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The map label for this gene is hemK [H]

Identifier: 124265715

GI number: 124265715

Start: 559502

End: 560329

Strand: Reverse

Name: hemK [H]

Synonym: Mpe_A0522

Alternate gene names: 124265715

Gene position: 560329-559502 (Counterclockwise)

Preceding gene: 124265716

Following gene: 124265714

Centisome position: 13.86

GC content: 71.26

Gene sequence:

>828_bases
GTGCCGCCCCCCGACAGCGTCGCCGCCGCGCTGCTGGCGGCCCGCGAGCGCGGCATCGACCGGCTCGACGCGCAGTGCCT
GCTCAGCGCGGTTCTCGCACGCCCCCGCAGCTGGCTGCTGGCGCACGCGGACGAGGCTCTCGATCCCCAGGCAGCCCGTC
ACTACGACGCCTTGCTGGCGCGCCGCGCTGCCGGCGAACCCTTGGCCTATGTGCTGGGCGAGAAGGAGTTCTTCGGCCTG
AGGCTGGAGGTGACGCCCGATGTCCTGATCCCCCGCGCCGATACCGAGACCCTGGTGGAATGGGCGCTCGAGCTGCTGCC
CTGCAATGTCGAGACTGCCGTGGCCGACCTTGGCACGGGAAGCGGCGCGATCGCGCTGGCGCTGGCCGCGCGACGCCCCA
CGTGCCGTGTGACCGCCGTGGACGCCAGCTCGGACGCCCTCGCGGTCGCCGAGCGGAACGGCGGCAGACTTGGCTTGGCG
GTCGAATGGCGGCTCAGCGACTGGTTCTCGGCCCTCGAAGGCCGCCGATTCGCGCTGATCGTCAGCAATCCGCCCTACAT
CGCCGATGGCGACTGCCACCTCGATGCCCTGACACATGAACCGCAGCGTGCGCTCACCTCCGGACCTGACGGCTTGGCAG
CGATCCGTCACATCGTTGCGAGCGCCGCGAGCTTCCTGACAGCGGGCGGCTGGCTGCTGATCGAGCACGGCTATGACCAA
GCCGAGGCGGTCCAGGCTTTGCTCGGCGTGGCGGGCTTCGAGCACATCGCCACCCGGCATGACCTGGGCGGCCAGCCACG
CTGCTCGGGCGGTCGCTGCCGCGACTGA

Upstream 100 bases:

>100_bases
TCATGGACGGTGACCTCGACCCGGTCGTGAAGGCGCTGGTAGCGGCGCGCGAGGCCGAGTTGCTGGCCGAGCTGGAAATC
GGCTGAGGATGAGCTGCCCA

Downstream 100 bases:

>100_bases
ACCTGGGAGGGCCCCGGCCCCGGTGCGCGGACCGTGCGAAAGATCGCACCGCCACGCGCGTGCCTGTTGCGATCCGACGA
CCCCGATCCCACAAGCCGTC

Product: hemK protein

Products: NA

Alternate protein names: M.VchAHemK2P [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MPPPDSVAAALLAARERGIDRLDAQCLLSAVLARPRSWLLAHADEALDPQAARHYDALLARRAAGEPLAYVLGEKEFFGL
RLEVTPDVLIPRADTETLVEWALELLPCNVETAVADLGTGSGAIALALAARRPTCRVTAVDASSDALAVAERNGGRLGLA
VEWRLSDWFSALEGRRFALIVSNPPYIADGDCHLDALTHEPQRALTSGPDGLAAIRHIVASAASFLTAGGWLLIEHGYDQ
AEAVQALLGVAGFEHIATRHDLGGQPRCSGGRCRD

Sequences:

>Translated_275_residues
MPPPDSVAAALLAARERGIDRLDAQCLLSAVLARPRSWLLAHADEALDPQAARHYDALLARRAAGEPLAYVLGEKEFFGL
RLEVTPDVLIPRADTETLVEWALELLPCNVETAVADLGTGSGAIALALAARRPTCRVTAVDASSDALAVAERNGGRLGLA
VEWRLSDWFSALEGRRFALIVSNPPYIADGDCHLDALTHEPQRALTSGPDGLAAIRHIVASAASFLTAGGWLLIEHGYDQ
AEAVQALLGVAGFEHIATRHDLGGQPRCSGGRCRD
>Mature_274_residues
PPPDSVAAALLAARERGIDRLDAQCLLSAVLARPRSWLLAHADEALDPQAARHYDALLARRAAGEPLAYVLGEKEFFGLR
LEVTPDVLIPRADTETLVEWALELLPCNVETAVADLGTGSGAIALALAARRPTCRVTAVDASSDALAVAERNGGRLGLAV
EWRLSDWFSALEGRRFALIVSNPPYIADGDCHLDALTHEPQRALTSGPDGLAAIRHIVASAASFLTAGGWLLIEHGYDQA
EAVQALLGVAGFEHIATRHDLGGQPRCSGGRCRD

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=249, Percent_Identity=32.5301204819277, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1787463, Length=255, Percent_Identity=45.8823529411765, Blast_Score=206, Evalue=1e-54,
Organism=Escherichia coli, GI87082085, Length=176, Percent_Identity=38.6363636363636, Blast_Score=96, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24582226, Length=243, Percent_Identity=27.5720164609054, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 29215; Mature: 29084

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPPDSVAAALLAARERGIDRLDAQCLLSAVLARPRSWLLAHADEALDPQAARHYDALLA
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHCCHHCCHHHHHHHHHHHH
RRAAGEPLAYVLGEKEFFGLRLEVTPDVLIPRADTETLVEWALELLPCNVETAVADLGTG
HHHCCCCCEEEECCCCCEEEEEEECCCEEECCCCHHHHHHHHHHHHCCCHHHHHHHCCCC
SGAIALALAARRPTCRVTAVDASSDALAVAERNGGRLGLAVEWRLSDWFSALEGRRFALI
CCCEEEEEECCCCCEEEEEECCCCCEEEEEECCCCEEEEEEEEEHHHHHHHHCCCEEEEE
VSNPPYIADGDCHLDALTHEPQRALTSGPDGLAAIRHIVASAASFLTAGGWLLIEHGYDQ
ECCCCEEECCCCEEHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCH
AEAVQALLGVAGFEHIATRHDLGGQPRCSGGRCRD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PPPDSVAAALLAARERGIDRLDAQCLLSAVLARPRSWLLAHADEALDPQAARHYDALLA
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHCCHHCCHHHHHHHHHHHH
RRAAGEPLAYVLGEKEFFGLRLEVTPDVLIPRADTETLVEWALELLPCNVETAVADLGTG
HHHCCCCCEEEECCCCCEEEEEEECCCEEECCCCHHHHHHHHHHHHCCCHHHHHHHCCCC
SGAIALALAARRPTCRVTAVDASSDALAVAERNGGRLGLAVEWRLSDWFSALEGRRFALI
CCCEEEEEECCCCCEEEEEECCCCCEEEEEECCCCEEEEEEEEEHHHHHHHHCCCEEEEE
VSNPPYIADGDCHLDALTHEPQRALTSGPDGLAAIRHIVASAASFLTAGGWLLIEHGYDQ
ECCCCEEECCCCEEHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCH
AEAVQALLGVAGFEHIATRHDLGGQPRCSGGRCRD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]