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The map label for this gene is hhoB [H]

Identifier: 124265615

GI number: 124265615

Start: 456637

End: 458052

Strand: Reverse

Name: hhoB [H]

Synonym: Mpe_A0422

Alternate gene names: 124265615

Gene position: 458052-456637 (Counterclockwise)

Preceding gene: 124265618

Following gene: 124265614

Centisome position: 11.33

GC content: 72.32

Gene sequence:

>1416_bases
ATGACGCGACCCCGAGCCTGGCGGCAGCGTGCACTCGGGCTGCTGTTCGCGCTGGCGAGCGGCGCCATCGGTGCGCAGAC
CGCCGCCCCCGCCTCCGCTCCCTCCTCCGCCCCGCTGCCCGGGATCGGCGCGCCATCGGTCGCCACCGCGCCGCTGCCCG
TGTCGCCGTCCGCGCAGCGGCTCTACGAGCGCGCGCGCGGCCAGCTGCTGCAGGTGCGCACGCTGCTGAAGGGGCAGGAC
AGCCAGGCCTCGGTCGGCTCGGGTTTCTTCGTCAGCGACGACGGCCTGATCGTCACCAACTACCACGTCGTCAGCCAGGT
GGCGCTGCAGCCCGATCGCTACCGGCTCACCTACACCCGCGTCGACGGCCGCGAGGGCGCGCTGCAGCTGCTGGGCTTCG
ACGCGATCCACGACCTGGCGCTCGTGAAGGCGCTGCCGCCGAACGGCCCGTCTCGCAAGAGCGGCGTCAGCGTGGTCGAC
GCAGCGGGCGAGCCGCTCGCCTTCCGCGCCGCGAACGACGCACTGGCCCAGGGCGAACGCATCTACTCGCTCGGCAACCC
GCTCGACGTCGGCTTCGCGGTGCTGGAAGGCAACTACAACGGGCTCGTCGAGCGCAGCTTCTACCCCAGCATCTTCTTCG
GCGGCGCGCTCAACTCCGGCATGAGCGGCGGGCCCGCGCTCGACGAGGCCGGCCGCGTGGTCGGCGTCAACGTCGCCACA
CGGCGCGACGGCCAACAGGTGAGCTTCCTGGTGCCGGCGCCGTTCGCGCAGGCCCTGGTGGAGCGGGCCCGCGGCGCGGC
GCCGATCACCGCGCCGGTCTATCCGCAGCTCACCGCGCAGCTGCTCGCGCACCAGGAGGCCGTGGTGCAACGCTTCGTCC
AGCAGCCCTGGCGCAGCGCCGGCCACCCGCACTACCTGATCCCCGTGCCACAGGAAGACTTCATGCGCTGCTGGGGCCGC
AGCACGCCGGCGGACACCAAGGGCCTGGAGTTCGAGCGCTCCGACTGCGAGATGGACACGCAGATCTTCGTCAGCGGCAG
CCTGCTCACCGGCTCGCTGGGCGCGCGCCACGAGGCCTACGACGGCCGCAAGCTCGGCTGGCTGCGCTTCACCGAGCGCT
ACAGCGCGAGCTTCCGCAACGAGAGCTTCGGGCGCCGCAACCCGAAGGAATTCACCGCGCCGCAGTGCAGCGAGCGCTTC
GTCGACCGCGACGGCCTGCCGCTGCGCGCAGTGCTGTGCCTGTCGGCCTACAAGCGCCTCGCCGGACTCTACGACGTCAG
CGTGCTGGTCGCCACACTCGACCAGGCCCGCGTCGGCGCGCAGGGCCGCCTCGACGCCCGCGGCGTCAGTTTCGACAACG
CGATGAAACTGGCCTCGCACTACCTGCAGGGCTACGGCGTGAAGGCGGCGCCATGA

Upstream 100 bases:

>100_bases
CCAGGCCCACCACGGCAATCCGCATCGATCGTCCTCCTTGCGCTCACGCGCCCTGAACCCGGGCCATGGTAAGCCGCAGC
CACCTGCCAGAATCGGCGCC

Downstream 100 bases:

>100_bases
GCCGTCTCGGCCTGATCGAGCTGCTCGACCGCGACGGCGCCGTGGCGCACCGCGTGCCGGTGCTGCGGTGGCCGGTCTCG
ATCGGCCGCGCGCTGGACTG

Product: trypsin-like serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTRPRAWRQRALGLLFALASGAIGAQTAAPASAPSSAPLPGIGAPSVATAPLPVSPSAQRLYERARGQLLQVRTLLKGQD
SQASVGSGFFVSDDGLIVTNYHVVSQVALQPDRYRLTYTRVDGREGALQLLGFDAIHDLALVKALPPNGPSRKSGVSVVD
AAGEPLAFRAANDALAQGERIYSLGNPLDVGFAVLEGNYNGLVERSFYPSIFFGGALNSGMSGGPALDEAGRVVGVNVAT
RRDGQQVSFLVPAPFAQALVERARGAAPITAPVYPQLTAQLLAHQEAVVQRFVQQPWRSAGHPHYLIPVPQEDFMRCWGR
STPADTKGLEFERSDCEMDTQIFVSGSLLTGSLGARHEAYDGRKLGWLRFTERYSASFRNESFGRRNPKEFTAPQCSERF
VDRDGLPLRAVLCLSAYKRLAGLYDVSVLVATLDQARVGAQGRLDARGVSFDNAMKLASHYLQGYGVKAAP

Sequences:

>Translated_471_residues
MTRPRAWRQRALGLLFALASGAIGAQTAAPASAPSSAPLPGIGAPSVATAPLPVSPSAQRLYERARGQLLQVRTLLKGQD
SQASVGSGFFVSDDGLIVTNYHVVSQVALQPDRYRLTYTRVDGREGALQLLGFDAIHDLALVKALPPNGPSRKSGVSVVD
AAGEPLAFRAANDALAQGERIYSLGNPLDVGFAVLEGNYNGLVERSFYPSIFFGGALNSGMSGGPALDEAGRVVGVNVAT
RRDGQQVSFLVPAPFAQALVERARGAAPITAPVYPQLTAQLLAHQEAVVQRFVQQPWRSAGHPHYLIPVPQEDFMRCWGR
STPADTKGLEFERSDCEMDTQIFVSGSLLTGSLGARHEAYDGRKLGWLRFTERYSASFRNESFGRRNPKEFTAPQCSERF
VDRDGLPLRAVLCLSAYKRLAGLYDVSVLVATLDQARVGAQGRLDARGVSFDNAMKLASHYLQGYGVKAAP
>Mature_470_residues
TRPRAWRQRALGLLFALASGAIGAQTAAPASAPSSAPLPGIGAPSVATAPLPVSPSAQRLYERARGQLLQVRTLLKGQDS
QASVGSGFFVSDDGLIVTNYHVVSQVALQPDRYRLTYTRVDGREGALQLLGFDAIHDLALVKALPPNGPSRKSGVSVVDA
AGEPLAFRAANDALAQGERIYSLGNPLDVGFAVLEGNYNGLVERSFYPSIFFGGALNSGMSGGPALDEAGRVVGVNVATR
RDGQQVSFLVPAPFAQALVERARGAAPITAPVYPQLTAQLLAHQEAVVQRFVQQPWRSAGHPHYLIPVPQEDFMRCWGRS
TPADTKGLEFERSDCEMDTQIFVSGSLLTGSLGARHEAYDGRKLGWLRFTERYSASFRNESFGRRNPKEFTAPQCSERFV
DRDGLPLRAVLCLSAYKRLAGLYDVSVLVATLDQARVGAQGRLDARGVSFDNAMKLASHYLQGYGVKAAP

Specific function: A putative protease, its function overlaps that of the related putative proteases HtrA and HhoA [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 50583; Mature: 50452

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPRAWRQRALGLLFALASGAIGAQTAAPASAPSSAPLPGIGAPSVATAPLPVSPSAQR
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
LYERARGQLLQVRTLLKGQDSQASVGSGFFVSDDGLIVTNYHVVSQVALQPDRYRLTYTR
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCEEEECHHHHHHHHCCCCCEEEEEEE
VDGREGALQLLGFDAIHDLALVKALPPNGPSRKSGVSVVDAAGEPLAFRAANDALAQGER
ECCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCEEEEECCHHHHCCCC
IYSLGNPLDVGFAVLEGNYNGLVERSFYPSIFFGGALNSGMSGGPALDEAGRVVGVNVAT
EEECCCCCCCCEEEEECCCCCEEECCCCCCEEECCCCCCCCCCCCCHHHCCCEEEEEEEE
RRDGQQVSFLVPAPFAQALVERARGAAPITAPVYPQLTAQLLAHQEAVVQRFVQQPWRSA
CCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GHPHYLIPVPQEDFMRCWGRSTPADTKGLEFERSDCEMDTQIFVSGSLLTGSLGARHEAY
CCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCEEECCCCCCCCCC
DGRKLGWLRFTERYSASFRNESFGRRNPKEFTAPQCSERFVDRDGLPLRAVLCLSAYKRL
CCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHH
AGLYDVSVLVATLDQARVGAQGRLDARGVSFDNAMKLASHYLQGYGVKAAP
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TRPRAWRQRALGLLFALASGAIGAQTAAPASAPSSAPLPGIGAPSVATAPLPVSPSAQR
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
LYERARGQLLQVRTLLKGQDSQASVGSGFFVSDDGLIVTNYHVVSQVALQPDRYRLTYTR
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCEEEECHHHHHHHHCCCCCEEEEEEE
VDGREGALQLLGFDAIHDLALVKALPPNGPSRKSGVSVVDAAGEPLAFRAANDALAQGER
ECCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCEEEEECCHHHHCCCC
IYSLGNPLDVGFAVLEGNYNGLVERSFYPSIFFGGALNSGMSGGPALDEAGRVVGVNVAT
EEECCCCCCCCEEEEECCCCCEEECCCCCCEEECCCCCCCCCCCCCHHHCCCEEEEEEEE
RRDGQQVSFLVPAPFAQALVERARGAAPITAPVYPQLTAQLLAHQEAVVQRFVQQPWRSA
CCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GHPHYLIPVPQEDFMRCWGRSTPADTKGLEFERSDCEMDTQIFVSGSLLTGSLGARHEAY
CCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCEEECCCCCCCCCC
DGRKLGWLRFTERYSASFRNESFGRRNPKEFTAPQCSERFVDRDGLPLRAVLCLSAYKRL
CCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHH
AGLYDVSVLVATLDQARVGAQGRLDARGVSFDNAMKLASHYLQGYGVKAAP
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]