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The map label for this gene is phoB [H]

Identifier: 124265864

GI number: 124265864

Start: 709310

End: 710311

Strand: Direct

Name: phoB [H]

Synonym: Mpe_A0671

Alternate gene names: 124265864

Gene position: 709310-710311 (Clockwise)

Preceding gene: 124265863

Following gene: 124265879

Centisome position: 17.54

GC content: 73.65

Gene sequence:

>1002_bases
ATGCTGCCGCGGCCGCCTGACTCTCCCGCCGACCCCAACGTGCCGCGCGGGCCGGAGCGCATGCGCCTCGGCGAGAACAG
CGACGTGGTGCTGATCGTCGACGACGTGCCGGACAACGTCTCGGTGCTGCACGATGCGCTCGACGAATCCGGCTACACCG
TGCTGGTCGCCACCAGCGGCGAGGCCGCGCTGGAACGCGCCGCCCACGCGCGGCCCGACGTGGTGCTGCTCGACGCGCTG
ATGCCCGGCATGGACGGCTTCGAGGTCGCGCGTCGGCTCAAGCGCGACGCCGCCACCGCGCACATCCCCATCGTCTTCAT
GACCGGCCTGGCCGAGACCGAGCACGTGGAGGCGGCGTTCGAGGCCGGCGGCGTGGACTACGTGACCAAGCCGATCCGCC
CACGCGAGGTCATCGCGCGCATCGCCGCCCATGTGCGCGGCGCGCGCCAGGCACGGCAGGCGCGCAGCGCGCTCGACGCC
TTCGGCCACGCCGTCATCACCGTGCGCGCCGGCGACGGCCGCGTGCTGTGGCAGACGCCGCTGGCGCGCGAGCTGCTGCA
GGCGCTGGACGCCACGCGCGAGGCCGGCACCCGCGGCCCGGTGCTCAGCGAGACCCTGCTCGACTGGATGCAGGCGCAGG
CGGTGCTGGCAGCCACCGAGCAGACCGGCTACCCCATCGTGCTGGCGCGCGAGGGCCGCCGCGTGAGCTTCGCGCTGCAC
GAGGCCACCGGCGAGGACGAGTGGCTGCTGGTGCTGACCGAGTCGAACGACCGCGCCAGCATCGAGGGCCTGGCGGTCGC
GTTCCGGCTCACCGGCCGTGAGGCCGAGGTGCTGCACTGGGTGGCCCAGGGCAAGACCAACCGCGACATCGGCGACATCC
TCGGCACCAGCCCGCGCACCGTGCACAAGCACCTGGAGCATGTGTTCGCCAAGCTCGGCGTCGAGACGCGCACCTCCGCG
GCGGCGATGGCGCTCGGCAAGCTCAAGCGCGGCGCTGCCTGA

Upstream 100 bases:

>100_bases
GCCGCCGCGGCCTGGACCGGCCCGGTGCGCGAGCTGGCCCAGCAGTTCCGCTTCGACGCCATCCGTGCGCTGCTGAATCC
CCGAGACGAGGAACCCGAAG

Downstream 100 bases:

>100_bases
GGTGCCGCGGCCGGGCCTCAGGCGAGGTCGTCGTCGGAGAGCGACTTGAACAGGCGGCCCGCCTGCGCCGCCAGCGTGAG
CAGGCCGCACACCAGCACCA

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MLPRPPDSPADPNVPRGPERMRLGENSDVVLIVDDVPDNVSVLHDALDESGYTVLVATSGEAALERAAHARPDVVLLDAL
MPGMDGFEVARRLKRDAATAHIPIVFMTGLAETEHVEAAFEAGGVDYVTKPIRPREVIARIAAHVRGARQARQARSALDA
FGHAVITVRAGDGRVLWQTPLARELLQALDATREAGTRGPVLSETLLDWMQAQAVLAATEQTGYPIVLAREGRRVSFALH
EATGEDEWLLVLTESNDRASIEGLAVAFRLTGREAEVLHWVAQGKTNRDIGDILGTSPRTVHKHLEHVFAKLGVETRTSA
AAMALGKLKRGAA

Sequences:

>Translated_333_residues
MLPRPPDSPADPNVPRGPERMRLGENSDVVLIVDDVPDNVSVLHDALDESGYTVLVATSGEAALERAAHARPDVVLLDAL
MPGMDGFEVARRLKRDAATAHIPIVFMTGLAETEHVEAAFEAGGVDYVTKPIRPREVIARIAAHVRGARQARQARSALDA
FGHAVITVRAGDGRVLWQTPLARELLQALDATREAGTRGPVLSETLLDWMQAQAVLAATEQTGYPIVLAREGRRVSFALH
EATGEDEWLLVLTESNDRASIEGLAVAFRLTGREAEVLHWVAQGKTNRDIGDILGTSPRTVHKHLEHVFAKLGVETRTSA
AAMALGKLKRGAA
>Mature_333_residues
MLPRPPDSPADPNVPRGPERMRLGENSDVVLIVDDVPDNVSVLHDALDESGYTVLVATSGEAALERAAHARPDVVLLDAL
MPGMDGFEVARRLKRDAATAHIPIVFMTGLAETEHVEAAFEAGGVDYVTKPIRPREVIARIAAHVRGARQARQARSALDA
FGHAVITVRAGDGRVLWQTPLARELLQALDATREAGTRGPVLSETLLDWMQAQAVLAATEQTGYPIVLAREGRRVSFALH
EATGEDEWLLVLTESNDRASIEGLAVAFRLTGREAEVLHWVAQGKTNRDIGDILGTSPRTVHKHLEHVFAKLGVETRTSA
AAMALGKLKRGAA

Specific function: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by phoB and phoR when phosphate is limited [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=171, Percent_Identity=31.5789473684211, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1786599, Length=117, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790860, Length=123, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788550, Length=104, Percent_Identity=38.4615384615385, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790299, Length=128, Percent_Identity=30.46875, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786784, Length=117, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789809, Length=145, Percent_Identity=30.3448275862069, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790437, Length=108, Percent_Identity=35.1851851851852, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI145693157, Length=133, Percent_Identity=30.0751879699248, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR011879
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 35923; Mature: 35923

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPRPPDSPADPNVPRGPERMRLGENSDVVLIVDDVPDNVSVLHDALDESGYTVLVATSG
CCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEEEECC
EAALERAAHARPDVVLLDALMPGMDGFEVARRLKRDAATAHIPIVFMTGLAETEHVEAAF
HHHHHHHHCCCCCEEEEEHHCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHH
EAGGVDYVTKPIRPREVIARIAAHVRGARQARQARSALDAFGHAVITVRAGDGRVLWQTP
HCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEECCH
LARELLQALDATREAGTRGPVLSETLLDWMQAQAVLAATEQTGYPIVLAREGRRVSFALH
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEE
EATGEDEWLLVLTESNDRASIEGLAVAFRLTGREAEVLHWVAQGKTNRDIGDILGTSPRT
CCCCCCCEEEEEECCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCHHHHHCCCCHH
VHKHLEHVFAKLGVETRTSAAAMALGKLKRGAA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLPRPPDSPADPNVPRGPERMRLGENSDVVLIVDDVPDNVSVLHDALDESGYTVLVATSG
CCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEEEECC
EAALERAAHARPDVVLLDALMPGMDGFEVARRLKRDAATAHIPIVFMTGLAETEHVEAAF
HHHHHHHHCCCCCEEEEEHHCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHH
EAGGVDYVTKPIRPREVIARIAAHVRGARQARQARSALDAFGHAVITVRAGDGRVLWQTP
HCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEECCH
LARELLQALDATREAGTRGPVLSETLLDWMQAQAVLAATEQTGYPIVLAREGRRVSFALH
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEE
EATGEDEWLLVLTESNDRASIEGLAVAFRLTGREAEVLHWVAQGKTNRDIGDILGTSPRT
CCCCCCCEEEEEECCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCHHHHHCCCCHH
VHKHLEHVFAKLGVETRTSAAAMALGKLKRGAA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2115874; 10984043 [H]