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The map label for this gene is zitB [H]

Identifier: 124265685

GI number: 124265685

Start: 534019

End: 535080

Strand: Reverse

Name: zitB [H]

Synonym: Mpe_A0492

Alternate gene names: 124265685

Gene position: 535080-534019 (Counterclockwise)

Preceding gene: 124265686

Following gene: 124265683

Centisome position: 13.23

GC content: 71.94

Gene sequence:

>1062_bases
ATGCACGCGCACGACCTCAGCCCCTGGCAGCACCGCCACGACTTCGCCGCCGACCGTGGGGCCGCCGAACGGCGTACCCA
CTGGGTGATCGGCATCACGCTCGTGATGATGATCGCCGAGATCGCGGCCGGCTGGTGGTGGCACTCGATGGCCCTGCTGG
CCGATGGCTGGCACATGGGCACGCACGCCGCCGCCATCGGCGTGGCGGCGCTGAGCTATGCGCTGGCGCGTCGCTGGGCC
GGCGATGCCCGCTTCTCGCTCGGGCCCTGGAAGGTCGAGGTGCTGGGGGCCTACACCAGCGCCGTACTGCTGGGCGTGGT
GGCGATCGGCATCGCGGTCGAGTCGGGCCTGCGCCTGTGGGCGCCGGAGCCGGTGGCCTACGACGAGTCGCTGGTCGTCG
CCGCGATCGGGCTGGCCGTCAACGCCGTGTGCGCGAAGCTGCTGCACGGCGGCCACGATCACGCGCCCGGCCCTGGGCAC
ACCGGCCACGATCACGGCCACCACGACCATCACGCACATCACGCACACGCCGTCGAACACACCGGACAGGAGCATGCCCA
TGCCGCCACCGACGGCAAGGACCTGAACCTGCGCGCCGCCTACCTGCACGTGCTGGCCGATGCCGCCACCTCCGTGCTGG
CGATCGGTGCGCTGCTGGCCGGCAAGTACGCCGGCTGGGTGTGGGTCGACCCGCTCGTCGGCCTGCTGGGCGCGGCGCTG
ATCGCGGTCTGGTCGTTCGGCCTGCTGCGACAGACGTCGACGATCCTGCTCGATCGCGAGATGGACCATCCGCTCGCGCA
TCAGGTGCGCGAGCAGCTCGAATCCGACGGCGACGCGCGCGTGGCCGACCTGCACCTGTGGCGTGTCGGCGATGCGCAGT
TCGCCTGCCAGGCCACGCTGGTGGCCGACACGCCGCTTGCCGCCGACCACTACCGCGACCGGCTCGACGGCCTGGCCGGC
CTGGCGCACGTGTCCATCGAGATCAATCGCTGCCGCGGTGCATCACTCACCGCCACCCAGGACCACCGCCACGGCCATGA
GCCGGGCCCCCACGCGCACTGA

Upstream 100 bases:

>100_bases
CGTCACGGCAATCGAACTCGCGAAGTGAGGCGCGCGACAGCGCGCGACGGCGGAGGTCACCGCCCACCGGGCCGCGCCTC
TGCCGGCTAAGCTAGGGCCC

Downstream 100 bases:

>100_bases
AATCTGCGCCGGCCGCAACCGGCCGAGCGGCGCGTTCGCCGCGCGTCAGAAGTGGATGCCGCGCATCATCTGCTGCAGCG
CCACCGCCTCGGCCGACAGC

Product: cation efflux system protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MHAHDLSPWQHRHDFAADRGAAERRTHWVIGITLVMMIAEIAAGWWWHSMALLADGWHMGTHAAAIGVAALSYALARRWA
GDARFSLGPWKVEVLGAYTSAVLLGVVAIGIAVESGLRLWAPEPVAYDESLVVAAIGLAVNAVCAKLLHGGHDHAPGPGH
TGHDHGHHDHHAHHAHAVEHTGQEHAHAATDGKDLNLRAAYLHVLADAATSVLAIGALLAGKYAGWVWVDPLVGLLGAAL
IAVWSFGLLRQTSTILLDREMDHPLAHQVREQLESDGDARVADLHLWRVGDAQFACQATLVADTPLAADHYRDRLDGLAG
LAHVSIEINRCRGASLTATQDHRHGHEPGPHAH

Sequences:

>Translated_353_residues
MHAHDLSPWQHRHDFAADRGAAERRTHWVIGITLVMMIAEIAAGWWWHSMALLADGWHMGTHAAAIGVAALSYALARRWA
GDARFSLGPWKVEVLGAYTSAVLLGVVAIGIAVESGLRLWAPEPVAYDESLVVAAIGLAVNAVCAKLLHGGHDHAPGPGH
TGHDHGHHDHHAHHAHAVEHTGQEHAHAATDGKDLNLRAAYLHVLADAATSVLAIGALLAGKYAGWVWVDPLVGLLGAAL
IAVWSFGLLRQTSTILLDREMDHPLAHQVREQLESDGDARVADLHLWRVGDAQFACQATLVADTPLAADHYRDRLDGLAG
LAHVSIEINRCRGASLTATQDHRHGHEPGPHAH
>Mature_353_residues
MHAHDLSPWQHRHDFAADRGAAERRTHWVIGITLVMMIAEIAAGWWWHSMALLADGWHMGTHAAAIGVAALSYALARRWA
GDARFSLGPWKVEVLGAYTSAVLLGVVAIGIAVESGLRLWAPEPVAYDESLVVAAIGLAVNAVCAKLLHGGHDHAPGPGH
TGHDHGHHDHHAHHAHAVEHTGQEHAHAATDGKDLNLRAAYLHVLADAATSVLAIGALLAGKYAGWVWVDPLVGLLGAAL
IAVWSFGLLRQTSTILLDREMDHPLAHQVREQLESDGDARVADLHLWRVGDAQFACQATLVADTPLAADHYRDRLDGLAG
LAHVSIEINRCRGASLTATQDHRHGHEPGPHAH

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI222080086, Length=302, Percent_Identity=26.158940397351, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI40255009, Length=302, Percent_Identity=26.158940397351, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI20070323, Length=270, Percent_Identity=28.5185185185185, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI21359890, Length=258, Percent_Identity=27.1317829457364, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI52352805, Length=282, Percent_Identity=25.177304964539, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786966, Length=270, Percent_Identity=29.2592592592593, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32564488, Length=267, Percent_Identity=30.7116104868914, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17555794, Length=299, Percent_Identity=27.0903010033445, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17555796, Length=298, Percent_Identity=27.1812080536913, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI193210990, Length=291, Percent_Identity=26.1168384879725, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323899, Length=328, Percent_Identity=25.3048780487805, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24656728, Length=311, Percent_Identity=27.3311897106109, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24656724, Length=311, Percent_Identity=27.3311897106109, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24656720, Length=311, Percent_Identity=27.3311897106109, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24656715, Length=311, Percent_Identity=27.3311897106109, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21357035, Length=311, Percent_Identity=27.3311897106109, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24645863, Length=274, Percent_Identity=25.1824817518248, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 37913; Mature: 37913

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAHDLSPWQHRHDFAADRGAAERRTHWVIGITLVMMIAEIAAGWWWHSMALLADGWHMG
CCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
THAAAIGVAALSYALARRWAGDARFSLGPWKVEVLGAYTSAVLLGVVAIGIAVESGLRLW
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEE
APEPVAYDESLVVAAIGLAVNAVCAKLLHGGHDHAPGPGHTGHDHGHHDHHAHHAHAVEH
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
TGQEHAHAATDGKDLNLRAAYLHVLADAATSVLAIGALLAGKYAGWVWVDPLVGLLGAAL
CCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHH
IAVWSFGLLRQTSTILLDREMDHPLAHQVREQLESDGDARVADLHLWRVGDAQFACQATL
HHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCEEEEEE
VADTPLAADHYRDRLDGLAGLAHVSIEINRCRGASLTATQDHRHGHEPGPHAH
EECCCCCHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHAHDLSPWQHRHDFAADRGAAERRTHWVIGITLVMMIAEIAAGWWWHSMALLADGWHMG
CCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
THAAAIGVAALSYALARRWAGDARFSLGPWKVEVLGAYTSAVLLGVVAIGIAVESGLRLW
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEE
APEPVAYDESLVVAAIGLAVNAVCAKLLHGGHDHAPGPGHTGHDHGHHDHHAHHAHAVEH
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
TGQEHAHAATDGKDLNLRAAYLHVLADAATSVLAIGALLAGKYAGWVWVDPLVGLLGAAL
CCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHH
IAVWSFGLLRQTSTILLDREMDHPLAHQVREQLESDGDARVADLHLWRVGDAQFACQATL
HHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCEEEEEE
VADTPLAADHYRDRLDGLAGLAHVSIEINRCRGASLTATQDHRHGHEPGPHAH
EECCCCCHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]