCCACGAACCCGACGCGCCCCGCGTCCGACTGCTGATCGTCGACGACCACCCGCTCGTGCGCGAGGGCCTGCGCTC
GCGCCTGCAGGCGATCGCCTGGCTCGAGGTGGTGGGCGAGGCCGGCAGCGCACGAGAGGCGCTGGAGCTGATCCCGCAGC
TGCACCCCGGCCTGGTGCTGATGGACGTCGGCATGCGCGAGATCAACGGCATCGAGCTCACCCGCCTGCTGGCGCAGCGC
CATCCGGCGGTGGCCGTGCTGGTGCTCAGCATGTACGACAACCCCGAGTACGTGCAGCAGGCCATGCAGGCCGGCGCCCG
CGGCTACGTGCTGAAGGACGCGCCCTCGGCCGACATCATCGCGGCCATCGAGGCGGTGTGCGCCGGCGGCACCTTCCTGA
GTCCGTCAGTGTCCAAGCGCCTGTTCCGCGGCCAGGCGCCGAAGCCGCTGGTCTCGCACCGGGAGAGCGAGATCCTCGCC
TGCCTGGCCGACGGCCTGTCGAGCAAGCAGATCGCCGAGCGGCTGGACCTGAGCGTGCGCACCGTCGAGACGCATCGCCA
GAACATCAAGCGCAAGCTGGGCATCGAGGGTCAGGCGGAGCTGATCAAGTACGCGGTCGAGCACGGCCGGCGCTACCGCG
AAGACGAGGGCTGA

Upstream 100 bases:

>100_bases
CCTCGATCGGCGGATCGTTCCGCATCCGCTCGCGCAGCGGTCTCACCGAGCTGATCGCCGACGTGCCCGAGGCGCAGCTG
CGCCGCCTGAAGGAGGCCTG

Downstream 100 bases:

>100_bases
GGTCCTCCCTCACCCCGGTCTGGTCCCTAAGTGGTCCCACGCAGCCCCCTACGTGGTGCGACGCTTGTTTCAGGATGCAC
CGCTGCGGACACTGACGCCC

Product: response regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MSHEPDAPRVRLLIVDDHPLVREGLRSRLQAIAWLEVVGEAGSAREALELIPQLHPGLVLMDVGMREINGIELTRLLAQR
HPAVAVLVLSMYDNPEYVQQAMQAGARGYVLKDAPSADIIAAIEAVCAGGTFLSPSVSKRLFRGQAPKPLVSHRESEILA
CLADGLSSKQIAERLDLSVRTVETHRQNIKRKLGIEGQAELIKYAVEHGRRYREDEG

Sequences:

>Translated_217_residues
MSHEPDAPRVRLLIVDDHPLVREGLRSRLQAIAWLEVVGEAGSAREALELIPQLHPGLVLMDVGMREINGIELTRLLAQR
HPAVAVLVLSMYDNPEYVQQAMQAGARGYVLKDAPSADIIAAIEAVCAGGTFLSPSVSKRLFRGQAPKPLVSHRESEILA
CLADGLSSKQIAERLDLSVRTVETHRQNIKRKLGIEGQAELIKYAVEHGRRYREDEG
>Mature_216_residues
SHEPDAPRVRLLIVDDHPLVREGLRSRLQAIAWLEVVGEAGSAREALELIPQLHPGLVLMDVGMREINGIELTRLLAQRH
PAVAVLVLSMYDNPEYVQQAMQAGARGYVLKDAPSADIIAAIEAVCAGGTFLSPSVSKRLFRGQAPKPLVSHRESEILAC
LADGLSSKQIAERLDLSVRTVETHRQNIKRKLGIEGQAELIKYAVEHGRRYREDEG

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790102, Length=194, Percent_Identity=37.6288659793814, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1788222, Length=207, Percent_Identity=32.8502415458937, Blast_Score=117, Evalue=4e-28,
Organism=Escherichia coli, GI1788521, Length=197, Percent_Identity=34.5177664974619, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1788546, Length=203, Percent_Identity=30.5418719211823, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786747, Length=199, Percent_Identity=32.1608040201005, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1788712, Length=198, Percent_Identity=29.7979797979798, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1787473, Length=182, Percent_Identity=33.5164835164835, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082052, Length=103, Percent_Identity=36.8932038834951, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23920; Mature: 23789

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHEPDAPRVRLLIVDDHPLVREGLRSRLQAIAWLEVVGEAGSAREALELIPQLHPGLVL
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEE
MDVGMREINGIELTRLLAQRHPAVAVLVLSMYDNPEYVQQAMQAGARGYVLKDAPSADII
EECCHHHHCHHHHHHHHHHHCCHHEEEEEHHCCCHHHHHHHHHCCCCCEEECCCCCHHHH
AAIEAVCAGGTFLSPSVSKRLFRGQAPKPLVSHRESEILACLADGLSSKQIAERLDLSVR
HHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHCCHHHHHHHHHCCCCHHHHHHHHCCHHH
TVETHRQNIKRKLGIEGQAELIKYAVEHGRRYREDEG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SHEPDAPRVRLLIVDDHPLVREGLRSRLQAIAWLEVVGEAGSAREALELIPQLHPGLVL
CCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEE
MDVGMREINGIELTRLLAQRHPAVAVLVLSMYDNPEYVQQAMQAGARGYVLKDAPSADII
EECCHHHHCHHHHHHHHHHHCCHHEEEEEHHCCCHHHHHHHHHCCCCCEEECCCCCHHHH
AAIEAVCAGGTFLSPSVSKRLFRGQAPKPLVSHRESEILACLADGLSSKQIAERLDLSVR
HHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHCCHHHHHHHHHCCCCHHHHHHHHCCHHH
TVETHRQNIKRKLGIEGQAELIKYAVEHGRRYREDEG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]