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The map label for this gene is mucB [H]

Identifier: 124265837

GI number: 124265837

Start: 677368

End: 678390

Strand: Direct

Name: mucB [H]

Synonym: Mpe_A0644

Alternate gene names: 124265837

Gene position: 677368-678390 (Clockwise)

Preceding gene: 124265836

Following gene: 124265838

Centisome position: 16.75

GC content: 67.74

Gene sequence:

>1023_bases
ATGCCGGCCGTCGTGCTGATGGCCGCGTTGTTGCCCTCCGCGACCCGAGCCCAGGCCGGGGGCGATCCGCTGGTCGAGGC
GCGCGATGCACGCTACTGGCTGGCGCGCATCCACGAGGCGGCCGGGAAGCGCAACTTCCAGGGAACGTTCGTCGTGACGG
CGGCCGGCTCGGTGGCGAGTTCGCGCATCGTGCACTTCTGCGACGGTCGCAACCAGTTCGAGCGCATCGAGTCGCTCGAT
GGTCAGCACCGTCAGGTCTACCGTCACAACGATCTCGTGCACAGCCTGTGGCCGCACAGCCGTGTCGCGGTGGTGGAGAC
GCGGCAGGCCATGGGGCAGTTCCCCCTGTTGCTGTCGGCCGGCGCTGACCGCATCGTGCCGTTCTACGACGTCAAGTCGC
TGGGCGACGGGCGCGTGGCGGGGCACGAGGCCAATGTGCTGCTGCTTCAACCCAAGGACGGCTACCGCTTCGGCTACCGC
CTGTGGGCCGAGCGCAGCTCCGGCCTCTTGTTGCGATCCGAGGTGTTCGACGAGCGCGATGTCGTGCTGGAGACCTCGGC
CTTTTCCGAGGTGTCCATCGGCGTGAAGCCCCGGCCGGAGTCGGTGCTGCAAGCGATGAAGCGACTGGACGGCTATCGCG
TCGAGCGACCGACGCTGCAGCAGGTGGACATCGGGCGAGAGGGGTGGTTGCTGAATGCCTTGCCACCGGGCTTCCGGCAC
GTCAGCAGCGTCAAGCGCCTGATGACCGTGGCTGGAGGGGAGCAGCCCCGGCCTGCTGCTGCCCAGGAAGAGTTCCCCTT
GGCGCCGCCTTCGGTGCTGCAGGTCATCTACTCCGATGGCCTCACCTACGTGTCGGTGTTCATCGAGCCCTACATGCCGC
GCCTGCACCGCCGGGAGATGCTGATGTCGCTGGGTGCAACCCAGACTCTGGTGAAGCGCCGGGGTGAATGGTGGATCACC
GTGATCGGCGATGTCCCCGTCGTGACCCTGCGCGCGTTCGCGGCGGCCTTGGAACCCCGCTGA

Upstream 100 bases:

>100_bases
GCGTGCCGTCGGGTTTCCTGCGCAGCGCGACCTACGACGGCGCCACGGCGGCCGCGCGCTGAACATGCTGCAGAACATCG
TCGCGCGGGGATGGCGCGCC

Downstream 100 bases:

>100_bases
CGGATTCGCGATCTCACTGCGCCGGGCCGCGGGGTCCCGCGGCCAAGGCTCCCTGATCGACTGTTGGTACGAGGTGATGA
TGCAAGAAGCAAGAACTGAA

Product: sigma E regulatory protein, MucB/RseB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MPAVVLMAALLPSATRAQAGGDPLVEARDARYWLARIHEAAGKRNFQGTFVVTAAGSVASSRIVHFCDGRNQFERIESLD
GQHRQVYRHNDLVHSLWPHSRVAVVETRQAMGQFPLLLSAGADRIVPFYDVKSLGDGRVAGHEANVLLLQPKDGYRFGYR
LWAERSSGLLLRSEVFDERDVVLETSAFSEVSIGVKPRPESVLQAMKRLDGYRVERPTLQQVDIGREGWLLNALPPGFRH
VSSVKRLMTVAGGEQPRPAAAQEEFPLAPPSVLQVIYSDGLTYVSVFIEPYMPRLHRREMLMSLGATQTLVKRRGEWWIT
VIGDVPVVTLRAFAAALEPR

Sequences:

>Translated_340_residues
MPAVVLMAALLPSATRAQAGGDPLVEARDARYWLARIHEAAGKRNFQGTFVVTAAGSVASSRIVHFCDGRNQFERIESLD
GQHRQVYRHNDLVHSLWPHSRVAVVETRQAMGQFPLLLSAGADRIVPFYDVKSLGDGRVAGHEANVLLLQPKDGYRFGYR
LWAERSSGLLLRSEVFDERDVVLETSAFSEVSIGVKPRPESVLQAMKRLDGYRVERPTLQQVDIGREGWLLNALPPGFRH
VSSVKRLMTVAGGEQPRPAAAQEEFPLAPPSVLQVIYSDGLTYVSVFIEPYMPRLHRREMLMSLGATQTLVKRRGEWWIT
VIGDVPVVTLRAFAAALEPR
>Mature_339_residues
PAVVLMAALLPSATRAQAGGDPLVEARDARYWLARIHEAAGKRNFQGTFVVTAAGSVASSRIVHFCDGRNQFERIESLDG
QHRQVYRHNDLVHSLWPHSRVAVVETRQAMGQFPLLLSAGADRIVPFYDVKSLGDGRVAGHEANVLLLQPKDGYRFGYRL
WAERSSGLLLRSEVFDERDVVLETSAFSEVSIGVKPRPESVLQAMKRLDGYRVERPTLQQVDIGREGWLLNALPPGFRHV
SSVKRLMTVAGGEQPRPAAAQEEFPLAPPSVLQVIYSDGLTYVSVFIEPYMPRLHRREMLMSLGATQTLVKRRGEWWITV
IGDVPVVTLRAFAAALEPR

Specific function: Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate- producing form. Inactivation of mucB causes conversion to mucoidy [H]

COG id: COG3026

COG function: function code T; Negative regulator of sigma E activity

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rseB family [H]

Homologues:

Organism=Escherichia coli, GI1788924, Length=308, Percent_Identity=23.0519480519481, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005588 [H]

Pfam domain/function: PF03888 MucB_RseB [H]

EC number: NA

Molecular weight: Translated: 37885; Mature: 37754

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAVVLMAALLPSATRAQAGGDPLVEARDARYWLARIHEAAGKRNFQGTFVVTAAGSVAS
CCHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHH
SRIVHFCDGRNQFERIESLDGQHRQVYRHNDLVHSLWPHSRVAVVETRQAMGQFPLLLSA
CCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCEEEEC
GADRIVPFYDVKSLGDGRVAGHEANVLLLQPKDGYRFGYRLWAERSSGLLLRSEVFDERD
CCCCCEEEHHHCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCCEEEEHHHCCCCC
VVLETSAFSEVSIGVKPRPESVLQAMKRLDGYRVERPTLQQVDIGREGWLLNALPPGFRH
EEEEECCCCEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCEECCCCCCHHH
VSSVKRLMTVAGGEQPRPAAAQEEFPLAPPSVLQVIYSDGLTYVSVFIEPYMPRLHRREM
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHH
LMSLGATQTLVKRRGEWWITVIGDVPVVTLRAFAAALEPR
HHHCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PAVVLMAALLPSATRAQAGGDPLVEARDARYWLARIHEAAGKRNFQGTFVVTAAGSVAS
CHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHH
SRIVHFCDGRNQFERIESLDGQHRQVYRHNDLVHSLWPHSRVAVVETRQAMGQFPLLLSA
CCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCEEEEC
GADRIVPFYDVKSLGDGRVAGHEANVLLLQPKDGYRFGYRLWAERSSGLLLRSEVFDERD
CCCCCEEEHHHCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCCEEEEHHHCCCCC
VVLETSAFSEVSIGVKPRPESVLQAMKRLDGYRVERPTLQQVDIGREGWLLNALPPGFRH
EEEEECCCCEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCEECCCCCCHHH
VSSVKRLMTVAGGEQPRPAAAQEEFPLAPPSVLQVIYSDGLTYVSVFIEPYMPRLHRREM
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHH
LMSLGATQTLVKRRGEWWITVIGDVPVVTLRAFAAALEPR
HHHCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8412698; 8378309; 8444793; 10984043 [H]