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The map label for this gene is gpmA

Identifier: 124265906

GI number: 124265906

Start: 741241

End: 741984

Strand: Reverse

Name: gpmA

Synonym: Mpe_A0713

Alternate gene names: 124265906

Gene position: 741984-741241 (Counterclockwise)

Preceding gene: 124265920

Following gene: 124265897

Centisome position: 18.35

GC content: 69.35

Gene sequence:

>744_bases
ATGACCCAACTCGTGCTGATCCGCCACGGCGAATCGACCTGGAACCTCGAGAACCGCTTCACCGGCTGGACCGATGTGGA
ACTCACTCCCACCGGCGTGGCCCAGGCCCAGCAGGCCGGCCGGCTGCTGAAGCAGGCCGGCATCGATTTCGACACCGTCT
ACACCTCGGTGCTCAAGCGCGCGATCTGGACCGCCTGGCACTGCCTCGACGGCATGGACCGCACCTGGCTGCCGGTCATC
AAGGACTGGCGCCTCAACGAGCGCCACTACGGCGGCCTGCAGGGCCTGAACAAGGCCGACATGGCCAAGCAGTTCGGCGA
CGAGCAGGTGCTGCTCTGGCGCCGCAGCTACGACGTGCCGCCGCCGCCGCTGGAAGCGAACGACCCGCGCAGCGAGCGCA
GCGACGTGCGCTACGCGAAGCTCGCGGCCAACCAGGTGCCGCTGACCGAGTGCCTGAAGGACACCGTGGCGCGCGTGCTG
CCGCTCTGGTACGGCACGCTGGCCCCGGCCATCGCCGCCGGCCAGCGGCTGGTGATCGTGGCGCACGGCAACAGCATCCG
CGCGCTGGTGAAGCACCTGAACAACATCTCCGACGCCGACATCGTGGGCGTGAACATCCCGAACGGCATCCCGCTGGTCT
ACGACCTGGACGCCAACCTGAAGCCCACGTCGAAGTACTACCTGGGCGGGGCCGACGCCGCCGCGCAGGCGGCCTCGGTG
TCCGCGCTGCAGGCGGACGGCTGA

Upstream 100 bases:

>100_bases
ACTTCACGGTGGGGGCGCGCGCGGCCAGCGCGGTCAGGGAGGCGGAAAGACAGCGATTCTAGAATCTGCGGCTATTCCCA
TTGCTGCCGCGACCCGCCTC

Downstream 100 bases:

>100_bases
GGCCGTGCCTCAGCCCACCAGGCCGTAGAGCCGCTCCGGCGCCACGCGCAGCACGAGCTGCAGGTCGGTCGCCCGGCCGG
CGATCTGGCAGCCCGGCTGG

Product: phosphoglycerate mutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MTQLVLIRHGESTWNLENRFTGWTDVELTPTGVAQAQQAGRLLKQAGIDFDTVYTSVLKRAIWTAWHCLDGMDRTWLPVI
KDWRLNERHYGGLQGLNKADMAKQFGDEQVLLWRRSYDVPPPPLEANDPRSERSDVRYAKLAANQVPLTECLKDTVARVL
PLWYGTLAPAIAAGQRLVIVAHGNSIRALVKHLNNISDADIVGVNIPNGIPLVYDLDANLKPTSKYYLGGADAAAQAASV
SALQADG

Sequences:

>Translated_247_residues
MTQLVLIRHGESTWNLENRFTGWTDVELTPTGVAQAQQAGRLLKQAGIDFDTVYTSVLKRAIWTAWHCLDGMDRTWLPVI
KDWRLNERHYGGLQGLNKADMAKQFGDEQVLLWRRSYDVPPPPLEANDPRSERSDVRYAKLAANQVPLTECLKDTVARVL
PLWYGTLAPAIAAGQRLVIVAHGNSIRALVKHLNNISDADIVGVNIPNGIPLVYDLDANLKPTSKYYLGGADAAAQAASV
SALQADG
>Mature_246_residues
TQLVLIRHGESTWNLENRFTGWTDVELTPTGVAQAQQAGRLLKQAGIDFDTVYTSVLKRAIWTAWHCLDGMDRTWLPVIK
DWRLNERHYGGLQGLNKADMAKQFGDEQVLLWRRSYDVPPPPLEANDPRSERSDVRYAKLAANQVPLTECLKDTVARVLP
LWYGTLAPAIAAGQRLVIVAHGNSIRALVKHLNNISDADIVGVNIPNGIPLVYDLDANLKPTSKYYLGGADAAAQAASVS
ALQADG

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=246, Percent_Identity=51.6260162601626, Blast_Score=276, Evalue=1e-74,
Organism=Homo sapiens, GI4505753, Length=246, Percent_Identity=52.8455284552846, Blast_Score=257, Evalue=8e-69,
Organism=Homo sapiens, GI71274132, Length=245, Percent_Identity=51.0204081632653, Blast_Score=244, Evalue=4e-65,
Organism=Homo sapiens, GI4502445, Length=240, Percent_Identity=46.25, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI40353764, Length=240, Percent_Identity=46.25, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI310129614, Length=161, Percent_Identity=58.3850931677019, Blast_Score=182, Evalue=2e-46,
Organism=Escherichia coli, GI1786970, Length=232, Percent_Identity=57.7586206896552, Blast_Score=296, Evalue=8e-82,
Organism=Saccharomyces cerevisiae, GI6322697, Length=229, Percent_Identity=52.4017467248908, Blast_Score=250, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6324516, Length=288, Percent_Identity=34.375, Blast_Score=141, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6320183, Length=291, Percent_Identity=31.2714776632302, Blast_Score=135, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24646216, Length=246, Percent_Identity=47.1544715447154, Blast_Score=234, Evalue=5e-62,
Organism=Drosophila melanogaster, GI85725270, Length=247, Percent_Identity=45.748987854251, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI85725272, Length=247, Percent_Identity=45.748987854251, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24650981, Length=247, Percent_Identity=45.748987854251, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI28571815, Length=218, Percent_Identity=40.8256880733945, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI28571817, Length=218, Percent_Identity=40.8256880733945, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24648979, Length=218, Percent_Identity=40.8256880733945, Blast_Score=169, Evalue=2e-42,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_METPP (A2SDN6)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001019910.1
- ProteinModelPortal:   A2SDN6
- SMR:   A2SDN6
- STRING:   A2SDN6
- GeneID:   4783898
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0713
- NMPDR:   fig|279263.3.peg.3272
- eggNOG:   COG0588
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- PhylomeDB:   A2SDN6
- BioCyc:   MPET420662:MPE_A0713-MONOMER
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 27223; Mature: 27092

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLVLIRHGESTWNLENRFTGWTDVELTPTGVAQAQQAGRLLKQAGIDFDTVYTSVLKR
CCEEEEEECCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AIWTAWHCLDGMDRTWLPVIKDWRLNERHYGGLQGLNKADMAKQFGDEQVLLWRRSYDVP
HHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCC
PPPLEANDPRSERSDVRYAKLAANQVPLTECLKDTVARVLPLWYGTLAPAIAAGQRLVIV
CCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
AHGNSIRALVKHLNNISDADIVGVNIPNGIPLVYDLDANLKPTSKYYLGGADAAAQAASV
ECCCHHHHHHHHHCCCCCCCEEEEECCCCCCEEEECCCCCCCCCEEEECCCHHHHHHHHH
SALQADG
HHHCCCC
>Mature Secondary Structure 
TQLVLIRHGESTWNLENRFTGWTDVELTPTGVAQAQQAGRLLKQAGIDFDTVYTSVLKR
CEEEEEECCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AIWTAWHCLDGMDRTWLPVIKDWRLNERHYGGLQGLNKADMAKQFGDEQVLLWRRSYDVP
HHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCC
PPPLEANDPRSERSDVRYAKLAANQVPLTECLKDTVARVLPLWYGTLAPAIAAGQRLVIV
CCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
AHGNSIRALVKHLNNISDADIVGVNIPNGIPLVYDLDANLKPTSKYYLGGADAAAQAASV
ECCCHHHHHHHHHCCCCCCCEEEEECCCCCCEEEECCCCCCCCCEEEECCCHHHHHHHHH
SALQADG
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA