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The map label for this gene is cysK [H]

Identifier: 124265643

GI number: 124265643

Start: 488195

End: 489115

Strand: Reverse

Name: cysK [H]

Synonym: Mpe_A0450

Alternate gene names: 124265643

Gene position: 489115-488195 (Counterclockwise)

Preceding gene: 124265667

Following gene: 124265640

Centisome position: 12.09

GC content: 70.14

Gene sequence:

>921_bases
ATGAAAGCCAACACCGTCCTCGACACCATCGGCAGCACCCCGCACATCCGCATGCAGCGGTTGTTCGGCGCCGGGCACGA
GGTGTGGATCAAGTCCGAGCGCAGCAACCCCGGCGGCTCGATCAAGGACCGCATCGCGCTGTCGATGGTCGAGGCGGCCG
AACGCGACGGCCGGCTGCGCAGCGGCGGCACGATCATCGAGCCGACCTCTGGCAACACCGGCGTCGGCCTGGCGATGGTG
GCCGCGGTCAAGGGCTACCGGCTGGTGCTGGTGATGCCCGACAGCATGAGCGTGGAGCGCCGCCGCCTGATGCTGGCCTA
CGGCGCGAGCTTCGTGCTGACGCCGCGCGAGCAGGGCATGAAGGGCGCGATCGCCAAGGCCCAGGAACTGATCGCCGCGA
CACCCGGTTCGTGGATGCCGCAGCAGTTCGACAACCCGGCCAACATCGACGTGCACGTGCGCACCACGGCGCAGGAGATC
CTGGCCGACTTCCCGCAGGGCCTGGACGCGTTGATCACCGGCGTGGGCACCGGCGGGCACATCACCGGCTGCGCGCAGGT
GCTGAAGGCGCAGTGGCCGCAGCTCAAGGTGTTCGCGGTGGAGCCGAGCGCCTCCCCGGTCATCTCGGGCGGCAAGCCGT
CTCCGCACCCGATCCAGGGCATCGGCGCCGGCTTCGTGCCGACCAACCTGCACACCGCGCTGCTCGACGGCGTGATCCAG
GTCGAGGCGGAAGCGGCCCGCGAGATGGCGCGGCGTTCGGCACGTGACGAAGGCCTGCTGGTGGGCATCTCGTCCGGGGC
CACGCTGGCGGCGATCGCCCAGAAGCTGCCCGAGCTGCCGGCCGGCAGCCGTGTGCTGGGATTCAACTACGACACCGGCG
AGCGCTATCTGTCGATCGAGGGCTTCCTGCCGGCGGAGTGA

Upstream 100 bases:

>100_bases
ACGGCCTTTCGGCCGGTGTGCCAGCGGCGGTCTGGCCCACTTCACCGATGGATTATCGTTGCAGCCGCGAGCACCGTCCG
CCCAACGCTGAGGAGACCCT

Downstream 100 bases:

>100_bases
TCAGGACCGCAGCCGGACCTGCTCCGGCTTGTCGGCCGGCAGCATCTCGAAGTGCGGCTCGAGCCGCTTGAACAGCGCCG
ACGGCCGGCCGTTCTTCTTC

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKANTVLDTIGSTPHIRMQRLFGAGHEVWIKSERSNPGGSIKDRIALSMVEAAERDGRLRSGGTIIEPTSGNTGVGLAMV
AAVKGYRLVLVMPDSMSVERRRLMLAYGASFVLTPREQGMKGAIAKAQELIAATPGSWMPQQFDNPANIDVHVRTTAQEI
LADFPQGLDALITGVGTGGHITGCAQVLKAQWPQLKVFAVEPSASPVISGGKPSPHPIQGIGAGFVPTNLHTALLDGVIQ
VEAEAAREMARRSARDEGLLVGISSGATLAAIAQKLPELPAGSRVLGFNYDTGERYLSIEGFLPAE

Sequences:

>Translated_306_residues
MKANTVLDTIGSTPHIRMQRLFGAGHEVWIKSERSNPGGSIKDRIALSMVEAAERDGRLRSGGTIIEPTSGNTGVGLAMV
AAVKGYRLVLVMPDSMSVERRRLMLAYGASFVLTPREQGMKGAIAKAQELIAATPGSWMPQQFDNPANIDVHVRTTAQEI
LADFPQGLDALITGVGTGGHITGCAQVLKAQWPQLKVFAVEPSASPVISGGKPSPHPIQGIGAGFVPTNLHTALLDGVIQ
VEAEAAREMARRSARDEGLLVGISSGATLAAIAQKLPELPAGSRVLGFNYDTGERYLSIEGFLPAE
>Mature_306_residues
MKANTVLDTIGSTPHIRMQRLFGAGHEVWIKSERSNPGGSIKDRIALSMVEAAERDGRLRSGGTIIEPTSGNTGVGLAMV
AAVKGYRLVLVMPDSMSVERRRLMLAYGASFVLTPREQGMKGAIAKAQELIAATPGSWMPQQFDNPANIDVHVRTTAQEI
LADFPQGLDALITGVGTGGHITGCAQVLKAQWPQLKVFAVEPSASPVISGGKPSPHPIQGIGAGFVPTNLHTALLDGVIQ
VEAEAAREMARRSARDEGLLVGISSGATLAAIAQKLPELPAGSRVLGFNYDTGERYLSIEGFLPAE

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=321, Percent_Identity=39.5638629283489, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI295821200, Length=321, Percent_Identity=39.5638629283489, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI4557415, Length=321, Percent_Identity=39.5638629283489, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI11345492, Length=201, Percent_Identity=31.8407960199005, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1788754, Length=305, Percent_Identity=46.8852459016393, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI2367138, Length=300, Percent_Identity=38, Blast_Score=192, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI115535073, Length=293, Percent_Identity=49.1467576791809, Blast_Score=225, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17535051, Length=295, Percent_Identity=41.6949152542373, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17562970, Length=299, Percent_Identity=40.4682274247492, Blast_Score=214, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI32566674, Length=294, Percent_Identity=41.156462585034, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17561720, Length=299, Percent_Identity=39.4648829431438, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17534315, Length=311, Percent_Identity=36.3344051446945, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25147552, Length=310, Percent_Identity=35.1612903225806, Blast_Score=154, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=39.4366197183099, Blast_Score=147, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17561716, Length=119, Percent_Identity=40.3361344537815, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=35.2380952380952, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321449, Length=326, Percent_Identity=33.7423312883436, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24643623, Length=305, Percent_Identity=35.7377049180328, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI20129101, Length=305, Percent_Identity=35.7377049180328, Blast_Score=163, Evalue=1e-40,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32310; Mature: 32310

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKANTVLDTIGSTPHIRMQRLFGAGHEVWIKSERSNPGGSIKDRIALSMVEAAERDGRLR
CCCCHHHHHCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCC
SGGTIIEPTSGNTGVGLAMVAAVKGYRLVLVMPDSMSVERRRLMLAYGASFVLTPREQGM
CCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHEEEEECCEEEECCHHCCC
KGAIAKAQELIAATPGSWMPQQFDNPANIDVHVRTTAQEILADFPQGLDALITGVGTGGH
HHHHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEECCHHHHHHHCCCCHHHHHHCCCCCCC
ITGCAQVLKAQWPQLKVFAVEPSASPVISGGKPSPHPIQGIGAGFVPTNLHTALLDGVIQ
HHHHHHHHHCCCCCEEEEEECCCCCCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHE
VEAEAAREMARRSARDEGLLVGISSGATLAAIAQKLPELPAGSRVLGFNYDTGERYLSIE
EHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEE
GFLPAE
CCCCCC
>Mature Secondary Structure
MKANTVLDTIGSTPHIRMQRLFGAGHEVWIKSERSNPGGSIKDRIALSMVEAAERDGRLR
CCCCHHHHHCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCC
SGGTIIEPTSGNTGVGLAMVAAVKGYRLVLVMPDSMSVERRRLMLAYGASFVLTPREQGM
CCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHEEEEECCEEEECCHHCCC
KGAIAKAQELIAATPGSWMPQQFDNPANIDVHVRTTAQEILADFPQGLDALITGVGTGGH
HHHHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEECCHHHHHHHCCCCHHHHHHCCCCCCC
ITGCAQVLKAQWPQLKVFAVEPSASPVISGGKPSPHPIQGIGAGFVPTNLHTALLDGVIQ
HHHHHHHHHCCCCCEEEEEECCCCCCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHE
VEAEAAREMARRSARDEGLLVGISSGATLAAIAQKLPELPAGSRVLGFNYDTGERYLSIE
EHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEE
GFLPAE
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8867384 [H]