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The map label for this gene is wzc [H]

Identifier: 124265929

GI number: 124265929

Start: 764816

End: 765763

Strand: Reverse

Name: wzc [H]

Synonym: Mpe_A0736

Alternate gene names: 124265929

Gene position: 765763-764816 (Counterclockwise)

Preceding gene: 124265930

Following gene: 124265928

Centisome position: 18.93

GC content: 68.57

Gene sequence:

>948_bases
ATGAGACGCGAACCCGTCATCGCCCACCAGCCGCTCGGCTCCTCGGCCGGAGCGGCCGACACCGACAACCCCTCGTTGTC
TTCCCCCGAGGGCACCGAGGATGTGAGCGACCTGCACGACCGCTCCATCGGCGACATCATCCGTGAGGCCAAGCGGCTGA
CCGACGCGCAGATCGAGAAGATCCTCGCCTACCAGCGCAAGCATGGCCTGCGCTTCGGCGAAGCCGCGGTGGCCCTCAAG
CTGGTGACGAACGACGACGTGCTGTGGGCACTGTCGCAGCAGTTCCACTACCCCTACGCGCCCAGCGGCAAGTCGGACTG
CAACCCGGAGCTGGTGGTCGCCGCCAACCCGTTCTGCGAGCAGGCCGAGGCTTTCCGCGAGCTGCGCAGCCAGCTGATGA
TGGGCGTGCTGAGCCTCAGCGAAGCGCGGCGCGCATTGGCCGTGGTGAGCCCCGACGTGGGCGATGGCAAGACCTTCGTC
GCCGCCAACATGGCGGTGGCCTTCAGCCAGCTCGGCGGGCGCGCGCTGCTGGTGGACGCCGACATGCGCACGCCGCGCCA
GCACAAGCTGTTCGGCATCGACAACAGCAACGGCCTCAGCAGCATTCTTTCGGGGCGCTCGCGGCAGAACGTGATCCACC
AGGTGCCCGACCTGCCCACGCTGTTCGTGCTGCCGGTGGGCGCGGTGCCACCCAACCCGCTGGAGCTGGTGCAACGCCCG
GCCTTCGGGTTGCTGATGCACGAGCTGCTGTCCAAGTTCGACCACGTGGTAGTCGACACGCCGGCTTCGGTGCATGGGGC
CGACGCCCGCGTGGTGGCCGCGAAGTGCGGTGCCGCCCTGGTGATCGGGCGGCGCGGCAAGAGCCGCATGAAGAGCATGC
AGACGCTGATCAACGCCCTGGCCAAGGGCCCCGCCCAGCTGGCGGGCGTGATCGTCAACGAGCAATAG

Upstream 100 bases:

>100_bases
TCGTGCTGCCCAAGACCAGCCGGCAGGACGCCCATGGCGGCTCGCGGCTGAAGCTGACCAAGGCGCGCGTCGTAAGAGGG
CTCGCTGGCCCCGCCCGATC

Downstream 100 bases:

>100_bases
GCTCCGGAGCCGCCGTGTTGCAAGCGCTTCGATCCCCAGGCGCCGACGGCGGCGTGGTGGCGCCGGCCCGCACGGGCGAC
GAGATCCGCGTCTCGGTGGT

Product: tyrosine kinase

Products: ADP; protein tyrosine phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MRREPVIAHQPLGSSAGAADTDNPSLSSPEGTEDVSDLHDRSIGDIIREAKRLTDAQIEKILAYQRKHGLRFGEAAVALK
LVTNDDVLWALSQQFHYPYAPSGKSDCNPELVVAANPFCEQAEAFRELRSQLMMGVLSLSEARRALAVVSPDVGDGKTFV
AANMAVAFSQLGGRALLVDADMRTPRQHKLFGIDNSNGLSSILSGRSRQNVIHQVPDLPTLFVLPVGAVPPNPLELVQRP
AFGLLMHELLSKFDHVVVDTPASVHGADARVVAAKCGAALVIGRRGKSRMKSMQTLINALAKGPAQLAGVIVNEQ

Sequences:

>Translated_315_residues
MRREPVIAHQPLGSSAGAADTDNPSLSSPEGTEDVSDLHDRSIGDIIREAKRLTDAQIEKILAYQRKHGLRFGEAAVALK
LVTNDDVLWALSQQFHYPYAPSGKSDCNPELVVAANPFCEQAEAFRELRSQLMMGVLSLSEARRALAVVSPDVGDGKTFV
AANMAVAFSQLGGRALLVDADMRTPRQHKLFGIDNSNGLSSILSGRSRQNVIHQVPDLPTLFVLPVGAVPPNPLELVQRP
AFGLLMHELLSKFDHVVVDTPASVHGADARVVAAKCGAALVIGRRGKSRMKSMQTLINALAKGPAQLAGVIVNEQ
>Mature_315_residues
MRREPVIAHQPLGSSAGAADTDNPSLSSPEGTEDVSDLHDRSIGDIIREAKRLTDAQIEKILAYQRKHGLRFGEAAVALK
LVTNDDVLWALSQQFHYPYAPSGKSDCNPELVVAANPFCEQAEAFRELRSQLMMGVLSLSEARRALAVVSPDVGDGKTFV
AANMAVAFSQLGGRALLVDADMRTPRQHKLFGIDNSNGLSSILSGRSRQNVIHQVPDLPTLFVLPVGAVPPNPLELVQRP
AFGLLMHELLSKFDHVVVDTPASVHGADARVVAAKCGAALVIGRRGKSRMKSMQTLINALAKGPAQLAGVIVNEQ

Specific function: Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium [H]

COG id: COG0489

COG function: function code D; ATPases involved in chromosome partitioning

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the etk/wzc family [H]

Homologues:

Organism=Escherichia coli, GI87082032, Length=204, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1787216, Length=198, Percent_Identity=31.8181818181818, Blast_Score=102, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR005702
- InterPro:   IPR003856 [H]

Pfam domain/function: PF01656 CbiA; PF02706 Wzz [H]

EC number: 2.7.1.112 [C]

Molecular weight: Translated: 33800; Mature: 33800

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRREPVIAHQPLGSSAGAADTDNPSLSSPEGTEDVSDLHDRSIGDIIREAKRLTDAQIEK
CCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILAYQRKHGLRFGEAAVALKLVTNDDVLWALSQQFHYPYAPSGKSDCNPELVVAANPFCE
HHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCHHH
QAEAFRELRSQLMMGVLSLSEARRALAVVSPDVGDGKTFVAANMAVAFSQLGGRALLVDA
HHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEHHHHHHHHHHCCCEEEEEEC
DMRTPRQHKLFGIDNSNGLSSILSGRSRQNVIHQVPDLPTLFVLPVGAVPPNPLELVQRP
CCCCCCCCEEEECCCCCCHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHCC
AFGLLMHELLSKFDHVVVDTPASVHGADARVVAAKCGAALVIGRRGKSRMKSMQTLINAL
HHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHH
AKGPAQLAGVIVNEQ
HCCHHHHEEEEECCC
>Mature Secondary Structure
MRREPVIAHQPLGSSAGAADTDNPSLSSPEGTEDVSDLHDRSIGDIIREAKRLTDAQIEK
CCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILAYQRKHGLRFGEAAVALKLVTNDDVLWALSQQFHYPYAPSGKSDCNPELVVAANPFCE
HHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCHHH
QAEAFRELRSQLMMGVLSLSEARRALAVVSPDVGDGKTFVAANMAVAFSQLGGRALLVDA
HHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEHHHHHHHHHHCCCEEEEEEC
DMRTPRQHKLFGIDNSNGLSSILSGRSRQNVIHQVPDLPTLFVLPVGAVPPNPLELVQRP
CCCCCCCCEEEECCCCCCHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHCC
AFGLLMHELLSKFDHVVVDTPASVHGADARVVAAKCGAALVIGRRGKSRMKSMQTLINAL
HHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHH
AKGPAQLAGVIVNEQ
HCCHHHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; a protein tyrosine [C]

Specific reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]