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The map label for this gene is degP [H]

Identifier: 124265838

GI number: 124265838

Start: 678467

End: 679996

Strand: Direct

Name: degP [H]

Synonym: Mpe_A0645

Alternate gene names: 124265838

Gene position: 678467-679996 (Clockwise)

Preceding gene: 124265837

Following gene: 124265840

Centisome position: 16.78

GC content: 68.24

Gene sequence:

>1530_bases
ATGATGCAAGAAGCAAGAACTGAAATGCCGCGCTCGTCGTGGCGCGCGCGTTCCTGGGTCTGGGTGGCGGCGGCGAGCAT
CGCCGGCGCCTCGACGCTGGGGGGGCTGCTGATGTCTCCGCATGCCAGCCATGCGCAGCCGGCCGTGGCAGCGGCACGTG
GCCTGCCCGACTTCACCGACCTCGTCGAGCAGGTCGGCCCGGCGGTGGTGAACATCCGGACTACCGAGCGCACCCGCGGT
GGCCAACGCGGCGGTGGGGGTGCCGGCCCGGAGATGGACGAGGAAATGCAGGAGTTCTTCCGTCGCTTCTTCGGCGTGCC
GCCGGGGCAACTGCCTGGGCAGCGCCAAGATCCGCGGCGGCAGGCACCGGACGAAGAGCAACAGCGTGGCGTGGGTTCCG
GCTTCATTTTCACGACCGACGGCTACGTGATGACCAACGCGCACGTGGTCGACGGTGCCGACGAGGTGTACGTCACGCTG
ACGGACAAGCGCGAGTTCAAGGCCAAGCTGATCGGTGCTGACAAGCGCACCGACGTGGCCGTGGTCAAGATCGAGGCCGC
AGGCCTGCCGTCGGTGAAGATCGGCGACGTCAGCAAGTTGAAGGTCGGCGAATGGGTCATGGCGATCGGCTCGCCCTTCG
GCCTGGAGAACACGGTCACGGCGGGCATCGTCAGCGCCAAGGCGCGCGACACCGGCGAGTTCGTCCCCTTCATCCAGACC
GACGTGGCCATCAATCCCGGCAACTCCGGCGGTCCGTTGATCAACCTGCGCGGCGAGGTGGTCGGCATCAACTCGCAGAT
CCTCAGCCGCTCGGGCGGCTTCATGGGCATCTCCTTTGCCATTCCGATGGACGAAGCCACGCGCGTGGCGGACCAGTTGC
GTGCCGGTGGCCGTGTGGTGCGGGGTCGCATCGGCGTGCAGATCGGCGAGGTGACGAAGGACGTGGCCGAATCGCTCGGC
CTCGGCAAGGCGGCGGGGGCCCTGGTGCGTTCGGTCGAGGCCGGCGGGCCGGCCGACAAAGCCGGCGTCGAGGCGGGCGA
CATCATCACGCGCTTCGATGGCAAGCCGGTCGAGAAATCCAGCGACCTGCCGCGTCTGGTGGGGGGAACCAAGCCGGGGA
GCAAGGCAAGCCTGCAGGTCTTCCGCCGCGGCAGCGCGCGAGATCTTGGTGTGACGGTGGCAGAACTCGAGCCCGAACCG
GGACGCCGGGCGGCCGCACCGGAGAGCAAGCAGGCGCCGACGCCGAGCGTGGTGTCCGGCCTGGGCTTGACGCTGGCCAA
CCTGAGCGAGGAGCAGAAGCGCGAACTCAAGCTGCGTGGCGGCGTGCGTGTGGAAGCGACCGAAGGTGCGGCGGCGCGCG
CGGGCTTGCGTGAAGGCGACGTGATCCTGTCGGTCGGCAATGTCGAGATCGTCGACGTGAAGCAGTTCGAGGCCGTGATC
GCCAAGGTCGACAAGAGCAAGCCCATCAACGTGCTGTTCAGGCGAGGAGAGTGGGCGCAGTACGCGCTGATCCGCACGGC
GACCCGCTGA

Upstream 100 bases:

>100_bases
GCGGCGGCCTTGGAACCCCGCTGACGGATTCGCGATCTCACTGCGCCGGGCCGCGGGGTCCCGCGGCCAAGGCTCCCTGA
TCGACTGTTGGTACGAGGTG

Downstream 100 bases:

>100_bases
CGCAGCGCGGGGAAGGGCGGCGCGACGGTCGATCCGGGTCGTCAAGCCGTCGCCCCAGTCGTCAGTCTGGTTTTCCGCCA
GCTGAAATCGATTCGGCGAT

Product: peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MMQEARTEMPRSSWRARSWVWVAAASIAGASTLGGLLMSPHASHAQPAVAAARGLPDFTDLVEQVGPAVVNIRTTERTRG
GQRGGGGAGPEMDEEMQEFFRRFFGVPPGQLPGQRQDPRRQAPDEEQQRGVGSGFIFTTDGYVMTNAHVVDGADEVYVTL
TDKREFKAKLIGADKRTDVAVVKIEAAGLPSVKIGDVSKLKVGEWVMAIGSPFGLENTVTAGIVSAKARDTGEFVPFIQT
DVAINPGNSGGPLINLRGEVVGINSQILSRSGGFMGISFAIPMDEATRVADQLRAGGRVVRGRIGVQIGEVTKDVAESLG
LGKAAGALVRSVEAGGPADKAGVEAGDIITRFDGKPVEKSSDLPRLVGGTKPGSKASLQVFRRGSARDLGVTVAELEPEP
GRRAAAPESKQAPTPSVVSGLGLTLANLSEEQKRELKLRGGVRVEATEGAAARAGLREGDVILSVGNVEIVDVKQFEAVI
AKVDKSKPINVLFRRGEWAQYALIRTATR

Sequences:

>Translated_509_residues
MMQEARTEMPRSSWRARSWVWVAAASIAGASTLGGLLMSPHASHAQPAVAAARGLPDFTDLVEQVGPAVVNIRTTERTRG
GQRGGGGAGPEMDEEMQEFFRRFFGVPPGQLPGQRQDPRRQAPDEEQQRGVGSGFIFTTDGYVMTNAHVVDGADEVYVTL
TDKREFKAKLIGADKRTDVAVVKIEAAGLPSVKIGDVSKLKVGEWVMAIGSPFGLENTVTAGIVSAKARDTGEFVPFIQT
DVAINPGNSGGPLINLRGEVVGINSQILSRSGGFMGISFAIPMDEATRVADQLRAGGRVVRGRIGVQIGEVTKDVAESLG
LGKAAGALVRSVEAGGPADKAGVEAGDIITRFDGKPVEKSSDLPRLVGGTKPGSKASLQVFRRGSARDLGVTVAELEPEP
GRRAAAPESKQAPTPSVVSGLGLTLANLSEEQKRELKLRGGVRVEATEGAAARAGLREGDVILSVGNVEIVDVKQFEAVI
AKVDKSKPINVLFRRGEWAQYALIRTATR
>Mature_509_residues
MMQEARTEMPRSSWRARSWVWVAAASIAGASTLGGLLMSPHASHAQPAVAAARGLPDFTDLVEQVGPAVVNIRTTERTRG
GQRGGGGAGPEMDEEMQEFFRRFFGVPPGQLPGQRQDPRRQAPDEEQQRGVGSGFIFTTDGYVMTNAHVVDGADEVYVTL
TDKREFKAKLIGADKRTDVAVVKIEAAGLPSVKIGDVSKLKVGEWVMAIGSPFGLENTVTAGIVSAKARDTGEFVPFIQT
DVAINPGNSGGPLINLRGEVVGINSQILSRSGGFMGISFAIPMDEATRVADQLRAGGRVVRGRIGVQIGEVTKDVAESLG
LGKAAGALVRSVEAGGPADKAGVEAGDIITRFDGKPVEKSSDLPRLVGGTKPGSKASLQVFRRGSARDLGVTVAELEPEP
GRRAAAPESKQAPTPSVVSGLGLTLANLSEEQKRELKLRGGVRVEATEGAAARAGLREGDVILSVGNVEIVDVKQFEAVI
AKVDKSKPINVLFRRGEWAQYALIRTATR

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=429, Percent_Identity=32.1678321678322, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI22129776, Length=284, Percent_Identity=36.9718309859155, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI24308541, Length=250, Percent_Identity=37.6, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI7019477, Length=275, Percent_Identity=36.3636363636364, Blast_Score=135, Evalue=1e-31,
Organism=Escherichia coli, GI1789629, Length=459, Percent_Identity=37.037037037037, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1786356, Length=493, Percent_Identity=33.2657200811359, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1789630, Length=280, Percent_Identity=39.6428571428571, Blast_Score=180, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24646839, Length=291, Percent_Identity=35.7388316151203, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 53743; Mature: 53743

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: PS50106 PDZ ; PS01094 UPF0076

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQEARTEMPRSSWRARSWVWVAAASIAGASTLGGLLMSPHASHAQPAVAAARGLPDFTD
CCCHHHHCCCHHHCCCCCEEEEEEHHHCCHHHHCHHHCCCCCCCCCHHHHHHCCCCHHHH
LVEQVGPAVVNIRTTERTRGGQRGGGGAGPEMDEEMQEFFRRFFGVPPGQLPGQRQDPRR
HHHHCCCEEEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
QAPDEEQQRGVGSGFIFTTDGYVMTNAHVVDGADEVYVTLTDKREFKAKLIGADKRTDVA
CCCCHHHHCCCCCCEEEEECCEEEECCEEECCCCEEEEEEECCCCHHHHEECCCCCCCEE
VVKIEAAGLPSVKIGDVSKLKVGEWVMAIGSPFGLENTVTAGIVSAKARDTGEFVPFIQT
EEEEEECCCCCEEECCCCEEEHHHHHHECCCCCCCCCCHHHHEEECCCCCCCCCCCEEEE
DVAINPGNSGGPLINLRGEVVGINSQILSRSGGFMGISFAIPMDEATRVADQLRAGGRVV
CEEECCCCCCCCEEEECCCEEECCHHHHHCCCCEEEEEEEECCHHHHHHHHHHHCCCEEE
RGRIGVQIGEVTKDVAESLGLGKAAGALVRSVEAGGPADKAGVEAGDIITRFDGKPVEKS
EEEECEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCC
SDLPRLVGGTKPGSKASLQVFRRGSARDLGVTVAELEPEPGRRAAAPESKQAPTPSVVSG
CCCCHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHH
LGLTLANLSEEQKRELKLRGGVRVEATEGAAARAGLREGDVILSVGNVEIVDVKQFEAVI
CCHHHHHCCHHHHHHHHHCCCEEEEECCCCHHHCCCCCCCEEEEECCEEEEEHHHHHHHH
AKVDKSKPINVLFRRGEWAQYALIRTATR
HHHCCCCCEEEEEECCCCCEEEEEEECCC
>Mature Secondary Structure
MMQEARTEMPRSSWRARSWVWVAAASIAGASTLGGLLMSPHASHAQPAVAAARGLPDFTD
CCCHHHHCCCHHHCCCCCEEEEEEHHHCCHHHHCHHHCCCCCCCCCHHHHHHCCCCHHHH
LVEQVGPAVVNIRTTERTRGGQRGGGGAGPEMDEEMQEFFRRFFGVPPGQLPGQRQDPRR
HHHHCCCEEEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
QAPDEEQQRGVGSGFIFTTDGYVMTNAHVVDGADEVYVTLTDKREFKAKLIGADKRTDVA
CCCCHHHHCCCCCCEEEEECCEEEECCEEECCCCEEEEEEECCCCHHHHEECCCCCCCEE
VVKIEAAGLPSVKIGDVSKLKVGEWVMAIGSPFGLENTVTAGIVSAKARDTGEFVPFIQT
EEEEEECCCCCEEECCCCEEEHHHHHHECCCCCCCCCCHHHHEEECCCCCCCCCCCEEEE
DVAINPGNSGGPLINLRGEVVGINSQILSRSGGFMGISFAIPMDEATRVADQLRAGGRVV
CEEECCCCCCCCEEEECCCEEECCHHHHHCCCCEEEEEEEECCHHHHHHHHHHHCCCEEE
RGRIGVQIGEVTKDVAESLGLGKAAGALVRSVEAGGPADKAGVEAGDIITRFDGKPVEKS
EEEECEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCC
SDLPRLVGGTKPGSKASLQVFRRGSARDLGVTVAELEPEPGRRAAAPESKQAPTPSVVSG
CCCCHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHH
LGLTLANLSEEQKRELKLRGGVRVEATEGAAARAGLREGDVILSVGNVEIVDVKQFEAVI
CCHHHHHCCHHHHHHHHHCCCEEEEECCCCHHHCCCCCCCEEEEECCEEEEEHHHHHHHH
AKVDKSKPINVLFRRGEWAQYALIRTATR
HHHCCCCCEEEEEECCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]